• Journal of Pharmaceutical Investigation
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• 제29권4호
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• pp.349-353
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• 1999

A novel polymeric tablet of tinidazole (TD) was formulated to treat Helicobacter pylori and Giardia lambria more efficiently with reduced hepatotoxicity by controlling the release of TD after oral administration. TD tablets containing various concentrations of either xanthan gum (XG, viscosity enhancer) and/or polycarbophil (PC, mucoadhesive) were prepared by the wet granulation method. In vitro release of TD into pH 2.0 and pH 5.0 buffer solutions was observed at 37°C by using an USP dissolution tester and an UV (313 nm) spectrophotometer. In vivo absorption of TD tablets was investigated in rabbits by measuring the blood concentration of TD after oral administration using a HPLC. Compared to a commercial TD tablet, in vitro release of TD in both pH 2.0 and pH 5.0 buffer solutions significantly decreased as the concentration: of XG or PC in the tablet increased up to 30%. However, when XG and PC was added in combination, TD was completely released in a pH 5.0 buffer solution within 8 hours, whereas the release of TD in pH 2.0 buffer solution significantly decreased. TD in a commercial tablet was rapidly absorbed after oral administration in rabbits. After oral administration of the polymeric tablets that contain both XG and PC, plasma concentration of TD dramatically decreased. Since the oral absorption of TD significantly decreased by the addition of XG and PC in the tablets while TD completely released in a pH 5.0 buffer solution, it was speculated that more TD was retained in the gastrointestinal tract. Thus, it was possible to control the release of TD by changing the content of XG and/or PC in the tablet, thereby manipulating the release rate and the gastrointestinal retention of TD after oral administration in rabbits.

• 인터넷정보학회논문지
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• 제21권5호
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• pp.1-7
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• 2020

강화학습에서 근사함수로써 사용되는 딥 인공 신경망은 이론적으로도 실제와 같은 근접한 결과를 나타낸다. 다양한 실질적인 성공 사례에서 시간차 학습(TD) 은 몬테-칼로 학습(MC) 보다 더 나은 결과를 보여주고 있다. 하지만, 일부 선행 연구 중에서 리워드가 매우 드문드문 발생하는 환경이거나, 딜레이가 생기는 경우, MC 가 TD 보다 더 나음을 보여주고 있다. 또한, 에이전트가 환경으로부터 받는 정보가 부분적일 때에, MC가 TD보다 우수함을 나타낸다. 이러한 환경들은 대부분 5-스텝 큐-러닝이나 20-스텝 큐-러닝으로 볼 수 있는데, 이러한 환경들은 성능-퇴보를 낮추는데 도움 되는 긴 롤-아웃 없이도 실험이 계속 진행될 수 있는 환경들이다. 즉, 긴롤-아웃에 상관없는 노이지가 있는 네트웍이 대표적인데, 이때에는 TD 보다는 시간적 에러에 견고한 MC 이거나 MC와 거의 동일한 학습이 더 나은 결과를 보여주고 있다. 이러한 해당 선행 연구들은 TD가 MC보다 낫다고 하는 기존의 통념에 위배되는 것이다. 다시 말하면, 해당 연구들은 TD만의 사용이 아니라, MC와 TD의 병합된 사용이 더 나음을 이론적이기 보다 경험적 예시로써 보여주고 있다. 따라서, 본 연구에서는 선행 연구들에서 보여준 결과를 바탕으로 하고, 해당 연구들에서 사용했던 특별한 리워드에 의한 복잡한 함수 없이, MC와 TD의 밸런스를 랜덤하게 맞추는 좀 더 간단한 방법으로 MC와 TD를 병합하고자 한다. 본 연구의 MC와 TD의 랜덤 병합에 의한 DQN과 TD-학습만을 사용한 이미 잘 알려진 DQN과 비교하여, 본 연구에서 제안한 MC와 TD의 랜덤 병합이 우수한 학습 방법임을 OpenAI Gym의 시뮬레이션을 통하여 증명하였다.

• Environmental Analysis Health and Toxicology
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• 제25권4호
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• pp.273-278
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• 2010

Objectives : This study was aimed to examine the acute toxicity assessment of two new algicides, thiazolidinediones derivatives (TD53 and TD49), which were synthesized to selectively control red tide, to the marine ecosystem. Methods : The assessment employed by a new method using Ulva pertusa Kjellman which has been recently accepted as a standard method of ISO. The toxicity was assessed by calculating the $EC_{50}$ (Effective Concentration of 50%), NOEC (No Observed Effect Concentration) and PNEC (Predicted No Effect Concentration) using acute toxicity data obtained from exposure experiments. $EC_{50}$ value of TD49 and TD53 was examined by 96-hrs exposure together with Solutol as a TD49 dispersing agent and DMSO as a TD53 solvent. Results : $EC_{50}$ value of TD53 was $1.65\;{\mu}M$. From the results, values of NOEC and PNEC were calculated to be $0.63\;{\mu}M$ and 1.65 nM, respectively. DMSO under the range of $0{\sim}10\;{\mu}M$, which is same solvent concentration used in examining TD53, showed no toxic effect. $EC_{50}$ value of TD49 was $0.18\;{\mu}M$ and that of Solutol was $1.70\;{\mu}M$. NOEC and PNEC of TD49 were $0.08\;{\mu}M$ and 0.18 nM, respectively and those for Solutol were $1.25\;{\mu}M$ and 1.25 nM, respectively. Conclusions : From the values of NOEC, PNEC of TD53 and TD49, TD49 showed 9 times stronger toxicity than TD53. On the other hand, DMSO showed no toxicity on the Ulva pertusa Kjellman, but Solutol was found to be a considerable toxicity by itself.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2003년도 International Meeting on Information Display
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• pp.7-10
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• 2003

Samsung SDI has developed a full color 5.0" WVGA AMOLED display with top emission and a super fine pitch of 0.1365mm(l86ppi), the world's highest resolution OLED display ever reported to date. Scan driver circuits and demux circuit were integrated into the display panel, using low temperature poly-Si TFT CMOS technology, and data driver circuit were mounted using COG chips. Peak luminescence was greater than 300cd/ $m^2$ with power consumption of 500mW with 30% of the pixels on illuminated.

• 한국임상약학회지
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• 제20권1호
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• pp.39-49
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• 2010

The present study was aimed to examine the occurrence and influencing factors therapeutic duplication (TD) of medications for anxiety disorders by analyzing the relevant prescription data. In this study, the prescription data issued on March 19, 2008 in domestic medical institutes were utilized. TD was defined as more than two medications under the same therapeutic classification per prescription based on the Anatomical Therapeutic Classification (ATC) code. The assessment of TD was performed based on the number of cases and on the ratio determined. To identify the influencing factor of TD, the variables related to the differences in the TD ratio were analyzed based on the results of the Chi-Square test conducted with the variables; patients, medical institutes, diseases, and treatments. The number and ratio of TD were determined to be 1,333 out of the total of 19,219 anxiety disorder cases, and 6.94%, most cases involving benzodiazepine derivatives, respectively. The TD ratio was found to be higher in relation to males than to females. Patients with national health insurance benefits have a higher TD ratio compared to the medical-aid beneficiaries. The TD ratios were highest in clinics, psychiatry divisions, and Gyeongsang district. The TD ratio of the cases with more than two anxiety disorders was found to be higher than that of the cases with only one anxiety disorder. As the number of medications per prescription increased, the TD ratio was shown to have become gradually higher. In conclusion, in order to prevent TD, the concurrent DUR system should be implemented. The prescribers and pharmacists must be educated regarding duplicated medications to promote the safe and effective use of medicines, without unnecessary TD.

• 한국전자통신학회논문지
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• 제4권1호
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• pp.60-65
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• 2009

차세대 이동통신 시스템에서는 고속 패킷 서비스가 주요 기능으로 부각되고 있다. 이러한 고속 패킷 서비스의 경우 불 연속적인 데이터의 전송 및 비 대칭적 대이터 트래픽의 특성으로 인하여 TD-CDMA 시스템에 대한 연구가 활발히 진행되고 있다. 이에 본 논문에서는 터보 부호를 적용한 TD-CDMA에 대하여 고찰하였다. 시스템의 특성을 고려하여 전송 프레임의 구성 방식, 물리채널구조 및 채널 부호화 방식등에 대하여 고찰하였다. 또한 TD-CDMA 시스템에 HARQ 기법중 하나인 Chase Combining 기법을 적용하여 그 성능을 분석하였다.

• 음성과학
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• 제15권3호
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• pp.79-94
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• 2008

The purpose of this study was to compare phonological awareness ability of students with Down Syndrome(DS) and typically developing children(TD). TD and DS were equal the reading abilities(reading recognition). The subject were 10 DS and 10 TD, and were examined by test of phonological awareness. The test of phonological awareness was composed according to phonological units(word, syllable, phoneme) and task types(deletion, discrimination, blending). The results obtained in this study were as follows: The total score of phonological awareness ability of DS were significantly lower than TD. And the score of phonological awareness ability according to phonological units and task types were significantly lower than TD. But both DS and TD performed better on phonological deletion and blending task than discrimination. TD and DS represented different correlation between task types and phonological units. This means that TD performed better on all types of tasks and phonological units than DS.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2002년도 International Meeting on Information Display
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• pp.325-328
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• 2002

We developed a high performance 2.2" active matrix OLED display for IMT-2000 mobile phone. Scan and Data driver circuits were integrated on the glass substrate, using low temperature poly-Si(LTPS) TFT CMOS technology. High efficiency EL materials were employed to the panel for low power consumption. Peak luminescence of the panel was higher than 250cd/$m^2$ with power consumption of 200mW.

• 한국약용작물학회지
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• 제16권2호
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• pp.69-73
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• 2008

넓은잎큰조롱의 경운깊이에 따른 생산성 및 품질향상을 위한 구명하기 위하여 경운깊이를 달리하여 2005년부터 2년간 시험한 결과, 만장은 경운깊이가 얕을수록 길어 경운깊이가 30 cm 일 때 685 cm 인데 비하여 경운깊이 10 cm 일 때 59 cm 가 더 길었으며, 경태와 건물중도 같은 경향으로 굵거나 무거웠다. 엽장, 엽폭, 엽중은 경운깊이가 얕을수록 양적인 생육을 보였으나, 엽록소 함량은 경운깊이가 깊을수록 증가하였다. 근수와 근장은 경운깊이가 깊을수록 많거나 길어지는 경향이었으나, 근태와 부패근은 경운깊이가 얕을수록 굵거나 많은 경향이었고, 근수량은 경운깊이가 깊을수록 많은 경향으로 경운깊이가 10 cm 일 때 $622\;kg/1000m^2$인데 비하여 20 cm 이상으로 경운할 때 $7{\sim}9%$ 증수되었다.

• 동의생리병리학회지
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• 제18권4호
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• pp.1218-1224
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• 2004

Tardive Dyskinesia(TD) may be defined as a syndrome consisting of abnormal, stereotyped involuntary movements, which occurs relatively late in the course of drug treatment and in the etiology of which the drug treatment is a necessary factor like schizophrenia, The frequently involved parts of the body in the schizophrenic patients who have TD were tongue, upper extremity, lips and perioral area, jaws, lower extremity, muscle of facial expression, trunk respectively. The last few years have seen a number of well-conducted clinical, biochemical, neuropathological, and therapeutic studies in patients with TD, but there is no satisfactory treatment for the majority of patients with TD. I used herb medicines and some acupoints like GV20(百會), Extra-point(鎭靜), Extra-point(間谷), Liv20(行間), of the chennel of Gall bladder to treated 2 schizophrenic patients with TD from December 2003 to May 2004. The patients with TD were somewhat improved. Nonetheless for just 2 cases, I might thought that this acupuncture therapy could be helpful to treat schizophrenic patients with TD.However, further studies should be followed.