• BMB Reports
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• 제28권4호
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• pp.331-335
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• 1995

Simian virus 40 (SV40) small-t antigen (small-t) has been known to regulate the activity of a cellular enzyme, protein phosphatase 2A (PP2A), composed of A. B, and C subunits, via binding to the A subunit In the study presented here, the stoichiometry of the binding of small-t to PP2A was determined to be 1: 1. It was also shown that small-t binds to the AC form of PP2A with a higher apparent affinity than it binds to the free A subunit. We also characterized the interaction of PP2A with wild-type and various mutant small-ts. A single-point mutant (Val134Met) and a double-point mutant (Trp147Gly;Leu152 Pro) of small-t exhibited 3-fold and 5-fold lower potencies in inhibiting PP2A activity. respectively. This suggests that the region around amino acids between 134 and 152 of small-t might be important in regulating the enzyme activity of PP2A.

• 한국물환경학회지
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• 제24권4호
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• pp.499-503
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• 2008

In order to control the non-point source pollution, a vegetative filter strips (VFS) was set up and the site-monitoring was performed. The objective of this study is to investigate the influence of the plant coverage on treatment efficiency of total nitrogen (T-N) and total phosphorus (T-P) using vegetative filter strips. According to the results, it seemed that the treatment efficiencies of T-N and T-P were closely related with the plant coverage ratio. The results showed that treatment efficiency of T-P average 50% at higher than 50% of the plant coverage and 20~23% at lower than 50% of the plant coverage. Also, the treatment efficiency of T-N increased with the increase of the plant coverage ratio.

• Journal of applied mathematics & informatics
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• 제23권1_2호
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• pp.167-182
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• 2007

The existence of solutions of the following multi-point boundary value problem $${x^{(n)}(t)=f(t,\;x(t),\;x'(t),{\cdots}, x^{(n-2)}(t))+r(t),\;0 is studied. Sufficient conditions for the existence of at least one solution of BVP(*) are established. It is of interest that the growth conditions imposed on f are allowed to be super-linear (the degrees of phases variables are allowed to be greater than 1 if it is a polynomial). The results are different from known ones since we don't apply the Green's functions of the corresponding problem and the method to obtain a priori bounds of solutions are different enough from known ones. Examples that can not be solved by known results are given to illustrate our theorems.

• Communications for Statistical Applications and Methods
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• 제19권2호
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• pp.237-246
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• 2012

다중 변환점(multiple change-point) 추론에 있어 소량자료에 관한 연구는 많지 않다. 본 논문에서는 소량 자료의 다중 변환점 추정을 위해 베이지안 비중심(noncentral) t 분포 변환점 모형을 제안하고, 제안된 모형 추론을 위해 메트로폴리스-해스팅스를 포함한 깁스 샘플링(Metropolis-Hastings-Within-Gibbs sampling) 알고리즘을 이용하였다. 모의실험 및 태풍 발생 수의 실증 분석결과는 제안된 모형과 알고리즘의 우수성을 보여 준다.

• 대한수학회보
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• 제49권4호
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• pp.799-813
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• 2012

In this paper, we first show that the iteration {$x_n$} defined by $x_{n+1}=P((1-{\alpha}_n)x_n +{\alpha}_nTP[{\beta}_nTx_n+(1-{\beta}_n)x_n])$ converges strongly to some fixed point of T when E is a real uniformly convex Banach space and T is a quasi-nonexpansive non-self mapping satisfying Condition A, which generalizes the result due to Shahzad [11]. Next, we show the strong convergence of the Mann iteration process with errors when E is a real uniformly convex Banach space and T is a quasi-nonexpansive self-mapping satisfying Condition A, which generalizes the result due to Senter-Dotson [10]. Finally, we show that the iteration {$x_n$} defined by $x_{n+1}={\alpha}_nSx_n+{\beta}_nT[{\alpha}^{\prime}_nSx_n+{\beta}^{\prime}_nTx_n+{\gamma}^{\prime}_n{\upsilon}_n]+{\gamma}_nu_n$ converges strongly to a common fixed point of T and S when E is a real uniformly convex Banach space and T, S are two quasi-nonexpansive self-mappings satisfying Condition D, which generalizes the result due to Ghosh-Debnath [3].

• Journal of applied mathematics & informatics
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• 제27권5_6호
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• pp.1211-1220
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• 2009

In this paper, we consider the multipoint boundary value problem for the one-dimensional p-Laplacian $({\phi}_p(u'))'$(t)+q(t)f(t,u(t),u'(t))=0, t $\in$ (0, 1), subject to the boundary conditions: $u(0)=\sum\limits_{i=1}^{n-2}{\alpha}_iu({\xi}_i),\;u(1)=\sum\limits_{i=1}^{n-2}{\beta}_iu({\xi}_i)$ where $\phi_p$(s) = $|s|^{n-2}s$, p > 1, $\xi_i$ $\in$ (0, 1) with 0 < $\xi_1$ < $\xi_2$ < $\cdots$ < $\xi{n-2}$ < 1 and ${\alpha}_i,\beta_i{\in}[0,1)$, 0< $\sum{\array}{{n=2}\\{i=1}}{\alpha}_i,\sum{\array}{{n=2}\\{i=1}}{\beta}_i$<1. Using a fixed point theorem due to Bai and Ge, we study the existence of at least three positive solutions to the above boundary value problem. The important point is that the nonlinear term f explicitly involves a first-order derivative.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집A
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• pp.345-350
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• 2001

In order to perform elastic-plastic fracture mechanical analyses, fracture resistance curves for concerned materials are required. 1T-CT specimen was used to obtain fracture resistance curves. But the fracture resistance curve by the 1T-CT specimen was very conservative to evaluate the integrity of the structure. And fracture resistance curve was affected by the specimen geometry and crack plane orientation. The objective of this paper is to be certain the conservativeness of the fracture resistance curve by the 1T-CT specimen and to provide the additional safety margin. For these, the fracture tests using the real pipe specimen and standard 1T-CT specimen test were performed. 4-point bending jig was manufactured for pipe test and direct current potential drop method was used to measure the crack extension and length for pipe test. From the pipe and the 1T-CT specimen test results, it was observed that the J-integral of the 1T-CT specimen test at the crack initiation point was very small compare to that of the pipe specimen test.

• 한국가시화정보학회지
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• 제13권1호
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• pp.35-42
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• 2015

CD4+ T-cell count determines the effectiveness for antiretroviral therapy (ART) in patients with human immunodeficiency virus (HIV). Although ART slows the progression of HIV to AIDS, rapid counting of CD4+ T lymphocytes with a drop of patient's blood sample is urgently needed to ensure timely ART treatment in rural areas. Recently point-of-care CD4 testing devices have been developed by using non-flow based imaging cytometer incorporated with a sample cartridge where CD4+ T cells are reacted with fluorescently tagged specific antibodies. Here we conducted an experimental study using a conventional fluorescence microscope-based imaging system to quantitate the interaction of CD4 antibodies with CD4+ T cells at different reaction conditions. We demonstrated that a fast and affordable point-of-care CD4 test is feasible with a far less amount of antibodies and a shorter incubation time compared with a conventional sample preparation protocol for flow cytometry. We also proposed a general method to evaluate and compare the detection limit across different CD4 counting platforms by using fluorescently labelled microbeads for intensity calibration.

• 한국관개배수논문집
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• 제18권2호
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• pp.54-65
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• 2011

This study was performed to analyze the influence of pollutant loads characteristics on the point and non-point sources in Saemangeum watershed area using Hydrological Simulation Program, Fortran (HSPF). The simulation items were flow, BOD, T-N, and T-P(2007~2010). The pollutant loads trend reflects the precipitation. Specifically, the point source loads were almost constant, but the non-point source loads were influenced in the precipitation. It was found that the effect of non-point source is larger than point source. The water quality had a clear trend by the season. However, pollutant loads did not show distinct seasonal changes. The reason is that the pollutant concentration is diluted by the increased flow at summer season. Therefore, it is important to control the non-point source in order to manage water quality in the region. For the management of Saemangeum lake, it is need to control of supplied pollutant loads from Saemangeum watershed.

• 대한두개안면성형외과학회지
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• 제13권1호
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• pp.4-10
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• 2012

Purpose: The objective of this retrospective study was to assess the skeletal stability after orthognathic surgery for patients with cleft lip and palate. The soft tissue changes in relation to the skeletal movement were also evaluated. Methods: Thirty one patients with cleft received orthognathic surgery by one surgeon at the Craniofacial Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Osseous and soft tissue landmarks were localized on lateral cephalograms taken at preoperative (T0), postoperative (T1), and after completion of orthodontic treatment (T2) stages. Surgical movement (T0.T1) and relapse (T1.T2) were measured and compared. Results: Mean anteroposterior horizontal advancement of maxilla at point A was 5.5 mm, and the mean horizontal relapse was 0.5 mm (9.1%). The degree of horizontal relapse was found to be correlated to the extent of maxillary advancement. Mean vertical lengthening of maxilla at point A was 3.2 mm, and the mean vertical relapse was 0.6 mm (18.8%). All cases had maxillary clockwise rotation with a mean of 4.4 degrees. The ratio for horizontal advancement of nasal tip/anterior nasal spine was 0.54/1, and the ratio of A' point/A point was 0.68/1 and 0.69/1 for the upper vermilion/upper incisor tip. Conclusion: Satisfactory skeletal stability with an acceptable relapse rate was obtained from this study. High soft tissue to skeletal tissue ratios were obtained. Two-jaw surgery, clockwise rotation, rigid fixation, and alar cinch suture appeared to be the contributing factors for favorable results.