• Genomics & Informatics
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• v.21 no.3
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• pp.37.1-37.11
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• 2023

Systemic lupus erythematosus (SLE) is an inflammatory-autoimmune disease with a complex multi-organ pathogenesis, and it is known to be associated with significant morbidity and mortality. Various genetic, immunological, endocrine, and environmental factors contribute to SLE. Genomic variants have been identified as potential contributors to SLE susceptibility across multiple continents. However, the specific pathogenic variants that drive SLE remain largely undefined. In this study, we sought to identify these pathogenic variants across various continents using genomic and bioinformatic-based methodologies. We found that the variants rs35677470, rs34536443, rs17849502, and rs13306575 are likely damaging in SLE. Furthermore, these four variants appear to affect the gene expression of NCF2, TYK2, and DNASE1L3 in whole blood tissue. Our findings suggest that these genomic variants warrant further research for validation in functional studies and clinical trials involving SLE patients. We conclude that the integration of genomic and bioinformatic-based databases could enhance our understanding of disease susceptibility, including that of SLE.

• English Language & Literature Teaching
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• no.6
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• pp.159-178
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• 2000

In systemic grammar an English clause is analysed simultaneously from the point view of its ideational function, interpersonal function and textual function. This study deals with only the ideational function of the three functions, which accounts for the underlying content of a clause. Transitivity is the subsystem of the ideational function. It specifies the different types of process that are recongnized in the language and the structures by which they are expressed. The purpose of the paper is to describe the transitivity of English clause on the basis of systemic approach. For this we analyzed the three subsystems of transitivity which are physical process, mental process and relational process in the form of features. And we described the sets of the features of the three different types of process in English clause in the framework of the system network.

• Tuberculosis and Respiratory Diseases
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• v.74 no.4
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• pp.151-162
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• 2013

Diffuse alveolar hemorrhage (DAH) is a life-threatening and medical emergency that can be caused by numerous disorders and presents with hemoptysis, anemia, and diffuse alveolar infiltrates. Early bronchoscopy with bronchoalveolar lavage is usually required to confirm the diagnosis and rule out infection. Most cases of DAH are caused by capillaritis associated with systemic autoimmune diseases such as anti-neutrophil cytoplasmic antibody-associated vasculitis, anti-glomerular basement membrane disease, and systemic lupus erythematosus, but DAH may also result from coagulation disorders, drugs, inhaled toxins, or transplantation. The diagnosis of DAH relies on clinical suspicion combined with laboratory, radiologic, and pathologic findings. Early recognition is crucial, because prompt diagnosis and treatment is necessary for survival. Corticosteroids and immunosuppressive agents remain the gold standard. In patients with DAH, biopsy of involved sites can help to identify the cause and to direct therapy. This article aims to provide a general review of the causes and clinical presentation of DAH and to recommend a diagnostic approach and a management plan for the most common causes.

• IMMUNE NETWORK
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• v.14 no.3
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• pp.138-148
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• 2014

MicroRNAs (miRNAs) are endogenous small RNA molecules best known for their function in post-transcriptional gene regulation. Immunologically, miRNA regulates the differentiation and function of immune cells and its malfunction contributes to the development of various autoimmune diseases including systemic lupus erythematosus (SLE). Over the last decade, accumulating researches provide evidence for the connection between dysregulated miRNA network and autoimmunity. Interruption of miRNA biogenesis machinery contributes to the abnormal T and B cell development and particularly a reduced suppressive function of regulatory T cells, leading to systemic autoimmune diseases. Additionally, multiple factors under autoimmune conditions interfere with miRNA generation via key miRNA processing enzymes, thus further skewing the miRNA expression profile. Indeed, several independent miRNA profiling studies reported significant differences between SLE patients and healthy controls. Despite the lack of a consistent expression pattern on individual dysregulated miRNAs in SLE among these studies, the aberrant expression of distinct groups of miRNAs causes overlapping functional outcomes including perturbed type I interferon signalling cascade, DNA hypomethylation and hyperactivation of T and B cells. The impact of specific miRNA-mediated regulation on function of major immune cells in lupus is also discussed. Although research on the clinical application of miRNAs is still immature, through an integrated approach with advances in next generation sequencing, novel tools in bioinformatics database analysis and new in vitro and in vivo models for functional evaluation, the diagnostic and therapeutic potentials of miRNAs may bring to fruition in the future.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.43 no.1
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• pp.42-45
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• 2017

The aim of this report was to discuss a complication resulting from a transconjunctival approach to treating an orbital fracture. A 30-year-old male patient presented with a fracture to the zygomatic orbital complex. He was treated with transconjunctival conventional surgical treatment. Two days after surgical treatment, the patient presented with secondary chemosis which was initially slight and then subsequently worsened. The clinical situation was managed with topical and systemic corticosteroids and resolved within one postoperative month. Two-year follow-up showed ptosis of the upper eyelid and limited infraversion in the affected eye. This unusual complication associated with an orbital trauma was resolved with minor functional alterations, although the consequences observed after 2 years were not completely satisfactory.

• Transactions of the Korean Society of Automotive Engineers
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• v.17 no.1
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• pp.120-129
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• 2009

Remanufacturing is an industrial manufacturing process. The merits of remanufacturing are to reuse old products to perform like a new product and to save energy, natural resources, landfill space and to reduce air pollution by less re-smelting. This paper proposes a systemic approach for activating the domestic remanufacturing industry. The approach is based on inside and outside regulations to apply remanufacturing companies. And, we analyzed the state and problems of remanufacturing industry for automobile parts. Also 5 essential tactics and 20 detail strategies are suggested. On the basis of the approach, the domestic remanufacturing industry will carry out the cooperation for their competitions.

• Journal of the Korea Safety Management & Science
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• v.13 no.1
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• pp.51-58
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• 2011

The uniformity of lighting distribution on the roadway is essential factor for drivers and pedestrians's safety during nighttime in urban streets. Also, the importance of roadside trees is one of the growing concern for better citizens' health and mitigating environmental impact on the urban street. But roadway lightings and roadside trees have different design or planting standards and they are not integrated in the systemic viewpoint for better safety of users during nighttime. The purpose of this study is to propose a simulation approach which assesses lighting quality in the view of illumination uniformity distribution of roadway lighting from design step and consider the layout of roadside trees. For improving lighting quality of roadway, simulation approach is needed for assessing the impact of diverse planting situation of trees and encouraged from beginning of design step for roadway construction.

• Journal of Chest Surgery
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• v.28 no.3
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• pp.316-319
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• 1995

Systemic emboli occur in approximately one-third of patients with cardiac myxoma. Embolization is common because of the friability of the tumor and intracardiac location. Embolic episodes in young patients with normal sinus rhythm should arouse suspicions of cardiac myxoma in the absence of active endocarditis. We present one case of 17 years old girl having saddle embolism combined with left atrial myxoma. We planned staged operation. First, the emergency thromboembolectomy of aortic bifurcation was performed through bilateral transfemoral approach with use of Forgaty catheter. One week later, the extirpation of myxoma was successfully done with ECC.

• Knowledge Management Research
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• v.12 no.2
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• pp.69-80
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• 2011

This paper reports on a structural view of a knowledge network comprised of clubs and organisationsexpressly concerned with cultural activities in a regional Australian city. Social network analysis showed an uneven distribution of power, influence, and prominence in the network. The network structure consisted of two modules of vertices clustered around particular categories of creative arts and these modules were linked most frequently by several organisations acting as communication hubs and boundary spanners. The implications of the findings include 'network weaving' for improving the network structure and developing a systemic approach for exploring the structures of social action that form community-based knowledge networks.

• Proceedings of the Polymer Society of Korea Conference
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• 2006.10a
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• pp.54-55
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• 2006

Polymeric micelles, supramolecular assemblies of block copolymers, are useful nanocarriers for the systemic delivery of drugs and genes. Recently, novel polymeric micelles with various functions such as the targetability and stimuli-sensitivity have been emerged as promising carriers that enhance the efficacy of drugs and genes with minimal side effects. This presentation focuses our recent approach to the preparation of functional block copolymers that are useful for constructing smart micellar delivery systems in advanced therapeutics, including chemo-gene therapy. Particular emphasis is placed on the characteristic behaviors of intracellular environment-sensitive micelles that selectively exert drug activity and gene expression in live cells.