• 생약학회지
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• 제40권4호
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• pp.388-393
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• 2009

Advanced glycation end products (AGEs) have been implicated in the development of diabetic complications. The AGEs inhibitors or cross-link breakers attenuate various functional and structural manifestations of diabetic complications. In this study, 64 herbal medicines from China and Vietnam have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, eight herbal medicines ($IC_{50}$<50 ${\mu}g$/ml) were found to have strong AGEs inhibitory activity compared with aminoguanidine (14 days, $IC_{50}$=75.98 ${\mu}g$/ml; 28 days, $IC_{50}$=88.27 ${\mu}g$/ml). Particularly, four herbal medicines, Buddleja officinalis (whole plant), Syzygium cuminii (leaf), Eugenia caryophyllate (seed), and Paeonia suffruticosa (root) showed more potent inhibitory activity (approximately 5-6 fold) than the positive control aminoguanidine.

• 한국정보처리학회논문지
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• 제5권10호
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• pp.2737-2749
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• 1998

최근의 생산자동화 설비에서 시각시스템을 이용한 검사의 중요성이 증가되고 있다.본 연구에서는 시각시스템을 이용한 반도체 외관검사 방법을 제안하였다. 기존의 연구가 특징점을 통한 칩의 위치 및 기울어짐에 집중되어 있으나 본 연구에서는 물체 영역분할 방법으로 검사 대상의 리드영역분할 및 리드 추출을 제안하였으며, 불량 검사 방법으로 치수에 의한 검사방법이 주를 이루나 본 연구에서는 모멘트를 이용한 불량 빈도에 의한 단계적 검사 방법을 제안하였다. 기존의 방법과 비교실험에서 제안 방법의 영역분할 방법과 순차적 방법의 우수성과 불변 모멘트를 이용한 검사의 유용성을 입증하였다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제15권4호
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• pp.445-453
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• 2015

A fully integrated cost-effective and low-power single chip Lithium-Ion (Li-Ion) battery protection IC (BPIC) for portable devices is presented. The control unit of the battery protection system and the MOSFET switches are integrated in a single package to protect the battery from over-charge, over-discharge, and over-current. The proposed BPIC enters into low-power standby mode when the battery becomes over-discharged. A new auto release function (ARF) is adopted to release the BPIC from standby mode and safely return it to normal operation mode. A new delay shorten mode (DSM) is also proposed to reduce the test time without increasing pin counts. The BPIC implemented in a $0.18-{\mu}m$ CMOS process occupies an area of $750{\mu}m{\times}610{\mu}m$. With DSM enabled, the measured test time is dramatically reduced from 56.82 s to 0.15 s. The BPIC chip consumes $3{\mu}A$ under normal operating conditions and $0.45{\mu}A$ under standby mode.

• 한국정밀공학회지
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• 제30권7호
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• pp.673-678
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• 2013

Driving gear units can be affected by various problems, including those associated with external or internal defects in the bearing, problems with the lubricant oil, high-loading of the railway, and frequent impacts generated by rail joints. Temperature monitoring is a basic method in diagnosing abnormal conditions in the reduction gear and other components. This paper describes a new wireless monitoring system for the temperature diagnosis of abnormal conditions of the reduction gear. Integrated circuit (IC)-type temperature sensors were installed in the reduction gear box of a high-speed railway car. The temperature data from the reduction gear were acquired and analyzed in situ during high-speed rail operation. Analysis of these data was used to alert the driver and/or maintenance personnel when problems occurred.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 심포지엄 논문집 정보 및 제어부문
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• pp.181-183
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• 2007

본 논문은 RF 리더기와 RF 태그 상호간의 통신시에 발생할 수 있는 충돌을 감지하고 이를 능동적으로 회피할수 있는 RFID(Radio Frequency IDentification)의 설계에 관한 내용이다. RFID는 사람, 자동차, 화물, 상품 등에 정보를 부가하는 시스템으로 그 부가정보를 무선통신매체를 이용하여 비접족으로 해독하는 시스템으로 기존의 바코드보다 데이터의 전송속도와 용량의 증가 그리고 편리성이 향상되는 장점이 있으나, 동시에 여러개의 RF태그와의 무선통신으로 인한 데이터의 충돌이 발생할 수 있다. 이러한 충돌을 감지하고 이를 적절하게 회피하는 것은 RFID 시스템의 신뢰성을 높이는데 필수적인 요소이다. RFID 태그로 사용되기 위해서는 건전지로 구동될 수 있도록 저전력소모가 요구되며 또한 통신의 시작과 충돌을 파악할 수 있는 캐리어 감지기능이 필수적이다. 본 논문에서는 이러한 조건들을 만족하는 Chipcon 사(社)의 양방향 RF IC를 사용하였다. Chipcon 사(社)의 양방향 RF IC는 다중 주파수 대역의 선택과 변조방식을 시리얼통신을 통해서 손쉽게 변경할 수 있기 때문에 충돌감지시 다양한 회피알고리즘을 상황에 맞게 구현할 수 있다. 본 논문에서는 양방향 RF IC를 사용하여 충돌을 감지하고 회피할 수 있는 RFID시스템을 설계하고 구현하였다.

• Preventive Nutrition and Food Science
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• 제11권2호
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• pp.100-104
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• 2006

The in vitro antimicrobial and antioxidant activities of the essential oil and methanol extracts of Ledum palustre L. were investigated. Using GC-MS analysis, we identified 37 compounds in the essential oil, constituting 87.58% of the total oil. There are several monoterpenes, of which sabinene is the major compound ($16{\sim}17%$). There are several oxygenated monoterpenes of which terpinen-4-ol(7.6%) and myrtenal (3.5%) are the main constituents. $\beta$-Selinene, a-selinene, $\gamma$-elemene, a-caryophyllene are the main sesquiterpenes ($2{\sim}6%$ range). The oil strongly reduced the diphenylpicrylhydrazyl radical ($IC_{50}=1.56{\mu}g/mL$) formation and exhibited a hydroxyl radical scavenging effect in the $Fe^{3+}-EDTA-H_2O_2$ deoxyribose system ($IC_{50}=2.7{\mu}g/mL$), and also inhibited the nonenzymatic lipid peroxidation of rat liver homogenate ($IC_{50}=13.5{\mu}g/mL$). The polar phase of the extract showed antioxidant activity. The oil showed antimicrobial activity against Streptococcus pneumoniae, Clostridium perfringens, Candida albicans, Mycobacterium smegmatis, Acinetobacter lwoffii and Candida krusei while the water-insoluble parts of the methanolic extracts exhibited slight or no activity. This study confirms that the essential oil of Ledum palustre L. possesses antioxidant and low antimicrobial properties in vitro.

• 생약학회지
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• 제43권4호
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• pp.345-351
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• 2012

In this study, 49 Korean herbal medicines have been investigated with an in vitro evaluation system using glycation end products (AGEs) formation inhibitory activity. Of these, 18 herbal medicines ($IC_{50}$ < $50{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Of these, five herbal medicines ($IC_{50}$ < $50{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, Mallotus japonicus (twigs and leaves), Rhus javanica (twigs and leaves), Boehmeria nivea (whole plants), Quercus acuta (stems), and Eurya japonica (stems) showed more potent inhibitory activity (approximately 9-37 fold) than the positive control aminoguanidine ($IC_{50}=76.47{\mu}g/ml$).

• Food Science and Biotechnology
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• 제18권1호
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• pp.207-212
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• 2009

Celandine (Chelidonium majus, family Papaveraceae) is an herb used extensively in traditional Korean medicine. To investigate its antioxidant and antiproliferative activities, the methanolic extract of celandine was introduced. The antioxidant properties of the extract were tested using various in vitro systems, including hydroxyl radical scavenging assay, DNA damage protection assay, 1,1-diphenyll-2-2-pricylhydrazyl (DPPH) free radical scavenging activity, metal chelating activity, and reducing power assay. The extract exhibited stronger antioxidant activity ($IC_{50}=7.92{\mu}g/mL$) against hydroxyl radicals in the Fenton system than butylated hydroxyanisole ($IC_{50}=51.46{\mu}g/mL$) and $\alpha$-tocopherol ($IC_{50}=67.48{\mu}g/mL$). Likewise, damage to the plasmid pBR 322 induced by hydroxyl radicals was found to be protected by the extract at a concentration of $400{\mu}g/mL$. Cellular proliferation and the induction of apoptosis were also examined by a cellular proliferation assay, flow cytometry, and mRNA expression analysis. Taken together, the extract significantly inhibited the growth of HT-29 cells in a concentration- and time-dependent manner, and gradually increased both the proportion of apoptotic cells and the expression of caspase-3. Overall, our research suggests that celandine possesses antioxidant and antiproliferative properties.

• 대한기계학회논문집A
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• 제30권10호
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• pp.1173-1178
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• 2006

In a primary reactor cooling system(RCS), a dissimilar weld zone exists between cast stainless steel(CF8M) in a pipe and low-alloy steel(SA508 cl.3) in a nozzle. Thermal aging is observed in CF8M as the RCS is exposed for a long period of time to a reactor operating temperature between 290 and $330^{\circ}C$, while no effect is observed in SA508 cl.3. The specimens are prepared by an artificially accelerated aging technique maintained for 300, 1800 and 3600 hrs at $430^{\circ}C$, respectively. The specimens for elastic-plastic fracture toughness tests are according to the process in the thermal notch is created in the heat affected zone(HAZ) of CF8M and deposited zone. From the experiments, the $J_{IC}$ value notched in HAZ of CF8M presented a rapid decrease up to 300 hours at $430^{\circ}C$ and slowly decreased according to the process in the thermal aging time. Also, the $J_{IC}$ value presented a lower value than that of the CF8M base metal. And, the $J_{IC}$ of the deposited zone presented the lowest value of all other cases.

• 대한화장품학회지
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• 제28권1호
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• pp.71-79
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• 2002

In the aged skin especially in the face and eyelid, deep and slight wrinkles are one of the remarkable phenomena of aging and the cause of wrinkle is various. Among the cause of wrinkles an oxidative stress plays an important roles in wrinkle formation process. It caused the lipid peroxidation of cell membrane, the increase of the MMPs(MatrixMetalloProteinase) gene expression and cellular DNA damage. These ROS induced materials may cause the degradation of collagen matrix system in the dermis and cause the formation of skin wrinkle. So, it is very important for protecting skin wrinkle formation to regulate ROS activity. In this study, we developed one active ingredient having multi functional activities such as activation of collagen synthesis, inhibition of MMPs activity, lipid peroxidation and free radical scavenging activity and inhibition of free radical induced DNA damage in vitro. Pericarpium castaneae extracts showed collagen synthesis increase in Normal Human Fibroblast and the inhibition of elastase activity (IC$\_$50/ of Elastase: 43.9$\mu\textrm{g}$/㎖). It showed also anti-oxidative activity (IC$\_$50/ : 48$\mu\textrm{g}$/㎖) and free radical scavenging activity(IC$\_$50/: 7.6$\mu\textrm{g}$/㎖). Conclusively, Pericarpium castaneae extracts may be used as an ingredient for new anti-wrinkle cosmetics.