• Title/Summary/Keyword: THRASH

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단백질 질량분석을 위한 THRASH 알고리즘 속도 향상 기법

  • Jeon Sang-hyun;Chang Hyeong Soo;Oh Han Bin
    • Proceedings of the Korean Information Science Society Conference
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    • 2005.07b
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    • pp.241-243
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    • 2005
  • Horn et al.에 의하여 개발된 THRASH 알고리즘은 대표적인 단백질 질량분석 플랫폼으로써, 극초분해능(ultra high resolution) Fourier Transform 질량분석법을 통해 얻어지는 고집적 전기분무 (electrospray ionization ESI) 질량 스펙트럼 데이터를 분석하는데 이용되고 있다. 하지만 이 알고리즘은 속도 면에서 부족하여 실시간 분석에 한계점을 보이고 있다. 이를 보완하기 위해 본 논문에서는 THRASH알고리즘의 속도를 향상시키는 기법을 제안하고 실험 결과를 통하여 새로운 기법이 융합된 알고리즘의 수행 속도가 기존 THRASH알고리즘의 속도를 비약적으로 향상시킬 수 있음을 보인다.

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Speed Improvement of an FTICR Mass Spectra Analysis Program by Simple Modifications

  • Jeon, Sang-Hyun;Chang, Hyeong-Soo;Hur, Man-Hoi;Kwon, Kyung-Hoon;Kim, Hyun-Sik;Yoo, Jong-Shin;Kim, Sung-Hwan;Park, Soo-Jin;Oh, Han-Bin
    • Bulletin of the Korean Chemical Society
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    • v.30 no.9
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    • pp.2061-2065
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    • 2009
  • Two simple algorithm modifications are made to the THRASH data retrieval program with the aim of improving analysis speed for complex Fourier transform ion cyclotron resonance (FTICR) mass spectra. Instead of calculating the least-squares fit for every charge state in the backup charge state determination algorithm, only some charge states are pre-selected based on the plausibility values obtained from the FT/Patterson analysis. Second, a modification is made to skip figure-of-merit (FOM) calculations in the central m/z region between two neighboring peaks in isotopic cluster distributions, in which signal intensities are negligible. These combined modifications result in a significant improvement in the analysis speed, which reduces analysis time as much as 50% for ubiquitin (8.6 kDa, 76 amino acids) FTICR MS and MS/MS spectra at the reliability (RL) value = 0.90 and five pre-selected charge states with minimal decreases in data analysis quality (Table 3).

Implementation of Voltage Control Dielectric Resonator Oscillator for FMCW Radar (FMCW 레이더용 전압제어 유전체 발진기의 구현)

  • 안용복;박창현;김장구;조현식;강상록;한석균;최병하
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2003.10a
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    • pp.398-402
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    • 2003
  • In this paper, a VCDRO(Voltage Control Dielectric Resonator Oscillator) applied to FMCW(Frequency Modulated Continuous Wave)Radar as stable source is implemented and constructed with a MESFET for low noise, a dielectric resonator of high frequency selectivity, and high Q varator diode to obtain a good phase noise performance and stable sweep characteristics. The designed circuits is simulated thrash harmonic balance simulation technique to provide the optimum performance. The measured result of a fabricated VCDRO shows that output is 2.22dBm at 12.05GHz, harmonic suppression -30dBc, phase noise -130dBc at 100kHz offset, and sweep range of varator diode $\pm$18.7MHz, respectively. This oscillator will be available to FMCW Radar.

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Implementation of Voltage Control Dielectric Resonator Oscillator for FMCW Radar (FMCW 레이더용 전압제어 유전체 발진기의 구현)

  • 안용복;박창현;김장구;최병하
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.8 no.4
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    • pp.906-911
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    • 2004
  • In this paper, a VCDRO(Voltage Control Dielectric Resonator Oscillator) applied to FMCW(Frequency Modulated Continuous Wave)Radar as stable source is implemented and constructed with a MESFET(Metal-semiconductor Field-Effect Transistor) for low noise, a dielectric resonate. of high frequency selectivity, and high Q varator diode to obtain a good phase noise performance and stable sweep characteristics. The designed circuits is simulated thrash harmonic balance simulation technique to provide the optimum performance. The measured result of a fabricated VCDRO shows that output is 2.22㏈m at 12.05GHz, harmonic suppression -30㏈c, phase noise -130㏈c at 100KHz offset, and sweep range of varator diode $\pm$18.7MHz, respectively. This oscillator will be available to FMCW Radar.