• Journal of Mechanical Science and Technology
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• v.19 no.2
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• pp.589-604
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• 2005

To overcome the drawback of currently available curved beam theories having non-symmetric thin-walled cross sections, a curved beam theory based on centroid-shear center formulation is presented for the spatially coupled free vibration and elastic analysis. For this, the displacement field is expressed by introducing displacement parameters defined at the centroid and shear center axes, respectively. Next the elastic strain and kinetic energies considering the thickness-curvature effect and the rotary inertia of curved beam are rigorously derived by degenerating the energies of the elastic continuum to those of curved beam. And then the equilibrium equations and the boundary conditions are consistently derived for curved beams having non-symmetric thin-walled cross section. It is emphasized that for curved beams with L- or T-shaped sections, this thin-walled curved beam theory can be easily reduced to the solid beam theory by simply putting the sectional properties associated with warping to zero. In order to illustrate the validity and the accuracy of this study, FE solutions using the Hermitian curved beam elements are presented and compared with the results by previous research and ABAQUS's shell elements.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2006.04a
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• pp.1033-1039
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• 2006

To overcome the drawback of currently available curved beam theories having non-symmetric thin-walled cross sections, a curved beam theory based on centroid-shear center formulation is presented for the spatially coupled free vibration and elastic analyses. For this, the elastic strain and kinetic energies considering the thickness-curvature effect and the rotary inertia of curved beam are derived by degenerating the energies of the elastic continuum to those of curved beam. And then the equilibrium equations and the boundary conditions are consistently derived for curved beams having non-symmetric thin-walled cross section. It is emphasized that for curved beams with L- or T-shaped sections, this thin-walled curved beam theory can be easily reduced to tl1e solid beam theory by simply putting the sectional properties associated with warping to zero. In order to illustrate the validity and the accuracy of this study, FE solutions using the Hermitian curved beam elements are presented and compared with the results by previous research and ABAQUS's shell elements.

• Archives of Pharmacal Research
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• v.29 no.10
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• pp.928-933
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• 2006

Percutaneous delivery of NSAIDs has advantages of avoiding hepatic first pass effect and delivering the drug for extended period of time at a sustained, concentrated level at the inflammation site that mainly acts at the joint and the related regions. To develop the new topical formulations of pranoprofen that have suitable bioadhesion, the gel was formulated using hydroxypropyl methylcellulose (HPMC) and poloxamer 407. The effects of temperature on drug release was performed at $32^{\circ}C$, $37^{\circ}C$ and $42^{\circ}C$ according to drug concentration of 0.04%, 0.08%, 0.12%, 0.16%, and 0.2% (w/w) using synthetic cellulose membrane at $37{\pm}0.5^{\circ}C$. The increase of temperature showed the increased drug release. The activation energy (Ea), which were calculated from the slope of lop P versus 1000/T plots was 11.22 kcal/ mol for 0.04%, 10.79 kcal/mol for 0.08%, 10.41 kcal/mol for 0.12% and 8.88 kcal/mol for 0.16% loading dose from the pranoprofen gel. To increase the drug permeation, some kinds of penetration enhancers such as the ethylene glycols, the propylene glycols, the glycerides, the non-ionic surfactants and the fatty acids were incorporated in the gel formulation. Among the various enhancers used, propylene glycol mono laurate showed the highest enhancing effects with the enhancement factor of 2.74. The results of this study suggest that development of topical gel formulation of pranoprofen containing an enhancer is feasible.

• Proceedings of the KSME Conference
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• 2000.04a
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• pp.194-199
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• 2000

The creep rate is affected by the temperature and in fact. if the temperature above $T_M/2(T_M:melting\;point)$. The aim of the present investigation is to study the relationship of static creep and cyclic creep behavior of pure copper and the formulation of these phenomena with the special attention to the instantaneous strain. strain rate from time and number of cycles have the same inclination Steady state creep rate depend upon maximum stress and can be expressed as linear function according to Power law creep equations Creep rupture time has relation with creep rate. and it make a group represented as the same direct line regardless of max stress, stress ratio and the temperature. Initial strain effect on continuous creep deformation. and have guantitative relationship between elastic and Plastic strain. LMP have similar tendency than OSDP and MHP according to temperature

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 1994.03a
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• pp.118-128
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• 1994

The planar anisotropic FEM analysis for predicting the earing profiles and draw-in amounts in the deep-drawing processes is introduced. An implicit, incremental, updated Lagrangian formulation with a rigid-viscoplastic constitutive equation is employed. Contact and friction are considered through the mesh-based unit vectors and the normal contact pressure. the consistent full set of governing relations, comprising equilibrium and geometric constraint equations, is appropriately linearized. Barlat's strain-rate potential is employed, whose in-plane anisotropic properties are taken into account with anisotropic coefficients and potential parameter. The linear triangular membrane elements are used for depicting the formed sheet. with the numerical simulations of deep drawing processes of flat-top cylindrical cup for the 2090-T3 aluminum effects on the earing behavior are examined. Earing predictions made for the 2090-T3 aluminum alloy sheet show good agreement with experiments, although some discrepancies were observed in the directional trend of cup height and thickness strains.

• Structural Engineering and Mechanics
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• v.49 no.1
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• pp.65-80
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• 2014

This paper reports on the development of a minimum cost design model and its application for obtaining economic designs for reinforced High Strength Concrete (HSC) T-sections in bending under ultimate limit state conditions. Cost objective functions, behavior constraint including material nonlinearities of steel and HSC, conditions on strain compatibility in steel and concrete and geometric design variable constraints are derived and implemented within the Conjugate Gradient optimization algorithm. Particular attention is paid to problem formulation, solution behavior and economic considerations. A typical example problem is considered to illustrate the applicability of the minimum cost design model and solution methodology. Results are confronted to design solutions derived from conventional design office methods to evaluate the performance of the cost model and its sensitivity to a wide range of unit cost ratios of construction materials and various classes of HSC described in Eurocode2. It is shown, among others that optimal solutions achieved using the present approach can lead to substantial savings in the amount of construction materials to be used. In addition, the proposed approach is practically simple, reliable and computationally effective compared to standard design procedures used in current engineering practice.

• Weed & Turfgrass Science
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• v.5 no.1
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• pp.35-41
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• 2016

Earthworm cast is a harmful factor which reduces the uniformity of management of turfgrass and play quality in golf courses and playground. This research was conducted to carry out the efficacy of some pesticide (bifenthrin GR + clothianidin GR, ethoprophos GR, imidacloprid SC, picoxystrobin WG, thiophanate-methyl WP) and tee tree (Camellia oliefera) extracts against reducing earthworm cast in golf courses. All tested materials were acted reducing earthworm cast, thiophanate-methyl among them showed the highest effect reducing earthworm casts in golf courses. Tea tree extracts was occurred similar efficacy among tested chemical pesticides. However, pellet type byproduct of tea seed extract and liquid formulation of tea tree extract were better than granule formulation of them. Byproduct of tea seed and tea tree extract can be used for alternative biological management material for reducing earthworm cast in heavily casting occurrence area.

• Journal of Pharmaceutical Investigation
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• v.37 no.6
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• pp.397-402
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• 2007

To evaluate the bioequivalence of two venlafaxine formulations, a standard 2-way randomized cross-over study was conducted in twenty-four healthy male Korean volunteers. A single oral dose of 75 mg of test formulation Venfaxine $OR^{(R)}$ (tablet) or reference formulation Efexor $XR^{(R)}$ (capsule) was administered with one-week washout period. Plasma concentrations of venlafaxine were assayed for over a period of 72 hours with a well validated method using liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS). The $mean{\pm}S.D$. of maximum concentration $(C_{max})$ and elimination half-life $(t_{1/2})$ were $64.7{\pm}28.5$ ng/mL, $9.2{\pm}3.0$ h, and $67.2{\pm}30.2$ ng/mL, $9.9{\pm}3.5$ h for test and reference formulations, respectively. Time to reach maximum concentration $(T_{max})$ expressed in median value (range), for the test and the reference, were 10 h (6-14) and 8h (4-12), respectively. Similarly, area under the plasma concentration-time curve, from time zero to last sampling time $(AUC_t)$ and from time zero to time infinity $(AUC_{inf})$, for test and reference formulations were $1185{\pm}755$, $1326{\pm}896$ and $1124{\pm}737$, $1185{\pm}755$ $ng{\cdot}h/mL$, respectively. The parametric 90% confidence intervals on the mean of the differences between the two formulations (test-reference) of the log transformed values of $AUC_t$, and $C_{max}$ were 0.9630 to 1.1383 and 0.8650 to 1.0446, respectively. The overall results indicate that the two formulations are bioequivalent and can be prescribe interchangeably.

• KIPS Transactions on Computer and Communication Systems
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• v.3 no.10
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• pp.383-392
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• 2014

The research for coatings is one of the most popular and active research in the polymer industry. For the coatings, electronics industry, medical and optical fields are growing more important. In particular, the trend is the increasing of the technical requirements for the performance and accuracy of the coatings by the development of automotive and electronic parts. In addition, the industry has a need of more intelligent and automated system in the industry is increasing by introduction of the IoT and big data analysis based on the environmental information and the context information. In this paper, we propose an optimization model for the design of experiments based coating formulation data objects using the Internet technologies and big data analytics. In this paper, the coating formulation was calculated based on the best data analysis is based on the experimental design, modify the operator with respect to the error caused based on the coating formulation used in the actual production site data and the corrected result data. Further optimization model to correct the reference value by leveraging big data analysis and Internet of things technology only existing coating formulation is applied as the reference data using a manufacturing environment and context information retrieval in color and quality, the most important factor in maintaining and was derived. Based on data obtained from an experiment and analysis is improving the accuracy of the combination data and making it possible to give a LOT shorter working hours per data. Also the data shortens the production time due to the reduction in the delivery time per treatment and It can contribute to cost reduction or the like defect rate reduced. Further, it is possible to obtain a standard data in the manufacturing process for the various models.

• The Korean Journal of Applied Statistics
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• v.6 no.1
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• pp.125-143
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• 1993

The primary objective of the paper is to review the development of approximations of the null distribution of a scan statistic and to show how these approximations were improved. Let $X_1, \cdots, X_N$ be a sequence of independent uniform random variables on an interval (0, t]. A can statistic is defined to be the maximum number of observations in a subinterval of length t $\leq$ T, when we continuously (or discretely) move the subinterval from 0 to T. A scan statistic is used to test whether certain events occur in a cluster aganist a null hypothesis of the uniformity. It is difficult to calculate the exact null distribution of a scan statistic. Several authors have suggested approximations of the null distribution of a scan statistic since Naus(1966). We conceive that a scan statistic can be used for detecting a "hot region" is defined to be a region at which the frequencies of mutations are relatively high. A "hot region" may be regarded as a generalized version of a hot spot. We leave it for a further study the concrete formulation of deteciton a "hot region" in a mutational spectrum.uot; in a mutational spectrum.