• Title/Summary/Keyword: System Risk Analysis

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Comparison of Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy Versus Concurrent Chemoradiotherapy Alone in Locoregionally Advanced Nasopharyngeal Carcinoma: a Meta-analysis of 793 Patients from 5 Randomized Controlled Trials

  • Liang, Zhong-Guo;Zhu, Xiao-Dong;Zhou, Zhi-Rui;Qu, Song;Du, You-Qin;Jiang, Yan-Ming
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.11
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    • pp.5747-5752
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    • 2012
  • Purpose: The main objective of the present study was to evaluate the efficacy and toxicity of concurrent chemoradiotherapy followed by adjuvant chemotherapy compared with concurrent chemoradiotherapy alone in the treatment of locoregionally advanced nasopharyngeal carcinoma. Methods: The search strategy included Pubmed, Embase, the Cochrane Library, China National Knowledge Internet Web, Chinese Biomedical Database and Wanfang Database. We also searched reference lists of articles and the volumes of abstracts of scientific meetings. Randomized controlled trials (RCTs) that compared concurrent chemoradiotherapy followed by adjuvant chemotherapy with concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma were included. Meta-analysis was performed with RevMan 5.1.0. The Grading of Recommendations Assessment, Development, and Evaluation system (GRADE) was used to rate the level of evidence. Results: Five studies were included. Risk ratios of 1.02 (95%CI 0.89-1.15), 0.93 (95%CI 0.72-1.21), 1.07 (95%CI 0.87-1.32), 0.95 (95%CI 0.80-1.13) were observed for 3 years overall survival, 5 years failure-free survival, 5 years locoregional failure-free survival and 5 years distant metastasis failure-free survival. There were no treatment-related deaths in both groups of five studies. Hematologic and gastrointestinal toxicity were the most significant for patients during adjuvant chemotherapy. The level of evidence was low. Conclusion: Compared with concurrent chemoradiotherapy alone, concurrent chemotherapy followed by adjuvant chemotherapy did not improve prognosis. More toxicity was found during adjuvant chemotherapy.

A Study on the Status and Cases of Occupational Accidents of Child-care Teachers (보육교사의 산업재해 현황 및 사례에 관한 연구)

  • Lim, Jin Seok;Jeong, Seong Choon;Kwon, Yogjun;Kim, Keun Jin;Do, Nam Hee;Lee, Jaehee;Choi, Yoon Kyung
    • Korean Journal of Childcare and Education
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    • v.16 no.4
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    • pp.73-92
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    • 2020
  • Objective: The purpose of this study is to examine occupational safety accidents of child care teacher and to suggest preventive measure in occupational safety health and safety for child-care teacher. Methods: We investigated laws, policy, and previous studies related occupational safety and health for child care teacher. Especially, we reviewed the legal definition of child-care teacher to identify whether Occupational Safety and Health acts cover child-care teacher. Also cross tabulation and a qualitative analysis were conducted for occupational accidents in child care centers from 2013-2018. Results: Safety and health related policies to protect child care centers have been carried out by child care Center Safety and Insurance Association and the Child Care Support Center, but it has mainly been functioned to protect children excluding child care teacher. The most occupational accidents occur in worker aged 40s. The most type of occupational accident were falling down on the floor and surface. Also we could find that there is a high risk of falls, and musculoskeletal disorders through qualitative analysis on occupational accidents cases of child-care teacher. Conclusion/Implications: We suggest to improve the system for protecting child care workers including strengthening occupational safety and health education for child care workers, expanding coverage of national project to prevent occupational accidents.

Outcomes of comprehensive fixed appliance orthodontic treatment: A systematic review with meta-analysis and methodological overview

  • Papageorgiou, Spyridon N.;Hochli, Damian;Eliades, Theodore
    • The korean journal of orthodontics
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    • v.47 no.6
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    • pp.401-413
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    • 2017
  • Objective: The aim of this systematic review was to assess the occlusal outcome and duration of fixed orthodontic therapy from clinical trials in humans with the Objective Grading System (OGS) proposed by the American Board of Orthodontics. Methods: Nine databases were searched up to October 2016 for prospective/retrospective clinical trials assessing the outcomes of orthodontic therapy with fixed appliances. After duplicate study selection, data extraction, and risk of bias assessment according to the Cochrane guidelines, random-effects meta-analyses of the mean OGS score and treatment duration were performed and 95% confidence intervals (CIs) were calculated. Results: A total of 34 relevant clinical trials including 6,207 patients (40% male, 60% female; average age, 18.4 years) were identified. The average OGS score after treatment was 27.9 points (95% CI, 25.3-30.6 points), while the average treatment duration was 24.9 months (95% CI, 24.6-25.1 months). There was no significant association between occlusal outcome and treatment duration, while considerable heterogeneity was identified. In addition, orthodontic treatment involving extraction of four premolars appeared to have an important effect on both outcomes and duration of treatment. Finally, only 10 (39%) of the identified studies matched compared groups by initial malocclusion severity, although meta-epidemiological evidence suggested that matching may have significantly influenced their results. Conclusions: The findings from this systematic review suggest that the occlusal outcomes of fixed appliance treatment vary considerably, with no significant association between treatment outcomes and duration. Prospective matched clinical studies that use the OGS tool are needed to compare the effectiveness of orthodontic appliances.

Analysis of Volatile Organic Compounds Emitted from Electronic Parts in PC/Monitor Set (PC/Monitor 구성 전자부품에서 방출되는 휘발성 유기화합물의 분석)

  • Ri, Chang Seop;Choe, Jong Woo;Baek, Kyu Won
    • Journal of the Korean Chemical Society
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    • v.44 no.4
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    • pp.343-349
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    • 2000
  • Volatile Organic Compounds(VOCs) emitted form electronicSince toluene, xylene, cyclohexanone, and benzofuran will bring on the deleterious smell and the health risk, eventhough very small amount of these areexposed to human body, quantitative analysis was achieved by GC-MS system. As a result of these analyses, except PCB(CEM-1) of which is one of the electronic parts, the left of electronic parts represented, imme-diately form 30 minutes to 1 hour after heating, the trends that toluene, xylene, cyclohexanone and phenol were consecuticely emitted very high. and toluene, xylene, phenol, cyclohexanone, and benzofuran from most of the electronic parts were emitted very frequently within the measuring period. Finally, Trans of electronic parts showed the highest concentration of emission, and xylene(550~2482 ${\mu}g/m^2$) was the most noticeably emitting compound of VOCs.

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Comparison of Preventive Health Behaviors in Adults Aged 50~64 in Korea and the United States (한국과 미국 50~64세 성인의 예방적 건강행위 비교)

  • Lee, Chung Yul;Kim, Jung Ae;Kim, Su Hee
    • Research in Community and Public Health Nursing
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    • v.24 no.2
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    • pp.161-171
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    • 2013
  • Purpose: The purpose of this study was to compare Preventive Health Behaviors (PHBs) in adults in Korea and the United States and identify factors influencing PHBs. Methods: This was a secondary data analysis study using data from the 2008 Korean National Health and Nutrition Examination Survey and the 2008 USA Behavioral Risk Factor Surveillance System. The PHBs were predicted using multiple linear regression analysis. Results: 1) The total score of PHBs was significantly higher in American males (5.11) than in Korean males (4.78). There was also a significant difference between Korean females' total score (6.57) and American females'(6.75). 2) Age, marriage, monthly income, subjective health status, and cardiovascular disease were significant factors of PHBs in Korean males (p<.001). However, age, marriage, education, monthly income, health insurance, subjective health status, and cardiovascular disease were significant factors in American males (p<.001). In Korean females, only age and education were significant predictors (p<.001). However, six variables(age, marriage, education, monthly income, health insurance, and subjective health status) were significant predictors in American females (p<.001). Conclusion: There were different variables in predicting PHBs between Koreans and Americans. Each country should focus on those significant predictors to promote the PHBs for adults.

Acoustic Emission Characteristic with Local Wall Thinning under Static and Cyclic Bending Load (정적 및 반복굽힘하중을 받는 감육된 탄소강배관의 AE 특성 평가)

  • Ahn, Seok-Hwan;Kim, Jin-Hwan;Nam, Ki-Woo;Park, In-Duck;Kim, Yong-Un
    • Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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    • 2002.05a
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    • pp.134-139
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    • 2002
  • Fracture behaviors of pipes with local wall thinning are very important for the integrity of nuclear power plant. However, effects of local wall thinning on strength and fracture behaviors of piping system were not well studied. Acoustic emission(AE) has been widely used in various fields because of its extreme sensitivity, dynamic detection ability and location of growing defects. In this study, we investigated failure modes of locally wall thinned pipes and AE signals by bending test. From test results, we could be divided four types of failure modes of ovalization, crack initiation after ovalization, local buckling and crack initiation after local buckling. And fracture behaviors such as elastic region, yielding range, plastic deformation range and crack progress could be evaluated by AE counts, accumulative counts and time-frequency analysis during bending test. It is expected to be basic data that can protect a risk according to local wall thinning of pipes, as a real time test of AE.

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The Study on Financial Firm's Performance Resulting from Security Countermeasures and the Moderating Effect of Transformational Leadership (금융기업의 보안대책이 금융 IT 보안책임과 위험감소 그리고 기업성과에 미치는 영향:변혁적 리더십의 조절효과)

  • Kim, Geuna;Kim, Sanghyun;Park, Keunjae
    • Journal of the Korean Operations Research and Management Science Society
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    • v.38 no.4
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    • pp.95-112
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    • 2013
  • Information system (IS) security continues to present a challenge for firms. Especially, IT security accident is recently taking place successively in the financial sector. Thus, a comprehensive measure on this is demanded. A large part of a research on security relies upon technical design in nature and is restrictive in a consideration of person and organizational issue. To achieve a goal of firm security, it is possible with an effort of organizational management and supervision for maintaining the technical and procedural status. Based on a theory of accountability, we propose that the security countermeasures of organization lead to an increase in accountability and reduction in risk of IT security in a financial firm and further to firm performance like promotion in firm reliability. In addition, we investigate which difference a theoretical model shows by comparison between South Korean and American financial firms. As a result of analysis, it found that South Korea and America have significant difference, but that a measure on the financing IT security is important for both countries. We aim to enhance interpretability of a research on security by comparatively analysis between countries and conducting a study focus on specific firm called financial business. Our study suggest new theoretical framework to a research of security and provide guideline on design of security to financial firm.

A Study on the Improvement of Reliability of Safety Instrumented Function of Hydrodesulfurization Reactor Heater (수소화 탈황 반응기 히터의 안전계장기능 신뢰도 향상에 관한 연구)

  • Kwak, Heung Sik;Park, Dal Jae
    • Journal of the Korean Society of Safety
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    • v.32 no.4
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    • pp.7-15
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    • 2017
  • International standards such as IEC-61508 and IEC-61511 require Safety Integrity Levels (SILs) for Safety Instrumented Functions (SIFs) in process industries. SIL verification is one of the methods for process safety description. Results of the SIL verification in some cases indicated that several Safety Instrumented Functions (SIFs) do not satisfy the required SIL. This results in some problems in terms of cost and risks to the industries. This study has been performed to improve the reliability of a safety instrumented function (SIF) installed in hydrodesulfurization reactor heater using Partial Stroke Testing (PST). Emergency shutdown system was chosen as an SIF in this study. SIL verification has been performed for cases chosen through the layer of protection analysis method. The probability of failure on demands (PFDs) for SIFs in fault tree analysis was $4.82{\times}10^{-3}$. As a result, the SIFs were unsuitable for the needed RRF, although they were capable of satisfying their target SIL 2. So, different PST intervals from 1 to 4 years were applied to the SIFs. It was found that the PFD of SIFs was $2.13{\times}10^{-3}$ and the RRF was 469 at the PST interval of one year, and this satisfies the RRF requirements in this case. It was also found that shorter interval of PST caused higher reliability of the SIF.

Urban Inundation Analysis using the Integrated Model of MOUSE and MIKE21 (MOUSE 및 MIKE21 통합모델을 이용한 도시유역의 침수분석)

  • Choi, Gye-Woon;Lee, Ho-Sun;Lee, So-Young
    • Journal of the Korean Society of Hazard Mitigation
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    • v.7 no.4
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    • pp.75-83
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    • 2007
  • Urbanized area has complex terrain with many flow paths. Almost stormwater is drained through pipe network because most area is impervious. And overland flow from the pipe network reform the surface flow. Therefore, it should be considered the drainage system and surface runoff both in urban inundation analysis. It is analyzed by using MIKE FLOOD integrated 1 dimension - 2 dimension model about Incheon Gyo urbanized watershed and compared with the results of 1 dimension model and 2 dimension model. At the result this approach linking of 2 dimension and 1 dimension pipe hydraulic model in MIKE FLOOD give accuracy that offers substantial improvement over earlier approach and more information about inundation such as water dapth, velocity or risk of flood, because it is possible to present storage of overland flow and topographical characteristic of area.

Nonlinear response of r.c. framed buildings retrofitted by different base-isolation systems under horizontal and vertical components of near-fault earthquakes

  • Mazza, Fabio;Mazza, Mirko;Vulcano, Alfonso
    • Earthquakes and Structures
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    • v.12 no.1
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    • pp.135-144
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    • 2017
  • Near-fault ground motions are characterized by high values of the ratio between the peak of vertical and horizontal ground accelerations, which can significantly affect the nonlinear response of a base-isolated structure. To check the effectiveness of different base-isolation systems for retrofitting a r.c. framed structure located in a near-fault area, a numerical investigation is carried out analyzing the nonlinear dynamic response of the fixed-base and isolated structures. For this purpose, a six-storey r.c. framed building is supposed to be retrofitted by insertion of an isolation system at the base for attaining performance levels imposed by current Italian code in a high-risk seismic zone. In particular, elastomeric (e.g., high-damping-laminated-rubber bearings, HDLRBs) and friction (e.g., steel-PTFE sliding bearings, SBs, or friction pendulum bearings, FPBs) isolators are considered, with reference to three cases of base isolation: HDLRBs acting alone (i.e., EBI structures); in-parallel combination of HDLRBs and SBs (i.e., EFBI structures); FPBs acting alone (i.e., FPBI structures). Different values of the stiffness ratio, defined as the ratio between the vertical and horizontal stiffnesses of the HDLRBs, sliding ratio, defined as the global sliding force divided by the maximum sliding force of the SBs, and in-plan distribution of friction coefficient for the FPs are investigated. The EBI, EFBI and FPBI base-isolation systems are designed assuming the same values of the fundamental vibration period and equivalent viscous damping ratio. The nonlinear dynamic analysis is carried out with reference to near-fault earthquakes, selected and scaled on the design hypotheses adopted for the test structures.