• Title/Summary/Keyword: T/A-50

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악성 종양 환자에서 방사선 치료 전, 후의 림프구 아형 분석 (Analysis of Lymphocyte Subsets in Peripheral Blood after Radiotherapy)

  • 최영민;김정기;이형식;허원주;김정만
    • Radiation Oncology Journal
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    • 제14권3호
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    • pp.229-236
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    • 1996
  • 목적 : 방사선 치료시 주기적으로 시행하는 말초 혈액 검사에서 백혈구 성분 중 림프구 수의 감소가 관찰되어, 저자는 방사선 치료 전, 후의 백혈구 성분 및 림프구 아형 분석을 시도하여 방사선 치료가 각 성분에 미치는 영향의 정도를 알아보고자 하였다. 대상 및 방법 : 1994년 12월부터 1995년 5월까지 동아대학교병원 치료방사선과에 내원한 환자 중 16명(폐암, 담관암, 식도암 : 2예, 뇌송과체 종양, 위암, 직장암, 악성 흑색종, 안상 배세포종, 방광암, 전립선 육종, 성상세포종, 다형성교모세포종, 다발성 골전이 폐암 : 1예)을 대상으로 하였다. 방사선 치료는 2700 cGy에서 6660 cGy까지 시행하여 정중앙 총 방사선량이 5400 cGy였다. 백혈구 및 감별계산에서 방사선 치료 전과 후의 백혈구 및 림프구, 단핵구, 과립구의 절대값과 백분을을 구하였고 림프구 아형의 분석은 유세포분석기를 이용하여 총 T 세포, 총 8 세포, 조력유발 T 세포, 억제유발 T 세포, 자연살해세포 등의 절대값과 백분유을 구하였다. 방사선 치료 전후의 절대값파 백분율을 비교하였으며 조력유발T세포에 대한 억제유발 T 세포의 비(Helper/Suppressor T cell ratio)의 변화도 분석하였다. 나아가 방사선량에 따른 각 구성비의 변화 정도를 분석하여 총 방사선량과의 상관 관계를 유추하고자하였다. 결과 : 각 환자에서 방사선 치료 전후에 측정한 값의 비교에서, 백혈구와 그 구성 성분인 림프구, 단핵구및 과립구의 수는 단핵구를 제외하고는 방사선 치료 전에 비하여 감소하였으며 특히 림프구 수의 감소는 통계적으로 유의한 차이를 보였다(p<0.05). 림프구 아형인 총 T 세포, 총 B세포, 조력유발 T 세포, 억제유발 T 세포, 자연살해세포 모두 치료전에 비해 감소하였으며(p$\geq$0.05), 조력유발 T 세포에 대한 억제유발 T 세포의 비(Helper/Suppressor T cell ratio)는 방사선 치료 전 1.52에서 치료후 1.11로 감소하였고(p<0.05) 방사선량에 따른 조력유발 T 세포에 대한 억제유발 T 세포의 비의 방사선 치료 전후에 50 Gy 미만군(5명)과 50 Gy 이상군(11명)에서 각각 0.75와 0.71이었다. 결론 : 방사선 치료 후 림프구 수와 조력유발 T 세포에 대한 억제유발 T 세포의 비는 감소하였고 억제유발 T 세포의 백분율은 증가하였다. 이상의 결과로 림프구 아형 중 조력유발 T 세포가 억제유발 T 세포보다 방사선에 보다 민감한 것으로 사료된다. 본 실험에서 방사선량에 따른 림프구 성분의 변화 분석은 대상군 수가 적고 일회 분할 방사선량이나 치료 부위의 넓이, 환자의 체표 면적의 차이에 따른 제한적 요소가 있었으며 향후 보다 많은 대상군에 대한 심도 깊은 분석이 요구된다.

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Development of Flight Control Laws for the T-50 Advanced Supersonic Jet Trainer

  • Kim, Chong-Sup;Hur, Gi-Bong;Hwang, Byung-Moon;Cho, In-Je;Kim, Seung-Jun
    • International Journal of Aeronautical and Space Sciences
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    • 제8권1호
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    • pp.32-45
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    • 2007
  • The T-50 advanced supersonic jet trainer employs the Relaxed Static Stability (RSS) concept to improve the aerodynamic performance while the flight control system stabilizes the unstable aircraft and provides adequate handling qualities. The T-50 flight control laws employ a proportional-plus-integral type controller based on a dynamic inversion method in longitudinal axis and a proportional type controller based on a blended roll system with simple roll rate feedback and beta-betadot feedback system. These control laws are verified by flight tests with various maneuver set flight envelopes and the control laws are updated to resolve flight test issues. This paper describes several concepts of flight control laws used in T-50 to resolve those flight test issues. Control laws for solving the roll-off problem during pitch maneuver in asymmetric loading configurations, improving the departure resistance in negative angle of attack conditions and enhancing the fine tracking performance in air-to-air tracking maneuvers are described with flight test data.

Evaluation of RPV according to alternative fracture toughness requirements

  • Lee, Sin-Ae;Lee, Sang-Hwan;Chang, Yoon-Suk
    • Structural Engineering and Mechanics
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    • 제53권6호
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    • pp.1271-1286
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    • 2015
  • Recently, US NRC revised fracture toughness requirements as 10CFR50.61a to reduce the conservatism of 10CFR50.61. However, unlike previous studies relating to the initial regulation, structural integrity evaluations based on the alternative regulation are not sufficient. In the present study, PTS and P-T limit curve evaluations were carried out by using both regulations and resulting data were compared. With regard to the PTS evaluation, the results obtained from the alternative requirements were satisfied with the criterion whereas those obtained from the initial requirements did not meet the criterion. Also, with regard to the P-T limit curve evaluation, operating margin by 10CFR50.61a was greater than that by 10CFR50.61.

Fire Resistance Properties of Chloroprene Rubber containing Inorganic Flame Retardant

  • Sung, Il Kyung;Park, Chan Young
    • Elastomers and Composites
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    • 제50권4호
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    • pp.279-285
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    • 2015
  • This study examined the mechanical properties and the flame retardant properties of CR rubber containing inorganic flame retardant with various contents of aluminium trihydroxide (ATH, $Al(OH)_3$). The content of aluminium trihydroxide was added in 0, 30, 50, 70 and 100 phr for T1~T5 samples. It was found that increasing the amount of addition over 30 phr resulted in decreasing the mechanical properties. On the other hand in oxygen index measurements T1 sample showed a value of 38.6%, indicating the improvement of flame retardant properties showed a value of 49.7~64.2%. In case of burn test, it was confirmed that CR rubber containing over ATH 50phr content showed performance corresponding to that of first grade fire-resistance.

Impact of Sulphur and Nitrogen Application on Seed and Xanthotoxin Yield in Ammi majus L.

  • Ahmad, Saif;Jamal, Arshad;Fazili, Inayat Saleem;Alam, Tanweer;Khan, Mather Ali;Kamaluddin, Kamaluddin;Iqbal, Mohd;Abdin, Malik Zainul
    • 한국작물학회지
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    • 제52권2호
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    • pp.153-161
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    • 2007
  • Field experiments were conducted to determine the physiological and biochemical basis of the interactive effect of sulphur (S) and nitrogen (N) application on seed and xanthotoxin yield of Ammi majus L. Six treatments were tested ($T_1$ = control-without manure and fertilizers, $T_2$ = manure @ 9 kg $plot^{-1}-10\;t\;ha^{-1},\;T_3=A_0N_{50}K_{25}P_{25},\;T_4=S_{40}N_{50}K_{25}P_{25},\;T_5=S_{40}N_{100}K_{25}P_{25}\;T_6=S_{20+20}N_{50+50}K_{25}P_{25})$). Nitrate reductase (NR) activity and ATP-sulphurylase activity in the leaves were measured at various phonological stages, as the two enzymes catalyze rate-limiting steps of the assimilatory pathways of nitrate and sulphate, respectively. The activities of these two enzymes were strongly correlated with seed and xanthotoxin yield. The highest nitrate reductase activity, ATP-sulphurylase activity and xanthotoxin yield were achieved with the treatment $T_4$. Any variation from this treatment decreased the activity of these enzymes, resulting in a reduction of the seed and xanthotoxin yield in Ammi majus L. The higher seed and xanthotoxin yield achieved in Ammi majus L. at treatment $T_4$ could be due to optimization of leaf soluble protein and photosynthetic rate, as these parameters are Influenced by S and N assimilation.

WASP5 & WASP Builder을 이용한 농업용저수지 유역의 수질관리 (Water Quality Management using WASPS & WASP Builder for a Basin of an Agricultural Reservoir)

  • 정팔진;고홍석;현미희;이은주
    • 한국물환경학회지
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    • 제20권5호
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    • pp.422-431
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    • 2004
  • Water quality modeling was performed for the purpose of diagnosis and prediction of water quality in Gyoung Choen reservoir, using EUTR05/WASP Build model. WASP Builder is capable of visual display in window and it has an advantage of updating and modification for data. Field data of 1992, Spring, Summer, and Fall, were used to calibrate model and these results were validated using data of 2000, Spring, Summer, and Fall. The reservoir was divided into 4 epilimnion segments. Water quality system for modeling were consist of BOD, Chlorophyll-a, DO, $NH_3-N$, $NO_3-N$, T-N, $PO_4-P$, T-P. The results of water quality modelling using EUTR05/WASP Builder, a range of the Correlation for calibration of BOD, T-N, T-P, and Chlorophyll-a according to three seasons are 0.63~0.90, 0.81~0.97, 0.75~0.98, and 0.77~0.98 respectively. And the correlation between simulated and observed values for verification of BOD, T-N, T-P, and Chlorophyll-a according to three seasons are 0.93, 0.94, 0.81, and 0.80 respectively. Among the pollutant sources for a basin of the Gyoung Choen reservoir, generated amount of livestock is the highest and BOD, T-N, T-P of generated loading percentage are 94%, 81%, and 95%. So, we suppose that inflow load amount will decrease 50% and increase 50% only livestock about current load amount. If increasing load amount of livestock 50% in segment 2 and 3, BOD, T-N, and T-P simulated increasing to range of $0.02~0.15mg/{\ell}$, $0.029~0.08mg/{\ell}$, $0.011~0.029mg/{\ell}$ in comparison with current water quality

광원의 색온도 및 연색성 변화에 관한연구 (A Study on the Color Temperature and the Color Rendering Variations of Light Sources)

  • 김훈;한종성
    • 한국조명전기설비학회지:조명전기설비
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    • 제5권2호
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    • pp.49-57
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    • 1991
  • 광원의 상관색온도와 연색성을 측정할 수 있는 간단한 시스템을 개발하였다. 전원전압과 전원주파수 변동시 백열전구와 각종 형광등의 색온도 및 연색성이 변화하는 경향을 측정하였다. 측정 결과, 통상 발생될 수 있는 전압변동의 범위 내에서 백열전구와 형광등의 색온도는 비교적 많이 변화하나, 연색평가수는 거의 변화하지 않는 것을 알 수 있었다. 또한 50kHz 까지의 주파수 변동 범위에서 형광등의 색온도와 연색성은 변화가 적었으나. 50kHz 이상으로 되면 많은 변화가 있을 것으로 예측된다.

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유속계 검정용수로에 관한 연구 (A study on the flume for a current meter rating)

  • 정준석;박정응
    • 물과 미래
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    • 제6권2호
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    • pp.30-37
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    • 1973
  • The coefficient of the current meter generally determined by the maker Its coefficient is subject to being changed with time. Therefore the coefficient of the current meter has to be checked up before it is ready to be used Such an inspection is termed a current meter rating The current meter equipped an electronic apparatus and all the others are to be rated in a rating flume. The price current meter which is most widely used for measuring flow velocities ranging between 0.3m/sec and 3.5m/sec has been used in this study. The length of the flume and the optimum range of the rating in the cross section are determined in the range of 20∼120cm deep, 50∼160cm wide of the flume. In this study, the 23 different kinds of the current meter rating enabled us to determine the constants a and b of the following equation. V=an+b(m/sec) where, n is number of revolution per second(n=N/T) V is velocity(v=D/T) The above constant can be determined by the least squares method and plotting, using the velocity(V=D/T) and the number of revolution per second(n=N/T) obtained from the running distance(D), time(T), the number of revolutin(N), and the running number(m). From the experiments the following conclusions are drawn: 1) The rating flume is large enough if the flume is 110∼120cm deep, and 40∼50m long. 2) The optimum depth for rating of a current meter is in the range of h=40∼50cm.

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Surfactant Effects upon Dissolution Patterns of Carbamazepine Immediate Release Tablet

  • Lee Hyeontae;Park Sang-Ae;Sah Hongkee
    • Archives of Pharmacal Research
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    • 제28권1호
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    • pp.120-126
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    • 2005
  • The objective of this study was to investigate the effects of sodium lauryl sulfate upon the saturation solubility of carbamazepine, its dissolution kinetics, and $T_{50\%}$ defined as the time required for dissolving $50\%$ of carbamazepine. Water, 0.1N-HCI, and phosphate buffers at pH 4.0 and 6.8 containing 0.1, 0.5, 1, and $2\%$ sodium lauryl sulfate were used as dissolution media. The dissolution study was conducted by using the USP dissolution apparatus II with an agitation rate of 75 rpm. Samples of the dissolution media were taken in 7, 15, 30, 45, 60, 75, and 90 min, and the amounts of carbamazepine were determined spectrophotometrically at 285 nm. All dissolution data were fitted well into a four-parameter exponential equation: $Q\;=\;a(1\;-\;e^{-bxt})\;+\;c(1\;-\;e^{-dxt})$. In this equation Q represented $\%$ carbamazepine dissolved at a time t, and a, b, c, and d were constants. This equation led to the calculation of dissolution rates at various time points and $T_{50\%}$. It was found that the dissolution rate of carbamazepine was directly proportional to the aqueous concentration of sodium lauryl sulfate. In addition, under our experimental conditions $T_{50%}$ values ranged from 37.8 to 4.9 min. It was interesting to note that $T_{50\%}$ declined rapidly as the surfactant concentration increased from 0.1 to $0.5\%$, whereas it declined more slowly at concentrations greater than $1\%$. These results clearly demonstrated that the dissolution rate of carbamazepine and duration of its dissolution test could be tailored by optimizing the amount of sodium lauryl sulfate in a dissolution medium.

발아온도에 따른 당근, 상추, 양파 및 파 종자의 Priming 효과 (Effect of Seed Priming of Carrot, Lettuce, Onion, and Welsh Onion Seeds as Affected by Germination Temperature)

  • 정연옥;김종철;조정래
    • 원예과학기술지
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    • 제18권3호
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    • pp.321-326
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    • 2000
  • 발아온도를 $10^{\circ}C$에서 $5^{\circ}C$ 간격으로 $35^{\circ}C$까지 달리한 후 priming 종자의 발아율, T50 및 평균발아소요일수(MDG)를 조사하였다. 당근은 -0.50MPa PEG 8000에서 priming한 종자가 무처리에 비하여 $10^{\circ}C$$35^{\circ}C$에서 발아율이 높았으며 T50 및 MDG는 모든 발아온도에서 단축효과가 있었다. 그러나 PEG에 100mM $K_3PO_4$ 혼용 priming시 PEG 단용 priming에 비하여 발아력에 영향을 미치지 못하였다. 상추의 무처리는 $30^{\circ}C$$10^{\circ}C$에서 단지 2%만 발아 되었으나 50mM $K_3PO_4$에 priming한 종자는 $30^{\circ}C$$35^{\circ}C$에서 각각 40%와 21%로 발아율 향상에 효과적이었다. 그리고 $K_3PO_4$ 단용 priming에 비하여 $K_3PO_4$에 200mM $KH_2PO_4$ 혼용 priming시 발아율은 낮았지만 T50 및 MDG는 더 단축되었다. 양파는 200mM $KH_2PO_4$, 파는 100mM $Ca(NO_3)_2$에서 priming시 $10^{\circ}C$$35^{\circ}C$에서 발아율 향상에 효과적이었다. 그리고 양파는 $KH_2PO_4$ 단용 priming보다 100mM $Ca(NO_3)_2$ 혼용priming, 파는 $Ca(NO_3)_2$ 단용 priming보다 100mM $KH_2PO_4$ 혼용 priming시 발아율은 향상시키지 못하였으나 T50 및 MDG 단축에는 더 효과적이었다.

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