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The Role of Lymphocyte Compartment and Cytokine in Coal Workers Pneumoconiosis (진폐증환자에서의 임파구 분획 및 싸이토카인의 역할)

  • Lee, Jung-Yeon;Yoo, Kwang-Ha;Ahn, Hae-Ryon;Kim, Sung-Ryul;Lee, Hae-Woon;Ahn, Cheol-Min;Kim, Hyung-Joong
    • Tuberculosis and Respiratory Diseases
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    • v.52 no.3
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    • pp.241-250
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    • 2002
  • Background : Coal-worker's pneumoconiosis(CWP) is characterized by a chronic inflammatory lung reaction associated with macrophage accumulation in the alveolar spaces. CWP is usually divided into two stage : simple pneumoconiosis(SP) where there are a limited number of fibrotic lesions remain limited, with radiological opacities smaller than 1cm and progressive massive fibrosis(PMF), which is characterized by the development of a perifocal extensive fibrotic response of the lung and severe alterations in pulmonary function. In this study, the lymphocyte compartment and cytokine were evaluated by measuring the serum levels in the control, SP and PMF groups. Materials and Methods : The coal workers selected for this study were employees(patients?) of the Tae-Baek and Dong-Hae hospital. All were men, 45-76 years old and the mean duration of their exposure to coal dust was 23.2 years in the lymphocyte compartment and 24.3 years in the cytokine checked group. According to X-ray examination results, the patients were classified into either one of the SP, PMF categories. The normal controls examined were 26-70 years old men. The serum cytokine levels were estimated by using an end point enzyme immunoassay technique. Results : T lymphocyte, helper and suppressor T cells were highly related to pneumoconiosis in this study. A statistically significant decrease in the number of suppressor T lymphocytes was observed in the simple pneumoconiosis patients and at the same time, there was an increase in the lymphocyte index. Howevere, there was no statistically difference in the serum cytokines levels among the SP, PMF and control groups. Conclusion : T lymphocyte, helper T, and suppressor T cells may be highly related to the development of CWP compared to the control group particularly in the early stage of pneumoconiosis. The changes observed in the immunological system in patients with pneumoconiosis may lie at the bottom of the pathogenesis of fibrosis. Further study is needed to evaluate the lymphocyte compartment as a marker for pneumoconiosis development in the early stage.

Roll Force Prediction of High-Strength Steel Using Foil Rolling Theory in Cold Skin Pass Rolling (고강도강의 냉간 조질 압연 시 호일 압연이론을 이용한 압연하중의 예측)

  • Song, Gil Ho;Jung, Jae Chook
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.37 no.2
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    • pp.271-277
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    • 2013
  • Skin pass rolling is a very important process for applying a certain elongation to a strip in the cold rolling and annealing processes, which play an important role in preventing the stretching of the yield point when the material is processed. The exact prediction of the rolling force is essential for obtaining a given elongation with the steel grade and strip size. Unlike hot rolling and cold rolling, skin pass rolling is used to apply an elongation of within 2% to the strip. Under a small reduction, it is difficult to predict the rolling force because the elastic deformation behavior of the rolls is complicated and a model for predicting the rolling force has not yet been established. Nevertheless, the exact prediction of the rolling force in skin pass rolling has gained increasing importance in recent times with the rapid development of high-strength steels for use in automobiles. In this study, the possibility of predicting the rolling force in skin pass rolling for producing various steel grades was examined using foil rolling theory, which is known to have similar elastic deformation behavior of rolls in the roll bite. It was found that a noncircular arc model is more accurate than a circular model in predicting the roll force of high-strength steel below TS 980 MPa in skin pass rolling.

Characteristics of Pollutant Washed-off from Highways with Storm Runoff Duration (아스팔트 포장 고속도로의 강우 지속시간별 오염물질 유출 경향)

  • Kim Lee-Hyun;Lee Eun-Ju;Ko Seok-Oh;Kang Hee-Man
    • International Journal of Highway Engineering
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    • v.8 no.1 s.27
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    • pp.99-106
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    • 2006
  • During the dry periods, many types of pollutant are accumulating on the paved surface by vehicle activities. Particularly, the highways are stormwater intensive landuses because of high imperviousness and high pollutant mass emissions from vehicles. The accumulated pollutants in highways are washed-off during a rainfall event and are highly contributing on water quality of receiving water bodies. The stormwater runoff from the highways are containing various pollutants such as metals, oil & grease and toxic chemicals originated from vehicles. Therefore, this research is performed to find pollutant characteristics in the magnitude of statistical pollutant concentrations during storm periods. During the monitoring periods, the first-flush phenomenon is visibly occurred on most storm events, which is confirmed from hydro- and pollute-graphs. The 95% confidence intervals of washed-off pollutant concentration are ranged to 154.7-257.1 mg/L for 755,138.9-197.6 mg/L for COD, 3.5-6.4 mg/L for oil & grease, 6.3-9.2 mg/L for TN and 2.3-3.31 mg/L for TP. The first flush effect is mostly occurred within initial 30 min of storm duration.

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Effects of Hydraulic Rentention Time on Anaerobic Digestion of the Mixture of Nightsoil and Septic Tank Sludge (소화조(消化槽)의 수리학적(水理學的) 체류시간(滯留時間)이 분뇨(糞尿)와 정화조(淨化槽)슬러지 혼합물(混合物)의 혐기성소화(嫌氣性消化)에 미치는 영향(影響))

  • Lee, Kwang Ho;Yang, Sang Hyun
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.3 no.3
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    • pp.117-127
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    • 1983
  • An experimental research was performed employing the two stage anaerobic digestion of the mixture of the nightsoil and septic tank sludge to determine the effects of various hydraulic retention time of the digestion on chemical characteristics and treatment effeciency, thus determining the proper retention time. Results of the research are as follows, 1. Volatile-acid decreased as HRT increased. 2. Alklinity and ammonia-N tended to increase as HRT increased as did pH values, however, were observed to be constant at higher HRT values than 15 days. 3. The removal efficiencies of TBOD, TCOD and VS increased as HRT increased. 4. The removal efficiency of volatile solid decreased as VS loading increased. 5. It was observed that the rates of gas production were: 0.33 with HRT of 5 days, 0.58 with HRT of 15 days and $0.57m^3/kg$ VS fed/day with HRT of 25 days respectively. It is believed that the highest rate of gas production was at HRT of 15 days. 6. The sludge settling experiment showed that the minimum settling time required to ensure the desired underflow concentraton was estimated to be 8.6 days.

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Folate-Related Nutrients, Genetic Polymorphisms, and Colorectal Cancer Risk: the Fukuoka Colorectal Cancer Study

  • Morita, Makiko;Yin, Guang;Yoshimitsu, Shin-Ichiro;Ohnaka, Keizo;Toyomura, Kengo;Kono, Suminori;Ueki, Takashi;Tanaka, Masao;Kakeji, Yoshihiro;Maehara, Yoshihiko;Okamura, Takeshi;Ikejiri, Koji;Futami, Kitaroh;Maekawa, Takafumi;Yasunami, Yohichi;Takenaka, Kenji;Ichimiya, Hitoshi;Terasaka, Reiji
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.6249-6256
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    • 2013
  • One-carbon metabolism plays an important role in colorectal carcinogenesis. Meta-analyses have suggested protective associations of folate and vitamin $B_6$ intakes with colorectal cancer primarily based on studies in Caucasians, and genetic polymorphisms pertaining to the folate metabolism have been a matter of interest. Less investigated are the roles of methionine synthase (MTR) and thymidylate synthetase (TS) polymorphisms in colorectal carcinogenesis. In a study of 816 cases and 815 community controls in Japan, we investigated associations of dietary intakes of folate, methionine, vitamin $B_2$, vitamin $B_6$, and vitamin $B_{12}$ with colorectal cancer risk. The associations with MTR 2756A>G, MTRR 66A>G, and TSER repeat polymorphism were examined in 685 cases and 778 controls. Methionine and vitamin $B_{12}$ intakes were inversely associated with colorectal cancer risk, but the associations were totally confounded by dietary calcium and n-3 fatty acids. The other nutrients showed no association with the risk even without adjustment for calcium and n-3 fatty acids. The TSER 2R allele was dose-dependently associated with an increased risk. The MTR and MTRR polymorphisms were unrelated to colorectal cancer risk. There was no measurable gene-gene or gene-nutrient interaction, but increased risk associated with the TSER 2R allele seemed to be confined to individuals with high folate status. This study does not support protective associations for folate and vitamin $B_6$. The TSER 2R allele may confer an increased risk of colorectal cancer. The role of the TSER polymorphism in colorectal carcinogenesis may differ by ethnicity.

Fine Structure of the Antennal Sensilla of the Millipede Oxidus gracilis(Polydesmida: Paradoxomatidae) (고운까막노래기(Oxidus gracilis) 안테나 감각모의 미세구조)

  • Chung, Kyung-Hwun;Moon, Myung-Jin
    • Applied Microscopy
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    • v.37 no.4
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    • pp.231-238
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    • 2007
  • Although the biological significance of the antennal sensillae to millipedes are widely understood, the structure and function of the antennal sensillae are still not clear and more precise analysis is required. Thus, this study initiate to reveal the fine structural characteristics of various sensory receptors on the antennae of millipede Oxidus gracilis were observed with field emission scanning electron microscopy(FESEM). The antennae generally include eight segments, called articles. On the surface of the antennae, there are a variety of sensory receptors which include olfactory and mechanical receptors. We could identify four different types of antennal sensillae in O. gracilis as follows: apical cone sensilla, trichoid sensilla, chatiform sensilla and basiconic sensilla. The most prominent is four large spital cone sensillae on distal tip of the 8th article. Both of trichoid and chaetiform sensillae are abundantly observed at the most of antennal articles. These sharply pointed structures are inclined and slightly curved toward the apex of the sensilla. The basiconic sensilla are further divided into three subtypes: large basiconic sensilla($Bs_1$), small basiconic sensilla($Bs_2$) and spiniform sensilla($Bs_3$). The $Bs_1$ is located at the 5th and 6th articles, while the $Bs_2\;and\;Bs_3 can be seen at the 5th and 7th articles, respectively.

Production of Triterpene Glycosides from Whole Plant Cultures of Centella asiatica (L.) Urban (병풀 (Centella asiatica L. Urban) 식물체 배양을 이용한 Triterpene Glycoside 생산)

  • Kim, Ok-Tae;Kim, Min-Young;Park, Yoon-Jung;Hong, Min-Hee;An, Jun-Chul;Oh, Man-Ho;Hwang, Baik
    • Journal of Plant Biotechnology
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    • v.29 no.4
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    • pp.281-285
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    • 2002
  • Whole plant cultures of Centella asiatica (L.) Urban in vitro were established and the effects of basal media, some macro elements and sucrose concentration on productivity of triterpene glycosides (madecassoside and asiaticoside: M$\varepsilon$A) were investigated. Among the media (MS, B5, RCM) tested, MS and 0.5 RCM medium were the best for plant growth and M$\varepsilon$A production, respectively. However, taking into account the M$\varepsilon$A productivity, B5 medium was superior (M$\varepsilon$A: 14.28 mg/g dry wt.). Major macronutrients of B5 medium adjusted with the concentration of 25 mM KNO$_3$,1 mM NaH$_2$PO$_4$, 1 mM CaCl$_2$ and 1~10 mM MgSO$_4$, caused elevated or optimized levels of M$\varepsilon$A. On sucrose concentration, the highest yields of M$\varepsilon$A were obtained from 6% sucrose.

Network-Adaptive HD Video Streaming with Cross-Layered WLAM Channel Monitoring (Cross Layer 기반의 무선랜 채널 모니터링을 적용한 네트워크 적응형 HD 비디오 스트리밍)

  • Park Sang-Hoon;Yoon Ha-Young;Kim Jong-Won;Cho Chang-Sik
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.31 no.4A
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    • pp.421-430
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    • 2006
  • In this paper, we propose a practical implementation of network-adaptive HD(high definition) MPEG-2 video streaming with a cross-layered channel monitoring(CLM) over the IEEE 802.11a WLAN(wireless local area network). For wireless channel monitoring, AP(access point) periodically measures the MAC(medium access control) layer transmission information and sends the monitoring information to a streaming server. This makes that the streaming server reacts more quickly as well as efficiently to the fluctuated wireless channel than that of the end-to-end monitoring(E2EM) scheme for the video adaptation. The streaming sewer dynamically performs the priority-based frame dropping to adjust the video sending rate according to the measured wireless channel condition. For this purpose, our streaming system nicely provides frame-based prioritized packetization by using a real-time stream parsing module. Various evaluation results over an IEEE 802.11a WLAM testbed are provided to verify the intended QoS adaptation capability The experimental results show that the proposed system can effectively mitigate the quality degradation of video streaming caused by the fluctuations of time-varying wireless channel condition.

Programmed APTES and OTS Patterns for the Multi-Channel FET of Single-Walled Carbon Nanotubes (SWCNT 다중채널 FET용 표면 프로그램된 APTES와 OTS 패턴을 이용한 공정에 대한 연구)

  • Kim, Byung-Cheul;Kim, Joo-Yeon;An, Ho-Myoung
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.8 no.1
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    • pp.37-44
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    • 2015
  • In this paper, we have investigated a selective assembly method of single-walled carbon nanotubes (SWCNTs) on a silicon substrate using only photolithographic process and then proposed a fabrication method of field effect transistors (FETs) using SWCNT-based patterns. The aminopropylethoxysilane (APTES) patterns, which are formed for positively charged surface molecular patterns, are utilized to assemble and align millions of SWCNTs and we can more effectively assemble on a silicon (Si) surface using this method than assembly processes using only the 1-octadecyltrichlorosilane (OTS). We investigated a selective assembly method of SWCNTs on a Si surface using surface-programmed APTES and OTS patterns and then a fabrication method of FETs. photoresist(PR) patterns were made using photolithographic process on the silicon dioxide (SiO2) grown Si substrate and the substrate was placed in the OTS solution (1:500 v/v in anhydrous hexane) to cover the bare SiO2 regions. After removing the PR, the substrate was placed in APTES solution to backfill the remaining SiO2 area. This surface-programmed substrate was placed into a SWCNT solution dispersed in dichlorobenzene. SWCNTs were attracted toward the positively charged molecular regions, and aligned along the APTES patterns. On the contrary, SWCNT were not assembled on the OTS patterns. In this process, positively charged surface molecular patterns are utilized to direct the assembly of negatively charged SWCNT on SiO2. As a result, the selectively assembled SWCNT channels can be obtained between two electrodes(source and drain electrodes). Finally, we can successfully fabricate SWCNT-based multi-channel FETs by using our self-assembled monolayer method.

Efficient Multiplex Audio Monitoring System in Digital Broadcasting (디지털 방송에서 효율적인 다중 오디오 모니터링 시스템)

  • Kim, Yoo-Won;Sohn, Surg-Won;Jo, Geun-Sik
    • Journal of the Korea Society of Computer and Information
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    • v.13 no.7
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    • pp.91-98
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    • 2008
  • In digital broadcasting, it is possible to multiplex maximum one hundred audio or music programs into MPEG-2 transport stream, which is suitable for transmitting through one channel. In order to check if multiplex music programs are transmitted well, we need a multiplex audio monitoring system that monitors the programs in real-time. In analog broadcasting, we have used hardware-based audio monitoring system for a small number music programs. However, the effectiveness of hardware-based audio monitoring system from the cost and function viewpoint is so low that a new system is needed for digital broadcasting. In this paper, we have designed and implemented a software-based audio monitoring system to satisfy these requirements. In this implementation, only one PC is used without other hardware facilities, and the system monitors digital broadcasting music programs effectively. Transmitted digital broadcasting streams are demultiplexed into many music programs and the realtime value of audio level and packet error information for these programs are displayed in the screen. Thus, the system detects and shows the abnormal transmitting programs automatically. Simulation results show that effective realtime multiplex audio monitoring is possible for digital broadcasting music programs.

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