• Bulletin of the Korean Chemical Society
• /
• v.30 no.5
• /
• pp.1193-1194
• /
• 2009

• The Korea Journal of Herbology
• /
• v.36 no.5
• /
• pp.59-67
• /
• 2021

Objectives : Hibiscus (Hibiscus sabdariffa L.) is rich in antioxidants such as flavonoids and anthocyanins and is known to have anti-inflammatory activity and anti-aging function of the skin, but there is no study on its effect on the skin barrier. This study aim to investigate the positive effect on the skin barrier by confirming the effect of water extracts of Hibiscus sabdariffa L. (WEHS) on the tight junction-related gene expression. Methods : The antioxidant efficacy of WEHS was investigated through ABTS and DPPH assays, and 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium was performed to examine the effect on cell viability. quantitative Reverse transcription polymerase chain reaction and immunoblot analysis were performed to confirm the effect of WEHS on the expression of tight junction-related genes, and immunofluorescence microscopy was used to confirm the movement of Claudin 1 protein into tight junctions. Results : WEHS showed strong antioxidant activity and induced an increase in both mRNA and protein expression levels of Claudin 1 among tight junction-related genes. The strong localization of Claudine 1 protein increased by WEHS to the tight junction was confirmed by immunofluorescence microscopy. Conclusions : Hibiscus was confirmed through this study to show antioxidant activity and the function of promoting the expression of the tight junction Claudin 1 gene, suggesting that Hibiscus can be used as a material for the prevention and treatment of skin moisturizing and atopy, which have an important influence on tight junction.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.20 no.4
• /
• pp.793-798
• /
• 2016

In this work, the memory window characteristics of vertical nanowire device with asymmetric source and drain was analyzed using bipolar junction transistor mode for 1T-DRAM application. A gate-all-around (GAA) MOSFET with higher doping concentration in the drain region than in the source region was used. The shape of GAA MOSFET was a tapered vertical structure that the source area is larger than the drain area. From hysteresis curves using bipolar junction mode, the memory windows were 1.08V in the forward mode and 0.16V in the reverse mode, respectively. We observed that the latch-up point was larger in the forward mode than in the reverse mode by 0.34V. To confirm the measurement results, the device simulation has been performed and the simulation results were consistent in the measurement ones. We knew that the device structure with higher doping concentration in the drain region was desirable for the 1T-DRAM using bipolar junction mode.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.18 no.1
• /
• pp.31-37
• /
• 2006

The present study has been experimentally investigated the effect of geometric and operating parameters on the two-phase flow distribution of refrigerants in a horizontal T-junction. The operating parameters were the kind of refrigerants (R-22, R- l34a, and R-410A), saturated temperature, and the inlet mass flux and quality. The geometric parameters were the tube diameter and the tube diameter ratio. The measured data of refrigerants were compared with the values predicted using the models developed by several researchers for air/water or steani/water two-phase flow. Among the operating parameters, the inlet Quality was the most sensitive to the mass flow rate ratio. Between the geometric parameters, the tube diameter ratio was more sensitive than tube diameter.

• Journal of electromagnetic engineering and science
• /
• v.4 no.4
• /
• pp.150-155
• /
• 2004

Universal design equations are presented for the H-plane T-junction power divider with a circular conducting post in a rectangular waveguide. For a given operating frequency and power split ratio, the post offset from the T-junction center line, the distance between the post and the waveguide wall, and the post diameter can be adjusted to obtain a minimum reflection at the input waveguide. Optimum values of the post offset are given in terms of the normalized frequency and the power split ratio. Corresponding values of the post diameter and the distance of the post from the waveguide wall are given in terms of the normalized frequency and the post offset.

• Journal of the Korean Society of Visualization
• /
• v.1 no.1
• /
• pp.75-81
• /
• 2003

A custom micro-PIV optics assembly has been used to measure the flow fold inside a T-junction of a microchannel. The micro-PIV system consists of microscope objectives of various magnifications, a dichroic cube, and an 8-bit CCD camera. Fluorescent particles of diameters 620 nm have been used with a Nd:YAG laser and color filters. A programmable syringe pump with Teflon tubings were used to inject particle-seeded distilled water into the channel at flow rates of 2.0, 4.0, 6.0 mL/hr. The micro-channels are fabricated with PDMS with a silicon mold, then O$_{2}$ -ion bonded onto a slide glass. Results show differences in flow characteristics and resolution according to fluid injection rates, and magnifications, respectively. The results include PIV data with vector-to-vector distances of 2 $\mu$m with 32 pixel-square interrogation windows at 50$\%$ overlap.

• Proceedings of the KSME Conference
• /
• 2008.11b
• /
• pp.2658-2663
• /
• 2008

In the present study, we designed a microfluidic flatform that generates monodisperse droplets with diameters ranging from hundreds of nanometers to several micrometers. To generate fine droplets, T-junction and flow-focusing geometry are integrated into the microfluidic channel. Relatively large aqueous droplets are generated at the upstream T-junction and transported toward the flow-focusing geometry, where each droplet is broken up into the targeted size by the action of viscous stresses. Because the droplet prior to rupture blocks the straight channel that leads to the flow-focusing geometry, it moves very slowly by the pressure difference applied between the advancing and receding regions of the moving droplet. This configuration enables very low flow rate of inner fluid and higher flow rate ratio between inner and outer fluids at the flow-focusing region. It is shown that the present microfluidic device can generate droplets with diameters about 1 micrometer size and standard deviation less than 3%.

• Fire Science and Engineering
• /
• v.33 no.1
• /
• pp.105-112
• /
• 2019

In this study, an architectural acoustics simulation was conducted to examine the clear and uniform transmission of emergency broadcasting sound in a T junction corridor space. The sound absorption performance of the corridor space and the location and spacing of the loudspeaker for emergency broadcasting were varied. The distribution of the sound pressure level and the distribution of sound transmission indices (STI, RASTI) were compared. The simulation showed that the loudspeaker for emergency broadcasting should be installed approximately 10 m from the center of the T junction corridor connection for clear voice transmission. Narrowing the 25 m installation interval of the NFSC shows that an even clearer and sufficient volume of emergency broadcast sound can be delivered evenly.

• Journal of The Korean Society of Integrative Medicine
• /
• v.9 no.2
• /
• pp.83-92
• /
• 2021

Purpose : Keratinocytes are the main cellular components involved in wound healing during re-epithelization and inflammation. Dysfunction of tight junction (TJ) adhesions is a major feature in the pathogenesis of various diseases. The purpose of this study was to identify the various effects of a Sparassis crispa water extract (SC) on HaCaT cells and to investigate whether these effects might be applicable to human skin. Methods : We investigated the effectiveness of SC on cell HaCaT viability using MTS. The antioxidant effect of SC was analyzed by comparing the effectiveness of ABTS to that of the well-known antioxidant resveratrol. Reverse-transcription quantitative polymerase chain reaction (qRT-PCR) is the most widely applied method Quantitative RT-PCR analysis has shown that SC in HaCaT cells affects mRNA expression of tight-junction genes associated with skin moisturization. In addition, Wound healing is one of the most complex processes in the human body. It involves the spatial and temporal synchronization of a variety of cell types with distinct roles in the phases of hemostasis, inflammation, growth, re-epithelialization, and remodeling. wound healing analysis demonstrated altered cell migration in SC-treated HaCaT cells. Results : MTS analysis in HaCaT cells was found to be more cytotoxic in SC at a concentration of 0.5 mg/㎖. Compared to 100 µM resveratrol, 4 mg/㎖ SC exhibited similar or superior antioxidant effects. SC treatment in HaCaT cells reduced levels of claudin 1, claudin 3, claudin 4, claudin 6, claudin 7, claudin 8, ZO-1, ZO-2, JAM-A, occludin, and Tricellulin mRNA expression by about 1.13 times. Wound healing analysis demonstrated altered cell migration in SC-treated HaCaT cells and HaCaT cell migration was also reduced to 73.2 % by SC treatment. Conclusion : SC, which acts as an antioxidant, reduces oxidative stress and prevents aging of the skin. Further research is needed to address the effects of SC on human skin given the observed alteration of mRNA expression of tight-junction genes and the decreased the cell migration of HaCaT cells.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.13 no.2
• /
• pp.33-39
• /
• 2013

In this paper, X/Ku band waveguide diplexers with H-plane T-junction for satellite communication systems is proposed and its characteristics is cinfirmed. Two frequency bands such as X(7.25 ~ 8.4 GHz) and Ku(12.25 ~ 14.5 GHz) can be separated by the proposed waveguide diplexers. A diplexers is normally including low pass filter, high pass filter and junction waveguide. To simplify the structure of the proposed diplexers, the proposed waveguide diplexers is using impedance matching technique on H-plane of the high pass filter without low pass filter. To use vertical and horizontal polarization, the proposed diplexers with orthomode transducer(OMT) characteristics is also designed. Therefore, it is confirmed that the proposed waveguide diplexers can be used as dual-band and dual-polarization diplexers for satellite communication feed systems.