• Journal of Ginseng Research
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• 제47권4호
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• pp.583-592
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• 2023

Background: Alcohol is one of the most commonly used psychoactive drugs. Due to its addictive characteristics, many people struggle with the side effects of alcohol. Korean Red Ginseng (KRG) is a traditional herbal medicine that is widely used to treat various health problems. However, the effects and mechanisms of KRG in alcohol-induced responses remain unclear. Therefore, the purpose of this study was to investigate the effects of KRG in alcohol-induced responses. Methods: We investigated two aspects: alcohol-induced addictive responses and spatial working memory impairments. To determine the effects of KRG in alcohol-induced addictive responses, we performed conditioned place preference tests and withdrawal symptom observations. To assess the effects of KRG in alcohol-induced spatial working memory impairment, Y-maze, Barnes maze, and novel object recognition tests were performed using mice after repeated alcohol and KRG exposure. To investigate the potential mechanism of KRG activity, gas chromatography-mass spectrometry and western blot analysis were performed. Results: KRG-treated mice showed dose-dependent restoration of impaired spatial working memory following repeated alcohol exposure. Furthermore, withdrawal symptoms to alcohol were reduced in mice treated with KRG and alcohol. The PKA-CREB signaling pathway was activated after alcohol administration, which was reduced by KRG. However, the levels of inflammatory cytokines were increased by alcohol and decreased by KRG. Conclusion: Taken together, KRG may alleviate alcohol-induced spatial working memory impairments and addictive responses through anti-neuroinflammatory activity rather than through the PKA-CREB signaling pathway.

• 한국간호교육학회지
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• 제30권1호
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• pp.49-60
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• 2024

Purpose: The coronavirus disease 2019 (COVID-19) pandemic has had significant physical and psychological impacts on registered nurses (RNs). This study aimed to identify long COVID symptoms and their associated factors specifically among RNs. Methods: This descriptive correlational study's sample comprised 189 nurses (31.57±5.98 years, 93.7% female) in Korea. Self-reported long COVID symptoms were assessed using the COVID-19 Yorkshire Rehabilitation Scale. Data were collected from December 31, 2022, to January 13, 2023, using the online survey method and were analyzed using independent t-test, Wilcoxon signed-rank test, one-way ANOVA, Pearson's correlation, and a multiple linear regression analysis with the IBM SPSS Statistics 26.0 program. Results: A total of 179 participants (94.7%) experienced one or more long COVID symptoms. The most prevalent symptoms were weakness (77.8%), fatigue (68.3%), breathlessness (67.7%), cough/throat sensitivity/voice change (50.3%), and sleep problems (50.3%). The factors related to long COVID symptoms were marital status, type of institution, working time, acute COVID-19 symptoms, and vaccination status. The quarantine period (β=.26, p<.001) and the nursing workforce after COVID-19 (β=-.17, p=.018) were significantly associated with long COVID symptoms (Adjusted R² =.33). Conclusion: Providing comprehensive recognition is necessary for the understanding of long COVID symptoms and their associated factors among nurses and could promote a long COVID symptom management education program targeted at nurses. Moreover, it could facilitate effective nursing care and education plans for long COVID patients.

• Clinical and Experimental Vaccine Research
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• 제12권4호
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• pp.265-290
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• 2023

Rare but serious thrombotic incidents in relation to thrombocytopenia, termed vaccine-induced immune thrombotic thrombocytopenia (VITT), have been observed since the vaccine rollout, particularly among replication-defective adenoviral vector-based severe acute respiratory syndrome coronavirus 2 vaccine recipients. Herein, we comprehensively reviewed and summarized reported studies of VITT following the coronavirus disease 2019 (COVID-19) vaccination to determine its prevalence, clinical characteristics, as well as its management. A literature search up to October 1, 2021 using PubMed and SCOPUS identified a combined total of 720 articles. Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline, after screening the titles and abstracts based on the eligibility criteria, the remaining 47 full-text articles were assessed for eligibility and 29 studies were included. Findings revealed that VITT cases are strongly related to viral vector-based vaccines, which are the AstraZeneca COVID-19 vaccine (95%) and the Janssen COVID-19 vaccine (4%), with much rarer reports involving messenger RNA-based vaccines such as the Moderna COVID-19 vaccine (0.2%) and the Pfizer COVID-19 vaccine (0.2%). The most severe manifestation of VITT is cerebral venous sinus thrombosis with 317 cases (70.4%) and the earliest primary symptom in the majority of cases is headache. Intravenous immunoglobulin and non-heparin anticoagulant are the main therapeutic options for managing immune responses and thrombosis, respectively. As there is emerging knowledge on and refinement of the published guidelines regarding VITT, this review may assist the medical communities in early VITT recognition, understanding the clinical presentations, diagnostic criteria as well as its management, offering a window of opportunity to VITT patients. Further larger sample size trials could further elucidate the link and safety profile.

• Korean Journal of Radiology
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• 제24권6호
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• pp.512-521
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• 2023

Objective: There is increasing recognition that left atrial (LA) strain can be a prognostic marker of various cardiac diseases. However, its prognostic value in acute myocarditis remains unclear. Therefore, this study aimed to evaluate whether cardiovascular magnetic resonance (CMR)-derived parameters of LA strain can predict outcomes in patients with acute myocarditis. Materials and Methods: We retrospectively analyzed the data of 47 consecutive patients (44.2 ± 18.3 years; 29 males) with acute myocarditis who underwent CMR in 13.5 ± 9.7 days (range, 0-31 days) of symptom onset. Various parameters, including feature-tracked CMR-derived LA strain, were measured using CMR. The composite endpoints included cardiac death, heart transplantation, implantable cardioverter-defibrillator or pacemaker implantation, rehospitalization following a cardiac event, atrial fibrillation, or embolic stroke. The Cox regression analysis was performed to identify associations between the variables derived from CMR and the composite endpoints. Results: After a median follow-up of 37 months, 20 of the 47 (42.6%) patients experienced the composite events. In the multivariable Cox regression analysis, LA reservoir and conduit strains were independent predictors of the composite endpoints, with an adjusted hazard ratio per 1% increase of 0.90 (95% confidence interval [CI], 0.84-0.96; P = 0.002) and 0.91 (95% CI, 0.84-0.98; P = 0.013), respectively. Conclusion: LA reservoir and conduit strains derived from CMR are independent predictors of adverse clinical outcomes in patients with acute myocarditis.

• 한국의사학회지
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• 제24권1호
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• pp.43-56
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• 2011

Everyone once in a life experience headaches as symptoms are very common. According to a study in a country of more than a week and as many as those who have experienced a headache amounts to 69.4%. In addition, the high reported prevalence of migraine in 30s for 80% of all migraine sufferers daily life interfere with work or was affected. In Western medicine, the cause of headaches is traction or deformation of pain induced tissue like scalp, subcutaneous tissue, muscle, fascia, extracranial arteriovenous, nerves, periosteum. But it turns out there are not cause why pain induced tissue is being tracted or deformated. Therefore, most of the western-therapy is mainly conducted with regimen for a temporary symptom reduction. Therefore, I examined how it has been developed in Chinese Ming Dynasty, the perception of headache, change in disease stage and an etiological cause. Oriental medicine in the treatment of headache is a more fundamental way to have an excellent treatment. The recognition of head in "素問($s{\grave{u}}$ $w{\grave{e}}n$)" and "靈樞($l{\acute{i}}ng$ $sh{\bar{u}}$)" began to appear in 'Soul-神($sh{\acute{e}}n$) dwelling place' and 'where to gather all the Yang-'諸陽之會($zh{\bar{u}}$ $y{\acute{a}}ng$ $zh{\bar{i}}$ $hu{\grave{i}}$)'. Also, head was recognized as '六腑($li{\grave{u}}f{\check{u}}$) 淸陽之氣($q{\bar{i}}ng$ $y{\acute{a}}ng$ $zh{\bar{i}}$ $q{\grave{i}}$) and 五臟($w{\check{u}}$ $z{\grave{a}}ng$) 精血($j{\bar{i}}ng$ $xu{\grave{e}}$) gathering place'. More specific structures such as the brain is considered a sea of marrow(髓海-$su{\check{i}}$ $h{\check{a}}i$) in "內經($n{\grave{e}}i$ $j{\bar{i}}ng$)" and came to recognized place where a stroke occurs. Accompanying development of the recognition about head, there had been changed about the perception of headache and the recognition of the cause and mechanism of headache. And the recognition of headache began to be completed in Ming Dynasty through Jin, Yuan Dynasty. Chinese Ming Dynasty, specially 樓英($l{\acute{o}}u$ $y{\bar{i}}ng$), in "醫學綱目($y{\bar{i}}xu{\acute{e}}$ $g{\bar{a}}ngm{\grave{u}}$)", first enumerated prescription in detail by separating postpartum headache. and proposed treatment of headache especially due to postpartum sepsis(敗血-$b{\grave{a}}i$ $xu{\grave{e}}$). 許浚($x{\check{u}}$ $j{\grave{u}}n$) accepted a variety of views without impartial opinion in explaining one kind of headache in "東醫寶鑑($d{\bar{o}}ng-y{\bar{i}}$ $b{\check{a}}oji{\grave{a}}n)$" 張景岳($zh{\bar{a}}ng$ $j{\check{i}}ng$ $yu{\grave{e}}$), in "景岳全書($j{\check{i}}ng$ $yu{\grave{e}}$ $qu{\acute{a}}nsh{\bar{u}}$)", established his own unique classification system-新舊表裏($x{\bar{i}}nji{\grave{u}}$ $bi{\check{a}}ol{\check{i}}$)-, and offered a clear way even in treatment. Acupuncture treatment of headache in the choice of meridian has been developed as a single acupuncture point. Using the classification of headache to come for future generation as a way of locating acupoints were developed. Chinese Ming Dynasty, there are special treatments like 導引按蹻法($d{\check{a}}o$ y ${\check{i}}n$ ${\grave{a}}n$ $ji{\check{a}}o$ $f{\check{a}}$), 搐鼻法($ch{\grave{u}}$ $b{\acute{i}}$ $f{\check{a}})$, 吐法($t{\check{u}}$ $f{\check{a}}$), 外貼法($w{\grave{a}}i$ $ti{\bar{e}}$ $f{\check{a}}$), 熨法($y{\grave{u}}n$ $f{\check{a}}$), 點眼法($di{\check{a}}n$ $y{\check{a}}n$ $f{\check{a}}$), 熏蒸法($x{\bar{u}}nzh{\bar{e}}ng$ $f{\check{a}}$), 香氣療法($xi{\bar{a}}ngq{\grave{i}}$ $li{\acute{a}}of{\check{a}}$). Most of this therapy in the treatment of headache, it is not used here, but if you use a good fit for today's environment can make a difference.

• 경영과정보연구
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• 제35권1호
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• pp.51-68
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• 2016

본 연구는 K-IFRS 도입과 함께 기존의 상각규정을 폐지하고 매기간 손상검사를 실시하도록 요구하는 영업권 회계변경이 영업권손상차손 인식의 적시성에 미친 영향을 분석하고자 수행되었다. 원칙중심기준인 K-IFRS는 회계정보의 목적적합성을 강화하고 적시성 있는 정보를 전달하기 위해 공정가치평가를 확대하였으며 동일한 맥락에서 영업권과 같은 '비한정내용연수의 무형자산'에 대한 손상검사를 1년에 1회 이상 수행하도록 요구하였다. 그러나 영업권 회계변경의 효과를 분석한 선행연구들은 새로운 손상검사절차가 경영자들의 재량에 의존하고 있어 영업권손상차손의 인식이 적시성 있게 수행되기 보다는 기회주의적으로 이용되고 있음을 지적하고 있다. 하지만 선행연구들은 개별 기업에서 관찰될 수 있는 손상징후를 고려하지 못한 채 회계변경 전 후의 영업권 감액 빈도와 크기에만 초점을 맞추어 분석하고 있어 그 결과에 편의(bias)를 포함할 수 있다. 본 연구는 이러한 선행연구들의 한계를 극복하기 위해 Ramanna and Watts(2012)의 손상징후에 대한 정의를 활용하여 새로운 손상차손절차가 적시성 있는 회계정보의 전달이라는 목적을 달성하고 있는지 검증하고자 하였다. 2008년부터 2011년까지 상장되어 있는 기업 중 영업권을 보유한 947개 기업-연도 표본을 대상으로 분석을 실시한 결과 영업권손상차손 인식의 적시성은 손상차손 인식여부를 더미변수의 형태로 이용한 로지스틱 회귀분석과 연속변수의 형태로 이용한 다변량 회귀분석 모두에서 K-IFRS 이전에 비해 이후 기간에 감소된 것으로 나타났다. 분석결과를 보다 강건하게 하기 위해 또 다른 영업권 손상징후를 이용하여 동일한 분석을 재차 수행한 결과도 일관된 모습으로 조사되었다. 이러한 결과는 회계기준 제정기관들이 영업권 회계기준 변경을 통해 보다 적시성있고 목적 적합한 회계수치를 작성하도록 의도하였던 것과 달리 경영자들이 그들에게 주어진 재량권을 악용하여 영업권손상차손 인식시기를 조정함으로써 영업권손상차손 인식의 적시성이 감소하였음을 보여주는 결과이다. 본 연구는 영업권손상인식의 적시성 변화를 분석한 선행연구들의 분석방법에서 나타날 수 있는 편의(bias)를 감소시킬 뿐만 아니라 영업권손상에 대한 징후를 고려한 분석을 실시하여 회계변경으로 인한 손상차손인식의 적시성 변화를 보다 직접적으로 분석하였다는 점에서 의의가 있다.

• Journal of Hospice and Palliative Care
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• 제14권1호
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• pp.28-33
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• 2011

목적: 임박사건(impending event)에 대한 인지는 보호자와의 보다 효과적인 의사소통을 위해 필요할 뿐 아니라, 임종실로 옮기는 시점을 결정하는데 있어서 매우 중요하다. 이 주제에 대한 지금까지의 연구는 대부분 임종 48시간을 전후한 시점에서 이미 '발생되어 있는' 증상의 나열에 불과하였다. 이에 '변화'의 시점에서 사망까지의 시간을 기준으로 하여 임박사건 간 48시간 이내 임종예측도를 비교하였다. 방법: 인천소재 완화의료병동에서 임종을 맞이한 160명의 환자 중 임종 전 일주일 동안의 의무기록이 있는 80명을 대상으로 하였다. 환자 및 보호자가 호소하는 주관적 증상 9가지와 의료인에 의해 관찰되는 객관적 징후 8가지를 선정하고 각 항목에 대한 '의미 있는 변화'의 기준을 사전에 정하였다. 결과: 증상에서는 수면량의 증가(53.8%), 징후에서는 혈압의 감소(87.5%)가 가장 높은 발생빈도를 보였다. 임종까지의 평균시간은 증상의 경우 안정 시 호흡곤란(46.8시간)이, 징후의 경우 산소포화도의 감소(13.6시간)와 혈압의 감소(36.9시간)가 48시간 이내였다. 48시간 임박사건으로서의 예측도는 증상의 경우, 양성예측도는 안정 시 호흡곤란이 가장 높았고(83%) 음성예측도는 안정 시 호흡곤란과 의식혼탁/섬망의 조합이 가장 높았으며(86%), 징후의 경우 양성 예측도는 모두 95% 이상이었고 음성예측도는 혈압의 감소와 산소포화도 감소의 조합에서 가장 높았다(60%). 증상과 징후의 발생양상은 유의한 차이를 보였다. 결론: 증상에서는 안정 시 호흡곤란과 의식혼탁/섬망이, 징후에서는 산소포화도나 혈압의 감소가 임종임박을 예측하는데 가장 유용한 임상지표로 생각된다.

• 대한정형도수물리치료학회지
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• 제4권1호
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• pp.71-82
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• 1998

The purpose of this study is to analyze the phases of back pain occurring on pregnant women, and to raise the necessity of the pain management on the basis of the former analysis. The objective group is 284 pregnant women who visited department of OBGY of hospital located both in Seoul and Andong. The results are as follows; 1. 204(71.8%) pregnant women were suffering from back pain. The ratio of pain occurrance in terms of the duration of pregnancy shows that 78.3% within 3 pregnant months, 68.4% between four and six months and 72.1% over seven month. Most common ares of pain was low back area rating 60.5%. 2. The most painful postural for the suffering women was lying on the back rating 35.9% and the next painful posture was standing rating 34.4%. And the most painful movement was to maintaining continues movement(57.8%). Twisting back rates the second(17.2%). These two variables were relevant each other(p<0.05). 3. 46.7% of pregnant women were experiencing nocturnal pain. Among women experienced the pain before pregnancy, 39.9% were suffering during the pregnancy. The occurrence of nocturnal pain was related to the pain before and after the pregnancy(p<0.05). 4. 58.8% of pregnant women who experience back pain take the pain for granted as a normal proceeding of pregnancy while 3.9% recognize the symptom as an abnormal. Pain recognition in accordance with the phases does not show much difference(p<0.05). 5. It is shown that the more one delivers the number of babies, the faster back pain occurs(p<0.01). 6. 32.3% of the pain-suffering women have family member(s) having back pain. Family member(s) of the women who does not experience the pain don't have the pain either. This case reports 46.1%. Statistically, these two variables are relevant(p<0.01). 7. 43.0% of back pain experiencing women does not have any particular management plan against the pain. 20.7% is exercising as for prevention. Women who recognize the necessity of some means of therapy for their pain marked 42.9%. The majority(65.8%) of women responded exercise gymnastic work-out are most appropriate pain management. The above results show that a great number of pregnant women is experiencing back pain, however, they properly managed. This span suggests that appropriate advocacy and education for pregnant women is necessary. It is recommended that positive contribution can be made to better health of pregnant women when pain management by physical therapist is given.

• 보건교육건강증진학회지
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• 제15권2호
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• pp.23-42
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• 1998

The purpose of this study is to show that, before registration of chronic degenerative diseases and enforcing management system in health centers, the management of hypertension could achieved comprehensively and continuously by knowing the realities of drug-taking and its related factors those who are being cared for in health centers. For one year, a questionnaire about drug-taking realities of hypertensive patient was distributed at 8 health centers in Taegu from March 24. 1997 to April 24. 1997. The questionnaires were then collected and analysed. The results are as follows: Of 691 patients, 77.4% of patient were taking medicine regularly every day. The reasons why patients weren't taking medicine every day was as follows: the blood pressure became normal(34%, the highest of the group), patients forgot(28.2%), it was difficult to buy the medicine(15.4%), there was no effect even though the patient took medicine continuously. The experience of medical treatment outside of health centers was 28.9%. The types and percentages of alternative medicine are herbs (50.5%), health food(24.5%), folk remedy(13.7%). Among them, 44.6% of patients didn't know if the medicine was effective. Medical treatment places excluding health centers was pharmacies(63.5%-the highest rate). In simple analysis, the older one was the more regularly one took the medicine, but there was no statistical relations. Of health activities, patients eating low-salt diet showed that they took the medicine regularly. Nonsmoking patients and those who experienced drug side-effect and those who doubted doctor's prescriptions and instructions showed that they took alternative, excluding modem medicine. Anti-hypertensive drug medication status according to recognition, attitude, experiences of hypertension showed that patients who thought that they should take anti-hypertensive drug during the whole life time took the medicine regularly(82.3%). The reasons for patients turning to alternatives varied. In case of having subjective symptom(34.1%), those who thought they knew the hypertension well(36.6%), they decided to use alternatives. In multiple logistic regression analysis the key statistics were as follows: The older patients, patients who ate low-salt diet, patients who thought that they should take anti-hypertensive drug during the whole life time, all showed that they took medicines regularly. And also patients who experienced drug side-effect, doubted prescriptions and instructions, and patients who had subjective symptoms, patients who thought that he knew the hypertension very well, all showed higher rate of using alternative medicine. In the future, at the health centers, to register and manage hypertension patients effectively, we must educate patients about regular drug-taking, and alternatives without doctor's prescriptions.

• 한국전자통신학회논문지
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• 제7권5호
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• pp.1221-1228
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• 2012

본 연구는 치위생학과 학생들을 대상으로 본인자각구취의 관련요인과 스트레스 및 강박증과의 관계를 파악하여 구취예방을 위한 기초자료를 제공하고자 실시되었다. 연구결과 전체 대상자의 스트레스 평균은 1.76점, 강박증의 평균은 1.62점, 본인자각구취도의 평균은 1.84점으로 나타났다. 혀에 흰 막이 가끔 끼는 군에서 스트레스 1.79점(p=0.003), 강박증 1.64점(p=0.042), 본인자각구취 1.89점(p=0.001), 본인의 구강 내 증상에서는 혀가 하얗고, 입안이 끈적인다고 느끼는 군에서 스트레스 2.02점(p=0.000), 본인자각구취 2.00점(p=0.000)으로 나타났다. 구강건조감에서는 자주 느끼는 군이 스트레스 2.23점(p=0.000), 강박증 1.95점(p=0.000), 본인자각구취 1.89점으로 나타났다(p=0.046). 본인자각구취는 강박증과 r=0.133으로 약한 양의 상관관계를 나타냈고, 스트레스와 강박증은 r=0.425로 높은 양의 상관관계를 나타냈다. 이에 구취의 다양한 원인을 파악함과 더불어 정서적 요인에 대해 관심을 가지며, 미래의 환자 구취 관리를 담당할 치과위생사로서 꾸준한 교육을 통한 인식의 고취가 필요하다.