• Bulletin of the Korean Chemical Society
• /
• v.31 no.6
• /
• pp.1509-1514
• /
• 2010

Methyl 3,4-di-(2'-hydroxyethoxy)benzylidenecyanoacetate (3) was prepared and condensed with terephthaloyl chloride to yield novel Y-type polyester (4) containing 3,4-dioxybenzylidenecyanoacetate groups as NLO-chromophores, which constituted parts of the polymer main chains. The resulting polymer 4 is soluble in common organic solvents such as acetone and N,N-dimethylformamide. Polymer 4 shows thermal stability up to $280^{\circ}C$ in thermogravimetric analysis with glass-transition temperature obtained from differential scanning calorimetry near $105^{\circ}C$. The second harmonic generation (SHG) coefficient ($d_{33}$) of poled polymer films at the 1064 nm fundamental wavelength is around 2.42 pm/V. The dipole alignment exhibits high thermal stability up to near $T_g$, and there is no SHG decay below $100^{\circ}C$ due to the partial main-chain character of polymer structure, which is acceptable for NLO device applications.

• Electronics and Telecommunications Trends
• /
• v.39 no.2
• /
• pp.77-92
• /
• 2024

The 3GPP (3rd Generation Partnership Project) mobile communication standard has emerged as a leading standard in the market over the past 20 years, driving continuous development in protocol stacks and libraries that support the standard within simulation software for communication network research. We summarize and analyze seven communication network simulators that support the 3GPP standard specifications related to core network technologies. Through comparisons, we aim to offer valuable insights for researchers and engineers engaged into research and development related to mobile communication networks based on 3GPP standards. Our findings can provide assistance for making informed decisions on simulator selection.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.32 no.3
• /
• pp.157-164
• /
• 2018

This study was designed to investigate the mechanism of the synergistic anticancer effect of Astragalus membranaceus (AM) and Adenophora triphylla var. japonica (AT) in H1299 human lung carcinoma cells. A combined treatment of ethanol extract of AM (EAM) and AT (EAT) explosively increased the reactive oxygen species (ROS) generation in H1299 cells compared to the single treatment of each of them. Co-treatment of N-acetyl-L-cysteine (NAC) with EAM and EAT markedly enhanced the cell viability and suppressed apoptosis in H1299 cells, suggesting that ROS generation contributed to the anticancer effect of EAM and EAT. Interestingly, the combined treatment of EAM and EAT down-regulated p-AKT in H1299 cells, which was abrogated by NAC treatment. These results clearly indicated that ROS generation mediated the inactivation of AKT. Co-treatment of LY294002 with EAM and EAT significantly reduced the cell viability at a concentration which EAM and EAT didn't show any cytotoxicity. In addition, the recovery of cell viability by co-treatment of NAC with EAM and EAT was quite reversed by LY294002 treatment, which confirmed that the inactivation of AKT played a pivotal role in ROS-mediated apoptosis. Taken together, our results demonstrated that the synergistic anticancer effect of EAM and EAT was mediated by ROS generation and inactivation of AKT. We provide a valuable preclinical data for the development of more effective combination of AM and AT to treat lung cancer.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.3
• /
• pp.260-266
• /
• 2018

The concept of customer utility, which affects customer's adoption, is important to understand the process of technology diffusion and substitution regarding multiple generation technology. This research defined the concept of attribute-based customer utility and developed a model for measuring attribute-based customer utility. Based on the literature review and modeling, we provided the definition and a model regarding customer utility and the accuracy of the model is verified through a case study of the semiconductor industry. Customer utility for a multiple generation technology needs to consider changes by generation, or time within the same generation, and is defined as the summation of both technological and economic utilities. In addition, we can model the measurement of customer utility after converting technological and economical attributes into utilities. This research is valuable in understanding not only customer utility as a driver of customer adoption, but also for establishing technological strategy after forecasting diffusion and substitution paths based on customer utility.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.16
• /
• pp.7261-7266
• /
• 2015

Breast cancer, the most common cancer in the women, is the leading cause of death. Necrotic signaling pathways will enable targeted therapeutic agents to eliminate apoptosis-resistant cancer cells. In the present study, the effect of shikonin on the induction of cell necroptosis or apoptosis was evaluated using the T-47D breast cancer cell line. The cell death modes, caspase-3 and 8 activities and the levels of reactive oxygen species (ROS) were assessed. Cell death mainly occurred through necroptosis. In the presence of Nec-1, caspase-3 mediated apoptosis was apparent in the shikonin treated cells. Shikonin stimulates ROS generation in the mitochondria of T-47D cells, which causes necroptosis or apoptosis. Induction of necroptosis, as a backup-programmed cell death pathway via ROS stimulation, offers a new strategy for the treatment of breast cancer.

• IMMUNE NETWORK
• /
• v.12 no.3
• /
• pp.71-83
• /
• 2012

T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained T cell receptor-mediated signalling and stabilized adhesion. High resolution microscopy indeed had a great impact in understanding the function and dynamic structure of immunological synapse. Trends of recent research are now moving towards understanding the mechanical part of immune system, expanding our knowledge in mechanosensitivity, force generation, and biophysics of cell-cell interaction. Actin cytoskeleton plays inevitable role in adaptive immune system, allowing it to bear dynamic and precise characteristics at the same time. The regulation of mechanical engine seems very complicated and overlapping, but it enables cells to be very sensitive to external signals such as surface rigidity. In this review, we focus on actin regulators and how immune cells regulate dynamic actin rearrangement process to drive the formation of immunological synapse.

• ETRI Journal
• /
• v.41 no.6
• /
• pp.863-872
• /
• 2019

Elliptic curve cryptography is a relatively lightweight public-key cryptography method for key generation and digital signature verification. Some lightweight curves (eg, Curve25519 and Curve Ed448) have been adopted by upcoming Transport Layer Security 1.3 (TLS 1.3) to replace the standardized NIST curves. However, the efficient implementation of Curve Ed448 on Internet of Things (IoT) devices remains underexplored. This study is focused on the optimization of the Curve Ed448 implementation on low-end IoT processors (ie, 8-bit AVR and 16-bit MSP processors). In particular, the three-level and two-level subtractive Karatsuba algorithms are adopted for multi-precision multiplication on AVR and MSP processors, respectively, and two-level Karatsuba routines are employed for multi-precision squaring. For modular reduction and finite field inversion, fast reduction and Fermat-based inversion operations are used to mitigate side-channel vulnerabilities. The scalar multiplication operation using the Montgomery ladder algorithm requires only 103 and 73 M clock cycles on AVR and MSP processors.

• Journal of the Korea Fashion and Costume Design Association
• /
• v.24 no.3
• /
• pp.111-125
• /
• 2022

Recently, the MZ generation has been leading overall fashion trends, and fashion companies focus on design, marketing, and new products targeting the MZ generation. However, it is expected that a fit problem may occur if the M and Z generations are combined when producing clothing. Therefore, this study aims to analyze the differences between the two groups by comparing the body size according to the classification of the M and Z generations. In addition, this study analyzes whether the body shape of the MZ generation is different from the past generations and analyzes major changes in body size for clothing manufacturing through graphical visualization. As for the research method, a t-test was conducted to verify the significant difference between the measurements for each age group. Generation M was defined as those who are 27-39 years old, and Generation Z was defined as those who are 20-26 years old. In order to examine the changes in body measurements according to the measurement year, the 7th Size Korea and 8th Size Korea data were analyzed. In order to examine the visual changes according to the measurement year and age group, major measurements of clothing construction were analyzed. As a result, it was found that Generation M had a significantly higher height item than Generation Z. Also, in terms of circumference, width, and thickness, Generation M was larger than Generation Z. But the size of the bra cup was larger in Generation Z than Generation M. As a result of analyzing the body size changes, in the height item, the 8th Size Korea measurements were found to be significantly higher in shoulder height and navel level waist height. In the length and circumference items, the 8th Size Korea measurements were larger than the 7th. In the width, thickness, and other items, the 8th measurements were larger than the 7th.

• Journal of the Korea Society for Simulation
• /
• v.17 no.3
• /
• pp.19-26
• /
• 2008

In this paper, we propose a dynamic prediction algorithm to predict the bond price using actual data set of treasure note (T-Note). The proposed algorithm is based on term structure model of the interest rates, which takes place in various financial modelling, such as the standard Gaussian Wiener process. To obtain cumulative distribution functions (CDFs) of actual data for the interest rate measurement used, we use the natural cubic spline (NCS) method, which is generally used as numerical methods for interpolation. Then we also use the random number generation scheme (RNGS) to calculate the pricing of bond through the obtained CDF. In empirical computer simulations, we show that the lower values of precision in the proposed prediction algorithm corresponds to sharper estimates. It is very reasonable on prediction.

• Journal of the Korea Society of Computer and Information
• /
• v.13 no.3
• /
• pp.45-55
• /
• 2008

Due to the increasing complexity of embedded system design, automatic code generation of embedded software and hardware-software co-design methodologies are gaining great interest from industries and academia. Such an automatic design methodologies are always demanding a formal system specification languages for defining designer's idea clearly and precisely. In this paper, we propose automatic embedded C code generation from SDL (Specification and Description Language, ITU-T recommended the SDL as a standard system description language) with considering a real-time uC/OS-II operating system. Our automatic embedded C code generator is expected to provide a fast specification, verification and performance evaluation platform for embedded software designs.