• Earthquakes and Structures
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• v.18 no.6
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• pp.709-718
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• 2020

Fragility curves are useful tools to estimate the damage probability of buildings owing to seismic actions. The purpose of this study is to investigate seismic vulnerability of reinforced concrete (RC) buildings, according to the 2007 and 2018 Turkish Seismic Codes, using fragility curves. For the numerical analyses, typical five- and seven-storey RC buildings were selected and incremental dynamic analyses (IDA) were performed. To complete the IDAs, eleven earthquake acceleration records multiplied by various scaling factors from 0.2g to 0.8g were used. To predict nonlinearity, a distributed hinge model that involves material and geometric nonlinearity of the structural members was used. Damages to confined concrete and reinforcement bar of structural members were obtained by considering the unit deformation demands of the 2007 Turkish Seismic Code (TSC-2007) and the 2018 Turkey Building Earthquake Code (TBEC-2018). Vulnerability evaluation of these buildings was performed using fragility curves based on the results of incremental dynamic analyses. Fragility curves were generated in terms of damage levels occurring in confined concrete and reinforcement bar of structural members with a lognormal distribution assumption. The fragility curves show that the probability of damage occurring is more according to TBEC-2018 than according to TSC-2007 for selected buildings.

• Earthquakes and Structures
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• v.25 no.4
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• pp.235-247
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• 2023

Bingöl, a city in eastern Türkiye, is located at a very close distance to the Karlıova Region which is a junction point of the North Anatolian Fault Zone and Eastern Anatolian Fault Zone. By bilateral step over of North Anatolian Fault Zone and Eastern Anatolian Fault Zone each other there occurred NorthWest-SouthEast extended right-lateral and NorthEast-SouthWest extended left-lateral fault zones. In this paper, a typical school building located in Bingöl Çeltiksuyu was selected as the case study. Information on the school building and Bingöl Earthquake (2003) have been given in the paper. This study aimed to determine the fragility curves of the school building according to HAZUS 2022, Turkish Seismic Codes 1998, 2007 and 2018. These codes have been introduced in terms of damage limits. Incremental dynamic analysis is a parametric analysis method that has recently emerged in several different forms to estimate more thoroughly structural performance under seismic loads. Fragility analysis is commonly using to estimate the damage probability of buildings. Incremental Dynamic Analysis have performed, and 1295 Incremental Dynamic Analysis output was evaluated to obtain fragility curves. 20 different ground motion records have been selected with magnitudes between 5.6M and 7.6M. Scaling factors of these ground motions were selected between 0.1g and 2g. Comparison has been made between HAZUS 2022 and Turkish Seismic Codes 1998, 2007 and 2018 in terms of damage states and how they affected fragility curves. TSC 1998 has more conservative strictions along with TSC 2018 than TSC2007 and HAZUS moderate and extensive damage limits.

• Structural Engineering and Mechanics
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• v.53 no.1
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• pp.1-16
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• 2015

Due to design codes and regulations and the variety of building plans in Turkey, it is very often seen that band-type windows are left for ventilation and lightening of the basements of buildings which are used for various purposes such as workplaces and storage. Therefore when the necessary support measures cannot be given, short columns are subjected to very high shear forces and so damage occurs. One of the precautions to avoid the damage of short column mechanisms in buildings where band-type windows are in the basement is to strengthen the short columns with fiber reinforced polymer (FRP). In this study, the effect of the FRP retrofitting process of the short columns around band-windowed structures, which are found especially in basement areas, is analyzed in accordance with Turkish Seismic Code 2007 (TSC 2007). Three different models which are bare frame, frame with short columns and retrofitted short columns with FRP, are created and analyzed according to TSC 2007 performance analysis methods to understand the effects of band windows in basements and the effect of FRP retrofitting.

• Journal of Korean Neurosurgical Society
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• v.41 no.6
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• pp.397-402
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• 2007

Objective : Balloon cells and dysplastic neurons are histopathological hallmarks of the cortical tubers of tuberous sclerosis complex [TSC] and focal cortical dysplasia [FCD] of the Taylor type. They are believed to be the epileptogenic substrate and cause therapeutic drug resistant epilepsy in man. P-glycoprotein [P-gp] is the product of multidrug resistance gene [MDR1], and it maintains intracellular drug concentration at a relatively low level. The authors investigated expression of P-gp in balloon cells and dysplastic neurons of cortical tubers in patients with TSC. Methods : An immunohistochemical study using the primary antibody for P-gp, as an indicative of drug resistance, was performed in the cortical tuber tissues in two patients of surgical resection for epilepsy and six autopsy cases. Results : Balloon cells of each lesion showed different intensity and number in P-gp immunopositivity. P-gp immunopositivity in balloon cells were 28.2%, and dysplastic neurons were 22.7%. These immunoreactivities were more prominent in balloon cells distributed in the subpial region than deeper region of the cortical tubers. Capillary endothelial cells within the cortical tubers also showed P-gp immunopositivity. Conclusion : In this study, the drug resistance protein P-glycoprotein in balloon cells and dysplastic neurons might explain medically refractory epilepsy in TSC.

• Clinical and Experimental Pediatrics
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• v.50 no.2
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• pp.178-181
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• 2007

Purpose : The renal manifestations of tuberous sclerosis complex (TSC) are remarkably diverse, including polycystic kidney disease, simple renal cysts, renal cell carcinomas, and angiomyolipomas. All of these occur in children as well as adults in TSC. Angiomyolipomas, which can cause spontaneous life-threatening hemorrhages, are by far the most prevalent and the greatest source of morbidity. Here, we will address our experience, adding to the literature on pediatric patients with TSC requiring evaluation and treatment for renal manifestations. Methods : A retrospective analysis was made on 19 patients in whom TSC was diagnosed between May 2001 and Oct. 2005 at Severance Hospital. All patients had clinical diagnoses of TSC as defined by the 1998 tuberous sclerosis complex consensus conference. Results : The patients consisted of 13 boys and 6 girls with a mean age of 7.3 years (range 1 to 22). The renal disease associated with TSC included angiomyolipoma in nine patients (47.4 percent), renal simple cyst in one (5.3 percent), hydronephrosis in one (5.3 percent) patient. Eight patients (42.1 percent) presented with normal kidney contours at abdominal ultrasonography. One patient underwent renal replacement therapy due to chronic renal insufficiency after nephrectomy. Hemorrhage from angiomyolipoma was not detected. Conclusion : In our review of 19 cases of TSC, renal manifestations are reported in 57.9 percent of patients. Asymptomatic angiomyolipoma associated with TSC grow gradually, although severe hemorrhages are rare. So patients with TSC should be followed up with serial computerized tomography or abdominal ultrasonography. And also, renal function should be monitored conservatively.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.5
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• pp.701-705
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• 2007

Seven rc mutant and seven normal male birds (Rhode Island Red suie, RIR) were used in this study to determine the effects of rc mutation on semen characteristics, testosterone profile and spermatogenic tissues. All birds were randomly selected at week 12 of age and housed in individual cages and were fed and watered ad libitum. The birds were exposed to a 14L:10D light cycle during experiment. Semen were collected at weeks 22 to 23 from each bird twice a week and evaluated for semen volume (SV), sperm concentration (SC), total sperm count (TSC), percent of sperm motility (%SM), dead sperm (%DS), and sperm metabolic activity (SMA). To determine the testosterone concentration (TC) in plasma, blood was collected at weeks 12, 16 and 18. Testicular tissue were collected, processed and evaluated for semineferous tubule diameter (STD), round spermatid number (RSN), percent elongated sperm (%ES) and semineferous tubules length (STL). Body weight (BW), comb weight (CW) and testes weight (TW) were weighted at the end of experiment (week 23). The SV, TSC and %SM were significantly higher in normal birds but the %DS was higher in blind birds (p<0.05). The SC did not differ significantly between the two groups but its value was higher in normal birds. The sperm metabolic activity in the first h of collection did not differ significantly between the two groups but after 24 h, the level of SMA in normal group was significantly higher (p<0.05). The level of TC did not differ significantly between the two genotype groups but normal birds had higher TC in all collections except the last one. The STD, RSN, %ES and STL in normal birds were higher when compared to blind birds but the differences were insignificant except for ES percent. The BW, CW and TW between the two groups did not differ significantly but the weights were higher in normal group compared to blind birds. Statistical analysis of semen characteristics, testosterone profile and histological factors were indicated detrimental effects of rc mutation in prepubertal RIR blind male birds due to lack of light.

• Korean Journal of Food Science and Technology
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• v.39 no.4
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• pp.386-389
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• 2007

The antioxidant activities of Phellinus igniarius (PI) and Ganoderma lucidum (GL) extracts were evaluated after far-infrared (FIR) irradiation. PI and GL were irradiated at $120^{\circ}C$ for 30, 60, 90 and 120 min with a FIR heater (2-14 ${\mu}m$), and then extracted by distilled water for 1 hr. Total sugar contents (TSC), total phenolic contents (TPC), radical scavenging ability (RSA), and reducing power (RP) were significantly increased by FIR irradiation. When PI was irradiated for 120 min, the TSC, TPC, RSA, and RP values of the PI extracts increased from 10.1 to 25.9 mg/g, 6.1 to 13.4 mg/g, 23.8 to 51.5%, and 0.222 to 0.363, respectively, compared to the untreated controls. The GL extracts, under the same conditions ($120^{\circ}C$ for 120 min), also increased in TSC, TPC, RSA, and RP from 11.1 to 22.6 mg/g, 2.5 to 5.8 mg/g, 14.5 to 18.6%, and 0.271 to 0.296, respectively. These results indicate that appropriate FIR irradiation of PI and GL could enhance the antioxidant activities of their extracts by increasing amounts of phenolic and sugar compounds.

• Steel and Composite Structures
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• v.23 no.5
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• pp.557-570
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• 2017

In this study, the seismic performance levels of four bridges are determined using finite element modeling based on ambient vibration testing. The study includes finite element modeling, analytical modal analyses, ambient vibration testing and earthquake analyses of the bridges. For the purpose, four prestressed precast I beam bridges that were constructed for the Ankara-Sivas high speed railway line are selected for analytical and experimental studies. In the study, firstly a literature review related to the dynamic behavior of bridges especially precast beam bridges is given and then the formulation part related to ambient vibration testing and structural performance according to Turkish Seismic Code (2007) is presented. Next, 3D finite element models of the bridge are described and modeled using LARSA 4D software, and analytical dynamic characteristics are obtained. Then ambient vibration testing conducted on the bridges under natural excitations and experimental natural frequencies are estimated. Lastly, time history analyses of the bridges under the 1999 Kocaeli, 1992 Erzincan, and 1999 Duzce Earthquakes are performed and seismic performance levels according to TSC2007 are determined. The results show that the damage on the bridges is all under the minimum damage limit which is in the minimum damage region under all three earthquakes.

• Food Science and Biotechnology
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• v.16 no.3
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• pp.457-462
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• 2007

Histone acetyltransferase (HAT) is a family of enzymes that regulate histone acetylation. Dysfunction of HAT plays a critical role in the development of cancer. Here we have screened the various plant extracts to find out the potent HAT inhibitors. The bellflower (Platycodon grandiflorum) root have exhibited approximately 30% of the inhibitory effects on HAT activity, especially p300 and CBP (CREB-binding protein) at the concentration of $100\;{\mu}g/mL$. The cell viability was decreased approximately 52% in LNCaP cell for 48 hr incubation. Furthermore, mRNA level of 3 androgen receptor target genes, PSA, NKX3.1, and TSC22 were decreased with bellflower root extract treatment ($100\;{\mu}g/mL$) in the presence of androgen. In ChIP assay, the acetylation of histone H3 and H4 in PSA promoter region was dramatically repressed by bellflower root treatment, but not TR target gene, Dl. Therefore, the potent HAT inhibitory effect of bellflower root led to the decreased transcription of AR target genes and prostate cancer cell growth with the repression of histone hyperacetylation.

• Structural Engineering and Mechanics
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• v.59 no.4
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• pp.719-737
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• 2016

The present study investigated the earthquake behavior of R/C structures considering the vertical earthquake motion with the help of a comparative study. For this aim, the linear time-history analyses of a high-rise R/C structure designed according to TSC-2007 requirements were conducted including and excluding the vertical earthquake motion. Earthquake records used in the analyses were selected based on the ratio of vertical peak acceleration to horizontal peak acceleration (V/H). The frequency-domain analyses of the earthquake records were also performed to compare the dominant frequency of the records with that of the structure. Based on the results obtained from the time-history analyses under the earthquake loading with (H+V) and without the vertical earthquake motion (H), the value of the overturning moment and the top-story vertical displacement were found to relatively increase when considering the vertical earthquake motion. The base shear force was also affected by this motion; however, its increase was lower compared to the overturning moment and the top-story vertical displacement. The other two parameters, the top-story lateral displacement and the top-story rotation angle, barely changed under H and H+V loading cases. Modal damping ratios and their variations in horizontal and vertical directions were also estimated using response acceleration records. No significant change in the horizontal damping ratio was observed whereas the vertical modal damping ratio noticeably increased under H+V loading. The results obtained from this study indicate that the desired structural earthquake performance cannot be provided under H+V loading due to the excessive increase in the overturning moment, and that the vertical damping ratio should be estimated considering the vertical earthquake motion.