• Title/Summary/Keyword: TFA

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Control Mechanism of AMPK and Autophagy for Mitochondrial Biogenesis (AMPK와 자식작용의 미토콘드리아 생합성 조절 기전)

  • Jeon, Byeong-Hwan
    • The Journal of the Korea Contents Association
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    • v.9 no.4
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    • pp.355-363
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    • 2009
  • Increased oxidative stress by abnormal mitochondrial function can damage cell signal transduction and gene expression, and induce insulin resistance or diabetes. Autophagy, however, improve insulin resistance by clearance of malfunctioning mitochondria. Exercise also recovers the muscle dysfunction and degeneration by activating mitochondrial biogenesis. As it seems that exercise and autophagy might act as an orchestrated network to induce mitochondrial biogenesis, we investigated whether autophagy is involved in AMPK signal pathway stimulated by exercise or AICAR to increase mitochondrial biogenesis. And it showed that PGC-1 and mtTFA, but not autophagy marker LC3 mRNA expression were significantly increased by 6 hr of acute exercise. On the other hand, PGC-1 and mtTFA mRNA expression were upregulated by AICAR treatment to C2C12 myotube. However these genes were not inhibited by LC3 siRNA transfection. These results provide the evidence that autopahgy affects on mitochondrial biogenesis through different signal pathway from AMPK signal transduction.

Fabrication of YBCO films on metal tapes by the TFA-MOD process (TFA-MOD법에 의한 금속기판 위 YBCO 박막 제조)

  • Shin Geo-Myung;Song Kyu-Jung;Park Chan;Moon Seung-Hyun;Yoo Sang-Im
    • Progress in Superconductivity
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    • v.7 no.1
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    • pp.92-96
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    • 2005
  • YBCO thin films on metal substrates were prepared by the metal-organic deposition using trifluoroacetates (TFA-MOD). To compensate the loss of Ba element from the precursor films due to the reaction with $CeO_2$ cap layer, we have employed Ba-excessive precursor solutions of $YBa_{2+x}Cu_{3}O_{7-{\delta}}$ ($0{\le}x{\le}0.1$). The precursor solutions were dip-coated on the metal substrates with $CeO_2$ cap layer, initially heated up to $400^{\circ}C$, and finally fired at the various high temperatures for 2 h in a reduced oxygen atmosphere. With this approach, YBCO films possessing critical temperature over 85 K could be successfully prepared on the metal substrates. The highest $T_{c,zero}$ value of 86 K was obtained from the Ba-excessive YBCO film of x=0.005 in $YBa_{2+x}Cu_{3}O_{7-{\delta}}$ fired at $750^{\circ}C$ for 2 h. However, unexpected $T_c$ suppression even in Ba-excessive YBCO samples requires further identification.

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Effect of heat-treatment parameter of YBCO film by TFA-MOD process (TFA-MOD법에 의한 YBCO 박막의 열처리변수 효과)

  • Jang, Seok-Hern;Lim, Jun-Hyung;Kim, Kyu-Tae;Lee, Jin-Sung;Yoon, Kyung-Min;Joo, Jin-Ho;Lee, Hee-Gyoun;Hong, Gye-Won
    • Progress in Superconductivity
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    • v.7 no.2
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    • pp.135-139
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    • 2006
  • We fabricated YBCO coated conductors (CCs) by TFA-MOD process and evaluated microstructure, texture formation, and critical temperature ($T_c$) and current ($I_c$). YBCO precursor solution was synthesized using metal-trifluoroacetates and dip coated on $LaAlO_3$(LAO) substrate. The phase formation and microstructure was characterized by X-ray diffraction and scanning electron microscopy (SEM) and the degree of texture was evaluated by pole-figure analysis. The CC was heat-treated in various calcining temperatures ($370^{\circ}C-460^{\circ}C$) and firing temperatures ($750^{\circ}C-800^{\circ}C$). As fired at $775^{\circ}C$ for 4h, the CC had the highest $T_c$ of 89.5 K and $I_c$ of 40 A/cm-width ($J_c=2.0\;MA/cm^2$). Microstructural observation indicated that the YBCO film was dense and homogeneous and had a strong cube texture without formation of second phase and its in-plane full-width at half-maxima; $5.2^{\circ}$ under optimum condition.

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Microstructural Observation of Multi-coated YBCO Films Prepared by TFA-MOD (TFA-MOD법으로 제조된 다층 YBCO 박막의 미세구조 관찰)

  • Jang, Seok-Hern;Lim, Jun-Hyung;Lee, Chang-Min;Hwang, Soo-Min;Choi, Jun-Hyuk;Shim, Jong-Hyun;Joo, Jin-Ho;Kim, Chan-Joong
    • Progress in Superconductivity
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    • v.9 no.2
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    • pp.167-172
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    • 2008
  • We fabricated $YBa_2Cu_3O_{7-x}$(YBCO) films on (00l) $LaAlO_3$ substrates prepared by metal organic deposition(MOD) method using trifluoroacetate(TFA) solution. The films with various thicknesses were prepared by repeating the dip-coating and calcining processes. The effects of film thickness on phase formation, microstructures, and critical properties were evaluated by X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The microstructure and resultant critical current($I_C$) and critical current density($J_C$) varied remarkably with film thickness: The ($I_C$) value increased from 39 to 160 A/cm-width as the number of coatings increased from one to four, while the corresponding $J_C$ was measured to be in the range of $0.84-1.21\;MA/cm^2$. Both the $I_C$ and $J_C$ decreased when an additional coating was applied due to microstructural degradation, indicating that the optimum thickness is in the range of $1.1-1.8\;{\mu}m$. The possible cause for the decrease in the $I_C$ and $J_C$ value for film thicker than $1.8\;{\mu}m$ include non-uniform thickness, increased surface roughness, and the poor formability of the YBCO phase and texture arising from the insufficient heat treatment time with respect to the increased thickness.

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Effects of the Heat Treatment Temperature and Thickness of YBCO Film Fabricated by TFA-MOD Method (TFA-MOD법을 이용한 YBCO 박막의 열처리 온도와 두께의 영향)

  • Jang Seok-Hern;Lim Jun-Hyung;Lee Jin-Sung;Yoon Kyung-Min;Kim Kyu-Tae;Joo Jin-Ho;Kim Chan-Joong;Nah Wan-Soo
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.19 no.5
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    • pp.467-476
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    • 2006
  • We fabricated the YBCO films on LAO substrate using the TFA-MOD method and evaluated the effects of heat treatment temperature and film thickness on the microstructure, degree of texture, and critical properties. The calcining and firing were peformed at the temperature range of $370^{\circ}C-460^{\circ}C\;and\;750^{\circ}C-800^{\circ}C$, respectively. For the films fired at $775^{\circ}C$ after calcining at $400^{\circ}C-430^{\circ}C$showed highest critical temperature (Tc-onset) of 89.5 K and critical current (Ic) of 40A/cm-width which corresponds to critical current density (Jc) of $1.8MA/cm^2$. The highest critical properties are probably attributed to the formation of purer YBCO phase, stronger biaxial texture, and higher oxygen content, according to the XRD, pole-figure, SEM, Raman analysis. From the multi-coated films, the Ic increased from 39 to 169 A/cm-width as the coating repeated to four times, while the corresponding Jc was measured from once to be in the range of $0.8-1.2MA/cm^2$. Both Ic and Jc degraded as the coating repeated further, indicating that the optimum thickness is in the range of $1.0{\mu}m-1.7{\mu}m$.

Fabrication of TFA-MOD YBCO Films Using the $Y_2Ba_1Cu_1O_x$ and $Ba_3Cu_5O_8$ Powders

  • Lim, Jun-Hyung;Jang, Seok-Hern;Yoon, Kyung-Min;Lee, Seung-Yi;Joo, Jin-Ho;Lee, Hoo-Jeong;Kim, Chan-Joong
    • Proceedings of the Korean Powder Metallurgy Institute Conference
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    • 2006.09b
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    • pp.1247-1248
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    • 2006
  • We fabricated YBCO film using a TFA-MOD method. In order to enhance the reaction kinetics and to control the formation of the second phases, $Y_2Ba_1Cu_1O_x$ and $Ba_3Cu_5O_8$ powders were used as precursors (the so called "211 process"). The films were calcined at $460^{\circ}C$ and then fired at $750^{\circ}C-800^{\circ}C$ in a 12.1% humidified $Ar-O_2$ atmosphere. We found that the microstructure varied significantly with the firing temperature. The textures of all of the films were similar and mainly biaxial. For the film fired at $775^{\circ}C$, the critical current was obtained to be 39 A/cm-width (corresponding critical current density is 2.0 MA/$cm^2$).

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