• Journal of the Korea Safety Management & Science
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• v.17 no.1
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• pp.93-101
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• 2015

The demand from customers on better products and systems seems to be ever increasing. To meet the demand, the systems are becoming more and more complicated in terms of both scale and functionality, thereby requiring enormous effort in the development. One bright spot of this trend is that such effort has been the driving forces of the remarkable advancement in modern systems development. On the other hand, safety issues appear to be critical in many large-scale systems such as transportation and weapon systems including high-speed trains, airplanes, ships, missiles/rockets launchers, and so on. Such systems turn out to be prone to a variety of faults and thus the resultant failure can cause disastrous accidents. For the reason, they can be referred to as safety-critical systems. The systems failure can be attributed to either random or systemic factors (or sometimes both). The objective of this paper is on how to reduce potential systemic failure in safety critical systems. To do so, a proper system design is pursued to minimize the risk of systemic failure. A focus is placed on the fact that complex systems have a lot of complicated interfaces among the system elements. To effectively handle the sources of hazards at the complicated interfaces and resultant failure, a method is developed by utilizing a design structure matrix. As a case study, the developed method is applied in the design of train control systems.

• Tuberculosis and Respiratory Diseases
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• v.75 no.3
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• pp.111-115
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• 2013

Although the relationship between malignancy risk with systemic sclerosis (SSc) has been inconclusive, there are some previous studies for a positive correlation. Most patients with SSc have some degree of lung parenchymal involvement in the form of interstitial thickening and fibrosis. Interstitial lung disease is the most common pulmonary manifestation of SSc. Interstitial lung disease following chemotherapy (5-fluorouracil, leucovorin, and oxaliplatin [FOLFOX]) is an uncommon life-threatening complication and it is induced by oxaliplatin. We report a case of multiple cancers in a patient with SSc and aggravated interstitial lung disease by chemotherapy.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.27 no.1
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• pp.5-10
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• 2016

Variable systemic diseases affect larynx and vocal fold and result in voice change. Asthma and chronic obstructive pulmonary disease make increase of intra-abdomimal pressure followed by reflux of gastric acid, which stimulate vagal-bronchopulomary reflex aggravating cough and respiratory disturbance. Fungal laryngitis in the general population is extremely rare, but can occur in immunocompromised AIDS patients. Although, initially, empirical antifungal therapy for candidiasis is often given without biopsy, diagnostic direct laryngoscopy and biopsy is imperative if a substantial clinical response is not rapidly achieved. In the highly active anti-retroviral therapy era, HIV-positive patients are living longer and are at higher risk for developing non-AIDS-defining malignancies. The incidence of head and neck cancer (HNC) which is related with human papilloma virus infection has increased. The survival is significantly lower among the AIDS-HNC patients with CD4 counts ${\leq}200cells/{\mu}L$. Rheumatoid arthritis (RA) cause voice disturbance by developing cricoarytenoid joints fixation or nodule on vocal fold. Post-menopausal voice disorder (PMVD) is caused by decreased secretion of estrogen-progesterone resulting in decrease of fundamental frequency (F0). Hormonal replacement therapy is helpful to reduce F0 decrease. RA and PMVD result in slight voice change, but it could crucial in professional voice user.

• Genomics & Informatics
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• v.14 no.3
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• pp.85-89
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• 2016

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organ systems. Although the etiology of SLE remains unclear, it is widely accepted that genetic factors could be involved in its pathogenesis. A number of genome-wide association studies (GWASs) have identified novel single-nucleotide polymorphisms (SNPs) associated with the risk of SLE in diverse populations. However, not all the SNP candidates identified from non-Asian populations have been validated in Koreans. In this study, we aimed to replicate the SNPs that were recently discovered in the GWAS; these SNPs have not been validated in Koreans or have only been replicated in Koreans with an insufficient sample size to conclude any association. For this, we selected five SNPs (rs1801274 in FCGR2A and rs2286672 in PLD2, rs887369 in CXorf21, rs9782955 in LYST, and rs3794060 in NADSYN1). Through the replication study with 656 cases and 622 controls, rs1801274 in FCGR2A was found to be significantly associated with SLE in Koreans (odds ratio, 1.26, 95% confidence interval, 1.06 to 1.50; p = 0.01 in allelic model). This association was also significant in two other models (dominant and recessive). The other four SNPs did not show a significant association. Our data support that FCGR polymorphisms play important roles in the susceptibility to SLE in diverse populations, including Koreans.

• Neonatal Medicine
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• v.16 no.2
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• pp.190-196
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• 2009

Purpose: Candida infection has increased in neonatal intensive care units (NICU). However, recent reports on systemic candida infections in preterm newborns are rare in Korea. The aim of this study was to examine the epidemiological features of systemic candida infection in very low birth weight infants (VLBW) over the past five years. Methods: We retrospectively reviewed the medical records of 19 patients with systemic candida infections in VLBW that were admitted to the neonatal intensive care units of three hospitals affiliated with the College of Medicine, The Catholic University of Korea from January 2004 to December 2008. We analyzed the birth weight, gestational age, age at diagnosis, risk factors, co-morbidity, antifungal treatment, and mortality rates among the 19 patients. Results: Systemic candida infections occurred in 19 cases (4.7%) among the VLBW infants. The mean birth weight and gestational age were 959.0$\pm$255.9 g and 26.7$\pm$2.1 weeks. The isolated Candida species were C. albicans (4), C. parapsilosis (9), C. glabrata (2), C. famata (2), and unkown subspecies (2). Most patients had various associated risk factors, including a central venous catheter, broad spectrum antibiotics, parenteral nutrition, intravenous lipid emulsion, endotracheal intubation and $H_2$ blocker therapy. There was no significant difference in the risk factors between newborns that survived and those that died with regard to the systemic candida infection, except for gestational age. Nine (47.4%) out of 19 patients with a candida infection died and four cases (21.2%) were directly related to the candida infection. Conclusion: The prevalence of systemic candida infection is increasing in VLBW infants. The majority of Candida species has shifted to C. non-albicans, especially C. parapsilosis. Because of the high mortality associated with candida infection in the NICU, prophylaxis and early treatment based on epidemiological features is necessary.

• The Journal of Bigdata
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• v.7 no.2
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• pp.225-234
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• 2022

In this paper, we study the recent changes in the credit risk interconnectedness in Korea. Using the CDS spread data from November 2015 to August 2022, we estimate the network structure of sovereign and corporate credit risk. The results show that sovereign and corporate credit risks are interconnected significantly, particularly with respect to the banking sector where FX-related transactions are made. Since 2022 when the monetary policy has become contractionary, such credit risk interconnectedness seems to be strengthened because of greater common exposure.

• Clinical and Experimental Pediatrics
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• v.58 no.3
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• pp.84-88
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• 2015

Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children, and can result in coronary artery lesions (CAL). A patient with KD who is resistant to treatment with intravenous immunoglobulin (IVIG) has a higher risk of developing CAL. Incomplete KD has increased in prevalence in recent years, and is another risk factor for the development of CAL. Although the pathogenesis of KD remains unclear, there has been increasing evidence for the role of genetic susceptibility to the disease since it was discovered in 1967. We retrospectively reviewed previous genetic research for known susceptibility genes in the pathogenesis of KD, IVIG resistance, and the development of CAL. This review revealed numerous potential susceptibility genes including genetic polymorphisms of ITPKC, CASP3, the transforming growth factor-${\beta}$ signaling pathway, B lymphoid tyrosine kinase, FCGR2A, KCNN2, and other genes, an imbalance of Th17/Treg, and a range of suggested future treatment options. The results of genetic research may improve our understanding of the pathogenesis of KD, and aid in the discovery of new treatment modalities for high-risk patients with KD.

• Korean Journal of Pharmacognosy
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• v.15 no.3
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• pp.147-149
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• 1984

To examine pollen preparations which are being sold as a health food, one of these pollen tablets and one of the capsules were selected and investigated by microscopy. It was shown that the pollen coat which can act as a potent allergen was not removed and that the tablets contained other impurities. The results suggest that they are not safe as a food and that they may cause systemic allergy to certain persons. On the contrary, the pollens of the capsule preparation did not have the pollen coat and, therefore, have a less risk of causing allergy.

• Journal of the Korean Society of Safety
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• v.26 no.5
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• pp.33-40
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• 2011

In the hazardous areas where explosive liquids, vapors and gases exist, electrical apparatus/equipment should have explosion-proof construction. The consuming of liquefied natural gas(LNG) has markedly increased in the industrial field, especially in aspect of some thermoprocessing equipment, boiler, dryer, furnace, annealer, kiln, regenerative thermal oxidizer(RTO) and so on. Because it has many merits, clean fuel, safety, no transportation/storage facility and so on. It is strongly recommend that the classification of hazards has to be decided to prevent and protect explosion which may occur in thermoprocessing equipment. In this paper, the operated thermoprocessing equipments in industrial area investigated and explosion risk assessment about LNG leakage from its facilities was performed through numerical calculation and computer simulation. Finally, we suggest the systemic/technical approach for safety assessments of thermoprocessing equipments consumed LNG fuel which are specially subjected to classification of hazardous area.

• KDI Journal of Economic Policy
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• v.28 no.1
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• pp.145-191
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• 2006

This paper studies implications of financial conglomeration for both financial risk of individual conglomerates and systemic risk potential in post-crisis Korea. Our analyses suggest that we cannot conclude that financial conglomerates are taking on higher risks relative to non-conglomerate independent institutions. We also find that larger financial institutions show a significantly higher profitability and lower variability in profitability operating on a superior efficient frontier. However, it turns out that the consolidation has raised systemic risk potential as direct and indirect interdependencies among large banking institutions have substantially increased. Furthermore, financial conglomerates have become more vulnerable to contagion risks from non-bank sectors and capital markets. In the face of the shifting risk structure, financial supervisory and regulatory systems must be upgraded toward a more risk-based, consolidated supervision. Prompt corrective action provision for financial conglomerates must be based upon fully consolidated group risks, and effective supervisory devices need to be introduced to avoid inadvertent extension of public safety net to cross-sectoral activities of financial conglomerates. It is also critical to strengthen internal control and risk management capacities at financial conglomerates, and to establish strong market discipline by improving information transparency and monitoring incentives in the financial market.