• 감성과학
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• 제23권2호
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• pp.51-60
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• 2020

본 연구의 목적은 심박 측정용 기기 및 의류에 있어 배터리 충전 및 기기의 부피감으로 인한 불편함을 개선하고, 사용자 편의성을 고려하여 목적에 따른 심박 측정을 가능케 하는 심박 측정용 스마트 의류 시스템을 개발하고자 하였다. 심박 측정 기기는 2가지 타입으로 모듈화되어 개발되었으며, 탈부착을 통해 목적형 및 지속적 심박 측정이 가능하도록 구성하였다. 목적형 심박측정 기기는 NFC(Near Field Communication), 심박 센서를 내장하고 필요시에 스마트 폰 태깅을 통해 심박 측정이 가능하게 하는 의류에 부착된 타입으로 개발되었으며, 지속형 심박 측정 기기는 BLE(Bluetooth Low Energy) 통신 및 배터리를 내장하여 목적형 기기와 결합을 통해 통신 및 전원을 지원, 지속적으로 심박 측정이 가능한 시스템으로 구성되었다. 심박 측정을 위한 섬유 전극은 은사 기반의 편물 전극으로, 심박 측정에 용이하도록 대흉근 아래에 위치하도록 디자인되었으며, 목적형 심박측정 기기가 전극과 연결되도록 구성되었다. 연동되는 어플리케이션은 사용자 경험요소, 주요기능 및 사용편의성 등을 고려하여 개발되었으며, 사용성 향상을 위하여 스마트 폰 태깅을 통해 자동 동기화가 되도록 개발되었다. 본 연구에서 개발된 심박측정 스마트 의류 시스템의 심박측정 정확도를 평가하기 위하여, 10명의 20대 남성 피험자를 대상으로 2단계의 실험을 설계하고 진행하였으며, POLAR RS800을 통해 측정되는 신호를 기준 심박으로 비교·분석하였다. 그 결과, 목적형 스마트 의류 시스템의 평균 심박수는 85.37, 기준 기기 심박수는 87.03으로 96.73%의 정확도를 갖는 것으로 분석되었으며, T 값 -1.892 (p=.091)로 두 신호간의 유의한 차이는 없는 것으로 분석되었다. 지속형 스마트 의류 시스템의 평균 심박수는 86.00, 기준 기기 심박수는 86.97로 97.16%의 정확도를 보였으며, T 값 -1.089(p=0.304)로 두 시스템 간의 측정 차이는 없는 것으로 분석되었다. 본 연구에서는 사용자의 목적에 따라 심박측정이 가능한 모듈형 스마트 의류 시스템을 개발하고 검증한 것에 의의가 있다. 또한, 모듈화 된 심박측정 의류 시스템 개발로 불필요한 기능으로 인한 가격 상승을 줄임으로써 이원화된 상품 기획의 가능성을 제시하였다.

• 대한물리의학회지
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• 제6권4호
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• pp.391-396
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• 2011

Purpose : The Purpose of this study is to investigate the values of foot pressure during gait cycle according to adaptation and sudden remove of various color information. Methods : Participants who met the criteria for this study (n=13). RS-Scan was used to measure plantar foot pressur according to Five kinds of color information in this study. Results : The adaptation of various color information is no statistically significant on all area. But sudden remove of various color information is statistically significant on T2-5, M5 and MF area. Conclusion : The results of this study suggest that sudden remove of various color information reduces the ability of balance during gait in normal adults. And these results means that increase risk of falling down according to sudden remove of various color information.

• PNF and Movement
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• 제9권4호
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• pp.49-55
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• 2011

Purpose : The aim of this study was to identify of bilateral trunk rotation(BTR) exercise and PNF exercise on gait in the individuals with malalignment syndrome. Methods : Subjects were 32 that were divided 2 groups in 20's generation. Interventions were trunk ratation exercise and PNF exercise. We used Medex for trunk rotation exercise. BTR group received exercise for three-sets (10min/set) along with stretching exercise ten-minutes, 3 times per week. PNF group took turns the D1 pattern in upper extremity and the D1 pattern in the opposite side of lower extremity for three-sets (10min/set). The measurement were force metatarsal 1 (FM 1), impulse metatarsal 1 (IM 1), force heel lat (FHL), impulse heel lat (IHL) by using footscan (RS scan). Statistical method was repeated measurement of ANOVA and p value was 0.05. Results : BTR and PNF group were significantly different in time(FM 1, IM 1, FHL, IHL). As different of right/left, BTR and PNF exercise were significantly different in FM 1, IM 1, FHL. Conclusion : BTR exercise was good exercise for malalignment but needs expensive equipment, for example, Medex. PNF exercise doesn't need expensive equipment but good method in malalignment syndrome person for gait ability. If PNF exercise is more experiment, PNF exercise could use variety for more patients.

• 대한의생명과학회지
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• 제27권1호
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• pp.12-18
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• 2021

Hypertension (HTN) is one of the cardiovascular disease risk factors. Peroxisome proliferator-activated receptor γ coactivator 1 alpha (PPARGC1A) is involved in a master modulator of mitochondrial biogenesis, and pulmonary arterial hypertension. In this study, we report results of PPARGC1A were associated with hypertension and its intermediate phenotype of systolic (SBP) and diastolic blood pressure (DBP) in the Korean population. In detail, identifying a susceptibility locus, 3 SNPs for HTN, 2 SNPs for SBP, 3 SNPs for DBP at P<0.05. Among them, rs1472095 in PPARGC1A gene statistically demonstrated one of the significant correlations with Hypertension (P-value=0.00359, OR=0.8, 95% CI=0.68~0.93). The minor allele (T) of PPARGC1A was statistically associated with the increased value of DBP, SBP, and the increase risk of hypertension. We aim to manifest a significant association between genetic variant in PPARGC1A and hypertension. This finding suggested that association of PPARGC1A genetic polymorphism and HTN accelerates our understanding of blood pressure control and underlines potential drug targets for treatment of hypertension.

• Journal of Animal Science and Technology
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• 제63권2호
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• pp.461-464
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• 2021

Escherichia coli normally colonizes the lower intestine of animals and humans, but some serotypes are foodborne pathogens. The Escherichia coli K_EC180 was isolated from swine feces that were collected from a weaner pig. In this genome announcement, E. coli K_EC180 was sequenced using PacBio RS II and Illumina NextSeq 500 platforms. The complete chromosome of E. coli K_EC180 is composed of one circular chromosome (5,017,281 bp) with 50.4% of guanine + cytosine (G + C) content, 4,935 of coding sequence (CDS), 88 of tRNA, and 22 of rRNA genes. The complete genome of E. coli K_EC180 contains the toxin genes such as shiga-like toxins (stxA and stxB).

• 한국가금학회지
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• 제29권4호
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• pp.279-286
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• 2002

본 연구는 오골계, 오골계교잡종(3원교잡)육의 한약제 첨가에 따른 저장시험에서는 한약증탕액구와 오골계증탕액구, 오골계교잡종증탕액구 0.1% 효소 처리한 오골계교잡종증탕 액구를 37$^{\circ}C$에서 56일간 저장하면서 TBARS, VBN, pH, 미생물수, 관능평가 등을 조사하여 적정 저장기간을 구명하고자 하였다. 증탕액의 저장기간 설정에서는 저장기간 중 성분변화를 측정하기 위하여 레토르트 포장지에 밀봉한 한약증탕액, 오골계증탕액, 오골계교잡종증탕액, 오골재래계를 flavourzyme으로 가수분해하여 제조한 증탕액을 37$^{\circ}C$에서 저장하면서TBhRS, VBN, pH, 미생물수, 관능평가를 실험한 결과는 다음과 같았다. 지방산패도는 대부분의 처리구에서 42일까지는 유의적인 차이가 나타나지 않았으나 56일째에 효소처리한 오골계 처리구에서 TBARS 값이 유의적으로 증가하였다. 단백질 변성도는 저장기간이 경과함에 따라 증가하는 경향을 나타내었으며, 특히 저장 56일째에 한약증탕액에 비해오골계, 오골계교잡종 및 효소처리 오골계교잡종증탕액에서 유의적으로 높은 값을 나타냈다. 관능평가에 있어서는 저장 42일부터 전체기호도에 있어서 변화를 보였다. 따라서, 증탕액의 저장은 37$^{\circ}C$에서 6주가 적정기간으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6519-6522
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• 2013

Background: Genetic polymorphisms of TP63 have been suggested to influence susceptibility to lung adenocarcinoma development in East Asian populations. This study aimed to investigate the relationship between common polymorphisms in the TP63 gene and the risk of lung adenocarcinoma, as well as interactions of the polymorphisms with environmental risk factors in Chinese non-smoking females. Methods: A case-control study of 260 cases and 318 controls was conducted. Data concerning demographic and risk factors were obtained for each subject. The genetic polymorphisms were determined by Taqman real-time PCR and statistical analyses were performed using SPSS software. Results: For 10937405, carriers of the CT genotype or at least one T allele (CT/TT) had lower risks of lung adenocarcinoma compared with the homozygous wild CC genotype in Chinese nonsmoking females (adjusted ORs were 0.68 and 0.69, 95%CIs were 0.48-0.97 and 0.50-0.97, P values were 0.033 and 0.030, respectively). Allele comparison showed that the T allele of rs10937405 was associated with a decreased risk of lung adenocarcinoma with an OR of 0.78 (95%CI=0.60-1.01, P=0.059). Our results showed that exposure to cooking oil fumes was associated with increased risk of lung adenocarcinoma in Chinese nonsmoking females (adjusted OR=1.58, 95%CI=1.11-2.25, P=0.011). However, we did not observe a significant interaction of cooking oil fumes and TP63 polymorphisms. Conclusion: TP63 polymorphism might be a genetic susceptibility factor for lung adenocarcinoma in Chinese non-smoking females, but no significant interaction was found with cooking oil fume exposure.

• Childhood Kidney Diseases
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• 제22권2호
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• pp.37-41
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• 2018

Purpose: Familial renal glucosuria (FRG, OMIM #233100) is a rare but relatively benign genetic condition characterized by persistent isolated glucosuria with a normal blood glucose level. We report three additional SLC5A2 mutations and examine their phenotypic and genetic characteristics in a Korean FRG cohort. We also reviewed the literature and summarized the genotypes of all Korean patients with FRG. Methods: A genetic analysis was conducted by directly sequencing all 14 exons of the SLC5A2 gene and their flanking regions in six unrelated Korean children with FRG and their family members. Novel non-synonymous single-nucleotide polymorphisms were identified and compared with known mutations that are repeatedly detected in the Korean population. Results: We found two novel mutations [c.274G>A (G92S) and c.1168C>T (L390F)] and one known [c.1382G>A (S461N)] mutation in each family and one recurrent mutation [c.1346G>A (G449D) (rs768392222)] in two pedigrees. The recurrent G449D was predicted to be "possibly damaging," with a score of 0.883 in Polyphen-2, while G92S, L390F, and S461N were predicted to be "probably damaging," with scores of 1.000, 0.999, and 0.996, respectively. Conclusions: Two novel, one previously reported, and one recurrent mutation were identified in six Korean FRG pedigrees as causative mutations of renal glucosuria. Sequence variations in the SLC5A2 gene were frequently detected in children with persistent isolated glucosuria. A long-term follow-up of this FRG cohort is needed to understand how these specific SGLT2 mutations impair kidney function and energy homeostasis.

• Genomics & Informatics
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• 제7권2호
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• pp.53-56
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• 2009

Recent evidence has strongly suggested that the CAP/TC10 pathway is involved in the trafficking, docking, and fusion of vesicles containing the insulin-responsive glucose transporter Glut4 to the plasma membrane. However, little is known about how the genes employed in the CAP/TC10 pathway are associated with the development of type 2 diabetes mellitus. In this study, we sequenced 4 genes of the CAP/TC10 pathway [SORBS1, CBL, CRK, and RHOQ] in 24 individuals to identify genetic variations in these loci. A total of 48 sequence variants were identified, including 23 novel variations. To investigate the possible association with type 2 diabetes mellitus, 3 single nucleotide polymorphisms from SORBS1, 3 from CBL, and 4 from RHOQ were genotyped in 1122 Korean type 2 diabetic patients and 1138 nondiabetic controls. Using logistic regression analysis, 1 significant association between SNP rs1376405 in RHOQ and type 2 diabetes mellitus [OR = 8.714 (C.I. 1.714-44.29), p = 0.009] was found in the recessive model. Our data demonstrate a positive association of the RHOQ gene in the CAP/TC10 pathway with T2DM in the Korean population.

• 한국재료학회지
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• 제7권3호
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• pp.213-217
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• 1997

200MHz 응향광변조기 (AOM: Acousto-Optic Modulator)는 제 2고조파(SHG: Second Harmonic Generation)녹색 레이저와 함께 DVDR(Digital Video Disk Recorder)에 적용되어 고밀도 광기록용으로 사용되었다. 이러한 고밀도 광기록 장치로써 사용되기 위해서는 고출력 레이저의 사용이 필수적이며, 레이저 빔이 통과하는 각 광학 소자들의 코팅막은 고출력 레이저 빔에 대해 높은 레이저 damage threshold를 가져야 한다. AOM의 음향공학재료로 사용되는 $TeO_{2}$단결정에 코팅막의 종류 및 증착조건을 변화시키며 E-beam 증착법으로 A/R코팅 시편을 준비하였다. 0.55W의 입력 power를 갖는Ar레이저를 사용하여 코팅의 광손상 정도를 확인하였다. $AI_{2}O_{3}$막에 비해 $ZrO_{2}$와 $SiO_{2}$막을 사용한 경우 레이저 damage threshold는 크게 향상되었다. 또한 AOM모듈을 제작 후 구동회로와 연결하여 약 20mW의 SHG power를 입력시키며 출력 power long term안정성을 측정하였다.