• Journal of Preventive Medicine and Public Health
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• 제21권1호
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• pp.99-112
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• 1988

1개 의과대학 본과 제 1,2,3학년 279명을 대상으로 1987년 3월중순부터 4월초순에 걸쳐 프레밍헴 A형행동양상척도(FTA)의 신뢰도와 타당도 그리고 사회심리학적인 변수와 혈압과의 관계를 조사해서 다음의 결과를 얻었다. SCL-90-R과 FTA의 신뢰도는 $0.57{\sim}0.91$의 범위였고 FTA의 요인분석에서 정열적경쟁요인(hard-driving competitiveness factor)과 조급요인(impatience factor)이 추출되었다. FTA의 총점은 비교체중이 클수록, 농촌출신이면 높은 경향을 보였으나 유의성은 없었고 SCL90-R과는 우울, 불안, 적대감, 편집증, 정신증하위척도와 비교적 낮은 유의한 정상관관계를 보였다. 혈압과의 단일 변수 분석에서 수축기혈압은 남자에서 비교체중과 가족력이 유의했고 남녀 공히 경제상태에 따른 차이가 있었다. 확장기혈압은 남자에서 비교체중과 음주량이 유의했고 여자에서는 비교체중이 유의한 상관관계를 보였다. 비교 체중의 영향을 제거하고서는 남자에서 음주량이 확장기혈압과 경제상태가 수축기혈압과 유의한 관계를 보였다. 단계적추가분석법에 의한 중회귀분석 결과 남자에서는 수축기혈압에서 비교체중과 경제상태가 중요변수로 선정되었고 확장기혈압에서는 비교체중과 음주량이 선정되었다. Alpha가 0.1수준에서는 수축기혈압에 SCL-90-R의 우울증 하위척도가 추가 선정되었다. 여자에서 수축기혈압은 경제상태와 비교체중이 선정되었고 확장기혈압에서도 비교체중이 선정되었으나 대상자 수가 적어서 불안정했다. FTA와 혈압과는 남녀 공히 관련이 없었다.

• 동의생리병리학회지
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• 제18권5호
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• pp.1505-1511
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• 2004

Inhibition of angiotensin converting enzyme (ACE) activity is one of the common antihypertensive methods functioned by drugs such as captopril, lisinopril and enalapril to serve as inhibitors of ACE. This study was designed to compare the effects of enalapril, an angiotensin-converting enzyme inhibitor and GLM002, an oriental medicine, on tail systolic pressure, aorta and plasma properties in spontaneously hypertensive rats (SHR) after 4 weeks of treatment. During the treatment, blood pressure was depressed to normal in GLM002 and enalapril groups. The treatments of enalapril and GLM002 were discontinued in 4 weeks. One week after the treatment stop, systolic blood pressure was smoothly increased in both groups; the increment of blood pressure was slightly greater in GLM002-SHR, but the increment of plasma ACE activity was proportionately similar in each group. In the aspects of the triglyceride, HDL and total cholesterol level, those levels were slightly different among each group. We also conducted clinical dosage of GLM002 to the patients who have mild and severe hypertension for approximately 7 weeks. Clinical treatments also showed remarkable efficiencies on blood pressure (systolic blood pressure, diastolic blood pressure), complete blood count (CBC) routine, differ count (NEUTRO, LYM, MONO, EOS and BASO) and R-chemistry. We conclude that GLM002, like already proven enalapril, plays a role as an angiotensin-converting enzyme inhibitor, and can be suggested as a drug candidate for curing hypertension.

• Journal of Yeungnam Medical Science
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• 제8권1호
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• pp.72-78
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• 1991

척추 마취로 제왕절개술을 받은 건강한 30명의 산모를 대상으로 ephedrine sulfate의 정맥적 주군(15명)과 정맥내 주사군(15명)의 산모혈압과 심박, 오심, 구토, Apgar scores, 산모와 태아의 혈압가스압 등을 비교 관찰하였든바 다음과 같은 결론을 얻었다. 1) 척추마취후 적주군의 수축기 산모혈압은 의의있는 변화가 없었으나(p>0.1), 정주군에는 5, 7분 후 술전치에 비해 통계학적으로 의의있게 하강하였으며(p<0.005), 적주군과의 비교에서도 의의있는 변화를 나타내었다(p<0.001). 2) 적주군에서 정주근보다 오심, 구토의 발생 빈도가 낮았다(p<0.001). 3) 산모의 심박, Apgar scores, 산모와 태아의 혈액 가스압에는 양군간 유의한 차이는 없었다. 이상과 같이 제왕절개술을 위한 척추 마취시 ephedrine의 예방적 정맥내 적주가 안전하고 효과적일 것으로 사료된다.

• Journal of Electrical Engineering and Technology
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• 제2권1호
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• pp.136-141
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• 2007

The Purpose Of This Paper Is To Use A Tactile Sensor To Compensate The Error Rate. Most Automated Sphygmomanometers Use The Oscillometric Method And Characteristic Ratio To Estimate Systolic And Diastolic Blood Pressure. However, Based On The Fact That Maximum Amplitude Of The Oscillometric Waveform And Characteristic Ratio Are Affected By Compliance Of The Aorta And Large Arteries, A Method To Measure The Artery Stiffness By Using A Tactile Sensor Was Chosen In Order To Integrate It With The Sphygmomanometer In The Future Instead Of Using Photoplethysmography. Since Tactile Sensors Have Very Weak Movements, Efforts Were Made To Maintain The Subject's Arm In A Fixed Position, And A 40hz Low Pass Filter Was Used To Eliminate Noise From The Power Source As Well As High Frequency Noise. An Analyzing Program Was Made To Get Time Delay Between The First And Second Peak Of The Averaged Digital Volume Pulse(${\Delta}t_{dvp}$), And The Subject's Height Was Divided By ${\Delta}t_{dvp}$ To Calculate The Stiffness Index Of The Arteries($Si_{dvp}$). Regression Equations Of Systolic And Diastolic Pressure Using $Si_{dvp}$ And Mean Arterial Pressure(Map) Were Computed From The Test Group (60 Subjects) Among A Total Of 121 Subjects(Age: $44.9{\pm}16.5$, Male: Female=40:81) And Were Tested In 61 Subjects To Compensate The Error Rate. Error Rates Considering All Subjects Were Systolic $4.62{\pm}9.39mmhg$, And Diastolic $14.40{\pm}9.62mmhg$, And Those In The Test Set Were $3.48{\pm}9.32mmhg,\;And\;14.34{\pm}9.67mmhg$ Each. Consequently, Error Rates Were Compensated Especially In Diastolic Pressure Using $Si_{dvp}$, Various Slopes From Digital Volume Pulse And Map To Systolic-$1.91{\pm}7.57mmhg$ And Diastolic $0.05{\pm}7.49mmhg$.

• Journal of Chest Surgery
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• 제23권2호
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• pp.245-252
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• 1990

To see the change of pulmonary arterial pressure after mitral valve replacement, postoperative cardiac catheterization and echocardiographies were performed in 12 patients of mitral valvular disease with pulmonary hypertension[systolic pulmonary arterial pressure>50 mm Hg]. The mean follow-up duration was 35.4[range: 15-47] months per patient. The following results were obtained. 1] Preoperative systolic pulmonary arterial pressure value of 66.17\ulcorner10.73mmHg decreased significantly to 29.17\ulcorner6.86mmHg postoperatively[p<0.01]. 2] Preoperative Pp/Ps value of 0.67\ulcorner0.13 decreased significantly to 0.28\ulcorner0.06 postoperatively[p<0.01]. 3] Preoperative PAWP value of 29.00\ulcorner4.02mmHg decreased significantly to 9.92\ulcorner4.27 mmHg postoperatively[p<0.01]. 4] Preoperative LAD value of 5.58\ulcorner1.20cm decreased significantly to 4.37\ulcorner0.67cm postoperatively [p<0.01]. In conclusion, pulmonary arterial hypertension secondary to mitral valvular disease could be reduced to normal range after successful mitral valve replacement.

• 대한지역사회영양학회지
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• 제18권3호
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• pp.269-282
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• 2013

This study was carried out to investigate bone mineral density (BMD), blood pressure, calcium, sodium intake and related biochemical variables, and to analyze the relationship between BMD, and blood pressure, physical characteristics, nutrient intakes of Korean adult women. The study subjects were 30~80years old, 513 women living in Seoul and Kyunggi area who participated in 2011 KNHANES. The study subjects were divided into three BMD groups; normal, n = 259 (50.4%), osteopenia, n = 169 (32.9%), and osteoporosis, n = 85 (16.7%). Average height and weight and fat free mass decreased with a decrease in BMD. Average BMD of normal, osteopenia, osteoporosis were 0.87, 0.79, $0.70g/cm^2$, and T-score were 0.42, -0.66, -1.62, respectively. Higher systolic blood pressure, alkaline phosphatase, and triglyceride were significantly associated with a decrease in the BMD. The rates of hypertension were significantly increased from normal to osteoporosis. i.e. 18.5% in normal, 34.3% in osteopenia and 63.5% in osteoporosis. Average nutrientintakes such as protein, fat, calcium, phosphorus, iron, sodium, potassium, vitamin A, vitamin B, vitamin B2, and vitamin C were significantly lower in subjects with lower BMD.n. Average calcium intake of normal, osteopernia and osteoporosis were 528.50, 416.96, 389.56 mg, respectively. There were significant negative correlations between calcium, phosphorus and age, systolic blood pressure, triglyceride. Also, there were negative correlation systolic blood pressure (incomplete sentence). In this study, we found low BMD according to low calcium intake increase the risk of osteoporosis and hypertension rather than sodium intake, also calcium intake decreased with increase age. Therefore, in order to prevent osteoporosis and hypertension, subjects need to be educated regarding the importance of calcium nutrients in diet.

• 디지털융복합연구
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• 제15권5호
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• pp.471-478
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• 2017

본 연구에서는 제주 해녀를 대상으로 식이성 톳 섭취가 혈압 및 총콜레스테롤 변화에 미치는 영향에 대해 알아보고자 하였다. 20명의 현직해녀지원자를 10명씩 나누어 톳 섭취 집단과 톳을 섭취하지 않을 집단으로 구분한 후, 8주 간톳 섭취 집단에게 일일 100g의 식이성 톳을 밥과 함께 섭취케 하여 차이를 비교하였다. 그 결과 첫째, 톳을 섭취한 집단의 수축기 혈압은 유의하게 감소하였다. 둘째, 이완기 혈압은 두 집단 모두 유의한 감소를 보였으며, 집단 간 차이는 없었다. 셋째, 수축기-이완기 혈압 차이는 톳을 섭취한 집단은 유의한 감소를 보였으며, 톳을 섭취하지 않은 집단은 증가하였다. 넷째, 총콜레스테롤은 톳을 섭취한 집단에서 유의한 감소가 나타났지만 톳을 섭취하지 않은 집단은 증가하였다. 이상의 결과는 톳을 일일 100g씩 밥과 함께 섭식함으로써 총콜레스테롤 감소 및 수축기 혈압 감소에 효과가 있었음을 나타낸다.

• 대한지역사회영양학회지
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• 제16권1호
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• pp.145-154
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• 2011

The purpose of this study was to evaluate the relationship between taste perceptions and risk factors for health of Korean elderly living in rural areas. Recognition thresholds for four basic tastes, drug consumption, BMI, fasting blood glucose, serum total cholesterol, serum triglyceride, systolic blood pressure, and diastolic blood pressure were assessed in 176 males and 312 females aged between 50 and 88 years. For the recognition threshold of the four basic tastes, alcohol drinking did not influence their sensitivities, but the alcohol drinking group preferred a higher pleasant concentration of NaCl than did the non-alcohol drinking group. However, smoking significantly decreased sensitivities of the four basic tastes. For the pleasant concentration of NaCl, the smoking group tended to prefer a higher concentration than the non-smoking group. Drug consumption, fasting blood glucose, serum total cholesterol, and serum triglycerides did not have a significant correlation to the sensitivity of the four basic tastes and preference of salty solution. Systolic blood pressure and diastolic blood pressure may have been positively correlated with the pleasant concentration of NaCl but did not correlate with the recognition thresholds of NaCl and sucrose. Further, systolic blood pressure was negatively correlated with the recognition thresholds of caffeine, whereas diastolic blood pressure was negatively correlated with the recognition thresholds of caffeine and citric acid. The finding that the risk factors for health correlated with taste perception has diagnostic and practical implications for health promotion for the elderly.

• Genomics & Informatics
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• 제8권3호
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• pp.103-107
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• 2010

The imputation of untyped SNPs enables researchers to validate association findings across SNP arrays and also enables them to test a large number of SNPs to reveal the fine structure of the association peak, facilitating interpretation of the results and the location of causal polymorphisms. In this study, we applied the imputation method to a genomewide association study and recapitulated the previously associated gene loci of blood pressure traits in Korean cohorts. A total of 1,827,004 SNPs were imputed by the IMPUTE program, and we conducted a genomewide association study for systolic and diastolic blood pressure. While no SNPs passed the Bonferroni correction p-value (p=$2.74{\times}10^{-8}$ for 1,827,004 SNPs), 12 novel loci for systolic blood pressure and 16 novel loci for diastolic blood pressure were detected by imputed SNPs, with $10^{-5}$ < p-value < $10^{-4}$. Moreover, 7 regions (ATP2B1, 10p15.1, ARHGEF12, ALX4, LIPC, 7q31.1, and TCF7L2) out of 14 genetic loci that were previously reported revealed that the imputed SNPs had lower p-values than those of genotyped SNPs. Moreover, a nonsynonymous SNP in the CSMD1 gene, one of the 14 genes, was found to be associated with systolic blood pressure (p<0.05). These results suggest that the imputation method can facilitate the discovery of novel SNPs as well as enhance the fine structure of the association peak in the loci.

• 한국융합학회논문지
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• 제10권8호
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• pp.53-58
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• 2019

최근 만성질환자 건강관리의 목적으로 혈압측정에 대한 접근성을 높이는 제품 연구가 지속적으로 이루어지고 있다. 기존 연구에서는 심전도(ECG)와 광전용전맥파(PPG)를 분석하여 수축기혈압과 이완기 혈압을 산출하는 방식을 사용하고 있다. 주 과제는 정확도와 재현성을 위한 분석 알고리즘 개발이다. 본 연구에서는 초소형 혈압측정장치를 개발하는 단계에서 장치의 크기를 줄이고 측정방법도 간단히 하는 동시에 알고리즘도 두 개의 PPG만을 이용하여 최고혈압(SBP)을 추출하고 이에 따른 최저혈압(DBP)을 구하고자 하였다. 이를 위해 두 개의 PPG에서 얻은 측정값과 SBP, DBP 관계를 통계적으로 추적하여 상호관계를 분석하였다. PPG의 차이 값인 DF_P는 SBP와 반비례 관계가 있으며, DBP와는 비례적 관계가 성립되어 알고리즘에 의해 혈압값을 유추할 수 있으며, SBP를 통해 DBP를 추적할 수 있다.