• The Journal of Asian Finance, Economics and Business
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• v.3 no.1
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• pp.33-41
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• 2016

Essences, needs and features of formation of national innovative development model of Kazakhstan are proved on the basis of analysis of various research approaches to realization of the modernization that exist in the world economic theory. For studying the problems of innovative development of the country, there was a need for the formulation of a number of definitions, disclosure of their contents, changing the approaches to reform, as well as adjusting their targets. In the article the general scientific research methods used dialectic, abstraction, systemic and situational approach, empirical and theoretical and analytical methods, and logic modeling. The proposed approach to the implementation of innovative development based on the use of evolutionary and institutional approaches to the study of the problems of implementing an effective innovation policy. This approach is intended to contribute to the development of a forward strategy of modernization, innovative development and higher competitiveness of the national economy. The study proved the causes and features of the implementation of innovative development model in Kazakhstan.

• Journal of Pharmaceutical Investigation
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• v.35 no.3
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• pp.157-163
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• 2005

The pellets with multiple drug release system (MDRS) of Diltiazem. HCl which consist of immediate drug release layer, drug reservoir layer and controlled release rate membrane, were prepared by using CF-Coater. As main factors for more effective MDRS of Diltiazem. HCl, ethylcellulose was used for the controlling drug release rate, and diethylphthalate was used for plasticizer, respectively. In vitro evaluation study was performed by comparative dissolution test between our test MDRS and reference Diltiazem. HCl preparation. The physical tests were performed using FT-IR and SEM. In vivo evaluation was also performed by observing the behavior of a plasma drug concentration after oral administration. The bioavailability was determined by analyzing the blood sample after oral administration to healthy, male volunteers once a day. As a result, there were no significant differences in bioequivalence parameters $(AUC_{\infty},\;C_{max},\;t_{1/2})$ between two systems. It might be concluded that our MDRS of Diltiazem. HCl could be an alternative delivery system to reference drug preparation.

• Steel and Composite Structures
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• v.35 no.1
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• pp.129-145
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• 2020

In typical, structural topology optimization plays a significant role to both increase stiffness and save mass of structures in the resulting design. This study contributes to a new numerical approach of topologically optimal design of Mindlin-Reissner plates considering Winkler foundation and mathematical formulations of multi-directional variable thickness of the plate by using multi-materials. While achieving optimal multi-material topologies of the plate with multi-directional variable thickness, the weight information of structures in terms of effective utilization of the material at the appropriate thickness location may be provided for engineers and designers of structures. Besides, numerical techniques of the well-established mixed interpolation of tensorial components 4 element (MITC4) is utilized to overcome a well-known shear locking problem occurring to thin plate models. The well-founded mathematical formulation of topology optimization problem with variable thickness Mindlin-Reissner plate structures by using multiple materials is derived in detail as one of main achievements of this article. Numerical examples verify that variable thickness Mindlin-Reissner plates on Winkler foundation have a significant effect on topologically optimal multi-material design results.

• Computers and Concrete
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• v.25 no.1
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• pp.1-14
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• 2020

This study presents applications of the multivariate adaptive regression splines (MARS) method for predicting the ultimate loading carrying capacity (N_u) of rectangular concrete-filled steel tubular (CFST) columns subjected to eccentric loading. A database containing 141 experimental data was collected from available literature to develop the MARS model with a total of seven variables that covered various geometrical and material properties including the width of rectangular steel tube (B), the depth of rectangular steel tube (H), the wall thickness of steel tube (t), the length of column (L), cylinder compressive strength of concrete (f'_c), yield strength of steel (f_y), and the load eccentricity (e). The proposed model is a combination of the MARS algorithm and the grid search cross-validation technique (abbreviated here as GS-MARS) in order to determine MARS' parameters. A new explicit formulation was derived from MARS for the mentioned input variables. The GS-MARS estimation accuracy was compared with four available mathematical methods presented in the current design codes, including AISC, ACI-318, AS, and Eurocode 4. The results in terms of criteria indices indicated that the MARS model was much better than the available formulae.

• Wind and Structures
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• v.18 no.4
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• pp.347-373
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• 2014

Since its development in the early 1980's the force balance technique has become a standard method in the efficient determination of structural loads and responses. Its usefulness lies in the simplicity of the physical model, the relatively short records required from the wind tunnel testing and its versatility in the use of the data for different sets of dynamic properties. Its major advantage has been the ability to provide results in a timely manner, assisting the structural engineer to fine-tune their building at an early stage of the structural development. The analysis of the wind tunnel data has evolved from the simple un-coupled system to sophisticated methods that include the correction for non-linear mode shapes, the handling of complex geometry and the handling of simultaneous measurements on multiple force balances for a building group. This paper will review some of the components in the force balance data analysis both in historical perspective and in its current advancement. The basic formulation of the force balance methodology in both frequency and time domains will be presented. This includes all coupling effects and allows the determination of the resultant quantities such as resultant accelerations, as well as various load effects that generally were not considered in earlier force balance analyses. Using a building model test carried out in the wind tunnel as an example case study, the effects of various simplifications and omissions are discussed.

• Steel and Composite Structures
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• v.29 no.5
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• pp.635-645
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• 2018

Beam-column joints play a significant role in static and dynamic performances of reinforced concrete frame structures. This study contributes a numerical approach of topologically optimal design of carbon fiber reinforced plastics (CFRP) to retrofit existing beam-column connections with crack patterns. In recent, CFRP is used commonly in the rehabilitation and strengthening of concrete members due to the remarkable properties, such as lightweight, anti-corrosion and simplicity to execute construction. With the target to provide an optimal CFRP configuration to effectively retrofit the beam-column connection under semi-failure situation such as given cracks, extended finite element method (X-FEM) is used by combining with multi-material topology optimization (MTO) as a mechanical description approach for strong discontinuity state to mechanically model cracked structures. The well founded mathematical formulation of topology optimization problem for cracked structures by using multiple materials is described in detail in this study. In addition, moved and regularized Heaviside functions (MRHF), that have the role of a filter in multiple materials case, is also considered. The numerical example results illustrated in two cases of beam-column joints with stationary cracks verify the validity, benefit and supremacy of the proposed method.

• Computers and Concrete
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• v.23 no.1
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• pp.37-47
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• 2019

In view of the increasing utility of concrete as a construction material, the major challenge is to improve the quality of construction. Nowadays the common problem faced by many of the concrete plants is the shortage of river sand as fine aggregate material. This led to the utilization of locally available materials from quarries as fine aggregate. With the percentage of fines present in Crushed Rock Fines (CRF)or crushed sand is more compared to river sand, it shows a better performance in terms of fresh properties. The present study deals with the formulation of SCC mix design based on the chosen plastic viscosity of the mix and the measured plastic viscosity of cement pastes incorporating supplementary cementitious materials with CRF and river sand as a fine aggregate. Four different combinations including two binary and one ternary mix are adopted for the current study. Influence of plastic viscosity of the mix on the fresh and hardened properties are investigated for SCC mixes with varying water to cement ratios. It is observed that for an increasing plastic viscosity of the mix, slump flow, T500 and J-ring spread increased but V-funnel and L-box decreased. Compressive, split tensile and flexural strengths decreased with the increase in plastic viscosity.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.3
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• pp.361-372
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• 2021

This research aimed to analyze the momentum strategy of foreign investors with the smallest trading transactions in the Indonesian stock market. This study applied a quantitative method approach using intraday transaction data of companies listed on the LQ-45 Index for March, April, and May 2017, obtained from the Indonesia Capital Market Institute (TICMI) which is a subsidiary of the Indonesia Stock Exchange (IDX). The number of companies with available data is 35 companies, consisting of 23 non-government stocks and 12 government stocks. The number of observations from the 35 companies was 8,686,030 observations where the government companies recorded 2,751, 545 and the non-government companies 1,387,016 observations. All data was then squeezed and grouped into small, medium, and large trade transaction orders. The data analysis method used was paired t-test with SPSS to analyze cumulative abnormal returns in the formulation and test periods. This study found that small foreign investors carried out momentum strategies on stocks listed on the LQ-45 Index. However, re-testing was done by separating government and non-government shares. It turned out that small foreign investors performed a momentum strategy on non-government and a contrarian strategy on government.

• Journal of Internet Computing and Services
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• v.23 no.5
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• pp.17-23
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• 2022

Network slicing is a promising paradigm and significant evolution for adjusting the heterogeneous services based on different requirements by placing dynamic virtual network functions (VNF) forwarding graph (VNFFG) and orchestrating service function chaining (SFC) based on criticalities of Quality of Service (QoS) classes. In system architecture, software-defined networks (SDN), network functions virtualization (NFV), and edge computing are used to provide resourceful data view, configurable virtual resources, and control interfaces for developing the modified deep reinforcement learning agent (MDRL-A). In this paper, task requests, tolerable delays, and required resources are differentiated for input state observations to identify the non-critical/critical classes, since each user equipment can execute different QoS application services. We design intelligent slicing for handing the cross-domain resource with MDRL-A in solving network problems and eliminating resource usage. The agent interacts with controllers and orchestrators to manage the flow rule installation and physical resource allocation in NFV infrastructure (NFVI) with the proposed formulation of completion time and criticality criteria. Simulation is conducted in SDN/NFV environment and capturing the QoS performances between conventional and MDRL-A approaches.

• Advances in nano research
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• v.12 no.2
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• pp.117-137
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• 2022

Effect of thickness stretching on free vibration, bending and buckling behavior of carbon nanotubes reinforced composite (CNTRC) laminated nanoplates rested on new variable elastic foundation is investigated in this paper using a developed four-unknown quasi-3D higher-order shear deformation theory (HSDT). The key feature of this theoretical formulation is that, in addition to considering the thickness stretching effect, the number of unknowns of the displacement field is reduced to four, and which is more than five in the other models. Two new forms of CNTs reinforcement distribution are proposed and analyzed based on cosine functions. By considering the higher-order nonlocal strain gradient theory, microstructure and length scale influences are included. Variational method is developed to derive the governing equation and Galerkin method is employed to derive an analytical solution of governing equilibrium equations. Two-dimensional variable Winkler elastic foundation is suggested in this study for the first time. A parametric study is executed to determine the impact of the reinforcement patterns, nonlocal parameter, length scale parameter, side-t-thickness ratio and aspect ratio, elastic foundation and various boundary conditions on bending, buckling and free vibration responses of the CNTRC plate.