• Genomics & Informatics
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• 제12권1호
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• pp.35-41
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• 2014

Single-nucleotide polymorphisms (SNPs) have been emerging out of the efforts to research human diseases and ethnic disparities. A semantic network is needed for in-depth understanding of the impacts of SNPs, because phenotypes are modulated by complex networks, including biochemical and physiological pathways. We identified ethnicity-specific SNPs by eliminating overlapped SNPs from HapMap samples, and the ethnicity-specific SNPs were mapped to the UCSC RefGene lists. Ethnicity-specific genes were identified as follows: 22 genes in the USA (CEU) individuals, 25 genes in the Japanese (JPT) individuals, and 332 genes in the African (YRI) individuals. To analyze the biologically functional implications for ethnicity-specific SNPs, we focused on constructing a semantic network model. Entities for the network represented by "Gene," "Pathway," "Disease," "Chemical," "Drug," "ClinicalTrials," "SNP," and relationships between entity-entity were obtained through curation. Our semantic modeling for ethnicity-specific SNPs showed interesting results in the three categories, including three diseases ("AIDS-associated nephropathy," "Hypertension," and "Pelvic infection"), one drug ("Methylphenidate"), and five pathways ("Hemostasis," "Systemic lupus erythematosus," "Prostate cancer," "Hepatitis C virus," and "Rheumatoid arthritis"). We found ethnicity-specific genes using the semantic modeling, and the majority of our findings was consistent with the previous studies - that an understanding of genetic variability explained ethnicity-specific disparities.

• 한국치위생학회지
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• 제13권4호
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• pp.589-596
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• 2013

Objectives : The aim of the study is to investigate the influence of the stress of adults on their oral mucosal diseases, dry mouth and physical, mental stress symptoms. Structured equation model (SEM) was used to analyze the hypotheses of the study. Methods : The subjects were 500 adultsfrom July 1 to December 31, 2012. The data were analyzed using SPSS 18.0 (SPSS 18.0 K for window, SPSS Inc USA) and IBM SPSS Amos 18.0 (SPSS Inc, Chicago, IL, USA) set at the level of significance as 0.05. Results : The level of stress had a direct influence on oral mucosal diseases, and oral mucosal diseases affected stress symptoms directly. The level of stress had a significant impact on stress symptoms, and that exercised an indirect influence on stress symptoms through the medium of oral mucosal diseases and dry mouth. The level of stress affected dry mouth in a direct effects, and dry mouth had a direct impact on stress symptoms. Conclusions : The stress of adults had direct and indirect impacts on their oral health and systemic diseases. The oral health of adults should be promoted to let them stay healthy, and how to help them to get rid of their stress should be considered to improve their quality of life.

• 한국산업정보학회논문지
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• 제23권3호
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• pp.87-95
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• 2018

최근 인공지능(Artificial Intelligence; A.I.)의 기술 발전과 함께 이에 대한 관심이 증가하고 있으며 관련 시장도 비약적으로 확대되고 있다. 아직은 초기단계이지만 2000년 이후 현재까지 계속 확장되고 있는 인공지능 기술 분야의 연구방향과 투자 분야에 대한 불확실성을 줄이는 것이 중요한 시점이다. 이러한 기술 변화와 시대적 요구에 따라서 본 연구는 빅데이터(Big Data) 분석방법 중 텍스트 마이닝(Text Mining)과 토픽모델링(Topic Modeling)을 활용하여 기술동향을 살펴보고, 핵심기술과 성장 가능성이 있는 연구의 향후 방향성을 제시하였다. 본 연구의 결과로부터 인공지능의 기술동향에 대한 이해를 바탕으로 향후 연구 방향에 대한 새로운 시사점을 도출할 수 있으리라 기대한다.

• 한국가구학회지
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• 제19권6호
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• pp.466-474
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• 2008

We suggest layered sculpture method and color painting method with new materials for the preparation of various expressions for aesthetic model of the furniture and interior articles made of river birch. Through the analysis of the layered sculpture method and preference, we try to set a new direction for the enhancement of the decoration for the furniture or article design made of birch plywood. Also, we study the fittest manufacturing process after selecting color painting materials different from the existing painting method and goes well with the furniture or article made of river birch. Color painting which systemic application of the layered plywood from birch and new paints such as Oriental dye is one of the best schemes to realize various possibility of the furniture and wooden article made of the layered plywood, and this research result has affected positive effect on the development fields such as wooden furniture and interior articles.

• Journal of Nutrition and Health
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• 제31권4호
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• pp.679-686
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• 1998

This study was performed to determine whether the infusion of nucleosides and a nucleotide mixture directly ito intestinal lumen can induce a regenerative effect on impaired intestinal mucosa. The effects of massive small bowel resention and also total parenteral nutrition were induced by surgical creation of Thirty-Vella fistual in male Sprague-Dawley rats. The rats received saline solution (Control group) or nucleosides and a nucleotide mixture(lower concentration group(Nucl) or higher concentration group (Nuc2) every two days into the fistula. Mucosal protein, DNA , ornithine decarboxylase(ODC) activity, and morphometry were evaluated at 9 or 21 days postoperation in the fistual and also in the residual ileal segment. On the 9th day, mucosal protein, DNA content, and villous surface area in the fistula and also in the residual ileum increased in rats that received nucleosides and a nucleotide mixture of lower concentration (Nuc 1). On the 21 th day, there were no significant differences in intestinal mucosa between the control group and the lower level nucleoside nucleotide mixture-treated group. The fistula villous height of the higher nucleosides and a nucleotide mixture group was higher than in the control rats. Fistula mucosal ODC activities were not significantly different between groups although the mucosal ODC activity of the residual ileal segment was increased on the 9th day. Our data suggests that this animal model is suitable for studying the effect of dietary factors on intestinal mucosal growth and regeneration after villous stropy , differentiating direct effects of diet on the intestine from systemic effects. It is also suggested that external nucleosides and nucleotides have supportive effects on intestinal mucosal regeneration.

• Journal of Pharmaceutical Investigation
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• 제32권4호
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• pp.259-265
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• 2002

Piroxicam is one of the NSAID, which is used in the systemic and topical treatment of a variety of inflammatory conditions. Conventionally, for topical use, the drug is formulated in gel. We designed an phonophoretic drug delivery system to investigate the piroxicam permeability and the influence of ultrasound application (continuous mode, pulsed mode), frequency (1.0 MHz, 3.0 MHz) and intensity $(1.0\;w/cm^2,\;1.5\;w/cm^2,\;2.0\;w/cm^2)$ with 0.5% piroxicam gel. Per cutaneous absorption studies were performed in vitro models to determine the rate of drug absorption via the skin. Permeation study using hairless mouse skin was performed at $37^{\circ}C$ using buffered saline (pH 7.4, 10% propylene glycol solution) as the receptor solution. Anti-inflammatory activity was determined using carrageenan-induced foot edema model in rat. A pronounced effect of ultrasound on the skin absorption of the piroxicam was observed at all ultrasound energy level studied. Ultrasound was carried out for 10 hr. The highest permeation was observed at intensity of $2.0\;w/cm^2$, frequency of 1.0 MHz and continuous output. The inclusion of phonophoresis was found to improve significantly the skin permeation in vitro and the anti-inflammatory activity in vivo.

• The Korean Journal of Physiology and Pharmacology
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• 제21권1호
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• pp.45-54
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• 2017

Our study aims to determine the metabolism and excretion of novel pulmonary-targeting docetaxel liposome (DTX-LP) using the in vitro and in vivo animal experimental models. The metabolism and excretion of DTX-LP and intravenous DTX (DTX-IN) in New Zealand rabbits were determined with ultra-performance liquid chromatography tandem mass spectrometry. We found DTX-LP and DTX-IN were similarly degraded in vitro by liver homogenates and microsomes, but not metabolized by lung homogenates. Ultra-performance liquid chromatography tandem mass spectrometry identified two shared DTX metabolites. The unconfirmed metabolite $M_{un}$ differed structurally from all DTX metabolites identified to date. DTX-LP likewise had a similar in vivo metabolism to DTX-IN. Conversely, DTX-LP showed significantly diminished excretion in rabbit feces or urine, approximately halving the cumulative excretion rates compared to DTX-IN. Liposomal delivery of DTX did not alter the in vitro or in vivo drug metabolism. Delayed excretion of pulmonary-targeting DTX-LP may greatly enhance the therapeutic efficacy and reduce the systemic toxicity in the chemotherapy of non-small cell lung cancer. The identification of $M_{un}$ may further suggest an alternative species-specific metabolic pathway.

• 시스템엔지니어링학술지
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• 제10권2호
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• pp.51-58
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• 2014

Manufacturing industry is one of the core sectors providing national competitiveness and economical impact Today's manufacturing industry is required to fulfill so called Sustainable Factory paradigm from the perspectives of environmental and social development. To cope with the requirements, researches for achieving sustainability in manufacturing system are actively carried out in the world from various perspectives. In this paper, we analyzed systemic characteristics of sustainable manufacturing system, and developed verification & validation strategy based on traceability between system requirement and functionality. The developed methods were applied to a European Project called the Foundation for the Sustainable Factory of the Future (FoFdation). Specifically, we analyzed and verified the deliverables of FoFdation by deriving systems architecture in terms of Component, Function, and Items. The results indicated that the FoFdation is pretty much compliant with the concept of Ubiquitous Factory, and can be used as an International Reference Model for the Smart Factoy, a world wide hot topic under the paradigm of IOT (Internet-Of-Things), if information processing part is supplemented.

• 산업경영시스템학회지
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• 제37권3호
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• pp.75-81
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• 2014

To establish a new creative economy, the worldwide efforts have been made to wriggle out the old economic paradigm after the financial crisis of 2008. When it comes to the limitation of the viability. the start up companies have a high risk of failure. Therefore business incubator (BI) should carry out the role to improve their viability. As for the maximization of the effect on the business incubating services as move in companies, it is important for BI to increase the level of business incubating services by the systemic and scientific measurement. This study showed that the quality of the BI center services was measured by Kano analysis and the previous research as follows. First, BI quality attribute by Timko's customer satisfaction came out into the attractive qualities on the 14 items that amount to the 70% of 20 business incubating services items. It is desirable to perform the strategy for the satisfaction. Secondly, basic business incubating services were interpreted as the one-dimensional quality like incubating spaces, parking facilities, security facilities, industry technology development funds, and incubating managers. Finally, training and educational service was recognized as indifferent quality. Futhermore, the improvement and the limitation of this study as well as the interpretation of analysis results are also provided.

• 약학회지
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• 제38권2호
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• pp.191-196
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• 1994

Higenamine is a tetrahydroisoquinoline alkaloid which was isolated as a cardiotonic principle from Aconiti tuber. 1.v. injection of higenamine was reported to increase the cardiac output and heart rate and to decrease the blood pressure and the systemic vascular resistance presumably by stimulating the adrenergic ${\beta}-receptors$. The anti-platelet and anti-thrombotic effects of higenamine were investigated in this paper. Higenamine(0.5 mg/ml) showed mild inhibitory effect against collagen induced platelet aggregation in vitro and the inhibito교 effect was increased with the pre-incubation$(5{\sim}30\;min)$ of platelet rich plasma(PRP) with higenamine. With the 30 min incubation, the platelet aggregation was almost completely inhibited. And the oral administration of higenamine$(50{\sim}200\;mg/kg)$ enhanced the survival in the mouse model of thrombosis and that of endotoxic shock. The anti-thrombotic and anti-septic effects of higenamine thus appear to be due to the ${\beta}-agonistic$ and the anti-platelet effects of this compound.