• Nutrition Research and Practice
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• v.3 no.1
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• pp.3-8
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• 2009

The matrix metalloproteinases (MMP) play an important role in tumor invasion, angiogenesis and inflammatory tissue destruction. Increased expression of MMP was observed in benign tissue hyperplasia and in atherosclerotic lesions. Invasive cancer cells utilize MMP to degrade the extracellular matrix and vascular basement membrane during metastasis, where MMP-2 has been implicated in the development and dissemination of malignancies. The present study attempted to examine the antiangiogenic activity of the medicinal herbs of Aspergillus usamii var. shirousamii-transformed Angelicae Gigantis Radix and Zizyphus jujube (tAgR and tZj) with respect to MMP-2 production and endothelial motility in phorbol 12-myristate 13-acetate (PMA)- or VEGF-exposed human umbilical vein endothelial cells (HUVEC). Nontoxic tAgR and tZj substantially suppressed PMA-induced MMP-2 secretion. In addition, $25{\mu}g/mL$ tAgR and tZj prevented vascular endothelial growth factor-stimulated endothelial cell transmigration and tube formation. The results reveal that tAgR and tZj dampened endothelial MMP-2 production leading to endothelial transmigration and tube formation. tAgR and tZj-mediated inhibition of endothelial MMP may boost a therapeutic efficacy during vascular angiogenesis.

• Journal of Gastric Cancer
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• v.16 no.4
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• pp.207-214
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• 2016

Purpose: The utility of N classification has been questioned after the 7th edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) was published. We evaluated the correlation between ratio-based N (rN) classification with the overall survival of pathological T4 gastric cancer patients who underwent D2 lymphadenectomy. Materials and Methods: We reviewed 222 cases of advanced gastric cancer patients who underwent curative gastrectomy between January 2006 and December 2015. The T4 gastric cancer patents were classified into four groups according to the lymph node ratio (the number of metastatic lymph nodes divided by the retrieved lymph nodes): rN0, 0%; rN1, ${\leq}13.3%$; rN2, ${\leq}40.0%$; and rN3, >40.0%. Results: The rN stage showed a large down stage migration compared with pathological T4N3 (AJCC/UICC). There was a significant difference in overall survival between rN2 and rN3 groups in patients with pT4N3 (P=0.013). In contrast, the difference in metastatic lymph nodes was not significant in these patients (${\geq}16$ vs. <15; P=0.177). In addition, the rN staging system showed a more distinct difference in overall survival than the pN staging system for pathological T4 gastric cancer patients. Conclusions: Our results confirm that rN staging could be a good alternative for pathological T4 gastric cancer patients who undergo D2 lymphadenectomy. However, before applying this system to gastric cancer patients who undergo D2 lymphadenectomy, a larger sample size is required to further evaluate the usefulness of the rN staging system for all stages, including less advanced stages.

• Bulletin of the Korean Mathematical Society
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• v.53 no.5
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• pp.1585-1596
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• 2016

In this paper we investigate the existence of nontrivial solutions for the following fractional boundary value problem (FBVP) $$\{_tD_T^{\alpha}(_0D_t^{\alpha}u(t))={\nabla}W(t,u(t)),\;t{\in}[0,T],\\u(0)=u(T)=0,$$ where ${\alpha}{\in}(1/2,1)$, $u{\in}{\mathbb{R}}^n$, $W{\in}C^1([0,T]{\times}{\mathbb{R}}^n,{\mathbb{R}})$ and ${\nabla}W(t,u)$ is the gradient of W(t, u) at u. The novelty of this paper is that, when the nonlinearity W(t, u) involves a combination of superquadratic and subquadratic terms, under some suitable assumptions we show that (FBVP) possesses at least two nontrivial solutions. Recent results in the literature are generalized and significantly improved.

• Journal of the Korean Society for Precision Engineering
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• v.29 no.3
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• pp.313-318
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• 2012

Application of composite structures on naval ships strongly depends on the mechanical strength and collapse behavior of the T-joints of the whole structure. Because of the weight advantages over single skin composite and bolt fastening joining, three types of T-joints using both honeycomb sandwich composite and adhesive bonding were suggested to determine the effect of T-joint configuration. It was found that joining with a urethane foam block and overlaminates using the secondary co-bonding technique improves T-joint strength.

• Communications of the Korean Mathematical Society
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• v.21 no.1
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• pp.11-16
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• 2006

In this article we show that if R is a Noetherian ring with the global dimension at most one, then every S-torsion free R-module T has a divisible envelope of the form $T{\hookrightarrow}S^{-1}T$

• Bulletin of the Korean Mathematical Society
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• v.55 no.4
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• pp.1093-1101
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• 2018

Let (RDTF, M) be a Milnor square. In this paper, it is proved that R is a ${\mathcal{C}}$-hereditary domain if and only if both D and T are ${\mathcal{C}}$-hereditary domains; R is an almost perfect domain if and only if D is a field and T is an almost perfect domain; R is a Matlis domain if and only if T is a Matlis domain. Furthermore, to give a negative answer to Lee, s question, we construct a counter example which is a C-hereditary domain R with $w.gl.dim(R)={\infty}$.

• The Plant Pathology Journal
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• v.21 no.3
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• pp.229-236
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• 2005

Molecular profIles of PCR-RFLP and sequence analysis of internal transcribed spacer (ITS) regions of rDNA were compared between morphologically distinguishable species of Trichoderma isolated from substrates of oyster mushroom in Korea, T. atroviride, T. citrinoviride, T. harzianum, T. longibrachiatum, T. virens, and two unidentified species, Trichoderma sp. 1 and 2. PCR­RFLP analysis divided the Trichoderma spp. into six RFLP groups, A, B, C, D, E, and F. The RFLP groups were generally agreed with described morphological species, except that the RFLP group A containing the two unidentified species. A neighbor-joining tree based on ITS sequences well supported RFLP groups observed by RFLP analysis of ITS regions of rDNA. Additionally, the two unidentified species, Trichoderma sp. 1 and 2, which could not be distinguished by PCR­RFLP analysis, were separated in sequence analysis of ITS regions of rDNA.

• Bulletin of the Korean Mathematical Society
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• v.35 no.2
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• pp.259-268
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• 1998

We give several characterizations of a TV-PVMD and we show that the localization R[X;S]$_{N_{\upsilon}}$ of a semigroup ring R[X;S] is a TV-PVMD if and only if R is a TV-PVMD where $N_{\upsilon}\;=\;\{f\;{\in}\;R[X]{\mid}(A_f)_{\upsilon} = R\}$ and S is a torsion free cancellative semigroup with zero.

• Journal of Pharmaceutical Investigation
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• v.33 no.1
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• pp.51-53
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• 2003

This study was conducted to compare the bioavailability of a generic product of Sinil Atenolol Tablets (Sinil Pharmaceutical Co., Ltd., Korea) with the innovator product, $Tenormin^{\circledR}$ Tablets in 20 healthy Korean volunteers. The volunteers received a single 50 mg dose of each atenolol formulation according to a randomized, two-way crossover design. Plasma samples were obtained over a 24-hour interval, and atenolol concentrations were determined by HPLC with a fluorescence detector. From the plasma atenolol concentration vs time curves, the following parameters were compared: area under the plasma concentration-time curve (AUC), peak plasma concentration $(C_{max})$, time to reach peak plasma concentration $(T_{max})$, and terminal first order elimination half-life $(t_{1/2})$. No statistically significant difference was obtained between the $T_{max}$ values, and the logarithmic transformed AUC and $C_{max}$ values of the two products. The 90% confidence for the ratio of the logarithmically transformed AUC and $C_{max}$ values of Sinil Atenolol Tablets over those of $Tenormin^{\circledR}$ Tablets were calculated to be between 0.99 and 1.07, and 1.04 and 1.16, respectively; both were within the bioequivalence limit of 0.80-1.25. The mean of $T_{max}$ in $Tenormin^{\circledR}$ Tablet group was 3.68 hour, and that in Sinil Atenolol Tablet group was 3.65 hour. The values of $t_{1/2}$ between the two products were found comparable, and the mean $t_{1/2}$ values of $Tenormin^{\circledR}$ Tablets and Sinil Atenolol Tablets were 5.9 and 6.0 hour, respectively. Based on these results, it was concluded that Sinil Atenolol Tablets were comparable to $Tenormin^{\circledR}$ Tablets in both the rate and extent of absorption, indicating that Sinil Atenolol Tablets were bioequivalent to the reference product, $Tenormin^{\circledR}$ Tablets

• Asian-Australasian Journal of Animal Sciences
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• v.11 no.1
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• pp.17-20
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• 1998

Sixteen local sheep (8 male + 8 female) of about six months old with average live weight 10.78 $({\pm}1.11)$ kg were allocated into four treatments. The treatments (T) are : $T_0$ = Restricted grazing without concentrate; $T_1$, $T_2$ and $T_3$ = Grazing + 100, 200 and 300 g concentrate per sheep daily. Live weight of grazing (7.30 hrs daily) sheep was recorded in each week. The uncastrated male sheep were slaughtered for carcass and non-carcass parameters. Statistically significant (p < 0.05) differences were observed in live weight gain (g/day) among the treatments ($T_0=15.71$; $T_1=22.66$; $T_2 =32.66$ and $T_3=40.47$). The dressing % were : ($T_0=32.75$, $T_1=38.50$, $T_2=36.90 $ and $T_3=37.75$). The warm carcass weight represented 37.21% of live weight. Significant (p < 0.01) correlation were observed for live weight with carcass weight (r = 0.99) and dressing % (r = 0.88). Concentrate supplement increase live weight gain in sheep on grazing. Live weight is a good indicator to assess carcass characteristics.