• 생명과학회지
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• 제18권6호
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• pp.764-769
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• 2008

커넥신(connexin) 32 유전자의 돌연변이가 씨엠티엑스(CMTX, X-linked Charcot-Marie-Tooth) 질환과 관련이 있다. 현재까지 300여개 이상의 돌연변이가 보고가 되었으나 이 질환에 대한 상세한 분자병리학적 원인을 거의 알려져 있지 않고 있다. 여러 연구를 통해서 커넥신 세포막채널이 간극결합채널이 갖고 있는 대부분의 생물리학적 특성을 갖고 있는 것으로 판명되었다. 이번 연구에서는 씨엠티엑스 질환과 관련된 두 개의 돌연변이체를 선정하여 간극결합채녈 대신 돌연변이체로 구성된 커넥신 세포막채널을 이용하여 단일채널수준에서 이들 돌연변이체의 특성을 조사하였다. M34T 돌연변이 세포막채널의 생물리학적 특성은 이들로 구성된 돌연변이 간극결합채널의 특성과 거의 유사하였다. 더욱이, 돌연변이 세포막채널을 이용한 연구를 통해서 간극결합채널을 이용한 연구에서는 밝혀지지 않았던 개폐극성의 역전, 빠른 개폐의 소실과 느린 개폐의 생성과 같은 새로운 사실을 알게 되었다. T86C 돌연변이 세포막채널 또한 이의 모체가 되는 커넥신 32 세포막채널과 유사한 특성을 갖고 있음을 알게 되었다. 이상의 결과를 통해서 커넥신 세포막을 이용한 연구가 씨엠티엑스 질환의 돌연변이체를 연구하는데 매우 유용할 것으로 생각된다.

• 재활간호학회지
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• 제19권1호
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• pp.30-42
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• 2016

Purpose: This study compared the importance and performance of rehabilitation nursing needs perceived by stroke patients and nurses. Methods: A total of 275 subjects were divided into two groups. One group was 136 stroke patients and the other was 139 nurses. Data were collected with the Rehabilitation Nursing Service Inventory. The data were analyzed by t-test and ANOVA using the SPSS/WIN 21.0 program. Results: The degree of importance and performance in rehabilitation nursing needs perceived by the stroke patients were $3.69{\pm}0.47$ and $3.48{\pm}0.50$, respectively, showing a significant difference (t=21.04, p<.001). The degree of importance and performance perceived by nurses were $3.84{\pm}0.42$ and $3.60{\pm}0.45$, respectively, showing a significant difference (t=26.53, p<.001). A significant difference in the degree of importance and performance in rehabilitation nursing needs was also observed between stroke patients and nurses (t=-2.78, p=.006; t=-2.12, p=.035). Conclusion: These findings showed that there was a perception gap between stroke patients and nurses. Therefore, it will necessary to identify methods for reducing this perception gap and developing rehabilitation nursing intervention considering the rehabilitation nursing needs of stroke patients.

• 생명과학회지
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• 제16권1호
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• pp.37-43
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• 2006

간극결합은 이웃하는 두 세포 사이에 형성된 이온채널이며 또한 단일세포막에서도 작용한다. 간극결합채널을 형성하는 아미노 말단의 10번째 아미노산 잔기 부위까지가 개폐극성(gating polarity)과 전류-전압관계에 영향을 미친다. 정상적인 Cx32 채널은 음성의 개폐극성과 내향적인 정류현상을 보이는 반면, 음성전하를 띠는 aspartate로 치환된 T8D 채널은 반대의 개폐극성과 직선의 정류현상을 보인다. 이러한 개폐극성과 정류현상의 변화가 전하 자체에 의한 것인지 아니면 아미노 말단의 구조적인 변화에 의한 것인지는 아직 불명확하다. 이러한 문제점을 규명하기 위하여 아미노 말단의 8번째 아미노산 잔기를 cysteine기로 치환시킨 T8C 채널을 만들어 substituted-cysteine accessibility method (SCAM) 방법으로 이 채널의 생물리학적 특성을 조사하고자 하였다. T8C 채널은 정상적인 Cx32 채널처럼 음성의 개폐극성과 내향적인 정류현상을 보였으며, cysteine기로 치환이 정상적인 Cx32 채널의 원래 구조를 변화시키지 않았다는 것을 의미한다. 본 연구에서는 이런 전하효과를 규명하기 위하여 음성 전하를 갖는 MTSES-와 양성전하를 갖는 MTSET+를 사용하였다. MTSES-를 처리하면 T8C 채널은 T8D 채널의 특성처럼 양성의 개폐극성과 직선의 정류현상을 보였다. 그러나 양성전하를 갖는 MTSET+를 처리한 경우에는 T8C 채널은 본래의 특성을 그대로 유지하였다. 작은 분자의 MTS에 의해서 부여된 전하가 아미노 말단의 구조적인 변화를 초래하지는 않을 것으로 생각된다. 따라서 반대의 전하를 띠는 MTSES-와 MTSET+가 서로 상반대는 영향을 미치는 것으로 보아 본 연구에서 관찰된 개폐극성과 전류-전압의 변화는 아미노말단의 구조적인 변화라기보다는 MTS에 의해서 부여된 전하 자체에 기인한다고 할 수 있다. 또한 MTS가 아미노말단의 8번째 부위에 접근하여 반응을 일으킬 수 있다는 결과는 간극결합채널의 아미노말단이 채널의 통로(pore)를 형성한다는 가설을 뒷받침한다.

• Journal of electromagnetic engineering and science
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• 제15권2호
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• pp.111-114
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• 2015

In this paper, we have proposed dual-band Phi-shaped slot gap filler antenna for satellite internet service applications. Some properties of the antenna such as return loss, radiation pattern, and gain have been simulated and measured. The proposed antenna has a Phi-shaped slot on the circular patch and is fabricated on the TLX-9 substrate. The radius of the circular patch is 25 mm, and it has a coaxial feeding structure. The dual-band Phi-shaped slot gap filler antenna has high-gain, small-size, simple-structure, and good radiation patterns at each band. The operating frequency band can be tuned by adjusting the length AL and FL of the Phi-shaped slot.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2002년도 제4회 영호남학술대회 논문집
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• pp.31-36
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• 2002

In this work $Cd_{4}GeSe_{6}$ and $Cd_{4}GeSe_{6}:Co^{2+}$ single crystals were grown by the chemical transport reaction method and the structure of $Cd_{4}GeSe_{6}$ and $Cd_{4}GeSe_{6}:Co$ single crystals were monoclinic structure. The temperature dependence of optical energy gap was fitted well to Varshni equation. Also, the entropy, enthalpy and heat capacity were deduced from the temperature dependence of optical energy gap.

• Progress in Superconductivity
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• 제10권1호
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• pp.1-5
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• 2008

Magnetocardiography (MCG) is a non-contact, non-invasive, and harmless diagnostic tool to detect the abnormal electrical conductivities of the heart caused by the various coronary artery disease or cardiac muscular disease. The purpose of this study is to identify whether MCG signals and MCG parameter values vary depending on the location of sensor assembly. It will be an important reference for the standard measurement. Four healthy male subjects (33.3$\pm$6.3 years) participated in this study. Basal recording was made at 20 mm apart from the chest surface. All subjects were requested to take a regular breathe while MCG was taken. The gap between the chest surface and the bottom of the sensor assembly was 20, 40, 60, and 80 mm. Recording was made using 64 channel MCG system (Axial type, first order gradiometer) developed by Korea Research Institute of Standards and Science (KRISS). After resting for two minutes in a supine position on the bed in magnetically shielded room, MCG were recorded for 30 s. As the sensor location is getting away from the chest surface signal, the amplitude of R and T wave peak decreases to 70% (at 40 mm gap), 50% (at 60 mm), and 37% (at 80 mm) of the reference strength measured (y = $1.3903e^{-0.0169x}$, $R^2$ = 0.99; where y=amplitude remained after reduction, x=distance between chest surface and sensor location). The regression equations may be used as a good reference to calculate how much strength will be decreased by the distance. In MCG parameters, most values of parameters were decreased as the gap was increased. As an example, the current moment at T-wave peak reduced to 52% (at 40 mm gap), 33% (at 60 mm), and 19% (at 80 mm). However, the difference caused by the gap could be reduced by considering the distance when the MCG parameters were calculated. The study results can be used as a useful reference to design the baseline and the sensor location.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2005년도 창립60주년 기념 추계 학술대회
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• pp.209.2-209.2
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• 2005

• 프린팅코리아
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• 제11권9호
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• pp.122-123
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• 2012

신진전산폼(주)(대표이사 이성국)는 지난 7월 26일 국내 최초로 도입한 HP T200 컬러 잉크젯 웹 프레스 오픈하우스를 개최하고, DM 출판 시장에 컬러 디지털 인쇄를 통한 새 바람을 일으킬 것이라고 선언했다. 이와 함께 한국HP도 첫 잉크젯 웹 프레스 공급으로 개인화 상업용 DM 및 출판 시장의 패러다임을 컬러 디지털 인쇄로 전환할 계획이라고 밝혔다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.65-65
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• 2003

The aim of this study was to investigate the effect of resveratrol on the oxidative stress-induced inhibition of gap junctional intercellular communication (GJIC) in HaCaT keratinocyte. Anti-oxidative activity of resveratrol was measured by a,a-diphenyl-b-picrylhydrazyl (DPPH) assay and dichlorodihydrofluorescein diacetate oxidation assay. GJIC of HaCaT keratinocyte was assessed using the scrape loading/dye transfer technique. Western blots and reverse transcription-polymerase chain reaction were also analyzed for Connexin 43 protein and mRNA expression, respectively. Resveratrol scavenged directly the stable DPPH radical over a concentration range of 4 mg/$\mell$ (78.2 $\pm$ 2.7% of control) to 500 mg/$\mell$ (29.9 $\pm$ 4.2% of control) and prevent to increase the intracellular fluorescence induced by oxidative stress significantly. Ultraviolet A irradiation (UVA) and 12-O-tetradecanoylphorbol-13-acetate markedly reduced GJIC, which was restored by resveratrol. There were no significant differences in the level of Connexin 43 protein and mRNA expression among any of the experimental groups. Our data suggests that resveratrol has the protective effect on the oxidative stress-induced inhibition of gap junctional intercellular communication in HaCaT keratinocyte and this protection is likely due to the scavenging of reactive oxygen species.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2008년도 International Meeting on Information Display
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• pp.340-343
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• 2008

This work reports the simple fabrication of the single cell gap transflective liquid crystal display (LCD) using wire grid polarizer. The nano sized wire grid polarizer was patterned on common electrode itself, on the reflective part of FFS (Fringe field switching) mode whereas the common electrode was unpatterned at transmissive part. However, this structure didn't show single gamma curve, so we further improved the device by patterning the common electrode at transmissive part. As a result, V-T curve of proposed structure shows single gamma curve. Such a device structure is free from in-cell retarder, compensation film and reflector and furthermore it is very thin and easy to fabricate.