• Natural Product Sciences
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• 제17권3호
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• pp.239-244
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• 2011

Immediate-type hypersensitivity is involved in many allergic diseases such as asthma, allergic rhinitis and anaphylaxis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. Stimulation of mast cells releases inflammatory mediators, such as histamine and pro-inflammatory cytokines with immune regulatory properties. We investigated the effect of the aqueous extract of Schizonepeta tenuifolia (AEST) (Labiatae) on the immediate-type allergic reaction. AEST inhibited compound 48/80-induced systemic allergic reaction. AEST attenuated immunoglobulin E (IgE)-mediated skin allergic reaction and histamine release from human mast cell line (HMC-1) cells. In addition, AEST decreased the gene expression and secretion of pro-inflammatory cytokines in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated HMC-1 cells. Our results indicate that AEST inhibits the mast cell-derived allergic reactions and involvement of histamine and pro-inflammatory cytokines in these effects.

• 한국치위생학회지
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• 제13권1호
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• pp.136-145
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• 2013

Objectives : The goal of this study is to investigate how occupational stress affects temporomandibular disorders (TMD), dry mouth and oral symptoms. Methods : For this study, workers from 5 areas were selected and the survey was carried out from June 1st to 30th, 2012. A total of 410 questionnaires were analyzed. Results : The analysis of the structural model shows that occupational stress has no significant influence on temporomandibular disorder and dry mouth symptoms, but does affect other oral symptoms. The results also reveal that dry mouth symptom and temporomandibular disorder both have a significant effect on oral symptoms. Conclusions : Oral symptoms and job stress appeared to directly and indirectly influence the psychological and social factors of job stress. A systemic investigation on the improvement of oral health in workers is urgently required.

• 시스템엔지니어링학술지
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• 제1권2호
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• pp.63-68
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• 2005

This study developed the planning process for technical management of engineering project applying systems engineering process in order to correctly design technical management activities early during the system development projects. The developed process describes a systemic design process of a product to be developed as well as the development process and the personnel team of project organization. As an outcome of the process implemented by a Model-Based Systems Engineering(MBSE) software, a systems engineering management plan(SEMP) and a risk management plan can easily be produced.

• 천문학회보
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• 제39권1호
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• pp.43.2-43.2
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• 2014

We investigate the ionized gas kinematics at the center of 6 nearby Seyfert galaxies, using the integral field spectroscopy data from the Calar Alto Legacy Integral Field spectroscopy Area survey Data Release 1. To understand the kinematic nature of the ionized gas in the narrow-line regions (NLRs), we measured the flux, velocity, and velocity dispersion of the [OIII] $5007{\AA}$ and Ha $6563{\AA}$ emission lines, after subtracting a best-fit stellar population model representing the stellar features. At the same time, we measured stellar velocity as a reference for the systemic velocity, and stellar velocity dispersion. We spatially resolved the velocity structure of the ionized gas using each emission line and compared it to that of stars. In this poster we present the flux, velocity, and velocity dispersion maps of the ionized gas and stars, and discuss the nature of the ionized gas outflows in the central kiloparsec scale.

• Biomolecules & Therapeutics
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• 제19권4호
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• pp.466-471
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• 2011

Allergic asthma is complex inflammatory airway disorder caused by genetic and environmental factors. Sulfamethoxazole, a sulfonamide, is the cause of drug rash with eosinophilia and systemic symptoms syndrome. Parasites infection also related with eosinophilia and allergic diseases. In the present study, we investigated the modulating effects of parasitic derivative and sulfamethoxazole (SMX) on allergic airway inflammation in the ovalbumin (OVA)-induced murine asthma model. Histopathological changes, cytokine secretion, and total and allergen-specific IgE were investigated. BALB/c mice were treated with Ascaris suum extract or SMX for 4 weeks before sensitized and challenged to ovalbumin. Pre-treatment of Ascaris suum extract decreased allergic inflammation in lung tissue and IL-4, total IgE, and OVA-specific IgE levels in bronchoalveolar lavage fluid. However, pre-treatment of SMX did not show any effects on allergic airway inflammation. These results indicate that parasitic infection has protective effects on allergic asthma, but the sulfamamides may not relate with allergic asthma.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.351.2-351.2
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• 2002

We have previously reported the synthesis and cytotoxic activities of a series of azaanthraquinone derivatives on the model of doxorubicin(Dox). Dox is known to intercalate into DNA and to inhibit topoisomerase II activity. But in the case of Quinone compounds like Dox. its use is limited because of systemic toxicities. primarily cardiotoxicity and myelosuppression. In this study. we describe the synthesis of benzoquinoxaline derivatives as DACA analogue. DACA has a neutral chromophore and acridine moiety and posions both topoisomerases I and ll with DNA intercalating activity. In order to delineate the SAR of benzoquinoxaline derivatives. an effcient sythetic rout to the target compounds without quinone group. Various attempted removal of quinone from benzoquinoxlinedione was unsuccessful. Diels-Alder rout applied for the synthesis of the target compounds will be discussed.

• Educational Technology International
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• 제22권2호
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• pp.169-197
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• 2021

Learning agility as high potentials is drawing attention as a competency for leading an uncertain future society. The present study aims to determine the factors of learning agility in higher education context for future society. To address this goal, Major factors related to learning agility were derived through literature review and statistically verified. For statistical analysis, the nationwide data were collected from 1,000 undergraduate students in South Korea by National Youth Policy Institute. The participants asked to answer 29 items of learning agility questionnaires (LAQ). The collected data were analyzed by descriptive statistical analysis, exploratory factor analysis, and confirmatory factor analysis. As a result, learning agility items were verified normality and reliability. Learning agility was identified seven factors; challenging mind, learning responsibility, reflecting experience, intellectual curiosity, systemic thinking, change adaptability, and logical thinking. Also, the structural model fit of the seven factors of learning agility was also confirmed to be good. Based on the findings of the present study, empirical, theoretical, and practical contributions were presented, and suggestions for further research were proposed in detail.

• International Journal of Internet, Broadcasting and Communication
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• 제14권4호
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• pp.154-162
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• 2022

This study aimed to systematically review the available body awareness interventions in patients with musculoskeletal disorders. A total of 3,462 studies were searched in relevant databases using the search keywords, and six studies that met the selection criteria after review were included in the final analysis. The qualitative level of the studies was classified using the five levels of evidence-based classification, and systematic analysis was conducted according to PICO model (patient/population, intervention, comparison and outcomes). Of the six studies included in the final analysis, there were one, three, and two randomized controlled trials, non-randomized two-group studies, and case reports, respectively. Body awareness therapy was applied to patients with idiopathic scoliosis, non-specific musculoskeletal disorder, hip osteoarthritis, and amputation, who showed positive improvements after the interventions. Our results suggested that body awareness therapy is an important intervention with positive effects on the recovery of patients with musculoskeletal disorders.

• Corrosion Science and Technology
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• 제3권2호
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• pp.72-80
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• 2004

Recently, the demand on the practical application of life-cycle cost effective design and rehabilitation of bridges is rapidly growing in civil engineering practice. However, in spite of impressive progress in the researches on the Life-Cycle Cost (LCC), the most researches have only focused on the theoretical point but did not fully incorporate the critical issues for the practical implementation. Thus, this paper is intended to suggest a systemic integrated approach to the practical application of various LCC methodologies for the design and rehabilitation of bridges, For that purpose, hierarchical definitions of LCC models are presented to categorize the approach of LCC assessment applicable for the practical implementation. And then, an integrated LCC system model is introduced with an emphasis on data uncertainty assessment and user-friendly knowledge-based database for its successful implementation. Finally, in order to demonstrate the LCC effectiveness for design and rehabilitation of real bridge structures, illustrative examples are discussed.

• 산업공학
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• 제22권1호
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• pp.26-37
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• 2009

BPM(Business Process Management) secures the agility of an enterprise through automation, integration, and optimization of business process. For the successful BPM introduction, the evaluation and selection of suitable processes for BPM are very important. But as to process evaluation and selection standards, in fact, various selection elements exist and they have to be considered. Therefore, it is very difficult to evaluate systematically and reasonably business processes for enterprises or concerned persons that plan to introduce BPM. This paper describes a Web-based business process evaluation model for BPM using BSC(Balanced Scorecard) and fuzzy AHP(Analytic Hierarchy Process). A Web-based business process evaluation system was implemented based on this and it provides many useful business process evaluation results to enterprises or concerned persons that have insufficient experience and knowledge about BPM, and initially plan to implement BPMS(Business Process Management System). Thus, this paper demonstrates the applicability of fuzzy AHP concept in business process evaluation and selection for BPM, and provides a systemic guidance in the decision-making process.