• Journal of the Korean Child Neurology Society
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• v.26 no.4
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• pp.272-275
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• 2018

KBG syndrome is a rare neurodevelopmental disorder characterized by intellectual disability, skeletal anomalies, short stature, craniofacial dysmorphism, and macrodontia. ANKRD11 gene mutation and 16q24.3 microdeletion have been reported to cause KBG syndrome. Here, we report two patients with ANKRD11 mutations who initially presented with neurologic symptoms such as developmental delay and seizures. Patient 1 was a 23-month-old boy who presented with a global developmental delay. Language delay was the most dominant feature. He had hypertelorism, hearing impairment, and behavior problems characterized as hyperactivity. A c.1903_1907delAAACA (p.Lys635GInfsTer26) mutation in ANKRD11 was identified with diagnostic exome sequencing. Patient 2 was a 14-month-old boy with developmental delay and seizure. He also had atrial septum defect, and ventricular septal defect. Generalized tonic seizures began at the age of 8 months. Electroencephalography showed generalized sharp and slow wave pattern. Seizures did not respond to antiepileptic drugs. A loss of function mutation c.5350_5351delTC (p.ser1784HisfsTer12) in ANKRD11 was identified with diagnostic exome sequencing. In both cases, characteristic features of KBG syndrome such as short stature or macrodontia, were absent, and they visited the hospital due to neurological symptoms. These findings suggest that more patients with mild phenotypes of KBG syndrome are being recognized with advances in diagnostic exome sequencing genetic technologies.

• Journal of Fisheries and Marine Sciences Education
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• v.26 no.6
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• pp.1417-1424
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• 2014

This study is supposed to offer data related to whether circulation training(aerobic and anaerobic exercise) focused on overweight women has positive effects on reducing fat and increasing muscles for middle-aged women. This study aims to investigate how the circulation training effect overweight middle-aged women's female hormone, blood lipid, which offers basic data of exercise program to keep the overweight middle-aged women healthy. Participants for the study are 30 to 45-year-women who were willing to take part in a M Sports Diet Program in G gu, B metropolitan city, did not have any disease. They were 29 overweight women and showed more than 30% of body fat percentage. Female hormone, blood lipid were measured twice before and in 12 weeks after exercise. The results obtained from this study are given as in the following. Although estrogen has significantly increased after the circulation training, there was no meaningful difference from the control group. After 12-weeks-circulation training, even though there were no meaningful differences. before the training, the circulation training group was significantly higher than the control group. Although TC has significantly decreased after the circulation training, there was no meaningful difference from the control group. the circulation training group was significantly lower than the control group. Even though TG was no significantly decreased after the circulation training, there was no significantly difference from the control group. the circulation training group was significantly lower than the control group. Even though HDL-C has significantly increased after the circulation training, there was no meaningful difference from the control group. the circulation training group was significantly higher than the control group. Even though LDL-C has significantly decreased after the circulation training, there was no significantly difference from the control group. the circulation training group was significantly lower than the control group.

• Journal of Environmental Science International
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• v.30 no.9
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• pp.709-717
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• 2021

This study evaluated the growth, physiological responses and productivity based on the intercropping ratio of cherry tomato (Lycopersicon esculentum L.) with basil (Ocimum basilicum L.). on the rooftops to determine out the efficient ratio in urban agriculture. From April to September 2019, an experiment was conducted on the rooftop of Konkuk University Glocal Campus. Cherry tomato and basil were selected as companion plants for eco-friendly urban agriculture on the rooftops. Each plot was created with a width of 100 cm, length of 100 cm, and height of 25 cm. After installing drainage and waterproof layers from bottom to top, substrate was laid out with a height of 20 cm. Intercropping ratio was consisted of a single tomato plant (TC), 2:1 tomato to basil (T₂B₁), 1:1 tomato to basil (T₁B₁), 1:2 tomato to basil 2 (T₁B₂), and a single basil plant (BC), were conducted using a randomized complete plot design with five treatments and three replication (a total 15 plots). Measurements were divided into growth, physiological responses, and productivity parameters, and detailed items were investigated and analyzed by classifying them into plant height, leaf length, leaf width, number of leaves, root length, root collar caliper, chlorophyll contents, fresh weight, dry weight, number of fruit, fruit caliper, fruit weight, and sugar content. Comparative analyses of cherry tomato with basil plants by intercropping ratio, growth, physiological, and productivity responses are determined to be efficient when the ratio of cherry tomato to basil ratio is 2:1 or 1:1.

• The Korean Journal of Food And Nutrition
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• v.33 no.6
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• pp.747-754
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• 2020

This study was conducted to evaluate the effect of high-oleate and normal-oleate peanut consumption on adipose mass and serum lipids in obese-induced C57BL/6J mice. After four weeks of the high-fat diet, mice were randomly divided into six groups: normal control (NC) diet, high-fat control (HFC) diet, high-oleate peanut-seed (HOPS) diet, normal-oleate peanut-seed (NOPS) diet, high-oleate peanut-oil (HOPO) diet, and olive-oil (OO) diet. After four weeks, all four experimental diet groups showed significantly lower body weight and epididymal fat weight than HFC group. In four experimental diet groups, serum triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were significantly lower, and high-density lipoprotein cholesterol (HDL-C) was significantly higher than HFC group. TG was significantly decreased in HOPS group (92.1±1.2 mg/dL) than NOPS group (101.7±5.3 mg/dL, p<0.05). Similarly, LDL-C was significantly lower in HOPS group (66.1±2.8 mg/dL) than NOPS (76.9±1.5 mg/dL, p<0.05), on the other hand, HDL-C indicated a significant elevation in HOPS (50.5±2.1 mg/dL) than NOPS group (45.2±1.6 mg/dL, p<0.05). This result suggests that the consumption of high-oleate peanut has a favorable effect on the plasma lipid profile.

• The Korea Journal of Herbology
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• v.33 no.2
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• pp.59-67
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• 2018

Objective : Plantago asiatica L. has been used for many years in Korea, China, and Japan for the treatment of many diseases such as anti-inflammatory, anti-asthma and diuretic. But the anti-obesity effect of Plantaginis asiaticae Folium has not been studied yet. Thus, this study aimed to demonstrate the anti-obesity efficacy of Plantaginis asiaticae Folium water extract (PAF) in high fat diet-induced obesity animal model. Method : Male, five-weeks old C57BL/6 mice were divided into 5 groups; ND (normal diet + 0.9% saline), HFD (high-fat diet + 0.9% saline), PC (high-fat diet + Garcinia cambogia 500 mg/kg), PAF 100, 300 (high-fat diet + PAF 100, 300 mg/kg. Treatments were performed daily for 6 weeks per os. We evaluated the changes of body weight, white adipose tissues weight, hepatic and fecal lipids level, pancreatic lipase activity and lipid profiles in plasma. Result : Body weights, adipose tissue weights and FER were significantly lower in mice fed the high-fat diet with PAF treatment than in mice fed the high-fat diet alone. In plasma, TG, TC, LDL-C, ATS and ALT levels significantly decreased in PAF groups compared with HFD group. Also, hepatic triglyceride (TG) levels decreased and fecal TG increased in PAF groups compared to HFD group. In addition, the activity of pancreatic lipase was decreased in the PAF groups compared to that of HFD group. Conclusion: These results suggest PAF extract is effective in preventing and improvement obesity, so it might be a potential and safe material for anti-obesity agent of weight control or functional supplements.

• The Korea Journal of Herbology
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• v.33 no.6
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• pp.61-70
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• 2018

Objectives : Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of hepatic triglycerides (TG) that leads to inflammation and fibrosis. Crataegi Fructus ethanol extract (CE) is a korean traditional herb that used for digestive diseases. It has been investigated that CE has the effect that prevent hepatotoxicity caused by CCl4 or GaIN and regulate the inflammatory in several organs. However, a hypolipidemic effect of CF has not been reported. Methods : The purpose of this study is that examine the lipid accumulation inhibitory effect of CE on NAFLD. We checked the body and liver weight change of MCD-diet induced mice with/without administration of CE. The blood lipid levels of C57BL/6J mice were checked by biochemistry. Also we observed the liver histology of MCD-diet induced mice and investigate the molecular mechanisms in MCD-diet-induced NAFLD in C57BL/6J mice. Results : CE improved MCD-diet-induced lipid accumulation and TG and TC levels. Also, CE decreased hepatic lipogenesis such as SREBP-1, $C/EBP{\alpha}$, $PPAR{\gamma}$, ACC and FAS. Besides, we also found out that CE increased AMPK phosphorylation. These results indicated that CE has the same ability to activate AMPK and then reduce SREBP-1, and FAS expression, finally leading to inhibit hepatic lipogenesis and hepatic antioxidative ability. Conclusions : In this report, we found CE exerted a regulatory effect on lipid accumulation by decreasing lipogenesis in MCD-diet induced NAFLD model. Therefore, CE extract may be active in the prevention of fatty liver.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.3
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• pp.20-37
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• 2023

Although traffic signal installations are continuously expanding, the effect of preventing traffic accidents remains unverified. Totally, 7,045 traffic accident data (such as signal violations) registered with TCS were manually searched for a 7-year period from 2013 to 2019 for 1,602 traffic signals in Daejeon Metropolitan City. The top 20 traffic accident intersections were identified, the traffic accident investigation records and field maps were viewed to compare the driving direction and signal phase of the violated vehicle, and the cause of the traffic accident was divided into insufficient signal operation design (operation) and driver negligence (intentional). Results of the analysis revealed that 75% of traffic accidents occurred in thru-left-turn traffic signals and overlap; moreover, extending the yellow time or operating all red signals due to countermeasures against traffic accidents occurring in yellow signals resulted in reduced traffic accidents. Data indicated that Permissive Left Turn requires improvement with the signal operation. In addition, since The Korean National Police Agency is not computerized for traffic accident sites and signal-related data, the lack of manpower necessitates improvement and utilization of TCS when establishing traffic accident prevention measures. It is believed that it will contribute to signal operation by analyzing vast amounts of data collected in the field and presenting improvement measures.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.5D
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• pp.741-747
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• 2008

Nowadays, the accuracy of the geoid model has been improved through development of the combination model which was composed of traditional gravimetric geoid and geometric geoid by the GPS/leveling data in USA and Japan. It is a state of the art method in geoid modeling field that what so called hybrid geoid. In this paper, as a basic study to develop Korean hybrid geoid model, we studied gravimetric geoid solutions using three gravity reduction methods (Helmert's condensation method, RTM method and Airy-isostatic method) and evaluated the usefulness of each method in context of precise geoid. The gravimetric geoid model were determined by restoring the gravity anomalies (included TC) and the indirect effects were made from various reduction methods on the EIGEN-CG03C reference field. The results are compared with respect to the geometric geoid undulation determined from 498 GPS/leveling after LSC fitting. The results showed that hybrid geoid with RTM (Residual terrain model) reduction method was most accurate method and the value of the difference compared to geometric geoid was $0.001{\pm}0.053m$.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.46 no.3
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• pp.15-22
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• 2023

BNKT Ceramics, one of the representative Pb free based piezoelectric ceramics, constitutes a perovskite(ABO3) structure. At this time, the perovskite structure (ABO3) is in the form where the corners of the octahedrons are connected, and in the unit cell, two ions, A and B, are cations, A ion is located at the body center, B ion is located at each corner, and an anion O is located at the center of each side. Since Bi, Na, and K sources constituting the A site are highly volatile at a sintering temperature of 1100℃ or higher, it is difficult to maintain uniformity of the composition. In order to solve this problem, there should be suppression of volatilization of the A site material or additional compensation of the volatilized. In this study, the basic composition of BNKT Ceramics was set to Bi_0.5(Na_0.78K_0.22)_0.5TiO₃ (= BNKT), and volatile site (Bi, Na, and K sources) were coated in the form of a shell to compensate additionally for the A site ions. In addition, the physical and electrical properties of BNKT and its coated with shell additives(= @BNK) were compared and analyzed, respectively. As a result of analyzing the crystal structure through XRD, both BNKT(Core) and @BNK(Shell) had perovskite phases, and the crystallinity was almost similar. Although the Curie temperature of the two sintered bodies was almost the same (TC = 290 ~ 300 ℃), it was confirmed that the d33 (piezoelectric coefficient) and Pr (residual polarization) values were different. The experimental results indicated that the additional compensation for a shell additive causes the coarsening, resulting in a decrease in sintering density and Pr(remanent polarization). However, coating shell additives to compensate for A site ion is an effective way to suppress volatilization. Based on these experimental results, it would be the biggest advantage to develop an eco-friendly material (Lead-free) that replaced lead (Pb), which is harmful to the human body. This lead-free piezoelectric material can be applied to a biomedical device or products(ex. earphones (hearing aids), heart rate monitors, ultrasonic vibrators, etc.) and skin beauty improvement products (mask packs for whitening and wrinkle improvement).

• The Korean Journal of Nuclear Medicine Technology
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• v.28 no.1
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• pp.57-69
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• 2024

Purpose: Quantitative analysis through count measurement in nuclear medicine planar images is limited by analysis techniques that are useful for obtaining various clinical information or by organ overlap or artifacts in actual clinical practice. On the other hand, the use of SPECT tomography images is quantitative analysis using volume rather than planar, which is not only free from problems such as projection overlap, but also has excellent quantitative accuracy. In the use of developing SPECT quantitative analysis technology, this study aims to compare the accuracy of quantitative analysis between ROI of the conventional planar images and VOI of the SPECT tomographic images in evaluating the count change happened by the volume change of the source. Materials and Methods: A ^99mTcO₄^- source(200.17 MBq) was filled with sterilized water in the syringe to create a phantom with an inner diameter volume of 60 cc, and a planar image and a SPECT image were obtained by reducing the volume by 15 cc (25%) respectively. ROI and VOI(threshold: 1~45%, 5% interval) were set for each image obtained to estimate true count and measure the total count, and compared with the preseted volumetric change rate(%). Results: When volume changes of 25%, 50%, and 75% occurred in the initial volume of 60 cc(100%) of the phantom, the average count changes of the measured planar image were 26.8%, 53.2%, 77.5%, and the average count changes of the SPECT image were 24.4%, 50.9%, and 76.8%. In this case, the VOI size(cm³) set showed an average change rate of 25.4%, 51.1%, and 76.6%. The highest threshold value for the accuracy of radioactive concentration by VOI size (average error -1.03%) was 35%, and the VOI size of the same threshold had an error of -17.1% on average compared to the actual volume. Conclusion: On average, the count-based volumetric change rate in nuclear medicine images was able to track changes more accurately using VOI than ROI, but there was no significant difference with relatively similar value. However, the accuracy of radioactive concentration according to individual VOI sizes did not match, but it is considered that a relatively accurate quantitative analysis can be expected when the size of VOI is set smaller than the actual volume.