• The Journal of Korean Physical Therapy
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• v.30 no.4
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• pp.123-128
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• 2018

Purpose: This study examined the effects of neuromuscular electrical stimulation (NMES) and horseback riding using a robotic device on the trunk muscle activity and gross motor function in children with spastic diplegia. Methods: Children with spastic diplegia were divided into two groups: an experimental group (NMES and horseback riding using a robotic device [n=10]) and a control group (placebo NMES and horseback riding using a robotic device [n=10]). Each group received general physical therapy and occupational therapy. Each intervention involved the administration of NMES for 15 minutes and horseback riding using robotic device therapy for 15 minutes three times a week for 4 weeks. The evaluation included both the rectus abdominis muscles (RA), external oblique muscles (EO), thoracic paraspinal muscles (TP), and lumbar paraspinal muscles (LP) activity and GMFM. Results: The RA, EO, TP, and LP muscle activity, GMFM C, D, and E were increased significantly in the experimental and control groups. A significant increase in both the TP muscle activity and GMFM D was observed in the experimental group compared to the control group. Conclusion: This study showed that horseback riding using a robotic device is an effective intervention for trunk muscle activity and GMFM in children with spastic diplegia. However, if NMES is added to the back muscles, it is possible to further increase the thoracic paraspinal muscle activity and standing ability.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5169-5173
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• 2015

To determine the efficacy of postoperative adjuvant chemotherapy with paclitaxel plus cisplatin (Taxol + DDP, TP therapy) for stage IIA esophageal squamous cell carcinoma (ESCC) and to investigate the expression of RUNX3 in lymph node metastasis-negative esophageal cancer and its relationship with medical prognosis, a retrospective summary of clinical treatment of 143 cases of stage IIA esophageal squamous cell carcinoma patients was made. The patients were divided into two groups, a surgery alone control group (52 patients) and a chemotherapy group that received postoperative TP therapy (91 patients). The disease-free and 5 year survival rates were compared between the groups and a multivariate analysis of prognostic factors was performed. The same analysis was performed for cases classified as RUNX3 positive and negative, with post-operative specimens assessed by immunohistochemistry. Although the disease-free and 5 year survival rates in control and chemotherapy groups did not significantly differ and there was no significance in RUNX3 negative cases, postoperative adjuvant chemotherapy in the chemotherapy group was shown to improve disease-free and 5 year survival rate compared to the control group in RUNX3 positive cases. On Cox regression multivariate analysis, postoperative adjuvant chemotherapy (P<0.01) was an independent prognostic factor for RUNX3 positive cases, suggesting that postoperative TP may be effective as adjuvant chemotherapy for stage IIA esophageal cancer patients with RUNX3 positive lesions.

• Journal of The Korean Society of Integrative Medicine
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• v.3 no.2
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• pp.63-72
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• 2015

Purpose: The purpose of this study was to investigate the foot pressure of subjects with hallux valgus following conservative management. Methods: The subjects (20 females) were divided into 2 groups; Hallux valgus group (10) and Control group (10) who could evaluate questionnaire & weight bearing X-ray. All the participants were evaluated distribution of foot pressure by Zebris FDM-S system with conservative management (taping therapy and hallux valgus device) during single-limb stance. Results: The Hallux valgus group (HVG) was significantly different than Control group (CG) in hallux valgus angle(p<0.05). The Hallux valgus group with Foot Device (HVG-FD), Hallux valgus group with Taping (HVG-Tp) and Hallux valgus group with Foot device and Taping (HVG-FD&Tp) was not significantly different than CG in hallux valgus angle (p<0.05). The HVG was not significantly different than CG in forefoot (p1, p2, p3), significantly different than CG in rearfoot (p7) about foot pressure during single-limb stance (p<0.05). The HVG-FO and HVG-FO and TP was significantly different than HVG in forefoot (p1, p2, p3), on significantly different than HVG in rearfoot (p7) about foot pressure during single-limb stance (p<0.05). There was significantly correlation HVG-FO and HVG-FO & TP in forefoot (p1, p2, p3) was negative correlation (p<0.05) and in rearfoot (p7) was positive correlation (p<0.05). Conclusion: This study showed that hallux valgus were effected hallux valgus angle and foot pressure by various treatment methods during single-limb stance. Further study is needed to measure various age and work with hallux valgus for clinical application.

• Journal of Naturopathy
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• v.11 no.1
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• pp.1-8
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• 2022

Background: A validation study is needed to make domestic applications of German Kneipp therapy. Purpose: The study aims to test the effect of a Kneipp therapeutic program in a domestic forest environment on the autonomic nervous system. Methods: The program was made considering the 4 key elements ('exercise', 'regulative therapy', 'nutrition', and 'phytotherapy') of the Kneipp therapy. Total 3 sessions (once a week for 5 hours in each session) were performed to 40 domestic adults divided into four groups (10 in each group). HRV was measured on the subjects before and after the intervention, and its 6 characteristic parameters (TP, VLF, LF, HF, LF/HF, CSI: Cumulative Stress Index) were compared for statistical analysis. Results: For 33 subjects excluding 7 who were disturbed by interrupt factors during measurements, significant improvements after the intervention, were observed in TP(8.64%, p < ..001), VLF(6.96%, p < .05), LF(15.86%, p < .001), HF(8.46%, p < .01), LF/HF(5.77%, p < .05) and CSI(-16.06%, p < ..001). Conclusions: The Kneipp therapy performed in the forest environment was shown to activate the autonomic nervous system and in particular the sympathetic and parasympatheric nervous to promote heart activity, and was also shown to most significantly reduce cumulative stress. The present observations would be the first preliminary evidence that the Kneipp therapeutic interventation in a domestic forest environment results in positive responses of the autonomic nervous system including stress relief.

• Molecules and Cells
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• v.37 no.8
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• pp.613-619
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• 2014

The optic nerve often suffers regenerative failure after injury, leading to serious visual impairment such as glaucoma. The main inhibitory factors, including Nogo-A, oligodendrocyte myelin glycoprotein, and myelin-associated glycoprotein, exert their inhibitory effects on axonal growth through the same receptor, the Nogo-66 receptor (NgR). Oncomodulin (OM), a calcium-binding protein with a molecular weight of an ~12 kDa, which is secreted from activated macrophages, has been demonstrated to have high and specific affinity for retinal ganglion cells (RGC) and promote greater axonal regeneration than other known polypeptide growth factors. Protamine has been reported to effectively deliver small interference RNA (siRNA) into cells. Accordingly, a fusion protein of OM and truncated protamine (tp) may be used as a vehicle for the delivery of NgR siRNA into RGC for gene therapy. To test this hypothesis, we constructed OM and tp fusion protein (OM/tp) expression vectors. Using the indirect immunofluorescence labeling method, OM/tp fusion proteins were found to have a high affinity for RGC. The gel shift assay showed that the OM/tp fusion proteins retained the capacity to bind to DNA. Using OM/tp fusion proteins as a delivery tool, the siRNA of NgR was effectively transfected into cells and significantly down-regulated NgR expression levels. More importantly, OM/tp-NgR siRNA dramatically promoted axonal growth of RGC compared with the application of OM/tp recombinant protein or NgR siRNA alone in vitro. In addition, OM/tp-NgR siRNA highly elevated intracellular cyclic adenosine monophosphate (cAMP) levels and inhibited activation of the Ras homolog gene family, member A (RhoA). Taken together, our data demonstrated that the recombinant OM/tp fusion proteins retained the functions of both OM and tp, and that OM/tp-NgR siRNA might potentially be used for the treatment of optic nerve injury.

• Journal of the korean academy of Pediatric Dentistry
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• v.50 no.1
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• pp.13-23
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• 2023

The purpose of this study was to compare the values of tongue pressure (TP), lip closing pressure (LCP), right buccal pressure (RBP), and left buccal pressure (LBP) and check the intraoral muscle imbalance and observe the changed values according to the myofunctional therapy (MFT) period. The MFT with a prefabricated appliance was performed on patients with certain muscular dysfunctions due to oral habits. And the improvement of perioral muscles was evaluated using a balloon-based pressure measurement. The group consisted of 21 patients with oral habits such as chronic mouth breathing, finger sucking, lip sucking, tongue thrusting, and atypical swallowing habits. When comparing the two groups before treatment, there was a significant difference in TP and LCP values. The TP increased the most in the first month since the start of myofunctional therapy, and the LCP increased the most between 3 and 6 months after treatment began. The values of TP, LCP, RBP, and LBP in the control group measured before treatment were very similar to the results of the experimental group 6 months after the myofunctional therapy. When the MFT was steadily performed, it was possible to observe a noticeable increase in the tongue and lip closing pressure. At least 6 months of myofunctional therapy is recommended for patients with intraoral muscle imbalance due to oral habits.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10893-10898
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• 2015

Several molecular markers have been proposed as predictors of outcome in patients with glioblastomas. We investigated the prognostic significance of $O^6$-methylguanine-DNA methyltransferase (MGMT) promoter methylation and TP53 mutation status dependent on isocitrate dehydrogenase 1 (IDH1) mutation in glioblastoma patients. A cohort of 78 patients with histologically confirmed glioblastomas treated with radiation therapy and chemotherapy were reviewed retrospectively. We evaluated the prognostic value of MGMT promoter methylation and TP53 mutation status with regard to progression-free survival (PFS) and overall survival (OS). It was revealed that mutations in IDH1, promoter methylation of MGMT, TP53 mutation, age, Karnofsky performance status (KFS), and extension of resection were independent prognostic factors. In patients with an IDH1 mutation, those with an MGMT methylation were associated with longer PFS (p=0.016) and OS (p=0.013). Nevertheless, the presence of TP53 mutation could stratify the PFS and OS of patients with IDH1 wild type (p=0.003 and 0.029 respectively, log-rank). The MGMT promoter methylation and TP53 mutation were associated with a favorable outcome of patients with and without mutant IDH1, respectively. The results indicate that glioblastomas with MGMT methylation or TP53 mutations have improved survival that may be influenced by IDH1 mutation status.

• Journal of the Korean Society of Physical Medicine
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• v.11 no.1
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• pp.107-114
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• 2016

PURPOSE: The purpose of the present study is to apply foot therapy at diverse temperatures to students in the Department of Physical Therapy who are experiencing clinical practice to find the most effective foot-bath temperatures for stress relief. METHODS: Sixty four students in the department of physical therapy who were undergoing the course on clinical practice participated in the present study. SDNN, TP, LF, and HF were measured to compare the control group, cold group, tepid group, and the hop group. The data were analyzed through analysis of covariance and paired t-tests. RESULTS: Although SDNN increased in the cold group and the tepid group, the differences were not statistically significant. TP and LF showed statistically significant increases in the cold group. In comparisons between the groups, the cold group showed statistically significant increases compared to the control group and the hot group. Although the tepid group also showed increases, the differences were not statistically significant. HF statistically decreased in the hot group. In comparisons between the groups, statistically significant differences appeared between the cold group and the hot group. CONCLUSION: Cold foot-bath was the most effective therapy on the stress of students in the department of physical therapy who were experiencing clinical practice. Tepid foot-bath had the same directivity but showed no statistically significant difference. Hot foot-bath was shown to rather increase stress.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.8
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• pp.3911-3916
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• 2016

Background: Triple negative (TN) and triple positive (TP) breast cancers both are aggressive types but TN generally has a shorter survival. Objectives: To compare the clinical characteristics and treatment outcomes for patients with TN versus TP breast cancer and to assess various prognostic factors affecting overall survival. Materials and Methods: A retrospective audit of 85 breast cancer patients was conducted in the Department of Radiation Oncology and Medical Oncology on patients from 2006 to 2013 for whom IHC for ER, PgR and Her-2 neu were available. The patients were stratified into: ER-, PR- and Her-2 neu- (Arm A, n=47) and ER+, PgR+ and Her-2 neu+ (Arm B, n=38). Results: TN subtype had higher numbers of premenopausal and advanced stage patients as compared to TP subtype. The locoregional recurrence (LRR) and distant metastatic rate was also higher in TN subtype but there was no definite pattern in both the arms. Among the prognostic factors, patients with premenopausal status and advanced stage in TN breast cancer had inferior survival (P=0.07) whereas for those with postmenopausal status and early stage there was no survival difference between the two arms. Conclusions: TN subtype tends to be more aggressive in terms of younger age and advanced stage at presentation, higher tumour grade, LRR and metastasis, suggesting need for future research efforts on providing aggressive treatment to these patients. We could attribute better outcome for TP subtype to receptor positivity enabling role of hormonal treatment and targeted therapy, although less number of patients received targeted therapy.

• Journal of the Korea Convergence Society
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• v.9 no.3
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• pp.131-135
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• 2018

The purpose of the present study was to examine the effects of full immersion virtual reality (VR) on the autonomic nervous system. The study was conducted with 17 men in their 20s. The subjects were given full immersion VR content, and electrocardiogram (ECG) signals were measured for five minutes before and after the application of the full immersion VR. The autonomic nervous system was evaluated by analyzing the LF, HF, TP, and LF/HF ratio of the ECG signal. The obtained data was analyzed by conducting a paired sample t-test. After applying full immersion VR, the subjects' HF and TP decreased significantly, while their LF/HF ratio increased significantly. According to the results of this study, Full immersion VR provided stress to the autonomic nervous system, but the changes were within the normal range of healthy adults. Therefore, full immersion VR can be safely applied to healthy adults.