• Journal of Ginseng Research
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• 제46권2호
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• pp.255-265
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• 2022

Background: Ginsenoside Rb1, a bioactive component isolated from the Panax ginseng, acts as a remedy to prevent myocardial injury. However, it is obscure whether the cardioprotective functions of Rb1 are related to the regulation of endogenous metabolites, and its potential molecular mechanism still needs further clarification, especially from a comprehensive metabolomics profiling perspective. Methods: The mice model of acute myocardial ischemia (AMI) and oxygen glucose deprivation (OGD)-induced cardiomyocytes injury were applied to explore the protective effect and mechanism of Rb1. Meanwhile, the comprehensive metabolomics profiling was conducted by high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (HPLC-Q/TOF-MS) and a tandem liquid chromatography and mass spectrometry (LC-MS). Results: Rb1 treatment profoundly reduced the infarct size and attenuated myocardial injury. The metabolic network map of 65 differential endogenous metabolites was constructed and provided a new inspiration for the treatment of AMI by Rb1, which was mainly associated with mitophagy. In vivo and in vitro experiments, Rb1 was found to improve mitochondrial morphology, mitochondrial function and promote mitophagy. Interestingly, the mitophagy inhibitor partly attenuated the cardioprotective effect of Rb1. Additionally, Rb1 markedly facilitated the phosphorylation of AMP-activated protein kinase α (AMPKα), and AMPK inhibition partially weakened the role of Rb1 in promoting mitophagy. Conclusions: Ginsenoside Rb1 protects acute myocardial ischemia injury through promoting mitophagy via AMPKα phosphorylation, which might lay the foundation for the further application of Rb1 in cardiovascular diseases.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2005년도 춘계학술대회 논문집
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• pp.744-749
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• 2005

The train configuration is based on one unit like basic 4 cars to multiple unit operation. Each unit has unique node such as train formation number. Some equipments(TC, CC) of TCMS are connected to the master TC through the LonWorks network. When the train is consist of multiple unit, TCMS has to implement quick network for data communication overall train. But a variable time delay is generated when it is performed communication with point to point type using train formation number. In this paper we propose new method to know the node information of adjacent unit. that is to add digital input signals notifying cab direction at any cabin. Also, we provide the optimized screen design that all collected information via network is displayed by each unit.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2004년도 추계학술대회 논문집
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• pp.1461-1466
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• 2004

Recently Domestic EMU's on board signal systems are gradually changed form Cab signal(Fix Block) to Distance-to-go. Interfaces with on board signal system, TCMS Redundancy structure is mainly required. This paper suggest Manaul/Automatic Driving based on TCMS-ATC interface and design of backup system which is operated by Stan-by Computer when one of it's Local Interface Unit(LIU) is out of oder. For the purpose of Precision Train Stop, Distance-to-go signal system require accuracy speed. Free-axle structure is required for this system This paper suggest Free-axle braking system that lack of brake-force is compensated by the distributed brake-force using TCMS. And one of braking system has out of order, compensation of brake-force for Free-axle system. Then we prove our design to Complete Car Test

• 한국철도학회:학술대회논문집
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• 한국철도학회 2005년도 추계학술대회 논문집
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• pp.282-286
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• 2005

Contents of these treatise propose method to embody station addition and passivity point correction. That store in TCMS's memory being downloaded all train running path data that is consisted of name of station and station code, departure station, destination station, train number, running time through PCMCIA memory card. Search relevant running path data and current station, destination station, the next station start time present to TCMS's display. In case it is no received information of station, device that do function of passenger broadcasting and pilot light does not act. This time, if input information of current station, relevant device does point revision.

• ETRI Journal
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• 제13권2호
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• pp.3-8
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• 1991

본 논문은 행정전산망용 주전산기 II (TICOM) 개발시 적용되는 형상관리업무를 효율적이며 체계적으로 수행하기 위한 형상관리용 소프트웨어 도구 (TCMS )의 설계 및 구현에 대해 기술한다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2002년도 추계학술대회 논문집(I)
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• pp.528-533
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• 2002

This paper proposes the Train Control Monitoring System (TCMS) for the LRT(light rail transit). With regard to information processing in car, we build a computer network in the car, turned the hardware required for train control into software, and developed the Train Control Monitoring System.

• Journal of Ginseng Research
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• 제48권2호
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• pp.163-170
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• 2024

Background: Mechanisms of synaptic plasticity in retinal ganglion cells (RGCs) are complex and the current knowledge cannot explain. Growth and regeneration of dendrites together with synaptic formation are the most important parameters for evaluating the cellular protective effects of various molecules. The effect of ginsenoside Rg1 (Rg1) on the growth of retinal ganglion cell processes has been poorly understood. Therefore, we investigated the effect of ginsenoside Rg1 on the neurite growth of RGCs. Methods: Expression of proteins and mRNA were detected by Western blot and qPCR. cAMP levels were determined by ELISA. In vivo effects of Rg1 on RGCs were evaluated by hematoxylin and eosin, and immunohistochemistry staining. Results: This study found that Rg1 promoted the growth and synaptic plasticity of RGCs neurite by activating the cAMP/PKA/CREB pathways. Meanwhile, Rg1 upregulated the expression of GAP43, Rac1 and PAX6, which are closely related to the growth of neurons. Meantime, H89, an antagonist of PKA, could block this effect of Rg1. In addition, we preliminarily explored the effect of Rg1 on enhancing the glycolysis of RGCs, which could be one of the mechanisms for its neuroprotective effects. Conclusion: Rg1 promoted neurite growth of RGCs through cAMP/PKA/CREB pathways. This study may lay a foundation for its clinical use of optic nerve diseases in the future.

• 한국시뮬레이션학회:학술대회논문집
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• 한국시뮬레이션학회 1998년도 추계학술대회 및 정기총회
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• pp.166-169
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• 1998

열차종합제어장치는 열차내에 설치되는 컴퓨터로서 통신 및 디지털 / 아날로그 입출력을 통해 각 주변기기의 제어와 감시기능을 수행한다. 이러한 열차종합제어장치는 열차운행의 안전성에 있어서 중요한 부분을 담당하고 있으므로 실제 차량에 탑재되기 전에 모든 기능이 제대로 동작하는 지 검증되어야 한다. 열차종합제어장치의 복잡한 기능을 검증하기 위해 열차종합제어장치 시뮬레이터의 구성은 필수적이며, 본 논문에서는 이러한 시뮬레이터의 기능 및 구성방안에 대해서 기술한다.

• 철도저널
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• 제16권2호
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• pp.41-44
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• 2013

• 한국철도학회:학술대회논문집
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• 한국철도학회 2011년도 춘계학술대회 논문집
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• pp.1716-1721
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• 2011

The Public Address and Passenger Information System of Rolling Stock should be able to perform automatic announcements in connection with TCMS(Train Control and Monitoring System), common announcements and emergency announcements for safe operation and the passengers. CCTV(Closed Circuit Television) System also should be able to watch passenger compartment for safety. Those equipments are very important thing for train service and safety. but the installation of equipment is restricted by space, weight, modulation. therefore, Passenger Information Intergrated System(PIIS) is required to consider economical efficiency, technical trend, expansion and space insufficiency. and system based on IP network has to be considered as new PIIS. so PIIS could meet economical efficiency and expansion. and it could go further and share network with TCMS and others.