• 대한약침학회지
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• 제6권1호
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• pp.76-94
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• 2003

Objectives : The purpose of this study was to investigate Acute$\cdot$Subacute Toxicity and Anti-cancer Effect of K-Herbal-acupuncture in mice and rats. Methods : Balb/c mice were injected intraperitoneally with K-herbal-acupuncture for $LD_{50}$ and acute toxicity test. Sprague-Dawley rats were injected intraperitoneally with K-herbal-acupuncture for subacute toxicity test. K-Herbal-acupuncture was injected on abdomen of mice with S-180 cancer cell line. Result : 1. $LD_{50}$ of K-Herbal-acupuncture was limited $4{\times}10^{-3}$ml/kg~$2{\times}10^{-3}$ml/kg by the test. 2. In acute toxicity test, all of mice were down to the moving reflex, but the weight of mice was increased in treatment group, compared with the normal group. (P<0.05) 3. In acute toxicity test of serum biochemical values of mice, glucose was increased in treatment II group, total cholesterol was increased both treatments.(P<0.05) 4. In subacute toxicity test, the clinical signs of toxication was down to the moving reflex, but it is not severe like acute toxicity test, and observed weight loss at the treatments. 5. In subacute toxicity test, liver weight was decreased compared with the normal group. (P<0.05) 6. In subacute toxicity test of complete blood count test (CBC) of rat, HCT was decreased in treatments, compared with the normal group.(P<0.05) 7. In subacute toxicity test of serum biochemical values of rat, uric acid and triglyceride were decreased, and glucose was increased in treatment groups compared with the control group. (P<0.05) 8. Median survival time was increased about $45\%$ in treatment groups compared with the control group.(P<0.05) 9. Natural killer cell activity was increased in B16F10 lung cancer model, but it was not in sarcoma-180 abdomen cancer. 10. In interleukin-2 productivity test, treatment groups didn't show significant change in lung cancer and abdomen cancer, compared with the normal group.(P<0.005) 11. In making an examination of metastatic cancer with the naked eye, melanoma metastasized in the Lung of C57BL/6 mice. The treated group showed more Melanoma than the control in the numbers and volume. Conclusion : According to the result, K-herbal-acupuncture need further study to know the function and effect in cancer.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1981년도 제15차 학술대회연제순서 및 초록
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• pp.38.1-38
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• 1981

현재 이과영역에서 청각기능을 진단하기 위해 순음 및 언어청각검사와 Impedance청각검사등을 이용한 여러가지 특수청각검사법이 사용되고 있으나 우리나라에서는 이에 대한 정상한국인 기준치의 연구가 몇몇 학자에 의해서만 산발적으로 보고되어 왔다. 금번 본 교실에서는 정상 청각기능을 가진 의과대 남학생 100명을 대상으로 일련의 특수청각검사를 실시하여 다음과 같은 기준치를 얻었기에 보고하는 바이다. 1) 언어판별치(PB score)는 전부 90%이상이었고 95%의 예가 우측귀에서는 94%이상이었고 좌측귀에서는 92%이상이었다. 2) M.C.L.(most comfortable level)은 우측귀가 45$\pm$15.4dB이었고 좌측귀는 46$\pm$17.9dB이었으며 그 범위는 우측귀가 11$\pm$12.1dB, 좌측귀는 13$\pm$13.5dB이었다. 3) U.C.L. (uncomfortable level)은 106dB이상이었던 예가 우측귀에서 43%, 좌측귀에서 45%였고 나머지 예에서는 95%의 예가 우측, 좌측 귀에서 모두 96dB이상이다. 4) SISI(short increment sensitivity index)는 95%의 예가 우측귀에서는 1,000Hz와 4,000Hz에서 각각 45%, 45%이내였고 좌측귀에서는 각각 55%, 70%이내였다. 5) Tone decay는 95%의 예가 양측귀 모두 2,000Hz와 4,000Hz에서 10dB이내였다. 6) SRT-PTA(speech reception threshold minus pure tone average)는 우측귀가 -1$\pm$9.2dB이었고 좌측귀는 0$\pm$10.0dB이었다. 7) UCL-SRT(uncomfortable leve minus speech reception threshold)는 UCL이 106dB이상이었던 예를 제외한 57례, 55례에서 우측귀가 98$\pm$11.7dB이었고 좌측귀가 99$\pm$13.5dB이었다. 8) Impedance청각검사 ㄱ) Tympanogram은 1례 (좌측귀, B형)를 제외한 모든 예에서 A형이었고 peak level은 우측귀가 22.8$\pm$32.94mm$H_2$O였고 좌측귀는 23.9$\pm$29.81mm$H_2$O이었다.ㄴ) Compliance는 우측귀가 0.6$\pm$0.54cc였고 좌측귀는 0.6$\pm$0.53cc이었다. ㄷ) 등골근반사(stapedial reflex) $\circled1$ 반대측에 자극음을 주었을 때 반사는 5000z, 1,000Hz, 2,000Hz 및 4,000Hz에서 우측귀가 각각84$\pm$17.7dB, 87$\pm$14.4dB, 79$\pm$13.7dB, 87$\pm$18.6dB에서 나타났고 좌측 귀는 각각 84$\pm$l5.9dB, 88$\pm$13.9dB, 84$\pm$16.8dB, 87$\pm$21.3dB에서 나타났다. 그리고 반사가 보이지 않은 에는 500Hz, 1,000Hz, 2,000Hz 및 4,000Hz에서 우측귀간 각각 1례, 1례, 1례, 3례였고 좌측귀는 각각 2례, 2례, 2례, 5례였다. $\circled2$ 동측에 자극음을 주었을 때 반사는 1,000Hz, 2,000Hz에서 우측귀가 각각 89$\pm$16.3dB, 82$\pm$15.9dB에서 나타났고 좌측귀는 각각 89$\pm$18.0dB, 83$\pm$18.9dB에서 나타났다. 그리고 반사가 보이지 않은 예는 1,000Hz에서만 우측귀가 1례, 좌측귀가 2례였다. 9) Impedance 청각검사를 이용한 구씨관 기능극은 -250mm$H_2O$와 +250mm$H_2O$를 준 때 우측귀에서는 각각 10례, 11례에서 반응이 없었으며 그 반응 범위는 14$\pm$26.9mm$H_2O$, 8$\pm$21.9mm$H_2O$였고 좌측귀에서는 각각 5례, 6례에서 반응이 없었으며 고 반응범위는 각각 2$\pm$22.5mm$H_2O$, 9$\pm$17.3mm$H_2$였다.

• 재활간호학회지
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• 제8권2호
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• pp.139-148
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• 2005

Purpose: This study was to examine the effects of foot reflexology on ADL and fatigue in stroke patients. Method: The subjects were 31 stroke patients hospitalized in the Oriental Medicine Hospital of D University from June to November, 2002. Foot reflexology was applied to the experimental group twice a week for 6 weeks, 40 minutes each. For the data analysis, $x^2$-test was conducted to verify the homogeneity of general characteristics and clinical characteristics, and t-test was done to verify the homogeneity of ADL and fatigue. To examine the relative efficacy of the intervention, ANOVA and ANCOVA were conducted. Results: After foot reflexology, the subjects in the experimental group showed significant improvement in ADL. They also had less physical, psychological, and neurosensory fatigue, which are three areas of fatigue. Conclusion: The results suggest that foot reflexology is an effective intervention that helps the body work efficiently, eases stress and strain, and enhances the homeostasis of the body through stimulating the reflex zone of internal organs in the body. Therefore, it is necessary to develop foot reflexology as an unique nursing intervention.

• Journal of Preventive Medicine and Public Health
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• 제26권2호
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• pp.282-292
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• 1993

Neurotoxicity in the workplace may occur with exposure to scores of chemicals. Although large acute outbreaks of the occupational neurological disease are rare, the incidence of occupational neurotoxicity in its subtler aspects is unknown. A working knowledge of both the major occupational neurotoxic solvents and the tools used by cliniical neurologists and neurotoxicologists to evaluate neurotoxicity in working populations is a necessity fur the occupational physician. To investigate the effects of carbon disulfide($CS_2$) on the peripheral nerve system using the nervous conduction study, 105 male workers working in the spinning room of a viscose rayon factory were examined and compared with a sex and age matched, unexposed 105 male controls using t-test analysis. 72.4% of $CS_2$-exposed workers complained of neurological symptoms, and the abnormal cases in nerve conduction study were 48.6%. The abnormal cases of nerve conduction study increased in number according as the age and duration of exposure increased. In this study, asymptomatic workers were confirmed to have subclinical neuropathy by nerve conduction study. Also as there were abnormal cases even in its duration of exposure below 4 years, nerve conduction study turned out to be ways of discovering of early peripheral neuropathy. In nerve conduction study, the amplitude, velocity, F-wave latency and H-reflex of the motor and sensory nerves in both upper and lower extremities were significant different between $CS_2$-exposed workers and the controls. From the pathological viewpoint, both segmental and axonal degenerations were assumed in this study.

• The Journal of Advanced Prosthodontics
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• 제9권2호
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• pp.93-98
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• 2017

PURPOSE. The purpose of this study was to compare the width ratio of maxillary anterior teeth according to age in the Korean population and to evaluate the maxillary central incisor width-to-length (W/L) ratio, given differences in age and gender. MATERIALS AND METHODS. Ninety-three Korean adults were divided into 3 groups (n = 31) by age. Group I was 20 - 39 years old, Group II was 40 - 59 years old, and Group III was over 60 years of age. After taking an impression and a cast model of the maxillary arch, the anterior teeth width ratio and central incisor W/L ratio were calculated from standard digital images of the cast models using a graph paper with a digital single lens reflex (DSLR) camera. The calculated ratios were compared among all groups and central incisor W/L ratio were analyzed according to age and gender. All comparative data were statistically analyzed with one-sample t-tests, one-way ANOVAs with Tukey tests, and independent t-tests. RESULTS. No significant differences in maxillary anterior teeth ratios were found among the age groups. The maxillary central incisor W/L ratios in Group III were the greatest and were significantly higher than those in the other groups. The central incisor W/L ratio of men was higher than that of women in Group II. CONCLUSION. Maxillary anterior teeth width ratios were similar in all age groups in the Korean population. The maxillary central incisor was observed as worn teeth in the group over 60 years of age, and a significant difference between genders was found in 40 to 50 year olds.

• 사상체질의학회지
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• 제23권1호
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• pp.132-138
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• 2011

1. Objectives: This case study reports a Taeumin patient with Gastro-esophageal reflux disease who had suffered from chest pain, heartburn, acid regurgitation and dyspepsia who improved after Yeoldahanso-tang(Reduohanshao-tang) medication. 2. Methods: This patient had started treatment with Yeoldahanso-tang(Reduohanshao-tang), three times per day for three months and assessed the changes of the main symptoms such as chest pain, heartburn and acid regurgitation from baseline to post-treatment using a questionnaire with visual analogue scale(VAS). Electrogastrography(EGG) was also performed for assessment of gastric function from baseline to post-treatment. 3. Results: After the treatment, symptoms of GERD such as chest pain, heartburn, and acid regurgitation are almost disappeared. The patient don't need to take the proton pump inhibitor therapy. There was significant increase of % bradygastria parameters in fed EEG after treatment with Yeoldahansotang(Reduohanshao-tang). And significant increase of the power ratio after treatment was shown (20.5), compared with initial EGG(0.0). 4. Conclusions: This results show Yeoldahanso-tang(Reduohanshao-tang) can be used to treat GERD with Dry-heat symptom of Taeumin. This results suggest that Sasang Constitutional treatment for GERD patients who has a chronic condition with highly recurrence rate, might be a candidate for a therapeutic agent. Also effects of Yeoldahanso-tang(Reduohanshaotang) on GERD need further studies such as clinical trials.

• 약학회지
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• 제22권3호
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• pp.163-174
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• 1978

차전자(Plantaginis Semen)은 우리나라 전국 각지의 원야와 노방의 자생하는 다년생 초목으로 Plantaginaceae(질경이과)에 속하는 Plantago major L. var. asiatica Decaisne 질경이의 종자를 말하며 그의 성분으로는 다량의 점액, 지방유, pentosan 및 galactan, succinic acid, plantanolic acid, adenine, choline. K-염등이 알려져 있다. 이 차전자는 한방과 민간에서 소염, 이뇨, 진해, 지사제로서 널리 사용되어 왔으며 그의 약리작용에 관해서는 이미 저자들이 가토를 이용한 실험에서 이의 methanol extract가 자궁수축작용, 호흡흥분작용, 혈압강하작용, 장관수축작용, 심장박동의 완제작용, 항이뇨작용이 있음을 보고한 바 있다. 그러나 그의 기전에 관해서는 거의 알려진 바가 없다. 따라서 저자들은 위의 여러가지 작용중 특히 혈압강하작용에 관한 본태를 파악하여 그의 실용성 여부를 구명코자 이 실험을 착수하였다.

• Archives of Plastic Surgery
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• 제33권4호
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• pp.521-524
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• 2006

Purpose: The history of biometry dates back to ancient Greek. The ideal body ratio from biometry is used as a guideline in many works of art. Biometry is also used as a medical standard to determine normal or abnormal. Since the biometry of face is so complicated, many surgeons tend to regard preoperative evaluation as a bother and substitute medical records with some photographs. We introduce a new method to measure $MRD_1$ and levator function using digital photographs, which becomes widely used lately. Methods: $MRD_1$ can be measured with the primary-gaze-view photo which is magnified by PhotoshopR 7.0.1. The distance from coneal reflex of ring flash to upper eyelid margin is converted to mm-unit using the piece of ruler attached on the patient's face. Levator function can be measured with up-gaze-view photo and down-gaze-view photo which are superimposed on another. The excursion distance of upper eyelid margin (a) and the excursion distance of eyebrow (b) are measured respectively. The levator function can be assessed through subtraction of two values (a-b). This method is simple and precise and can be applied directly to patient without photos. Results: Using magnified digital photos and computer, this method can reduce personal error and instrumental error. Taking some digital photos doesn't take long time, so it can reduce the effort of preoperative evaluation and discomfort of patients. Conclusion: Digital photo-biometry is useful for retrospective study. Especially reducing personal error, it is useful when the number of specimens is huge. New levator function test is much more useful for Asian-specific eyes than Berke's method allowing frontalis muscle compensation.

• 대한소아치과학회지
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• 제23권3호
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• pp.717-728
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• 1996

The effects of electro-acupuncture on the pain threshold and the amplitude of dEMG(di-gastric EMG) evoked by the noxious electric stimulation on teeth and gingiva in dogs were studied. Experiments were carried out with 10 dogs weighing 5-8kg. Each animal was anestheticed with Entobar given intraperitoneally in an initial dose of 30mg/kg. Maintenance dose of 5mg/kg/hr was given through a cannula, in the femoral vein, as required to keep up light anesthesia. Bipolar stimulating wire electrodes, 0.1mm in diameter, insulated except for tips, were inserted into the upper canine and palatal gingiva. Rectangular aluminium plate electrodes (15$\times$5mm) were placed on acupuncture points, called Yin-Hsiang, located at both sides of the upper jaw. Rectangular biphasic current pulses of 2Hz, with a $250{\mu}sec$ duration, were delivered for 15 minutes. The dEMG activities were recorded from the anterior belly of the digastric muscle(one of the jaw opening muscles) using bipolar wire electrodes. The magnitude of the jaw opening reflex at different intensties of electro-acupuncture(1volt 4volt and 10volt) was estimated by averaging the 30 superimposed dEMGs recorded on an oscilloscope and audiomonitor. Data were analysed statistically with ANOV A and paired t-test. The obtained results were as follows: 1. Pain thresholds were increased 7.7 %, 15.4 %, 17.3 % in the teeth and 11.1 %, 19.0 %, 25.4 % in the gingiva as the intensities of electro-acupuncture increased incrementally. 2. Amplitudes of dEMG were decreaed 8.3%, 22.4%, 27.4% in the teeth and 9.8%, 36.5%, 42.2 % in the gingiva as the intensities of electro-acupuncture increased incrementally. 3. Inhibition of pain responses by the electroacupuncture was more effective in the gingiva than in the teeth.

• Archives of Plastic Surgery
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• 제34권4호
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• pp.531-534
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• 2007

Purpose: Plastic surgeons are responsible for the management of spinal cord injury patients with upper and lower extremity reconstruction, pressure sore, and wounds. Derailment of autonomic nervous systems caused by injury to the spinal cord may result in fatal autonomic dysreflexia. Autonomic dysreflexia is a syndrome of massive imbalance of reflex sympathetic discharge occurring in patients with spinal cord lesion above the splanchnic outflow(T6). It is characterized by a sudden onset and severe increase in blood pressure and is potentially life threatening. The other classic symptoms are headache, chest pain, sweating, and bradycardia. In order to lower the blood pressure, it is important to remove the noxious stimulus for autonomic dysreflexia. If such symptoms last for more than 15 minutes despite conservative interventions, antihypertension drugs are recommended. Methods: In this case study, we report an autonomic dysreflexia case that developed in a 45 year-old tetraplegia patient with sacral pressure sore. When he got bladder irrigation, his blood pressure went up very high and his mentality became stuporous. He was sent to ICU for his blood pressure and mental care. ICU care made his vital sign stabilized and his mentality alert. Results: After the patient underwent proper treatment like inotropic agent, he was transferred to the general ward and his pressure sore on sacral area was coveraged with gluteus maximus myocutaneous advancement flap. Conclusion: If treatment is not effective, the patients have to undergo sudden, severe hypertension, which can cause stroke or death. To provide safe and effective care, plastic surgeons should be able to recognize and treat autonomic dysreflexia.