• Preventive Nutrition and Food Science
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• v.16 no.4
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• pp.376-380
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• 2011

We investigated the total phenolic and flavonoid contents and the antimicrobial activity of ethanol extracts obtained from Saussurea lappa C.B. Clarke. The ethanol extracts of S. lappa C.B. Clarke were fractionated with various solvents (n-hexane, chloroform, and n-butanol). The antimicrobial activity of S. lappa C.B. Clarke was examined by disc-diffusion and micro-dilution susceptibility assays with six food-borne pathogens, and compared to that of the synthetic antibiotics. It is found that the S. lappa C.B. Clarke ethanol extract and n-hexane fraction have strong activity against B. cereus and V. parahaemolyticus strains compared to ampicillin. The inhibitory concentration ($IC_{50}$) values of hexane fraction against L. monocytogenes, B. cereus, and B. subtilis were 62.5, 250 and 500 ppm, respectively. Therefore, these data suggest that S. lappa C.B. Clarke may be useful as antimicrobial agents against food-borne pathogens.

• The Journal of the Acoustical Society of Korea
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• v.28 no.2E
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• pp.43-50
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• 2009

To get more natural synthetic speech generated by a Korean TTS (Text-To-Speech) system, we have to know all the possible prosodic rules in Korean spoken language. We should find out these rules from linguistic, phonetic information or from real speech. In general, all of these rules should be integrated into a prosody-generation algorithm in a TTS system. But this algorithm cannot cover up all the possible prosodic rules in a language and it is not perfect, so the naturalness of synthesized speech cannot be as good as we expect. ANNs (Artificial Neural Networks) can be trained to learn the prosodic rules in Korean spoken language. To train and test ANNs, we need to prepare the prosodic patterns of all the phonemic segments in a prosodic corpus. A prosodic corpus will include meaningful sentences to represent all the possible prosodic rules. Sentences in the corpus were made by picking up a series of words from the list of PB (phonetically Balanced) isolated words. These sentences in the corpus were read by speakers, recorded, and collected as a speech database. By analyzing recorded real speech, we can extract prosodic pattern about each phoneme, and assign them as target and test patterns for ANNs. ANNs can learn the prosody from natural speech and generate prosodic patterns of the central phonemic segment in phoneme strings as output response of ANNs when phoneme strings of a sentence are given to ANNs as input stimuli.

• Journal of Industrial Technology
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• v.21 no.A
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• pp.167-179
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• 2001

This paper discusses an index-based subsequence matching that supports time warping in large sequence databases. Time warping enables finding sequences with similar patterns even when they are of different lengths. In earlier work, we suggested an efficient method for whole matching under time warping. This method constructs a multidimensional index on a set of feature vectors, which are invariant to time warping, from data sequences. For filtering at feature space, it also applies a lower-bound function, which consistently underestimates the time warping distance as well as satisfies the triangular inequality. In this paper, we incorporate the prefix-querying approach based on sliding windows into the earlier approach. For indexing, we extract a feature vector from every subsequence inside a sliding window and construct a multi-dimensional index using a feature vector as indexing attributes. For query precessing, we perform a series of index searches using the feature vectors of qualifying query prefixes. Our approach provides effective and scalable subsequence matching even with a large volume of a database. We also prove that our approach does not incur false dismissal. To verily the superiority of our method, we perform extensive experiments. The results reseal that our method achieves significant speedup with real-world S&P 500 stock data and with very large synthetic data.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.38 no.1
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• pp.19-32
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• 2001

This paper proposes a local adaptive thresholding method based on a water flow model, in which an image surface is considered as a 3-dimensional (3-D) terrain. To extract characters from backgrounds, we pour water onto the terrain surface. Water flows down to the lower regions of the terrain and fills valleys. Then, the amount of filled water is thresholded, in which the proposed thresholding method is applied to gray level document images consisting of characters and backgrounds. The proposed method based on a water flow model shows the property of locally adaptive thresholding. Computer simulation with synthetic and real document images shows that the proposed method yields effective adaptive thresholding results for binarization of document images.

• 한국지구물리탐사학회:학술대회논문집
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• 2003.11a
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• pp.383-389
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• 2003

Clay minerals show a distinct induced-polarization phenomenon, which is one of the most important factors for predicting groundwater flow and contaminant transport. This paper presents a step-by-step process to estimate Cole-Cole parameters from spectral induced-polarization (IP) data measured on the surface of three-dimensional earth. First, the inversion of low-frequency resistivity survey data is made to identify the dc resistivity ${\rho}_dc$ of a volume having IP effects. The other parameters, chargeability m, time constant $\tau$, and frequency dependence c, are sought for the polarizable volume. Next, using multi-frequency data, c can be obtained as high or low asymptotes of the slope of log phase vs. log frequency. Further, for low m, intrinsic $\tau$ is approximated by apparent one, ${\tau}_a$, which is derived from the relation ${{\omega}{\tau}}_a$=1 at an angular frequency $\omega$, where the imaginary component of spectral IP data has an extreme value. Finally, to obtain intrinsic m a two-step linearized procedure has been derived. For a body of given $\tau$ and c, forward modeling with a progression of m values yields a plot of observed vs. intrinsic imaginary components for a frequency. Since this plot is essentially linear, to extract the intrinsic imaginary component is quite simple with an observed value. Using the plot of intrinsic imaginary component vs. m, intrinsic m is determined. We present a synthetic example to illustrate that the Cole-Cole parameters can be recovered from spectral IP data.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.38 no.4
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• pp.422-433
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• 2001

In this paper, we propose a flew edge detection method based on water flow model, in which gradient image surface is considered as a 3-dimensional (3-D) geographical feature. The edges of the objects in the background can be detected by the large gradient magnitude areas and to make the edges immersed it is required to invert the gradient image. The proposed edge detector uses a water flow model based enhancement and locally adaptive thresholding technique applied to the inverted gradient image resulting in better noise performance. Computer simulations with a few synthetic and real images show that the Proposed method can extract edge contour effectively.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2305-2309
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• 2012

Crocin, the main pigment of Crocus sativus L., has been shown to have antiproliferative effects on cancer cells, but the involved mechanisms are only poor understood. This study focused on probable effect of crocin on the immortality of hepatic cancer cells. Cytotoxicity of crocin ($IC_{50}$ 3 mg/ml) in hepatocarcinoma HepG2 cells was determined after 48 h by neutral red uptake assay and MTT test. Immortality was investigated through quantification of relative telomerase activity with a quantitative real-time PCR-based telomerase repeat amplification protocol (qTRAP). Telomerase activity in 0.5 ${\mu}g$ protein extract of HepG2 cells treated with 3 mg/ml crocin was reduced to about 51% as compared to untreated control cells. Two mechanisms of inhibition, i.e. interaction of crocin with telomeric quadruplex sequences and down regulation of hTERT expression, were examined using FRET analysis to measure melting temperature of a synthetic telomeric oligonucleotide in the presence of crocin and quantitative real-time RT-PCR, respectively. No significant changes were observed in the $T_m$ telomeric oligonucleotides, while the relative expression level of the catalytic subunit of telomerase (hTERT) gene showed a 60% decrease as compared to untreated control cells. In conclusion, telomerase activity of HepG2 cells decreases after treatment with crocin, which is probably caused by down-regulation of the expression of the catalytic subunit of the enzyme.

• Journal of information and communication convergence engineering
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• v.13 no.4
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• pp.275-279
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• 2015

There are several methods to record three dimensional (3D) information of objects such as lens array based integral imaging, synthetic aperture integral imaging (SAII), computer synthesized integral imaging (CSII), axially distributed image sensing (ADS), and axially distributed stereo image sensing (ADSS). ADSS method is capable of recording partially occluded 3D objects and reconstructing high-resolution slice plane images. In this paper, we present a computational method for depth extraction of partially occluded 3D objects using ADSS. In the proposed method, the high resolution elemental stereo image pairs are recorded by simply moving the stereo camera along the optical axis and the recorded elemental image pairs are used to reconstruct 3D slice images using the computational reconstruction algorithm. To extract depth information of partially occluded 3D object, we utilize the edge enhancement and simple block matching algorithm between two reconstructed slice image pair. To demonstrate the proposed method, we carry out the preliminary experiments and the results are presented.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.34 no.2
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• pp.195-206
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• 2016

The remote sensing technique using SAR data have many advantages when applied to the disaster site due to its wide coverage and all-weather acquisition availability. Although a single-pol (polarimetric) SAR image cannot represent the land surface better than a quad-pol SAR image can, single-pol SAR data are worth using for disaster-induced change detection. In this paper, an automatic change detection method based on a mixture of GGDs (generalized Gaussian distribution) is proposed, and usability of the textural features and intensity is evaluated by using the proposed method. Three ALOS/PALSAR images were used in the experiments, and the study site was Norita City, which was affected by the 2011 Tohoku earthquake. The experiment results showed that the proposed automatic change detection method is practical for disaster sites where the large areas change. The intensity information is useful for detecting disaster-induced changes with a 68.3% g-mean, but the texture information is not. The autocorrelation and correlation show the interesting implication that they tend not to extract agricultural areas in the change detection map. Therefore, the final tsunami-induced change map is produced by the combination of three maps: one is derived from the intensity information and used as an initial map, and the others are derived from the textural information and used as auxiliary data.

• Korean Journal of Remote Sensing
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• v.27 no.3
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• pp.225-234
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• 2011

This study proposes an inversion algorithm to extract the surface parameters, such as surface roughness and soil moisture contents, using multi-frequency SAR data. The study areas include the tidal flats of Jebu Island and the reclaimed lands of Hwaong district on the western coasts of the Korean peninsula. SAR data of three frequencies were accordingly calibrated to provide precise backscattering coefficients through absolute radiometric calibration. The root mean square (RMS) height and the correlation length, which can describe the surface roughness, were extracted from the backscattering coefficients using the inversion of the Integral Equation Method (IEM). The IEM model was appropriately modified to accommodate the environmental conditions of tidal flats. Volumetric soil moisture was also simultaneously extracted from the dielectric constant using the empirical model, which define the relations between volumetric soil moistures and dielectric constants. The results obtained from the proposed algorithm were verified with the in-situ measurements, and we confirmed that multi-frequency SAR observations combined with the surface scattering model for tidal flats can be used to quantitatively retrieve the geophysical surface parameters in tidal flats.