• Earthquakes and Structures
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• 제18권6호
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• pp.709-718
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• 2020

Fragility curves are useful tools to estimate the damage probability of buildings owing to seismic actions. The purpose of this study is to investigate seismic vulnerability of reinforced concrete (RC) buildings, according to the 2007 and 2018 Turkish Seismic Codes, using fragility curves. For the numerical analyses, typical five- and seven-storey RC buildings were selected and incremental dynamic analyses (IDA) were performed. To complete the IDAs, eleven earthquake acceleration records multiplied by various scaling factors from 0.2g to 0.8g were used. To predict nonlinearity, a distributed hinge model that involves material and geometric nonlinearity of the structural members was used. Damages to confined concrete and reinforcement bar of structural members were obtained by considering the unit deformation demands of the 2007 Turkish Seismic Code (TSC-2007) and the 2018 Turkey Building Earthquake Code (TBEC-2018). Vulnerability evaluation of these buildings was performed using fragility curves based on the results of incremental dynamic analyses. Fragility curves were generated in terms of damage levels occurring in confined concrete and reinforcement bar of structural members with a lognormal distribution assumption. The fragility curves show that the probability of damage occurring is more according to TBEC-2018 than according to TSC-2007 for selected buildings.

• Earthquakes and Structures
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• 제25권4호
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• pp.235-247
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• 2023

Bingöl, a city in eastern Türkiye, is located at a very close distance to the Karlıova Region which is a junction point of the North Anatolian Fault Zone and Eastern Anatolian Fault Zone. By bilateral step over of North Anatolian Fault Zone and Eastern Anatolian Fault Zone each other there occurred NorthWest-SouthEast extended right-lateral and NorthEast-SouthWest extended left-lateral fault zones. In this paper, a typical school building located in Bingöl Çeltiksuyu was selected as the case study. Information on the school building and Bingöl Earthquake (2003) have been given in the paper. This study aimed to determine the fragility curves of the school building according to HAZUS 2022, Turkish Seismic Codes 1998, 2007 and 2018. These codes have been introduced in terms of damage limits. Incremental dynamic analysis is a parametric analysis method that has recently emerged in several different forms to estimate more thoroughly structural performance under seismic loads. Fragility analysis is commonly using to estimate the damage probability of buildings. Incremental Dynamic Analysis have performed, and 1295 Incremental Dynamic Analysis output was evaluated to obtain fragility curves. 20 different ground motion records have been selected with magnitudes between 5.6M and 7.6M. Scaling factors of these ground motions were selected between 0.1g and 2g. Comparison has been made between HAZUS 2022 and Turkish Seismic Codes 1998, 2007 and 2018 in terms of damage states and how they affected fragility curves. TSC 1998 has more conservative strictions along with TSC 2018 than TSC2007 and HAZUS moderate and extensive damage limits.

• Structural Engineering and Mechanics
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• 제53권1호
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• pp.1-16
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• 2015

Due to design codes and regulations and the variety of building plans in Turkey, it is very often seen that band-type windows are left for ventilation and lightening of the basements of buildings which are used for various purposes such as workplaces and storage. Therefore when the necessary support measures cannot be given, short columns are subjected to very high shear forces and so damage occurs. One of the precautions to avoid the damage of short column mechanisms in buildings where band-type windows are in the basement is to strengthen the short columns with fiber reinforced polymer (FRP). In this study, the effect of the FRP retrofitting process of the short columns around band-windowed structures, which are found especially in basement areas, is analyzed in accordance with Turkish Seismic Code 2007 (TSC 2007). Three different models which are bare frame, frame with short columns and retrofitted short columns with FRP, are created and analyzed according to TSC 2007 performance analysis methods to understand the effects of band windows in basements and the effect of FRP retrofitting.

• Journal of Korean Neurosurgical Society
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• 제41권6호
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• pp.397-402
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• 2007

Objective : Balloon cells and dysplastic neurons are histopathological hallmarks of the cortical tubers of tuberous sclerosis complex [TSC] and focal cortical dysplasia [FCD] of the Taylor type. They are believed to be the epileptogenic substrate and cause therapeutic drug resistant epilepsy in man. P-glycoprotein [P-gp] is the product of multidrug resistance gene [MDR1], and it maintains intracellular drug concentration at a relatively low level. The authors investigated expression of P-gp in balloon cells and dysplastic neurons of cortical tubers in patients with TSC. Methods : An immunohistochemical study using the primary antibody for P-gp, as an indicative of drug resistance, was performed in the cortical tuber tissues in two patients of surgical resection for epilepsy and six autopsy cases. Results : Balloon cells of each lesion showed different intensity and number in P-gp immunopositivity. P-gp immunopositivity in balloon cells were 28.2%, and dysplastic neurons were 22.7%. These immunoreactivities were more prominent in balloon cells distributed in the subpial region than deeper region of the cortical tubers. Capillary endothelial cells within the cortical tubers also showed P-gp immunopositivity. Conclusion : In this study, the drug resistance protein P-glycoprotein in balloon cells and dysplastic neurons might explain medically refractory epilepsy in TSC.

• Clinical and Experimental Pediatrics
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• 제50권2호
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• pp.178-181
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• 2007

목 적: 결절성 경화증은 신경 피부 증후군의 대표적인 질환으로, 중추 신경계 외에도 신장, 심장 등 여러 장기를 침범한다. 신장에서 발견되는 종양은 혈관근지방종, 신 낭종 및 신세포암 등이 있으며, 혈관근지방종의 합병증은 결절성 경화증 환자의 예후에 중요한 인자이다. 저자는 결절성 경화증 환자들을 다년간 추적 관찰하며 다양한 임상 양상 중, 신장에서의 발현과 그 예후를 분석하여 보고자 하였다. 방 법: 2001년 3월부터 2005년 10월까지 세브란스 병원 소아과에 입원하여 결절성 경화증으로 진단 및 치료받은 19명의 환자를 대상으로 후향적 의무기록 고찰을 통해 분석하였다. 모든 환자들은 복부 초음파검사 또는 복부 컴퓨터 단층 촬영검사 등의 신장학적인 검사를 주기적으로 반복 시행하였다. 결 과: 총 19명중 남자 13명, 여자 6명으로 성비는 2.2:1이었다. 총 11례(57.9%) 의 환자에서 신장의 이상이 발견되었으며, 혈관근지방종 9례(47.4%), 단순 신 낭종 1례(5.3%), 수신증 1례(5.3%)가 있었다. 혈관근지방종으로 진단될 당시의 평균 연령은 8.7세(3-19세)였으며, 출혈이 동반된 환자는 없었다. 2례의 환자가 신동맥 색전술을 시행받았으며, 1례의 환자는 신절제술 후 만성 신부전증으로 이행되었다. 결 론: 결절성 경화증 환자들에서의 신장을 비롯한 타 장기들에서의 발현을 염두에 두어야 하며, 복부 초음파 검사 혹은 복부 컴퓨터 단층 촬영검사를 포함한 신장학적인 검사는 다년간 지속적으로 추적 관찰해야 한다.

• Asian-Australasian Journal of Animal Sciences
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• 제20권5호
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• pp.701-705
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• 2007

Seven rc mutant and seven normal male birds (Rhode Island Red suie, RIR) were used in this study to determine the effects of rc mutation on semen characteristics, testosterone profile and spermatogenic tissues. All birds were randomly selected at week 12 of age and housed in individual cages and were fed and watered ad libitum. The birds were exposed to a 14L:10D light cycle during experiment. Semen were collected at weeks 22 to 23 from each bird twice a week and evaluated for semen volume (SV), sperm concentration (SC), total sperm count (TSC), percent of sperm motility (%SM), dead sperm (%DS), and sperm metabolic activity (SMA). To determine the testosterone concentration (TC) in plasma, blood was collected at weeks 12, 16 and 18. Testicular tissue were collected, processed and evaluated for semineferous tubule diameter (STD), round spermatid number (RSN), percent elongated sperm (%ES) and semineferous tubules length (STL). Body weight (BW), comb weight (CW) and testes weight (TW) were weighted at the end of experiment (week 23). The SV, TSC and %SM were significantly higher in normal birds but the %DS was higher in blind birds (p<0.05). The SC did not differ significantly between the two groups but its value was higher in normal birds. The sperm metabolic activity in the first h of collection did not differ significantly between the two groups but after 24 h, the level of SMA in normal group was significantly higher (p<0.05). The level of TC did not differ significantly between the two genotype groups but normal birds had higher TC in all collections except the last one. The STD, RSN, %ES and STL in normal birds were higher when compared to blind birds but the differences were insignificant except for ES percent. The BW, CW and TW between the two groups did not differ significantly but the weights were higher in normal group compared to blind birds. Statistical analysis of semen characteristics, testosterone profile and histological factors were indicated detrimental effects of rc mutation in prepubertal RIR blind male birds due to lack of light.

• 한국식품과학회지
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• 제39권4호
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• pp.386-389
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• 2007

원적외선 조사가 상황버섯과 영지버섯의 항산화능에 미치는 영향을 조사하기 위하여 30, 60, 90 그리고 120분 간격으로 원적외선을 조사를 한 후, 물 추출물을 제조하여 실험에 이용하였다. 상황버섯 추출물은 원적외선 처리시간에 비례하여 갈변도, 총당, 총페놀, 라디컬소거능 및 환원력이 증가하였으며, 120분 처리 후 갈변도는 2.1 배, 총당은 2.6배, 총페놀은 2.2배 , 라디컬 소거능은 2.2배, 환원력은 1.6 배 증가하였다. 또한, 원적외선 120분 조사에 의해 영지버섯 추출물의 갈변도, 총당, 총페놀 및 라디컬소거능도 각각 1.7배, 2.0배, 2.3배, 1.3배 증가하였다. 그러나 환원력은 유의적인 차이를 보이지 않았으며, 전체적인 효과는 상황버섯에 비해 다소 낮았다. 이상의 결과 원적외선 조사가 상황버섯과 영지 버섯의 당류 및 페놀화합물의 추출을 촉진하여 항산화능을 향상시킴을 확인하였다.

• Steel and Composite Structures
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• 제23권5호
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• pp.557-570
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• 2017

In this study, the seismic performance levels of four bridges are determined using finite element modeling based on ambient vibration testing. The study includes finite element modeling, analytical modal analyses, ambient vibration testing and earthquake analyses of the bridges. For the purpose, four prestressed precast I beam bridges that were constructed for the Ankara-Sivas high speed railway line are selected for analytical and experimental studies. In the study, firstly a literature review related to the dynamic behavior of bridges especially precast beam bridges is given and then the formulation part related to ambient vibration testing and structural performance according to Turkish Seismic Code (2007) is presented. Next, 3D finite element models of the bridge are described and modeled using LARSA 4D software, and analytical dynamic characteristics are obtained. Then ambient vibration testing conducted on the bridges under natural excitations and experimental natural frequencies are estimated. Lastly, time history analyses of the bridges under the 1999 Kocaeli, 1992 Erzincan, and 1999 Duzce Earthquakes are performed and seismic performance levels according to TSC2007 are determined. The results show that the damage on the bridges is all under the minimum damage limit which is in the minimum damage region under all three earthquakes.

• Food Science and Biotechnology
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• 제16권3호
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• pp.457-462
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• 2007

Histone acetyltransferase (HAT) is a family of enzymes that regulate histone acetylation. Dysfunction of HAT plays a critical role in the development of cancer. Here we have screened the various plant extracts to find out the potent HAT inhibitors. The bellflower (Platycodon grandiflorum) root have exhibited approximately 30% of the inhibitory effects on HAT activity, especially p300 and CBP (CREB-binding protein) at the concentration of $100\;{\mu}g/mL$. The cell viability was decreased approximately 52% in LNCaP cell for 48 hr incubation. Furthermore, mRNA level of 3 androgen receptor target genes, PSA, NKX3.1, and TSC22 were decreased with bellflower root extract treatment ($100\;{\mu}g/mL$) in the presence of androgen. In ChIP assay, the acetylation of histone H3 and H4 in PSA promoter region was dramatically repressed by bellflower root treatment, but not TR target gene, Dl. Therefore, the potent HAT inhibitory effect of bellflower root led to the decreased transcription of AR target genes and prostate cancer cell growth with the repression of histone hyperacetylation.

• Structural Engineering and Mechanics
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• 제59권4호
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• pp.719-737
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• 2016

The present study investigated the earthquake behavior of R/C structures considering the vertical earthquake motion with the help of a comparative study. For this aim, the linear time-history analyses of a high-rise R/C structure designed according to TSC-2007 requirements were conducted including and excluding the vertical earthquake motion. Earthquake records used in the analyses were selected based on the ratio of vertical peak acceleration to horizontal peak acceleration (V/H). The frequency-domain analyses of the earthquake records were also performed to compare the dominant frequency of the records with that of the structure. Based on the results obtained from the time-history analyses under the earthquake loading with (H+V) and without the vertical earthquake motion (H), the value of the overturning moment and the top-story vertical displacement were found to relatively increase when considering the vertical earthquake motion. The base shear force was also affected by this motion; however, its increase was lower compared to the overturning moment and the top-story vertical displacement. The other two parameters, the top-story lateral displacement and the top-story rotation angle, barely changed under H and H+V loading cases. Modal damping ratios and their variations in horizontal and vertical directions were also estimated using response acceleration records. No significant change in the horizontal damping ratio was observed whereas the vertical modal damping ratio noticeably increased under H+V loading. The results obtained from this study indicate that the desired structural earthquake performance cannot be provided under H+V loading due to the excessive increase in the overturning moment, and that the vertical damping ratio should be estimated considering the vertical earthquake motion.