• Journal of Endocrine Surgery
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• v.18 no.4
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• pp.236-239
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• 2018

Secondary hyperparathyroidism (SHPTH) occurs commonly in patients with end-stage renal disease (ESRD). Uncontrolled SHPTH is associated with complications of calcium deposition including calciphylaxis and elevated rates of cardiovascular morbidity. Current treatment recommendations for medically refractory disease include total parathyroidectomy, often with autotransplantation (TPTH+AT) of minced parathyroid gland. Surgical intervention is associated with a reduction in cardiovascular mortality. We report a case of a 56-year-old man with ESRD who developed SHPTH and underwent TPTH+AT of parathyroid tissue into the right brachioradialis muscle. Over the course of 7 years he developed a mass at the site of the autotransplanted gland as well as recurrent refractory hyperparathyroidism with increased forearm uptake noted on sestamibi scan. After excision of this mass, pathology demonstrated hyperplasia of the minced gland fragments which were embedded within a mass of fibroadipose tissue rather than the muscle tissue it was originally transplanted in.

• Proceedings of the Korea Society of Environmental Biology Conference
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• 2001.12a
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• pp.109-110
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• 2001

• Korean Journal of Environmental Biology
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• v.21 no.2
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• pp.158-163
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• 2003

This study was conducted te evaluate the effect of organotin compounds on rotifer(Brachionus plicatilis), which is important as food organism of aqua-cultured fish and shellfish. To evaluate the texicities of tributyltin compounds such as tributyltin chloride (TBTC), tributyltin oxide (TBTO), tributyltin acetate (TBTA) and tributyltin benzoate (TBTB), and triphenyltin compounds such as triphenyltin chloride (TPTC), triphenyltin fluoride (TPTF), triphenyltin hydroxide (TPTB), the survival rates of rotifer exposed to these compounds were measured as the 96 hr-$LC_{50}$. Exposed concentrations Were from 0.5 to 8 bbp depending on compounds. Based on 96 hr-$LC_{50}$ Value, the Order of toxicity in TBTs was TBTA(1.1 ppb)>TBTC (2.0)>TBTB (3.3)>TBTO(5.6), and that in TPTs was TPTF (1.0)$\geq$TPTC(1.1)>TPTH(1.6). Triphenyltin compounds were slightly higher toxic than tributyltins. The toxicity is likely to depend on alkyl or aryl group other than halogen or the other substituted radicals.

• Korean Journal of Radiology
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• v.25 no.3
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• pp.289-300
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• 2024

Objective: To prospectively evaluate the outcomes of ultrasound (US)-guided radiofrequency ablation (RFA) in tertiary hyperparathyroidism (THPT). Materials and Methods: Patients with THPT underwent RFA between September 2017 and January 2022. Laboratory parameters, including serum intact parathyroid hormone (iPTH) levels, were monitored for 48 months after RFA and compared with the levels at baseline. Complications related to RFA and changes in hyperparathyroidism-related clinical symptoms were recorded before and after RFA. Results: A total of 42 patients with THPT were recruited for this study. Ultimately, 36 patients with renal failure and 2 patients who underwent successful renal transplantation (male:female, 17:21; median age, 54.5 years) were enrolled. The follow-up time was 21.5 ± 19.0 months in the 36 patients with renal failure. In these 36 patients, iPTH levels were significantly decreased to 261.1 pg/mL at 48 months compared with the baseline value of 1284.9 pg/mL (P = 0.012). Persistent hyperparathyroidism, defined as iPTH levels maintained at > 585.0 pg/mL for 6 months after treatment, occurred in 4.0% of patients (1/25). Recurrent hyperparathyroidism, defined as iPTH levels > 585.0 pg/mL after 6 months, were 4.0% (1/25) and 0.0% (0/9) at 6 months and 4 years after treatment, respectively. In two patients with THPT after successful renal transplantation, iPTH decreased from the baseline value of 242.5 and 115.9 pg/mL to 171.0 and 62.0 pg/mL at 6 months after treatment. All complications resolved within 6 months of ablation without medical intervention, except in 10.5% (4/38) patients with permanent hypocalcemia. The overall symptom recovery rate was 58.8% (10/17). The severity scores for bone pain, arthralgia, and itchy skin associated with hyperparathyroidism improved after treatment (P < 0.05). Conclusion: US-guided RFA is an effective and safe alternative to surgery in the treatment of patients with TPTH and improves hyperparathyroidism-related clinical symptoms.