• Korean Journal of Pharmacognosy
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• v.45 no.3
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• pp.256-261
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• 2014

Bee venom (BV) therapy has been used as a traditional medicine to treat a variety of conditions, such as arthritis, back pain, cancerous tumors, and skin diseases. However, regulatory effects of BV on tumor necrosis factor (TNF)-${\alpha}$-induced HaCaT cell migration or anti-inflammatory have not been explored. In the present study, we investigated the effects of BV on HaCaT cell migration and anti-inflammation. HaCaT cell migration was evaluated by wound-healing assay. The pro-inflammatory cytokines such as TNF-${\alpha}$, interleukin (IL)-$1{\beta}$, and IL-8 were examined by ELISA or Western blotting. BV treatment led to an increase in migration of HaCaT cells for 24 and 48 h. Especially, 10 ng/ml of BV were significantly increased HaCaT cell migration. Also, BV suppressed the secretion of TNF-${\alpha}$, IL-$1{\beta}$, and IL-8 in culture medium with HaCaT cells. In addition, Western blot results demonstrate that BV suppressed the expression of TNF-${\alpha}$ and IL-$1{\beta}$, in HaCaT cells. Especially, 1 or 10 ng/ml of BV markedly decreased the expression of pro-inflammatory cytokines. These results demonstrate the potential of BV for the prevention of skin inflammation induced by TNF-${\alpha}$.

• Journal of Gastric Cancer
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• v.12 no.3
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• pp.164-172
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• 2012

Purpose: The purpose of this study is to investigate the prognostic significance of tumor size for 5-year survival rate in patients with gastric cancer. Materials and Methods: A total of 1,697 patients with gastric cancer, who underwent potentially curative gastrectomy, were evaluated. Patients were divided into 4 groups as follows, according to the median size of early and advanced gastric cancer, respectively: small early gastric cancer (tumor size ${\leq}3$ cm), large early gastric cancer (tumor size >3 cm), small advanced gastric cancer (tumor size ${\leq}$ 6 cm), and large advanced gastric cancer (tumor size >6 cm). The prognostic value of tumor size for 5-year survival rate was investigated. Results: In a univariate analysis, tumor size is a significant prognostic factor in advanced gastric cancer, but not in early gastric cancer. Multivariate analysis showed that tumor size is an independent prognostic factor for 5-year survival rate in advanced gastric cancer (P=0.003, hazard ratio=1.372, 95% confidence interval=1.115~1.690). When advanced gastric cancer is subdivided into 2 groups, according to serosa invasion: Group 1; serosa negative (T2 and T3, 7th AJCC), and Group 2; serosa positive (T4a and T4b, 7th AJCC), tumor size is an independent prognostic factor in Group 1 (P=0.011, hazard ratio=1.810, 95% confidence interval=1.149~2.852) and in Group 2 (P=0.033, hazard ratio=1.288, 95% confidence interval=1.020~1.627), respectively. Conclusions: Tumor size is an independent prognostic factor in advanced gastric cancer irrespective of the serosa invasion, but not in early gastric cancer.

• Journal of Korean Society on Water Environment
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• v.33 no.6
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• pp.650-660
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• 2017

In this study, pollutant emission characteristics by water damage period analyzed 11 items (water temperature, pH, DO, EC, BOD, COD, TOC, SS, T-N, T-P and flow) with load duration curve, time series load curve and factor analysis for three years (2014-2016). Load duration curve is applied to judge the level of impaired waterbody and estimate impaired level by pollutants such as BOD and T-P in this study depending on variation of stream flow. Water quality standard exceeded the flow of mid-range and low-range by flow condition evaluation using load duration curve. This watershed was influenced by point source more than non-point source. Cumulative excess rate of BOD and T-P kept water quality standard for all seasons (spring, summer, autumn and winter) except BOD 59% in spring. Water quality changes were influenced by pollutants of basic environmental treatment facilities and agricultural areas during spring and summer. Results of factor analysis were classified commonly first factor (BOD, COD, and TOC) and second factor (flow, water temperature and SS). Therefore, effects of artificial pollutants and maintenance water must be controlled seasonally and reduced relative to water damage caused by point pollution sources with effluent standard strengthened in the target watershed.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.6 no.4
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• pp.80-88
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• 1997

An experimental investigation of the fatigue through crack growth behavior under simple stepped variable loading condition has been performed using Al7075-T651. Experiments were carried out by using cantilever bending type specimens, with chevron notches on a small electro-magnetic test machine. Tensile overloads have a retarding effect on the fatigue crack growth rates, therefore tensile overloads were used for the beneficial effect on the fatigue life. While in most cases compressive overloads have only a vanishing effect on crack growth rates, some experiments with single edge crack tension specimens reveal a marked growth retardation. The stress ratios used in this investigations varies from R=0.32 to 0.81, from R=0.04 to 0.76, from R=-0.15 to 0.73, and from R=-0.33 to 0.68 and the peak load for each case was not varied. The crack growth and crack closure were measured by Kikukawa's compliance method with a strain gauge mounted on the backside of each specimens. The results obtained are as follows. When the stepped variable load was applied, the smaller the stress ration was, the larger the delayed retardation of the crack growth rate was. The fatigue crack growh rate data obtained for through cracks were plotted well against the effective stress intensity factor range from 4.0 to 20.0MP{a^{SQRT}m}. It was found that the effective stress intensity factor range ratio was related well to the opening stress intensity factor, the maximum stress intensity factor, and crack length.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.7
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• pp.2159-2166
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• 1996

The stochastic properties of variation in fatigue crack growth are important in reliability and stability of structures. In this study,the stochastic model for the variation of fatigue crack growth rate was proposed in consideration of nonhomogeneity of materials. For this model, experiments were ocnducted on 7075-T6 aluminum alloy under the constant stress intensity factor range. The variation of fatigue crack growth rate was expressed by random variables Z and r based on the variation of material coefficients C and m in the paris-Erodogan's equation. The distribution of fatigue life with respect to the stress intensity factor range was evaluated by the stochastic Markov chain model based on the Paris-Erdogan's equation. The merit of proposed model is that only a small number of test are required to determine this this function, and fatigue crack growth life is easily predicted at the given stress intensity factor range.

• Journal of the Society of Naval Architects of Korea
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• v.52 no.5
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• pp.372-379
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• 2015

The blade root fillets which have strong influences on the performance of propellers in the both structural and hydrodynamic points of view, are mechanical parts for smooth connection surface with a blade and a hub. A few related researches (Sabol, 1983; Kennedy, 1997) have noted that 3T-T/3 double radius section design would be suitable for reducing Stress Concentration Factor(SCF) and increasing Cavitation Inception Speed(CIS). In this paper, it is confirmed that this compound cross-section design has come close to the optimum solution in the shape optimization standpoint so that it could protect the propeller blade under the frequent and various loading cases. On that basis, we suggest the definite and simple fillet design methodology that has the cross-section with nT-T/n compound radius and elliptic shape which could sustain the given derivatives information as well as the offsets at the boundary and all inner region of the fillet surface. In addition, the result of design is presented in form of IGES file format in order to connect with NC machine seamlessly.

• Journal of Korean Society of Water and Wastewater
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• v.21 no.6
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• pp.755-761
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• 2007

Disinfection performance in clearwell is generally measured by CT, which is expressed by $C{\times}T$. C is represented by disinfection concentration, and T is represented by $T_{10}$ which means 90% contact time in clearwell. In order to improve Disinfection performance, augmentation of $T_{10}$ is required. Guide wall has been generally used to improve $T_{10}$ because $T_{10}$ changes according to flow field. In this study, porous media is proposed instead of guide wall, and disinfection performance between guide wall and porous media wall are compared. Flow field and $T_{10}$ in each clearwell are investigated as well. Improved Disinfection performance appear in case of porous media wall compare to guide wall, and best performance occur in porosity factor ${\beta}$ 1e+4.

• Journal of the Korean Society of Clothing and Textiles
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• v.31 no.8
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• pp.1273-1285
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• 2007

The purpose of this study is to understand consumer emotion about T-shirts web pages and to provide the basis for effective design plan of them. 72 T-shirts web pages through 62 sites have been chosen as stimulus pictures, and the valuation tools are composed of 21 pairs of image adjective and 3 questions for valuation of consumption emotion. Data has been collected on subjects of 480 men and women at the age of $16{\sim}27$ who live in Busan. The image factors are Aestheticism, Activeness, Stability, Intimacy. The types of T-shirts web pages are classified into four groups. The image according to the type of T-shirts web pages has showed meaningful differences in all factors, and the differences of image factors according to design elements have been meaningfully presented. In the relation between consumption emotion and image of T-shirts web pages, Impulse needs, Buying needs, Recommendation needs are related to Aestheticism factor and Stability factor. The consumption emotion according to the type of T-shirts web pages is appeared high in the type 2(Refine image) and 3(Vivid image). The valuation of consumption emotion according design elements has presented meaningful differences all design elements except menu.

• The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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• v.10 no.1
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• pp.1-11
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• 1981

In this paper, a new performance equation of bath tubs has been derived, which is very characteristically illuminating and in good agreement with experiments : $$T=T_{\infty}+(T_0-T_{\infty})e-\frac{k(A'_f+A_0)}{Mc_{P{\Delta}x}t$$, where $T_{\infty}$ is the temperature of the bathroom, $T_0$ that of the bathwater at t=0, k the overall heat conductivity of the tub- wall, $A'_f$ the equivalent surface area to the wall, $A_0$ the submerged area of the tub-wall, M mass of the bath-water, $C_p$ the specific heat of the bathwater and ${\Delta}x$ the thickness of the tub-wall. Here the equivalent-free surface area is written as $$A'_f=mA_f,\;m=const.(1-{\phi})^{0.88}$$ : where m is a numerical factor which is determined by a simple experiment and some calculation, {\phi}$ the relative humidity and $A_f$ the real free-surface area. From this study, it has been clarified that cooling of bath-water is mainly due to mass-transfer through evaporation from the free surface and conductive heat loss through the tub-wall is minor, which rather gaily mock at common sense. The effect of keeping bathwater warn by increase of the tub-wall thickness is also analyzed by a new idea of the thickness gain factor.

• Journal of Korean Society on Water Environment
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• v.30 no.2
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• pp.119-127
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• 2014

The objective of this study is to evaluate and analyze Sumjin River Basin water environment system. It was necessary to improve the water quality. The data were collected from 2010 January to 2012 December including Water Temperature, pH, DO, EC, $BOD_5$, COD, TOC, SS, T-N, T-P. The data were used to study were required to; Correlation Analysis; Principle Component Analysis; Factor Analysis. The results were as followed. According to correlation analysis on $BOD_5$ against COD, TOC it revealed that the each value of correlation coefficient were 0.715 and 0.719; this means the strength of the relationship is strong. The same analysis on T-P against $BOD_5$, COD, TOC, SS has revealed that the range of the correlation coefficient value fell between 0.482 and 0.608 which means strength of the relationship between them remained normal. Through correlation analysis, it has been found that all elements except T-N have high correlation. The results of principal component analysis to target the overall water quality was extracted to three main components. The cumulative contribution rate is 68.990%. In the case of seasonal water quality, Spring and Summer are extracted to each of four main components. The cumulative contribution rate is 81.515% and 73.550% respectively. Fall and Winter are extracted to each of three main components. The cumulative contribution rate is 65.072% and 72.721% respectively. There is no seasonality in the case of factor analysis. The first common factor is $BOD_5$, COD, TOC, SS, T-P, which were classified. Totally speaking, Sumjin River Basin water system gets highly affected by the nutrient salts, organic matter and suspended solid at the same time.