• BMB Reports
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• v.42 no.12
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• pp.788-793
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• 2009

TLX2 is an orphan homeodomain transcription factor whose expression is mainly associated with tissues derived from neural crest cells. Recently, we have demonstrated that PHOX2A and PHOX2B are able to enhance the neural cell-type specific expression of human TLX2 by binding distally the 5' -flanking region. In the present work, to deepen into the TLX2 transcription regulation, we have focused on the proximal 5'-flanking region of the gene, mapping the transcription start site and identifying a minimal promoter necessary and sufficient for the basal transcription in cell lines from different origin. Site-directed mutagenesis has allowed to demonstrate that the integrity of this sequence is crucial for gene expression, while electrophoretic mobility shift assays and chromatin immunoprecipitation experiments have revealed that such an activity is dependent on the binding of a PBX factor. Consistent with these findings, such a basal promoter activity has resulted to be enhanced by the previously reported PHOX2-responding sequence.

• Journal of the Ergonomics Society of Korea
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• v.32 no.2
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• pp.167-177
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• 2013

Objective: This study aims to compare the usefulness of subjective measures which are comprised of existing methods like NASA-TLX, Bedford-scale and ZEIS and newly developed method like DALI in measuring drivers' mental workload in terms of validity, sensitivity and diagnosticity. Background: Nowadays, with the development of intelligent vehicle and HMI, mental workload of driver has become more and more important. For this reason, the studies on drivers' mental workload about driving situation and the use of information technology equipment such as mobile phones and navigations were conducted intensively. However, the studies on measuring drivers' mental workload were rarely conducted. Moreover, most of studies on comparison of subjective measures were used with performance based measure. However, performance based measures can cause distraction effect with subjective measures. Method: Participants (N=19) were engaged in a driving simulation experiment in 2 driving contexts (downtown driving and highway driving context). The experiment has 2 sessions according to driving contexts. The level of difficulties by driving contexts were adjusted according to existence of intersections, traffic signs and signals, billboards and the number of doublings. Moreover, as criteria of concurrent validity and sensitivity, the EEG data were recorded before and during the sessions. Results: The results indicated that all subjective methods were correlates with EEG in high-way driving. On the contrary to this, in downtown driving, all subjective methods were not correlates with EEG. In terms of sensitivity, multi-dimensional scales (NASA-TLX, DALI) were the only ones to identify differences between high way and downtown driving. Finally, in terms of diagnosticity, DALI was the most suitable method for evaluating drivers' mental workload in driving context. Conclusion: The DALI as newly developed method dedicated to evaluate driver's mental workload was superior in terms of sensitivity and diagnosticity. However, researchers should consider the characteristics of each subjective method synthetically according to research objective by selecting the method in subjective measures. Application: The results of this study could be applied to the intelligent vehicle and next generation of HMI design to decrease mental workload of driver and for the development of new subjective method in vehicle domain.

• Journal of Korean Institute of Industrial Engineers
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• v.28 no.2
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• pp.178-186
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• 2002

The objective of this study is to evaluate impact of computer-based man-machine interfaces of Korea Next Generation Reactor (KNGR) on the operator mental workload. Empirical experiments were conducted to measure the operator mental workloads of KNGR and Yong-Gwang Unit 3 and 4, respectively. A comparison analysis based on a NASA TLX revealed that Yong-Gwang Unit 3 and 4 were superior to KNGR in terms of the mental workload. Post-hoc analyses showed that the mental workload of senior reactor operators was significantly higher than those of reactor and turbine operators, regardless of plant types. The implications of the findings were discussed in detail.

• Journal of the Korean Society for Library and Information Science
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• v.48 no.2
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• pp.379-398
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• 2014

This pilot study explored the effect of mental demand on a Web searcher's thoughts, emotions, efforts, and performance in Web searches in order to address whether or not there is any difference between searchers exposed to mental demand manipulation and searchers not exposed. Research data were collected via think-aloud protocol (TAP) with a dual-task in experiments and interviews with 10 subjects who participated in this study. For the searcher's thoughts, relevance judgment was found to be hindered by mental demand. For the searcher's emotions, the experimental group was more frustrated than the control group. With respect to the searcher's efforts, searchers for the experimental group with mental demand manipulation were more likely to spend more time, make fewer queries, and visit fewer pages but work harder to find more relevant information that they needed. Lastly, with regard to the searcher's performance, it is likely that performance was highly dependent upon the completion of the search tasks for both groups. The NASA-TLX six components and cognitive load scores of searchers did not make a significant difference in the outcome. The findings support the use of a dual-task methodology as a promising approach for the assessment of cognitive load induced by complex Web searches.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.30 no.2
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• pp.44-54
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• 2022

An empirical analysis was conducted on the workload of helicopter pilots flying in high-risk flight environments such as ground obstacles and weather effects at low altitudes. To evaluate the workload, an independent sample t-test was performed using the NASA-TLX evaluation method most suitable for the aviation field, and the workload score was calculated by applying the analytical stratification method (AHP) to compare and analyze private and commercial pilots. There is a significant difference in mean between private and commercial pilots and the result of work load was obtained over 70%. This paper studied the 'surprise and startle effect' on the helicopter field for the first time. In the future, it is intended to contribute to the safe operation of helicopters by presenting a method for effective safety management by utilizing it in the field of education and training for helicopter pilots and providing basic data for preventing accidents caused by human error.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.2
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• pp.245-251
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• 2017

The proposed variable pawer divider in this paper is composed of one equal power 2-way Wilkinson power divider, two variable phase shifters with 90-degree phase variation to be connected two output paths of the 2-way power divider, and one branchline coupler to combine output signals of two variable phase shifter. The proposed variable power divider can theoretically have an arbitrary power division ratio ranging from ${\infty}:1$ to ${\infty}:1$ due to 90-degrees phase variation of two phase shifter. The proposed power divider circuit fabricates on laminated TLX-9(h=20 mil, er=2.5; Taconic) with a center frequency of 1.7 GHz. The power division ratio of the fabricated prototype varies from about 1:100 to 200:1, with an input reflection characteristic(S11) of below -16 dB, an insertion loss of about -1.0 dB, and an isolation characteristic of below -17 dB between two output ports in the range 1.65-1.75 GHz.

• Journal of electromagnetic engineering and science
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• v.15 no.2
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• pp.111-114
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• 2015

In this paper, we have proposed dual-band Phi-shaped slot gap filler antenna for satellite internet service applications. Some properties of the antenna such as return loss, radiation pattern, and gain have been simulated and measured. The proposed antenna has a Phi-shaped slot on the circular patch and is fabricated on the TLX-9 substrate. The radius of the circular patch is 25 mm, and it has a coaxial feeding structure. The dual-band Phi-shaped slot gap filler antenna has high-gain, small-size, simple-structure, and good radiation patterns at each band. The operating frequency band can be tuned by adjusting the length AL and FL of the Phi-shaped slot.

• Proceedings of the KIEE Conference
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• 2005.07c
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• pp.2309-2311
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• 2005

A broadband microstrip balun is proposed and designed using a ${\lambda}/4$short-stub in order to compensate phase imbalance. For the demonstration, two baluns are proposed and designed using a ${\lambda}/4$ shorted stub. One is a modified form of the conventional Wilkinson balun, and the other is a modified ring hybrid. Baluns are implemented on TLX-9 substrate of which the dielectric constant is 2.54 and the thickness is 0.5mm. The measurements show a bandwidth of 500MHz at the center frequency of 2GHz.

• Journal of Korean Institute of Industrial Engineers
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• v.43 no.3
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• pp.176-183
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• 2017

In recent years, studies about multitasking becomes more important. During multitasking, operators can feel frustration when they are interrupted during the task and frustration can affect operator's emotional state and performance. However there is no research on measuring the frustration quantitatively in multitasking environment. In this paper, we suggested quantitative measurement of frustration during multitasking. In order to measure the frustration, we made a mathematical representation with emotional decay model and the initial intensity of frustration based on cognitive closure theory. The amount of initial intensity could be represented as the ratio of actual remaining time to expected remaining time. By the experiment, we measured the frustration during the experiment and compared this values with values of frustration dimension of NASA-TLX. Finally we got the linear regression model with a good accuracy ($R^2=0.986$). This study contributes to measuring the emotion quantitatively by the relation of expected and actual remaining time in multitasking environment.

• Proceedings of the KSR Conference
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• 2007.11a
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• pp.1722-1730
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• 2007

According to the result of recent studies, it was revealed that the error of safety-related personnel still plays a significant role in the accidents and/or incidents of a railway system. Accordingly, in order to reduce as well as prevent human errors, it is necessary to: (1) identify the root cause of accidents/incidents, and (2) conduct a research that can provide a systematic as well as an effective way to deal with the identified human errors. To this end, it is essential to suggest appropriate countermeasures based on the result of a task load analysis, which can soundly reduce a high level of the task load put on safety-related personnel. In the light of this concern, about the tasks of railway traffic signallers, a detailed task analysis was conducted in this study. After that, the associated task load scores were quantified by NASA-TLX technique that is one of the most well-known subjective workload measurement techniques. As a result, a set of significant tasks that could put a high task load on railway traffic signallers was identified.