• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.05a
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• pp.110-110
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• 2002

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05a
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• pp.110-110
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• 2002

15-Deoxy-$\Delta$12, 14-prostaglandin J2 (15-deoxy-PGJ2), a naturally occurring ligand activates the peroxisome proliferator-activated receptor-$\gamma$(PPAR-$\gamma$). It was known to have promoting ability of nerve growth factor(NGF)-induced neurite extension. However, it is not clear yet as to what signaling pathway is involved in its promoting ability of neurite extension.(omitted)

• Journal of Sericultural and Entomological Science
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• v.42 no.1
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• pp.14-23
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• 2000

The mitochondrial genome of domesticated silkworm (Bombyx mori) was mapped with five restriction endonucleases (BamHI, EcoRI, HindIII, PstI and XbaI), the entire genome was cloned with HindIII and EcoRI. From the end sequencing results of 5$^1$and 3$^1$region for full genome set of eleven mitochondrial clones, the seven mitochondrial genes (NADH dehydrogenase 6, ATPase 6, ATPase 8, tRN $A^{Lys}$, tRN $A^{Asp}$, tRN $A^{Thr}$ and tRN $A^{Phe}$ of mori were identified on the basis of their nucleotide sequence homology. The nucleotide composition of NADH dehydrogenase 6 was heavily biased towards adenine and thymine, which accounted for 87.76%. On basis of the sequence similarity with published tRNA genes from six insect species, the tRN $A^{Lys}$, tRN $A^{Asp}$ and tRN $A^{Thr}$ were showed stable canonical clover-leaf tRNA structures with acceptible anticodons. However, both the DHU and T$\psi$C arms of tRN $A^{Phe}$ could not form any stable stem-loop structure. The two overlapping gene pairs (tRN $A^{Lys}$ -tRN $A^{ASP}$ and ATPase8-ATPase6) were found from our sequencing results. The genes are encoded on the same strad. ATPase8 and ATPase6 overlaps (ATGATAA) which are a single example of overlapping events between abutted protein-coding genes are common, and there is evidence that the two proteins are transcribed from a single bicistronic message by initiation at 5$^1$terminal start site for ATPase8 and at an internal start site for ATPase6. Ultimately, this result will provide assistance in designing oligo-nucleotides for PCR amplification, and sequencing the specific mitochondrial genes for phylogenetics of geographic races, genetically improved silkworm strains and wild silkworm (mandarina) which is estimated as ancestal of domesticated silkworm.sticated silkworm.

• Journal of Intelligence and Information Systems
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• v.21 no.4
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• pp.79-92
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• 2015

Knowledge map is widely used to represent knowledge in many domains. This paper presents a method of integrating the national R&D data and assists of users to navigate the integrated data via using a knowledge map service. The knowledge map service is built by using a lightweight ontology and a topic modeling method. The national R&D data is integrated with the research project as its center, i.e., the other R&D data such as research papers, patents, and reports are connected with the research project as its outputs. The lightweight ontology is used to represent the simple relationships between the integrated data such as project-outputs relationships, document-author relationships, and document-topic relationships. Knowledge map enables us to infer further relationships such as co-author and co-topic relationships. To extract the relationships between the integrated data, a Relational Data-to-Triples transformer is implemented. Also, a topic modeling approach is introduced to extract the document-topic relationships. A triple store is used to manage and process the ontology data while preserving the network characteristics of knowledge map service. Knowledge map can be divided into two types: one is a knowledge map used in the area of knowledge management to store, manage and process the organizations' data as knowledge, the other is a knowledge map for analyzing and representing knowledge extracted from the science & technology documents. This research focuses on the latter one. In this research, a knowledge map service is introduced for integrating the national R&D data obtained from National Digital Science Library (NDSL) and National Science & Technology Information Service (NTIS), which are two major repository and service of national R&D data servicing in Korea. A lightweight ontology is used to design and build a knowledge map. Using the lightweight ontology enables us to represent and process knowledge as a simple network and it fits in with the knowledge navigation and visualization characteristics of the knowledge map. The lightweight ontology is used to represent the entities and their relationships in the knowledge maps, and an ontology repository is created to store and process the ontology. In the ontologies, researchers are implicitly connected by the national R&D data as the author relationships and the performer relationships. A knowledge map for displaying researchers' network is created, and the researchers' network is created by the co-authoring relationships of the national R&D documents and the co-participation relationships of the national R&D projects. To sum up, a knowledge map-service system based on topic modeling and ontology is introduced for processing knowledge about the national R&D data such as research projects, papers, patent, project reports, and Global Trends Briefing (GTB) data. The system has goals 1) to integrate the national R&D data obtained from NDSL and NTIS, 2) to provide a semantic & topic based information search on the integrated data, and 3) to provide a knowledge map services based on the semantic analysis and knowledge processing. The S&T information such as research papers, research reports, patents and GTB are daily updated from NDSL, and the R&D projects information including their participants and output information are updated from the NTIS. The S&T information and the national R&D information are obtained and integrated to the integrated database. Knowledge base is constructed by transforming the relational data into triples referencing R&D ontology. In addition, a topic modeling method is employed to extract the relationships between the S&T documents and topic keyword/s representing the documents. The topic modeling approach enables us to extract the relationships and topic keyword/s based on the semantics, not based on the simple keyword/s. Lastly, we show an experiment on the construction of the integrated knowledge base using the lightweight ontology and topic modeling, and the knowledge map services created based on the knowledge base are also introduced.

• Nutrition Research and Practice
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• v.5 no.6
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• pp.527-532
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• 2011

ESR1 has been listed in the Human Obesity Gene Map as candidate gene associated with obesity. Thus, in this study, we investigated the effect of the ESR1 rs1884051 polymorphism on obesity-related variables, together with their modulations by dietary intake in Korean men. The obesity-related variables and dietary intake of 3,039 Korean men aged 40-59 years from KoGES database were analyzed. Body weight (P = 0.007), BMI (P = 0.003), waist-hip ratio (= 0.011), fat body mass (P = 0.010), and body fat percentage (P = 0.040) were significantly lower in subjects with the minor T allele of ESR1 rs1884051 than in subjects carrying the C allele. Moreover, the rs1884051 T allele was associated with a decreased risk of obesity prevalence (P = 0.040). Among the subjects whose total energy intake was below the median, carrier of the minor T allele of ESR1 rs1884051 had a lower BMI (P = 0.003) when compared with subjects carrying the C allele. In addition, among subjects whose plant protein intake was above the median, carrier of the minor T allele of ESR1 rs1884051 had a lower BMI (P = 0.044) compared with subjects carrying the C allele. Our findings demonstrate that there is a significant association between the ESR1 rs1884051 variant and obesity-related variables and this association can be potentially modified by dietary energy and plant protein intake.

• Korean Journal of Veterinary Research
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• v.42 no.1
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• pp.123-130
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• 2002

To investigate the cardiopulmonary and anesthetic effects of propofol in dogs, experimental dogs were randomly divided into 4 groups (propofol infusion anesthesia, P/INF, propofol intermittent anesthesia, P/INTER, propofol induction anesthesia, P/ISO, thiopental Na induction anesthesia, T/ISO) and monitored analgesic and anesthetic effects, recovery time, body temperature, heart rate, mean arterial pressure, respiratory rate, systolic and diastolic pressure. In all groups, apnea was not observed. In the P/INF group, the respiratory rate(RR) was slightly decreased, but in the P/INTER group, RR was increased and shallowing. In the groups of P/ISO and T/ISO, the respiratory rate was decreased. Heart rate(HR) was increased after induction anesthesia in all groups, but gradually decreased. Mean arterial pressure(MAP) was decreased after injection anesthesia in the groups of P/INF and P/INTER. In the groups of P/ISO and T/ISO, however, MAP was slightly increased. Systolic and diastolic arterial pressure were gradually decreased after induction anesthesia, but not significantly. In the groups of P/INF and P/ISO, recovery time was shorter than the groups of P/INTER and T/ISO. In all groups, body temperature of animals was decreased gradually according to time but no significant changes were observed. Propofol injection doesn't make the complete loss of responses of animals, especially, in the P/INTER group. In the P/INF group, deep pain was present until the end of anesthetic period. During recovery period, any other side effects except incoordination were not monitored. The present study suggested that infusion anesthesia was superior to intermittent anesthesia as injection anesthetic agent, and propofol was better than thiopental Na as induction anesthetic agent.

• The Pure and Applied Mathematics
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• v.6 no.1
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• pp.39-45
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• 1999

The concept of pseudoLindelof spaces is introduced. It is shown that the followings are equivalent: (a) for any two disjoint zero-sets in X, at least one of them is Lindelof, (b) $\mid$vX{\;}-{\;}X$\mid${\leq}{\;}1$, and (c) for any space T with $X{\;}{\subseteq}{\;}T$, there is an embedding $f{\;}:{\;}vX{\;}{\rightarrow}{\;}vT$ such that f(x) = x for all $x{\;}{\in}{\;}X$ and that if $X{\;}{\times}{\;}Y$ is a z-embedded pseudoLindelof subspace of $vX{\;}{\times}{\;}vY,{\;}then{\;}v(X{\;}{\times}{\;}Y){\;}={\;}vX{\;}{\times}{\;}vY$.

• Journal of Applied and Pure Mathematics
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• v.4 no.1_2
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• pp.1-7
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• 2022

A mapping T : R → R (not necessarily additive) is called multiplicative left 𝛼-centralizer if T(xy) = T(x)𝛼(y) for all x, y ∈ R. A mapping F : R → R (not necessarily additive) is called multiplicative (generalized)(𝛼, 𝛽)-derivation if there exists a map (neither necessarily additive nor derivation) f : R → R such that F(xy) = F(x)𝛼(y) + 𝛽(x)f(y) for all x, y ∈ R, where 𝛼 and 𝛽 are automorphisms on R. The main purpose of this paper is to study some algebraic identities with multiplicative (generalized) (𝛼, 𝛽)-derivations and multiplicative left 𝛼-centralizer on the left ideal of a prime ring R.

• Publications of The Korean Astronomical Society
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• v.34 no.1
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• pp.1-16
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• 2019

"Hon-Chon-Jeon-Do" is a woodcut star map with the size of $79.4cm{\times}127.5cm$, and was widely disseminated as it was made into a set with Kim, Jung Ho's "Yeoji-Jeon-Do". This study confirmed that Yixiang kaocheng xubian ("의상고성속편") star catalogue was used as a source to produce the star map, and the stereographic projection was applied with the projection center being the mid-point (Q) between the celestial and ecliptic north poles. The 'mid-circle' around the Q is arisen between the equator and the ecliptic, and on this circle, the hour angle and the ecliptic longitude of a star can be marked using the same scale. This means that the hour of the day and the season of the year can be read on the same dial of the mid-circle, and the application of this character in the practical use was the key point of the star map production. By observing either transits or positions of the 28 xiu (宿), it is easy to find the corresponding season and time by simply reading the dial on the mid-circle. This is just the function of a portable almanac and thus by disseminating it widely, the convenience of the people would have been promoted. For this reason, it can be stated that "Hon-Chon-Jeon-Do" was a practical astronomical tool which was produced by the western astronomical projection method and was used to find time and season. Choi, Han Ki and Kim, Jung Ho are strong candidates for the makers of this star map. The time of production is estimated to be 1848 ~ 1857, and "Hon-Chon-Jeon-Do" could be regarded as a good contributor to popularization of astronomy in the late Joseon Dynasty.

• Journal of the Chungcheong Mathematical Society
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• v.17 no.1
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• pp.1-17
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• 2004

In this paper, the concept of semi-compatibility in Menger space is introduced and it is used to prove results on the existence of a unique common fixed point of four self-maps. These results are a very wide improvement of Mishra [8], Dedeic and Sarapa [3, 4], Cain and Kasril [1], and Sehgal and Bharucha Reid [10].