• The Journal of Korean Medicine
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• v.26 no.3 s.63
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• pp.204-214
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• 2005

Objectives : The verity extract of the Gagam-Hyungbang-Gihwang-tang (GHG) was assessed to determine the mechanisms of its antioxidant activity. Methods : The fellowing effects were measured : GHG exhibited a concentration-treatment; scavenging ${\alpha},\;{\alpha}-diphenyl-\beta-picrylhydrazyl$ (DPPH) radical, linoleic acid oxidation in a thiocyanate assay system, and superoxide anion, hydroxyl radical-induced DNA nicking. We investigated mRNA levels such as superoxide-dismutase. Results : The GHG extract showed dose-dependent free radical scavenging activity, including DPPH radicals, hydroxyl radicals, and superoxide anion, using different systems. The GHG was also found to be effective in protecting plasmid DNA against the strand breakage induced by hydroxyl radicals in Fenton's reaction mixture. Furthermore, SOD-1 mRNA expression levels increased in tat hepatoma H4IIE cells Conclusions : We expect that GHG will to helpful to the development of antioxidant activity treatments.

• Journal of the Society of Naval Architects of Korea
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• v.46 no.1
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• pp.87-95
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• 2009

The applicability of optimization techniques for hull surface fitting has been important in the ship design process. In this research, the Genetic Algorithm has been used as a searching technique for solving surface fitting problem and minimizing errors between B-spline surface and the ship's offset data. The encoded design variables are the location of the vertex points and parametric values. The sufficient accuracy in surface fitting implies not only various techniques for computer-aided design, but also the future production design.

• Journal of Power Electronics
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• v.13 no.1
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• pp.9-19
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• 2013

In this paper, a ripple input current embedded switched-inductor Z-source inverter (rESL-ZSI) and a continuous input current embedded switched-inductor Z-source inverter (cESL-ZSI) are proposed by inserting two dc sources into the switched-inductor cells. The proposed inverters provide a high boost voltage inversion ability, a lower voltage stress across the active switching devices, a continuous input current and a reduced voltage stress on the capacitors. In addition, they can suppress the startup inrush current, which otherwise might destroy the devices. This paper presents the operating principles, analysis, and simulation results, and compares them to the conventional switched-inductor Z-source inverter. In order to verify the performance of the proposed converters, a laboratory prototype was constructed with 60 $V_{dc}$ input to test both configurations.

• Journal of Korean Elementary Science Education
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• v.18 no.1
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• pp.29-39
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• 1999

The purpose of this investigation was to examine and compare pre-service and in-service elementary school teachers' beliefs about Science-Technology-and Society (STS), particularly beliefs about the nature of science and technology, their interaction within society, and the epistemology of science. Large percentage of pre-service and in-service elementary school teachers were understood to perceive as follows : 1. they regarded the science as 〃Knowledge scheme aiming content'and technology as 'skill for solution of actual problems'. 2. they revealed themselves to perceive tat science/ technology influence our lives through new terms and ideas, that science/ technology is affected by governmental policies and that all the people concerned including scientist and technologist should participate in the course of decision making. 3. they perceived that scientist perform their studies by characteristic abilities and that the studies are affected by their religious viewpoint. Moreover, they were understood to perceive that scientific knowledge are constructed through social interaction. 4. they perceived that scientist discover and develop scientific laws by scientific methods such as verification and certification, and that those scientific laws could be changed later.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.83.1-83.1
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• 2013

반도체 미세화, Glass 대면적화에 따른 산포관리 및 불량방지 필요(공정이격관리), 설비 데이터만으로는 Sensitivity가 낮아 공정 관리 어려움에 따른 대안 필요, 향후 추가 센서에 대한 접목이 용이한 SW Frame 필요, 양산적용을 위한 설비 및 FAB Host의 자동화 연계 개발 필요, 이종데이터의 통합를 통한 최적의 진단 및 관리가 필요합니다(SCM:툴박스). 즉, 기존의 장비 Parameter가 아닌 실제 공정시 Chamber로부터 얻을 수 있는 물리, 전기, 화학적인 데이터를 적합한 이종(異種) 센서를 직접 부착하여 이들 데이터를 통합 관리 분석 및 실시간 Monitoring을 통한 공정 진단 및 실시간 진단을 실행하는 솔루션입니다. 실 공정 시 적용이 유리한 OES 데이터를 주요 인자로 이외의 기타 데이터를 추가로 통합하여 특화된 분석환경과 공정 모니터링을 통하여 TAT (Turn Around Time)를 줄이고, MTBC (Mean Time Between Clean)를 늘림으로써 궁극적으로 칩메이커의 제품의 가격 경쟁력을 확보 할 수 있는 기능이며, 설비사 입장에서는 자사설비의 지능형 시스템을 위한 제반 기술이기도 합니다.

• Bulletin of the Korean Mathematical Society
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• v.56 no.2
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• pp.419-437
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• 2019

This paper investigates skew ${\Theta}-{\lambda}$-constacyclic codes over $R=F_0{\oplus}F_1{\oplus}{\cdots}{\oplus}F_{k-1}$, where $F{_i}^{\prime}s$ are finite fields. The structures of skew ${\lambda}$-constacyclic codes over finite commutative semi-simple rings and their duals are provided. Moreover, skew ${\lambda}$-constacyclic codes of arbitrary length are studied under a new definition. We also show that a skew cyclic code of arbitrary length over finite commutative semi-simple rings is equivalent to either a cyclic code over R or a quasi-cyclic code over R.

• YAKHAK HOEJI
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• v.15 no.3_4
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• pp.87-92
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• 1971

Fourteen novel N,N'-disubstitued thiourea derivatives were synthesized by Hugershof reaction. Antitubercular activities of ten compounds against Mycobacterium tuberculosis H$_{37}$ Rv were tested and was found tat 1-cyclohexyl-3-(4-benzenesulfonepiperidide)-2-thiourea was considerably active at 1mg/ml and 1-$\alpha$-naphthyl-3-(4-benzenesulfonepiperidide)-2-thiourea was slightly active at 1mg/ml. Antibacterial activity of the newly synthesized compounds against E. coli, Sta. aureus and Streptococcus hemolyticus were also tested. 1-cyclohexyl-3-(4-benzenesulfonepiperidide)-2-thiourea was makedly active against E. coli, Sta, aureus and Streptococcus hemolyticus; Phenol coefficients against E. coli, Sta, aureus and Streptococcus hemolyticus were 30,17.5 and 21.3, respectively. 1,1'-p-phenylene-3,3'bis[N-(2-thiazolyl)-sulfamylphenyl]-2,2'-dithiourea and 1-$\alpha$-naphthyl-3-(4-benzenesulfonepiperidide)-2-thiourea were considerably active against E. coli: phenol coefficients, 18.8 and 37.5 respectively. 1-(4-ethoxyphenyl)3-(4-sulfamylphenyl)-2-thiourea was active against Streptococcus hemolyticus: phenol coefficients, 22.5. 1-$\alpha$-naphthyl-3-(4-sulfamylphenyl)-2-thiourea, 1-$\betha$-naphthyl-3-[4-N-(2-thiazolyl)-sulfamylphenyl]-2-thiourea and 1-$\alpha$-naphthyl-3-(4-benzenesulfonepiperidide)-2-thiourea were active against Sta. aureus: phenol coefficients, 17.5, 20.0 and 18.8 respectively.

• The Journal of Korean Society of Virology
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• v.26 no.2
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• pp.141-150
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• 1996

본 연구에서는 $CD4^+$ T 세포를 일회성으로 감염시킬 수 있고 $CD4^+$ T 세포에 HIV-1 envelope 유전자를 전달할 수 있는 바이러스 입자를 생산하는 HIV-1 complementation system을 개발하였고 이 system을 이용하여 $CD4^+$ T 세포에 선택적으로 HIV-1 envelope 당단백질을 발현시켰다. 이 system은 Gag/Gag-Pol expressor와 Env expressor로 구성되어있다. Gag/Gag-Pol expressor는 바이러스 입자 생산에 필요한 구조단백질과 기능단백질을 발현시키지만 packaging signal이 결핍되어 바이러스 입자로 유전자가 들어가지 못하도록 제조되었다. Env expressor는 Tat, Rev와 envelope 당단백질을 발현시키고 packaging signal을 갖고 있어 바이러스 입자로 envelope 유전자가 들어가도록 제조되었다. Gag/Gag-Pol expressor로부터 Gag와 Gag-Pol의 발현은 Rev 단백질을 요구하였고 Env expressor로부터 Rev 단백질 이 제공될 때 Gag와 Gag-Pol 단백질은 효율적으로 발현되었다. Gag/Gag-Pol과 Env expressor로 cotransfection된 COS-1 세포에서 $CD4^+$ T 세포를 일회성으로 감염시킬 수 있는 바이러스 입자가 생산되었다. 생산된 바이러스 입자는 $CD4^+$ T 세포에 HIV-1 envelope 유전자를 전달하여 envelope 당단백질을 발현시켰고 복제 가능한 자손 바이러스의 생성을 유도하지 못하였다. 본 연구에서 개발된 방법은 $CD4^+$ T 세포에서 envelope 당단백질의 기능을 분석하고 관심 있는 유전자를 $CD4^+$ T 세포에 전달하는 바이러스 입자의 생산에 이용할 수 있다.

• Toxicological Research
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• v.4 no.1
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• pp.37-45
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• 1988

Primary cultures of adult rat hepatocytes were used to study in vitro cytotoxic effects of T-2 toxin on liver cells. When T-2 toxin was added to the culture, a significant depression of the hormonal induction of ${\alpha}$-aminoisobutyric acid (AIB) uptake and tyrosine aminotransferase (TAT) activity was observed. However, T-2 toxin did not affect the uptake of ouabain into hepatocytes. Protein synthesis was inhibited by T-2 toxin, but RNA synthesis was not severely affected. The inhibitory effects of T-2 toxin on protein synthesis was diminished rapidly with culture time and the hepatocytes culture maintained control level of protein synthesis within 24 hrs.

• Research in Mathematical Education
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• v.19 no.2
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• pp.89-100
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• 2015

The study investigated pre-service teachers' knowledge and computational skills by using Triangular Arithmagon. Participants included 90 pre-service teachers from two schools in the United States and Taiwan. The Triangular Arithmagons Test (TAT) was used to measure pre-service teachers' performance in whole number, fractions, and decimals operations (i.e., addition, subtraction, multiplication, and division), each of which included level-1 (basic) and level-2 (advanced) tests. MANOVA analysis was performed to compare the performance between teachers from the United States and Taiwan. Results indicated that overall, pre-service teachers in Taiwan outperformed those in the United States, especially on the advanced-level tests. Pre-service teachers in the United States were found to have poor ability of solving complex operation problems. Different curriculum plans and teaching methods may lead to the performance gap between the two countries.