• 제목, 요약, 키워드: TAM model

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Up-regulation of HOXB cluster genes are epigenetically regulated in tamoxifen-resistant MCF7 breast cancer cells

  • Yang, Seoyeon;Lee, Ji-Yeon;Hur, Ho;Oh, Ji Hoon;Kim, Myoung Hee
    • BMB Reports
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    • v.51 no.9
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    • pp.450-455
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    • 2018
  • Tamoxifen (TAM) is commonly used to treat estrogen receptor (ER)-positive breast cancer. Despite the remarkable benefits, resistance to TAM presents a serious therapeutic challenge. Since several HOX transcription factors have been proposed as strong candidates in the development of resistance to TAM therapy in breast cancer, we generated an in vitro model of acquired TAM resistance using ER-positive MCF7 breast cancer cells (MCF7-TAMR), and analyzed the expression pattern and epigenetic states of HOX genes. HOXB cluster genes were uniquely up-regulated in MCF7-TAMR cells. Survival analysis of in slico data showed the correlation of high expression of HOXB genes with poor response to TAM in ER-positive breast cancer patients treated with TAM. Gain- and loss-of-function experiments showed that the overexpression of multi HOXB genes in MCF7 renders cancer cells more resistant to TAM, whereas the knockdown restores TAM sensitivity. Furthermore, activation of HOXB genes in MCF7-TAMR was associated with histone modifications, particularly the gain of H3K9ac. These findings imply that the activation of HOXB genes mediate the development of TAM resistance, and represent a target for development of new strategies to prevent or reverse TAM resistance.

The Effect of Mobile Fashion Shopping Characteristics on Consumer's Purchase Intention - Applying the Technology Acceptance Model - (모바일 패션 쇼핑 특성이 소비자의 구매의도에 미치는 영향 - 기술수용모델(Technology Acceptance Model)을 적용 -)

  • Chae, Jin Mie
    • Fashion & Textile Research Journal
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    • v.18 no.1
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    • pp.38-47
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    • 2016
  • This research analyzes the influence of mobile commerce characteristics on consumer's purchase intention using a theoretical Technology Acceptance Model (TAM) constructed on previous studies and a review of the literature to explain the effect of mobile fashion shopping characteristics on consumer's purchase intention. In constructing structural equation model, Mobile commerce characteristics variables such as 'security', 'enjoyment', and 'personalization' were selected as external variables affecting TAM. A questionnaire was distributed to consumers in their 20's-30's who had purchased fashion products using a mobile shopping channel. Statistical methods of confirmatory factor analysis, correlation, and covariance structural analysis using Amos 19.0 package were employed for the analysis of 453 effective data responses. The results were as follows. First, extended TAM was shown be the appropriate model to explain the influence of mobile commerce characteristics on consumer's purchase intention in mobile fashion shopping. Second, 'security' had a significant positive influence on perceived usefulness (PU), however it affected perceived ease of use (PEOU) negatively. Third, 'enjoyment' had a significant influence only on PEOU, while 'personalization' was found to affect both PEOU and PU significantly. Fourth, PEOU affected PU significantly. Finally, both PEOU and PU had a significant influence on consumer's purchase intention.

Determinants of the user's Intention to use of Mobile banking (Mobile Banking 사용 의도 결정 요인)

  • Han, Sang-Il
    • The Journal of Society for e-Business Studies
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    • v.10 no.3
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    • pp.135-157
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    • 2005
  • Based on literature relating to the theory of planned behavior(TPB) and the TAM, this study extends the applicability of the TAM in a mobile banking context, by adding one trust-based construct('perceived credibility') and two resource-based constructs('perceived efficacy' and 'perceived cost') and technical suitability constructs to the model, while paying careful attention to the placing of these constructs in the TAM's existing nomological structure. Data collected from 182 users in Korea were tested against the extended TAM, using the structural equation modeling approach. The results strongly support the extended TAM in predicting users intentions to adopt mobile banking. Several implications for IT/IS acceptance research and mobile banking management practices are discussed.

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A Study of Influencing Factors Upon Using C4I Systems: The Perspective of Mediating Variables in a Structured Model (C4I 시스템 사용의 영향 요인에 관한 연구: 구조모형의 매개변수의 관점에서)

  • Kim, Chong-Man;Kim, In-Jai
    • Asia pacific journal of information systems
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    • v.19 no.2
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    • pp.73-94
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    • 2009
  • The general aspects for the future warfare shows that the concept of firepower and maneuver centric warfare has been replacing with that of information and knowledge centric warfare. Thus, some developed countries are now trying to establish the information systems to perform intelligent warfare and innovate defense operations. The C4I(Command, Control, Communication, Computers and Intelligence for the Warrior) systems make it possible to do modern and systematic war operations. The basic idea of this study is to investigate how TAM(Technology Acceptance Model) can explain the acceptance behavior in military organizations. Because TAM is inadequate in explaining the acceptance processes forcomplex technologies and strict organizations, a revised research model based upon TAM was developed in order to assess the usage of the C4I system. The purpose of this study is to investigate factors affecting the usage of C4I in the Korean Army. The research model, based upon TAM, was extended through a belief construct such as self-efficacy as one of mediating variables. The self-efficacy has been used as a mediating variable for technology acceptance, and the variable was included in the research model. The external variables were selected on the basis of previous research. The external variables can be classified into following: 1) technological, 2) organizational, and 3) environmental factors on the basis of TOE(Technology-Organization-Environment) framework. The technological factor includes the information quality and the task-technology fitness. The organizational factor includes the influence of senior colleagues. The environmental factor includes the education/train data. The external variables are considered very important for explaining the behavior patterns of information technology or systems. A structured questionnaire was developed and administrated to those who were using the C4I system. Total 329 data were used for statistical data analyses. A confirmatory factor analysis and structured equation model were used as main statistical methods. Model fitness Indexes for measurement and structured models were verified before all 18 hypotheses were tested. This study shows that the perceived usefulness and the self-efficacy played their roles more than the perceived ease of use did in TAM. In military organizations, the perceived usefulness showed its mediating effects between external variables and dependent variable, but the perceived ease of use did not. These results imply that the perceived usefulness can explain the acceptance processes better than the perceived ease of use in the army. The self-efficacy was also used as one of the three mediating variables, and showed its mediating effects in explaining the acceptance processes. Such results also show that the self-efficacy can be selected as one possible belief construct in TAM. The perceived usefulness was influenced by such factors as senior colleagues, the information quality, and the task-technology fitness. The self-efficacy was affected by education/train and task-technology fitness. The actual usage of C4I was influenced not by the perceived ease of use but by the perceived usefulness and selfefficacy. This study suggests the followings: (1) An extended TAM can be applied to such strict organizations as the army; (2) Three mediation variables are included in the research model and tested at real situations; and (3) Several other implications are discussed.

Factor Analysis of the Cloud Service Adoption Intension of Korean Firms: Applying the TAM and VAM (TAM과 VAM을 적용한 기업의 클라우드 서비스 채택의도의 영향요인 분석)

  • Seo, Kwang-Kyu
    • Journal of Digital Convergence
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    • v.11 no.12
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    • pp.155-160
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    • 2013
  • The global recession circumstances, cloud computing has emerged as a new paradigm in the business IT sector. This paper explores the analysis of cloud service adoption Intension of Korean firms. Especially, we focus on Infrastructure as a Service (IaaS) among cloud services and apply TAM (Technology Acceptance Model) and VAM (Value-based Adoption Model) to analyze cloud service adoption intension The proposed exploratory model tests a number of hypotheses to understand the importance factors of IaaS adoption intension with TAM and VAM included additional cloud service characteristics such as scalability, agility, security, efficiency and reliability. Eventually, the findings of this study can not only help company users gain insights into IaaS adoption, but also help cloud service providers to develop their service effectively and improve marketing strategy in B2B cloud service market.

Determinant Factors Including Functional Attributes for Accepting Digital Multimedia Broadcasting Service (기능적 속성을 고려한 DMB 서비스의 채택 결정요인 분석)

  • Kim, Soo-Hyun
    • Journal of Information Technology Applications and Management
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    • v.14 no.4
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    • pp.61-74
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    • 2007
  • In this paper we consider the Digital Multimedia Broadcasting (DMB) Service that starts recently in Korea and gains popularity. DMB makes it possible to watch high quality TV programs while we are in motion. The service provider or the service researcher are interested in the factors that influence the user's choice of new service such as DMB. Understanding the factors make them create the powerful marketing strategies and develop the new service or product that is attractive for users. We therefore find the factors influencing the user's choice of DMB service, and propose a model for analyzing the relationship between the factors and the intention of buying. The model is based on the Technology Acceptance Model (TAM). We extend the TAM by adding factors including functional attributes of DMB service. We survey the significant functional attributes influencing the intention of buying by using the proposed model.

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The Relationship between Use of Internet Banking and Security Anxiety: Extending TAM (인터넷 뱅킹 사용과 보안우려의 관계: 기술수용모형의 확장)

  • Hwang Ha Jin;Lee Ung Gyu
    • Proceedings of the Korea Association of Information Systems Conference
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    • pp.93-105
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    • 2003
  • Although, recently, studies on Internet banking users' behavior have been frequently found in some academic journals, most of them have ignored security anxiety which may be considered as important factors influencing usages of Internet banking. We propose an research model for Internet banking users which is an extended version of the Technology Acceptance Model(TAM) by adding new variable, security anxiety. For empirical support of our model, we survey for 298 samples and analyze it by structured equation model(SEM). In result, our proposed model is proved as a valid one in which all hypotheses except one are accepted and the values of model fitness are relatively high.

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A Study on Consumers' Clothing Buying Intention Adopted By the Technology Acceptance Model (혁신기술수용모델(TAM)을 적용한 스마트 의류 구매의도 연구)

  • Kang, Keang-Young;Jin, Hyun-Jeong
    • Journal of the Korean Society of Clothing and Textiles
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    • v.31 no.8
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    • pp.1211-1221
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    • 2007
  • This research investigates the effects of fashion innovativeness and technology innovativeness on the attitude and the buying intention of smart clothing. This study employs TAM(Technology Acceptance Model) proposed by Davis(1989) as a theoretical framework. Two hundred sixty-five respondents comprised a sample used to examine a structural model. The structural equation model using AMOS was performed to test hypotheses. Fashion innovativeness was found to affect perceived usefulness while technology innovativeness affected perceived ease of use. Perceived usefulness was found to influence attitude towards smart clothing. Perceived ease of use was also found to affect attitude towards smart clothing. The attitude towards smart clothing has a direct effect on the buying intention of smart clothing. In addition, this study revealed that employing TAM to investigate the adoption of smart clothing was appropriate. Lastly, implications of this research and suggestions for future studies were discussed.

Korean Students' Intentions to Use Mobile-Assisted Language Learning: Applying the Technology Acceptance Model

  • Kim, Gyoo-mi;Lee, Sang-jun
    • International Journal of Contents
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    • v.12 no.3
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    • pp.47-53
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    • 2016
  • The purpose of this study was to examine how Korean students accept and use mobile-assisted language learning (MALL) and investigate related factors that potentially affect MALL usage. The participants were 244 undergraduate students who were surveyed with a questionnaire. The research model, which included students' self-efficacy, content reliability, interactivity, perceived enjoyment, perceived usefulness, perceived ease of use, attitude, and behavioral intention to use MALL, was developed based on the technology acceptance model (TAM). The structural equation modeling (SEM) technique was employed in order to analyze the overall results of modified TAM and the research model. The results indicated that TAM was a good theoretical tool to understand students' acceptance of MALL. In addition, all constructs, with the exception of self-efficacy and interactivity, had significant effects on students' acceptance possibilities of MALL. Limitations and suggestions for the further study are also presented.

Understanding Acceptance of Fintech Service in Korea: Focused on Decomposed TPB into TAM (우리나라 소비자의 핀테크 수용 모형의 탐색: 기술수용모형의 분해계획행동이론을 중심으로)

  • Joo, Jihyuk
    • Journal of Digital Convergence
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    • v.15 no.4
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    • pp.171-179
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    • 2017
  • This study explored an appropriate research model that could explain and predict the spread of fintech, a new financial services in Korea. We reviewed two theoretical frameworks, theory of planned behavior(TPB) and technology acceptance model(TAM), which are frequently cited to explain human behavior and new technology adoption, respectively. Then, we proposed a decomposed theory of planned behavior(DTPB) as a research model and examined the model through PLS path modeling. As a result, every path except PEOU-ATT path in TAM is significant, and the explanatory power toward behavioral intention(R2=0.573) is also significantly greater in the proposed model. Accordingly, the proposed DTPB is appropriate to explain the spread of fintech in Korea. Finally, suggestions for the following studies are discussed.