• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4481-4485
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• 2012

Background: Chemotherapy induced leutropenia has been shown to be associated with improved treatment outcomes in selected solid tumors. We studied the association of chemotherapy induced leutropenia with treatment related outcomes in advanced non-small-cell lung cancer. Methods: This is a prospective analysis of patients receiving chemotherapy for advanced NSCLC at the Shandong Cancer Hospital from 2005-07.The chemotherapy included cisplatin $35mg/m^2$, IV on $d_{1,2}$ and vinorelbine $25mg/m^2$ IV on $d_{1,8}$ every 21 days. Patients were stratified into three groups (A) those experiencing grades 0 leucopenia, group (B) grades 1-2 and group (C) grades 3-4. The outcomes studied were response rate (RR), disease control rate (DCR), and time to progression (TTP). Results: 128 patients were studied. The RRs in groups A, B and C were 30.8%, 56.8% and 71.4%, respectively, p=0.010. The DCRs were 61.5%, 83.8% and 92.9%, respectively, p=0.009 and the median TTPs were 150 days (95%CI: 91-209), 189 days (95%CI: 181-197) and 207 days (95%CI: 172-242), p=0.009. The differences in RR and TTP were significant. In patients whose CIL kept on 10 days at least, the TTP was significantly prolonged, p=0.0213, and the same was the case for those experiencing grades 1-2 leucopenia and ECOG 0, p=0.0412. Conclusions: Occurrence of CIL correlated with RR and TTP in patients with advanced NSCLC receiving cisplatin and vinorelbine chemotherapy, especially in patients experiencing grades 1-2 leucopenia and ECOG 0, and the same for those with CIL persisting for 10 days at least. CIL could be a biological measure of drug activity and a marker of efficacy.

• Journal of Information Processing Systems
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• 제15권4호
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• pp.865-889
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• 2019

The need for cyber resilience is increasingly important in our technology-dependent society where computing devices and data have been, and will continue to be, the target of cyber-attackers, particularly advanced persistent threat (APT) and nation-state/sponsored actors. APT and nation-state/sponsored actors tend to be more sophisticated, having access to significantly more resources and time to facilitate their attacks, which in most cases are not financially driven (unlike typical cyber-criminals). For example, such threat actors often utilize a broad range of attack vectors, cyber and/or physical, and constantly evolve their attack tactics. Thus, having up-to-date and detailed information of APT's tactics, techniques, and procedures (TTPs) facilitates the design of effective defense strategies as the focus of this paper. Specifically, we posit the importance of taxonomies in categorizing cyber-attacks. Note, however, that existing information about APT attack campaigns is fragmented across practitioner, government (including intelligence/classified), and academic publications, and existing taxonomies generally have a narrow scope (e.g., to a limited number of APT campaigns). Therefore, in this paper, we leverage the Cyber Kill Chain (CKC) model to "decompose" any complex attack and identify the relevant characteristics of such attacks. We then comprehensively analyze more than 40 APT campaigns disclosed before 2018 to build our taxonomy. Such taxonomy can facilitate incident response and cyber threat hunting by aiding in understanding of the potential attacks to organizations as well as which attacks may surface. In addition, the taxonomy can allow national security and intelligence agencies and businesses to share their analysis of ongoing, sensitive APT campaigns without the need to disclose detailed information about the campaigns. It can also notify future security policies and mitigation strategy formulation.

• 정보보호학회논문지
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• 제32권3호
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• pp.527-545
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• 2022

본 연구에서는 조직화된 공격 주체가 수행하는 APT 공격을 효과적으로 탐지하기 위하여, 공격체인을 구성하여 공격을 탐지하는 시스템을 구축하였다. 공격체인 기반 APT 공격 탐지 시스템은 다양한 호스트 및 네트워크 모니터링 도구에서 생성하는 이벤트를 수집하고 저장하는 '이벤트 수집 및 저장부', 이벤트로부터 MITRE ATT&CK^®에 정의된 공격기술 수준의 단위공격을 탐지하는 '단위공격 탐지부', 단위공격으로 생성된 이벤트로부터 Provenance Graph 기반의 인과관계 분석을 수행하여 공격체인을 구성하는 '공격체인 구성부'로 구성하였다. 시스템을 검증하기 위하여 테스트베드를 구축하고 MITRE ATT&CK Evaluation 프로그램에서 제공하는 모의공격 시나리오를 수행하였다. 실험 결과 모의공격 시나리오에 대해 공격체인이 효과적으로 구성되는 것을 확인하였다. 본 연구에서 구현한 시스템을 이용하면, 공격을 단편적인 부분으로 이해하기보다 공격의 진행 흐름 관점에서 이해하고 대응할 수 있을 것이다.