• 대한원격탐사학회지
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• 제24권6호
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• pp.605-612
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• 2008

본 연구에서는, MTSAT-1R 위성 자료를 이용하여 표면도달일사량 (SSI: Solar Surface Insolation)을 산출한다. 표면도달일사량은 태양-지구에너지시스템, 기후변화, 그리고 농업 생산 예측 모델 활용과 같은 다양한 분야에 사용되는 주요 변수이다. 대부분의 표면도달일사량 산출모델은 지상 관측 일사계 자료를 이용하여 모델의 검 보정을 수행한다. 위성자료를 이용하여 산출된 표면도달일사량과 지상 관측 일사값을 서로 비교할 때, 기기 차에 의해 발생하는 시스템 오차가 존재한다. 지상 관측 일사계의 경우에는 2분마다 관측된 전천 일사량을 평균하여 시간일사 대푯값으로 제공하다. 반면 위성을 이용하여 산출된 표면 도달일사량의 경우에는, 특정시간에 대한 순간 관측 값을 이용하며, 단위 화소 크기에 대한 공간 해상도로 제공된다. 시스템 차에 의해 발생하는 시간적 불일치는 지상 관측 값과의 검 보정 시, 오차 값을 포함한다. 본 연구에서는, 시간 불일치 조정을 통해 보다 향상된 표면도달일사량 검증 기법을 제공하고자 한다.

• Journal of Ginseng Research
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• 제45권2호
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• pp.264-272
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• 2021

Background: Gintonin is a ginseng-derived exogenous G-protein-coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors. A recent study demonstrated that systemic treatment with gintonin enhances paracellular permeability of the blood-brain barrier (BBB) through the LPA1/3 receptor. However, little is known about whether gintonin can enhance brain delivery of donepezil (DPZ) (Aricept), which is a representative cognition-improving drug used in AD clinics. In the present study, we examined whether systemic administration of gintonin can stimulate brain delivery of DPZ. Methods: We administered gintonin and DPZ alone or coadministered gintonin with DPZ intravenously or orally to rats. Then we collected the cerebral spinal fluid (CSF) and serum and determined the DPZ concentration through liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Results: Intravenous, but not oral, coadministration of gintonin with DPZ increased the CSF concentration of DPZ in a concentration- and time-dependent manner. Gintonin-mediated enhancement of brain delivery of DPZ was blocked by Ki16425, a LPA1/3 receptor antagonist. Coadministration of vascular endothelial growth factor (VEGF) + gintonin with DPZ similarly increased CSF DPZ concentration. However, gintonin-mediated enhancement of brain delivery of DPZ was blocked by axitinip, a VEGF receptor antagonist. Mannitol, a BBB disrupting agent that increases the BBB permeability, enhanced gintonin-mediated enhancement of brain delivery of DPZ. Conclusions: We found that intravenous, but not oral, coadministration of gintonin facilitates brain delivery of DPZ from plasma via LPA1/3 and VEGF receptors. Gintonin is a potential candidate as a ginseng-derived novel agent for the brain delivery of DPZ for treatment of patients with AD.

• 한국식품위생안전성학회지
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• 제24권4호
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• pp.352-356
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• 2009

본 연구는 최근 JECFA에서 이슈화된 식품첨가물의 평가 정보를 파악하여 국내에서 선제적 위해관리에 활용할 수있도록 하기 위하여, 제 69차 JECFA 회의에 의제로 선정된 PDMS의 독성자료 검토 및 monograph 작성 내용에 대하여 소개하고자 수행되었다. PDMS의 독성자료 검토는 'Guidelines for the preparation of toxicological working papers for the Joint FAO/WHO Expert Committee on Food Additives'에 근거하였고, 평가 의뢰 시 제공된 자료 및 추가적으로 검색된 자료를 활용하였다. PDMS는 거품제거와 뭉침 방지를 위하여 간장, 제당, 당밀, 유제품, 쨈, 과즙제품, 두부 등의 제조 시 첨가물로 사용된다. 15,000-20,000 Da 이하의 분자량을 가지는 PDMS가 혈관을 통해 좀 더 쉽게 흡수될 수 있다는 문제가 제기되어, 기존에 설정된 ADI 0-1.5 mg/kg bw/day의 검토가 요구되었다. 이에 따라 흡수, 분포, 배설에 대한 자료와 독성시험자료의 검토가 수행되었다. 검토 결과 PDMS는 체내로 흡수가 거의 이루어지지 않고 대부분 배설되었으며, 급성독성, 아만성독성, 만성독성시험에서 특이적인 전신증상이 관찰되지 않았다. 그러나 급성독성, 아만성독성 및 만성독성시험에서 안구독성이 일관되게 관찰되었으며 이 안구독성의 기전이 확실하게 밝혀지지 않았다. 따라서 이전에 설정된 ADI 0-1.5mg/kg bw/day 값에 안구독성에 대한 추가적인 safety factor 2를 적용하여 temporary ADI 0-0.8 mg/kg bw/day로 재설정하였다. 또한 독성시험에서 관찰된 안구독성의 타당성을 설명하기 위한 추가적인 연구결과를 2010년까지 제공하도록 요청하였다.

• 한국식품영양학회지
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• 제21권4호
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• pp.430-435
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• 2008

The main cause of diabetic neuropathy, one of the most debilitating complications, is the chronic hyperglycemia, the increase sorbitol or the decrease of nerve growth factor(NGF). NGF, a protein, plays a major role in the development and maintenance of peripheral nervous system. Systemic administration of NGF prevents manifestations of neuropathy in rodent models of diabetic neuropathy. In the previous investigation, we report the hypoglycemia effect of Dioscorea rhizoma extract(DRE) in diabetic mice. The present study shows protective effect of DRE on diabetic neuropathy by induction of NGF protein. We investigated the NGF level in salivary gland and sciatic nerve of normal mouse and the effect of DRE on sciatic nerve conductivity and thermal hyperalgesia test in Type 2 db/db mouse. DRE increased endogenous NGF level in salivary gland and sciatic nerve of mouse. And sensory nerve conductivity velocity(SNCV), motor nerve conductivity velocity(MNCV) and thermal hyperalgesia increased in DRE treatment mice compared with control group. On the basis of our results, we conclude that DRE increase induction of endogenous NGF level and have protective effect on diabetic neuropathy by induction of NGF. Therefore, we propose that long-term use of DRE might help prevention of diabetes-associated complication; diabetic neuropathy.

• 보건의료산업학회지
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• 제8권3호
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• pp.49-61
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• 2014

Due to the rapid population's aging, the life span's expansion and social & cultural characteristics, the standards of age classes in senescence are changed. Thus, this study aimed to identify the influential factors on health care utilization in the elderly by age class, and targeted 2,937 adults in their ages over 55 years old from the Korea Health Panel's 2009 Yearly Integrated Data. This study investigated the target health care utilization in the elderly in relation with the gender, the education level, the health-care insurance type, the income, the current job state, the chronic disease. In order to analyze the influential factors on health care utilization in the elderly, the multiple linear regression analysis was conducted to the data. As the results from this study, Concerning the influential factors on the health care utilization, the income, the subjective health state, the chronic disease and the regularly meals for the young-old influenced. Concerning the influential factors on the health care utilization, the subjective health state for the old. Concerning the influential factors on the health care utilization, the subjective health state, the income for the older-old influenced. Concerning the influential factors on the health care utilization, the education level, the spouse, the economic activity and the drinking oldest-old influenced. Therefore, it will need to provide systemic health-care & medical services, to develop health-care & medical programs and the health-care & medical policies and to execute them according to the age classes in senescence.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제35권6호
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• pp.396-401
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• 2013

Chronic osteomyelitis is an infection and inflammation of the bone or bone marrow, causing ischemia in bone marrow due to lack of blood, nutrients, and oxygen supply to the bone marrow, eventually leading to necrosis of bone marrow. A current method for treatment of chronic osteomyelitis is administration of systemic antibiotics followed by removal of the infected bone and tissues. Because infected tissue of chronic osteomyelitis is surrounded by avascular necrotic bone, supply of blood and antibiotics to the infected area is diminished. For effective treatment, high plasma concentrations of antibiotics should be provided for a prolonged period. However, long term high serum level of antibiotics may result in undesirable adverse effects. For delivery of a sufficient concentration of antibiotic to the infected area while avoiding the adverse effect, implantation of a local antibiotic delivery system is suggested. One of the implantation systems that has been utilized is antibiotic impregnated polymethyl methacrylate.

• 동아시아식생활학회지
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• 제23권1호
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• pp.23-30
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• 2013

The purpose of this study was to evaluate the effects of several types of bibimbab (a Korean traditional meal of mixed rice with assorted vegetables), on various immune activities. Compared to control animals in a mouse model (given hamburgers), the oral administration of a portion of bibimbab containing wild plants significantly increased splenic B/T, thymic Th lymphocyte subpopulations, serum IFN-${\gamma}$ production, and enhanced hemagglutination titers up to 300%. Also, a consumption of mushroom-bulgogi bibimbab and Jeonju-style bibimbab markedly decreased compound 48/80-induced systemic anaphylaxis (immediate hypersensitivity), while bibimbab with wild plants inhibited SRBC-induced delayed type hypersensitivity. These results suggest that bibimbab with wild plants both up-regulate on immune activities and have anti-allergenic properties.

• 농촌지도와개발
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• 제21권2호
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• pp.143-184
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• 2014

이 연구의 목적은 가나의 농촌지도사업과 농업기술의 국제협력시스템의 현황과 방향을 탐색하는 것이다. 향후 농촌지도사업의 역할은 지금까지 해 오던 것과는 매우 다를 것이다. 농업기술시스템의 촉진자로서의 농촌지도의 역할은 민간부분의 증가와 함께 증가될 것이다. 공공 농촌지도사업은 민간 부분에서는 농민들의 다양한 요구에 부응할 수 없기 때문에 계속적으로 그 중요성이 증가할 것이다. 향후 이러한 변화와 함께, 가나의 농촌지도시스템에서 내적인 개혁은 도전에 직면하게 될 것이다. 국제협력시스템은 외부의 이해당사자와 농촌지도사업의 파트너십을 형성하는데 중요한 역할을 할 것이다. 종자산업으로부터 나타난 혁신은 역동적이고 시스템적인 과정이었다. KAFECI는 그러한 변화가 2-3년안에 일어난다면 이러한 변화를 유연하게 받아들여야 한다. 기술이전과 전파의 도구나 틀은 다양한 사회경제적인 배경속에서 공동의 목적을 향해 도전하는 혁신적인 플렛폼으로서 발전되어져야 한다.

• Tuberculosis and Respiratory Diseases
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• 제67권4호
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• pp.303-310
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• 2009

Background: Elevated expression of cyclooxygenase-2 (COX-2) and Polo-like kinase-1 (PLK-1) is observed in a wide variety of cancers. Augmented expression of COX-2 and enhanced production of prostaglandin $E_2(PGE_2)$ are associated with increased tumor cell survival and malignancy; COX-2 has been implicated in the control of human non-small cell lung carcinoma (NSCLC) cell growth. PLK-1 siRNA induced the cell death of lung cancer cells and the systemic administration of PLK-1 siRNA/atelocollagen complex inhibited the growth of lung cancer in a liver metastatic murine model. COX-2 and PLK-1 are involved in proliferation and in cell cycle regulation, and there is a significant correlation between their interaction in prostate carcinoma. Methods: In this study, we investigated the pattern of COX-2 and PLK-1 expression in NSCLC, after treatment with IL-1$\beta$, COX-2 inhibitor and PLK-1 siRNA. Results: Expression of PLK-1 was decreased in A549 COX-2 sense cells, and was increased in A549 COX-2 anti-sense cells. Knock out of PLK-1 expression by PLK-1 siRNA augmented COX-2 expression in A549 and NCl-H157 cells. When A549 and NCI-H157 cells were treated with COX-2 inhibitor on a dose-dependent basis, PLK-1 and COX-2 were reduced. However, when the expression of COX-2 was induced by IL-1$\beta$, the production of PLK-1 decreased. Conclusion: These results demonstrate that COX-2 and PLK-1 are regulated and inhibited by each other in NSCLC, and suggest that these proteins have a reverse relationship in NSCLC.

• 대한후두음성언어의학회지
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• 제20권2호
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• pp.136-140
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• 2009

Background and Objectives: Recurrent respiratory papillomatosis (RRP) is difficult to treat because of its tendency to recur and spread throughout the aerodigestive tract. We aimed to estimate the effect of intralesional injections of cidofovir in patients with RRP. Materials and Method: Within the period from January 2003 to July 2007, 13 patients aged 2 to 61 years were treated with intralesional injections of cidofovir combined with surgical excision of RRP. Cidofovir was injected intralesionaly at a concentration of 5 mg/cc after complete removal of the papilloma with $CO_2$ laser or microdebrider. We evaluated the effect of intralesional cidofovir therapy by comparing pre-treatment mean interval of recurrence with post-treatment interval of recurrence. Results: Of 13 patients, two patients showed complete response during follow up period and four patients showed partial response. Seven patients did not respond to cidofovir at all. Mean pre-treatment mean interval of recurrence was 9 months and mean post-treatment interval of recurrence was 13.1 months (p=0.039). There was a statistical significance between the injected dose of cidofovir and post-treatment interval of recurrence (p=0.009). There were no local or systemic side effects caused by cidofovir. Conculsion : Intralesional injection of cidofovir seems to have a potential of a safe and effective adjuvant therapy of RRP. There was a positive correlation between the injected dose of cidofovir and patient clinical outcomes so that administration of higher doses and more frequency of injections should be needed to reduce recurrence. Further study regarding injection therapy regimen for RRP is required.