• Title/Summary/Keyword: THz Imaging

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Application of Terahertz Spectroscopy and Imaging in the Diagnosis of Prostate Cancer

  • Zhang, Ping;Zhong, Shuncong;Zhang, Junxi;Ding, Jian;Liu, Zhenxiang;Huang, Yi;Zhou, Ning;Nsengiyumva, Walter;Zhang, Tianfu
    • Current Optics and Photonics
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    • v.4 no.1
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    • pp.31-43
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    • 2020
  • The feasibility of the application of terahertz electromagnetic waves in the diagnosis of prostate cancer was examined. Four samples of incomplete cancerous prostatic paraffin-embedded tissues were examined using terahertz spectral imaging (TPI) system and the results obtained by comparing the absorption coefficient and refractive index of prostate tumor, normal prostate tissue and smooth muscle from one of the paraffin tissue masses examined were reported. Three hundred and sixty cases of absorption coefficients from one of the paraffin tissues examined were used as raw data to classify these three tissues using the Principal Component Analysis (PCA) and Least Squares Support Vector Machine (LS-SVM). An excellent classification with an accuracy of 92.22% in the prediction set was achieved. Using the distribution information of THz reflection signal intensity from sample surface and absorption coefficient of the sample, an attempt was made to use the TPI system to identify the boundaries of the different tissues involved (prostate tumors, normal and smooth muscles). The location of three identified regions in the terahertz images (frequency domain slice absorption coefficient imaging, 1.2 THz) were compared with those obtained from the histopathologic examination. The tissue tumor region had a distinctively visible color and could well be distinguished from other tissue regions in terahertz images. Results indicate that a THz spectroscopy imaging system can be efficiently used in conjunction with the proposed advanced computer-based mathematical analysis method to identify tumor regions in the paraffin tissue mass of prostate cancer.

Wide-Band Measurements of Antenna-Coupled Microbolometers for THz Imaging

  • Tamminen, Aleksi;Ala-Laurinaho, Juha;Mallat, Juha;Luukanen, Arttu;Grossman, Erich N.;Raisanen, Antti V.
    • Journal of electromagnetic engineering and science
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    • v.10 no.3
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    • pp.132-137
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    • 2010
  • We present results of room-temperature characterization of lithographically manufactured antenna-coupled NbN micro-bolometers. The bolometers are assembled together with a hyper-hemispherical Si lens to couple the incident radiation to the bolometer from the back-side of the substrate. The bolometers are designed to operate at 300~1,000 GHz and they are characterized at 321~782 GHz. Radiation patterns are measured at 321 GHz, 400 GHz, 654 GHz, and at 782 GHz. The frequency dependency of the beamwidth is studied with several azimuthal beam profile measurements at 321~500 GHz.

Low Loss Highly Birefringent Porous Core Fiber for Single Mode Terahertz Wave Guidance

  • Habib, Md. Ahasan;Anower, Md. Shamim
    • Current Optics and Photonics
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    • v.2 no.3
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    • pp.215-220
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    • 2018
  • A novel porous-core hexagonal lattice photonic crystal fiber (PCF) is designed and analyzed for efficient terahertz (THz) wave propagation. The finite element method based Comsol v4.2 software is used for numerical analysis of the proposed fiber. A perfectly matched layer boundary condition is used to characterize the guiding properties. Rectangular air-holes are used inside the core to introduce asymmetry for attaining high birefringence. By intentionally rotating the rectangular air holes of porous core structure, an ultrahigh birefringence of 0.045 and low effective material loss of $0.086cm^{-1}$ can be obtained at the operating frequency of 0.85 THz. Moreover, single-mode properties, power fraction in air core and confinement loss of the proposed PCF are also analyzed. This is expected to be useful for wideband imaging and telecom applications.

Imaging with terahertz electromagnetic pulses (테라헤르츠 전자기파 펄스의 변조를 이용한 이미징의 해상도 연구)

  • Oh, Seung-Jae;Kang, Chul;Son, Ju-Hyuk
    • Korean Journal of Optics and Photonics
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    • v.15 no.1
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    • pp.46-50
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    • 2004
  • Images were acquired by the modulation of terahertz electromagnetic signals and compared by modulation frequencies. For the real-time acquisition of images a fast scanning method has been adopted utilizing a galvanometer. The acquired time domain waveforms were transformed into frequency domain data by fast Fourier transformations (FFT). We chose some frequency components to compare the resolution of images. The beam profiles at the focal position were measured by a knife-edge technique. Beam diameter was shown to decrease as the frequency increased. By scanning one- and two-dimensional samples a significant image enhancement was observed with the frequency increment. A nondesouctive imaging system using ㎔ electromagnetic pulses was also demonstrated.

Study of Noncontact Condition Diagnosis on Painting with Terahertz Waves (테라헤르츠파를 이용한 회화문화재 상태진단 적용연구)

  • Baek, Na Yeon;Kang, Dai Ill;Ha, Tae Woo;Sim, Kyung Ik;Lee, Ho Won;Kim, Jae Hoon;Lee, Han Hyoung
    • Journal of Conservation Science
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    • v.32 no.2
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    • pp.235-247
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    • 2016
  • Conventional imaging techniques such as ultraviolet, infrared, and X-ray are used mainly to diagnose the damaged parts of the painted cultural assets in Korea. These techniques, however, have limits in diagnosing damages of interlayer parts. We have performed and extensive study on the applicability of Terahertz(THz) analysis technique, introduced recently to this field of study on cultural properties in Korea, to diagnose painted cultural assets. The specimens, produced to imitate the damage types of Korean painted properties, were analyzed over their painting, supporting, and backing layers by terahertz pulse imaging technique. The analyzed results provided information about the cracks, the separated areas, and the separated distances between layers on the specimens. Our research, then, was extended to real painted cultural remains, Birojana Sam-shin Gwebul-do at Bongseon Temple in Namyang-ju, Korea National Treasure Number 1792, through which we have obtained 3D information about the extent and pattern of damages to the asset. These results demonstrate that terahertz 3D imaging technique has the capability of noncontact 3D diagnosis on painted cultural properties.