• Toxicological Research
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• v.14 no.4
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• pp.525-533
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• 1998

The covalent interactions of toluenediisocyanate (TDI) with macromolecules were investigated both in vitro and in vivo. In vitro incubations of 2,4- and 2,6-TDI with DNA or proteins resulted in dose-dependent formation of TDI-protein and TDI-DNA adducts. TDI-treated DNA was highly resistant to enzymatic digestion and thermal hydrolysis, but was readily hydrolyzed under acidic conditions by releasing its corresponding toluenediamine (TDA), suggesting that TDI caused the crosslinking of DNA. Reaction of TDI with albumin and globin resulted in the formation of several adducts, and some adducts were formed in blood of TDI-treated rats in a dose-dependent fashion. Administration of TDI to rats resulted also in a dose-dependent binding of TDI to hepatic tissue. Levels of TDI-albumin adducts were 10 times higher than those of TDI-globin adducts; the biological half lives of TDI-albumin and TDI-globin adducts were 1.2 and 12.5 days, respectively. Globin adducts were detected up to 28 days after the treatment. Hepatic TDI protein adducts were persistent for a substantial period whereas the levels of hepatic TDI-DNA adduct were decreased rapidly. These results indicate that the isocyanato group of TDI is not readily hydrolyzed under physiological conditions, is transported to other organs, and is bound to DNA and/or proteins without further metabolic activation. As the adducted products degrade in the body, TDA is released and introduced to the liver. TDA may additionally bind to hepatic tissue after metabolic activation. Thus, the toxic effect of TDI exposure is considered to persist during the lifetime of the adducted biological macromolecules.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.23 no.4
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• pp.341-347
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• 2013

Objectives: The aim of this study is to investigate the differences in airborne TDI concentrations based on the filter collection method and liquid collection method and to compare airborne TDIs concentrations by sampling method change when using the filter collection method in the spray-painting process. Methods: For the sample measurement, the filter collection method(OSHA#42) and liquid collection method(NIOSH#5522) were used; for the sampling method, the full-period single sampling and full-period consecutive sampling methods were used. The samples were collected in spray-painting and drying process locations. Results: In all samples collected from the spray-painting and drying process locations through the filter collection and liquid collection methods, greater amounts of 2,6-TDI than 2,4-TDI were detected. When the TDI collection concentrations based on the sampling methods were compared, the concentrations of 2,4-TDI and 2,6-TDI collected by the consecutive sampling method were higher than the concentrations of 2,4-TDI and 2,6-TDI collected by the single sampling method for both the filter collection method and liquid collection method used in the spray-painting process. These differences were statistically significant. Conclusions: When TDI collection concentrations based on the sample measurement methods were compared, the concentration of 2,4-TDI and 2,6-TDI collected through the liquid collection method were higher than the concentrations of 2,4-TDI and 2,6-TDI collected by the filter collection method, and the differences were statistically significant. In the drying process, no difference was shown in the collection concentrations of 2,4-TDI and 2,6-TDI with the two measurement methods.

• Korean Journal of Remote Sensing
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• v.18 no.2
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• pp.91-96
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• 2002

The performance characteristics of a satellite imager using a Time Delay and Integration(TDI) Charge Coupled Device (CCD) with fixed integration time is investigated for the variation of satellite altitude and tilt angle. In consequence of the investigation TDI synchronization using tilt imaging is proposed as a solution to compensate geometric performance degradation due to altitude decrease. The tilt angle optimized for the TDI synchronization at decreased altitude is presented. This result can be used for a TDI CCD imager with variable integration time in a certain range as well.

• Bulletin of the Korean Space Science Society
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• 2003.10a
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• pp.104-104
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• 2003

본 포스터에서는 다목적 위성 2호의 주 탑재체인 MSC(Multi-Spectral Camera)가 TDI(Time Delayed Integration) 방식을 채택함에 따라, TDI에 의해 MSC 영상 자료가 어떻게 영향을 받게 되는 지를 연구한 내용을 설명한다. MSC는 지상 해상도가 1m인 고해상도에서 영상을 촬영하기 때문에 상대적으로 입사 광량이 부족한 문제를 안고 있음에 따라 32 line의 TDI 방식을 사용한다. TDI 방식을 사용하여 MSC에서 직하방향으로 영상을 촬영할 경우, 영상의 가운데 pixel에서 멀어질수록 TDI에 의해 영상의 MTF 값이 떨어지는 결과가 발생한다. 또한, 다목적 위성 2호는 Roll 축을 중심으로 $\pm$30도 Pitch 축을 중심으로 $\pm$30도 tilt를 하여 영상을 촬영하도록 운영될 예정이기 때문에 더더욱 TDI에 의채 영상의 MTF 값이 떨어지는 결과가 발생하게 된다. 이외에도 TDI는 다목적 위성 2호의 고도가 감소하거나, Yaw 축의 변화, Jitter 등에 의해서도 영상의 MTF 값이 감소하게 된다. 물론 MSC CCD pixel의 sampling rate인 Line Rate 값을 각각의 경우에 따라 적절한 값을 부여함으로써 TDI에 의한 MTF 값의 감소를 많은 부분은 수습할 수 있으나 완벽한 보정은 힘든 상황이다.

• Korean Chemical Engineering Research
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• v.50 no.3
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• pp.417-420
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• 2012

This study is about reduction reaction making 2, 4-dinitrotoluene (2, 4-DNT) to 2, 4-toluene diisocyanate (2,4-TDI) with Pd/$SiO_2$. Catalytic systems based on Pd/$SiO_2$ at about $200^{\circ}C$ and under 100 bars of carbon monoxide. We studied the effect of pyridine on the yield of the TDI. TDI was not created without pyridine, but created with pyridine, at the reaction result. According to research, homogeneous synthesis of TDI with direct carbonylation, palladium and pyridine complexion is known to catalyze. When adding pyridine the reason of TDI synthesis is palladium leaching, ICP-AES was performed to confirm it. As a result, the proportion of Pd loaded in $SiO_2$ was decreased 52% than before, after the reaction by adding 20 vol% pyridine. Generating TDI by adding pyridine might be the effect of the complex ion, which is composed of leached palladium and pyridine.

• Korean Journal of Remote Sensing
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• v.20 no.4
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• pp.227-234
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• 2004

The synchronization of Time Delay and Integration (TDI) against the temporal variation of osculating altitude in the operation of high resolution satellite imager was studied. The characteristics of osculating altitude variation was analyzed and its impact on the performance of TDI imger was also investigated. A practical ]me rate control method was proposed to compensate instantaneous TDI mismatch due to the osculating altitude variation, so that geometrical performance enhancement was achieved by the proposed method. This study is applicable to real satellite operation and can be useful for satellite image quality enhancement.

• IMMUNE NETWORK
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• v.2 no.3
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• pp.158-165
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• 2002

Background: Toluene diisocyanate (TDI) can cause contact allergy and occupational asthma, but the mechanism underlying sensitization to this chemical compound remains controversal. Also the correlation of mast cell with contact hypersensitivity (CHS) and the role of mast cell in the TDI-induced CHS is unknown. This issue was investigated by administrating TDI on the skin of genetically mast cell-deficient WBB6F1/$J-Kit^{W}/Kit^{W-v}$ ($W/W^{V}$) and congenic normal WBB6F1/J-Kit+/+ (+/+) mice. Methods: To development of animal model of TDI-induced CHS and to investigate the correlation of mast cell with CHS and the role of mast cell in the TDI-induced CHS, $W/W^V$ and +/+ mice were sensitized with TDI on the back skin at day 1 and day 8, and then challenged with 1% TDI on the ear at day 15. At 1, 2, 4, 8, and 24 hours after 1% TDI challenge, the ear thicknesses were measured. It was investigated the histologic changes of dermis in the ear of $W/W^V$ and +/+ mice at 24 hours after 1% TDI challenge. Results: TDI induced a significant ear swelling response in $W/W^V$ and +/+ mice. TDI induced the significant infiltrations of polymorphonuclear leukocytes and eosinophils in $W/W^V$ and +/+ mice, but not of mast cells in normal mice. And TDI increased a characteristic extent of mast cell degranulation in normal mice. There were no significant differences in the ear swelling and the infiltrations of polymorphonuclear leukocytes and eosinophils of normal versus $W/W^V$ mice, either at baseline or after TDI-induced CHS. Conclusion: From the above results, TDI can be used as a murine CHS model, and the mast cells may not be essential in TDI-induced CHS.

• Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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• 2004.03a
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• pp.235-240
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• 2004

Time Delay and Integration (TDI) 기법을 사용하는 고해상도 위성 영상기에 있어서 실제 위성 운영시 발생하는 위성 고도의 순간적 변화에 대한 TDI 일치를 연구하였다. 시간에 따라 변하는 순간 고도의 특성을 분석하였고 순간 고도 변화가 TDI 불일치를 초래하여 위성 영상 기기의 성능에 미치는 영향을 분석하였다. TDI 시간 지연을 조절하여 실제 위성 운영에서 순간적으로 발생하는 TDI 불일치를 보정하고 성능을 향상시킬 수 있는 가능성을 연구하였다. 본 연구 결과는 위성 영상 품질 향상에 활용될 수 있다.

• Tuberculosis and Respiratory Diseases
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• v.53 no.2
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• pp.101-112
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• 2002

Background : Toluene diisocyanate(TDI) is a leading cause of occupational asthma. However, the pathogenesis of TDI-induced asthma is largely unknown because there is no suitable animal model. Materials and Methods : We developed a murine model of TDI-induced asthma by performing two sensitization with 3% TDI and one challenge with 1% TDI using ultrasonic nebulization. Results : Similar to occupational asthma in humans, murine TDI-induced asthma includes findings 1) increased inflammatory cells, including neutrophils and eosinophils, 2) histologic changes, including infiltration of inflammatory cells around bronchioles, thickened airway epithelium, contraction of bronchioles, and accumulation of mucus and debris in the bronchioles, 3) increased MMP-9 activity in inflammatory cells in the airway lumen, 4) airway hyperrespnosiveness. Administraion of an MMP inhibitor, MMPI-I, remarkably reduced all these pathophysiological findings. Conclusion : Therefore, we conclude that TDI-induced occupational asthma is associated with the induction of MMP-9 in inflammatory cells, and the inhibition of MMP-9 may be a good therapeutic strategy.

• Korean Journal of Ecology and Environment
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• v.43 no.1
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• pp.117-128
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• 2010

The water qualities of Namdae-stream, Yeongok-stream and Sacheon-stream were examined, by using physicochemical factors, trophic status and epilithic diatoms from May 2008 to February 2009. The physicochemical water qualities of three streams were, except for some construction areas and sites of downstream, generally good, having less concentration than BOD of $2\;mg\;L^{-1}$. As for the sites of downstream, there were ongoing pollution such as graduation of nutrients in Namdae-stream and Sacheon-stream, due to salinity of seawater and topographical feature of the closed estuary. The examination of trophic status of Namdae-stream showed mesotrophic status in all the sites. Also, eutrophication was in progress as from the upstream to the downstream of Yeongok-stream, and Sacheon-stream showed eutrophic status in all its sites. As a result of the biological water quality assessment, Namdae-stream, excluding the downstream site, came out to be $\beta\sim\alpha$-oligosaprobic, and biological water quality was good, having TDI less than 50. Some construction sites and downstream site of Namdae-stream are $\beta$-mesosaprobic, and with the TDI over 70, the biological water quality assessment came out to be polluted. Yeongok-stream is $\beta\sim\alpha$-oligosaprobic, and its biological water quality is good, having TDI less than 40. Sacheon-stream, excluding the upstream site on May 2008 and February 2009, is $\beta\sim\alpha$-mesosaprobic, and its TDI over 70 shows that it has been polluted. The correlation analysis showed a high correlation in both DAlpo and TDI. Also, biological assessment of water quality (DAIpo, TDI) showed higher correlation with TSI rather than BOD.