• Journal of Microbiology and Biotechnology
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• 제30권4호
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• pp.552-560
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• 2020

Human carbonic anhydrase (CA) isozyme II has been used as protein target for disorder treatment including glaucoma. Current clinically used sulfonamide-based CA inhibitors can induce side effects, and so alternatives are required. This study aimed to investigate a natural CA inhibitor from Murraya paniculata. The previously developed yeast-based assay was used to screen 14 compounds isolated from M. paniculata and identified by NMR analysis for anti-human CA isozyme II (hCAII) activity. Cytotoxicity of the compounds was also tested using the same yeast-based assay but in a different cultivation condition. Two flavonoid candidate compounds, 5, 6, 7, 8, 3', 4', 5'-heptamethoxyflavone (4) and 3, 5, 7, 8, 3', 4', 5'-heptamethoxyflavone (9), showed potent inhibitory activity against hCAII with a minimal effective concentration of 10.8 and 21.5 μM, respectively, while they both exhibited no cytotoxic effect, even at the highest concentration tested (170 μM). The results from an in vitro esterase assay of the two candidates confirmed their hCAII inhibitory activity with IC₅₀ values of 24.0 and 34.3 μM, respectively. To investigate the potential inhibition mechanism of compound 4, in silico molecular docking was performed using the FlexX and SwissDock software. This revealed that compound 4 coordinated with the Zn²⁺ ion in the hCAII active site through its methoxy oxygen at a distance of 1.60 Å (FlexX) or 2.29 Å (SwissDock). The interaction energy of compound 4 with hCAII was -13.36 kcal/mol. Thus, compound 4 is a potent novel flavonoid-based hCAII inhibitor and may be useful for further anti-CAII design and development.

• Spatial Information Research
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• 제18권4호
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• pp.75-88
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• 2010

최근 모바일 기기 및 우선 통신의 발달로 인하여 지오센서 네트워크가 실생활의 다양한 분야에서 활용되고 있다. 이에 따라 센서 노드의 제한된 에너지를 효율적으로 사용할 수 있는 미들웨어에 대한 연구가 활발히 진행되고 있다. 그러나 기존 미들웨어들은 센서 노드의 고유한 처리 능력 몇 가능을 고려하여 개발하지 않았기 때문에, 제한된 시스템 자원만을 사용하는 센서 노드에서는 운영이 불가능하다. 따라서 본 논문에서는 지오센서 네트워크에서 에너지 효율성을 자원하는 바이트코드 기반 데이터 서비스 미들웨어를 설계 및 구현한다. 제안하는 미들웨어는 첫째, 하드웨어 추상화를 지원하는 데이터 관리자와 최소한의 바이트코도 명령어를 통하여, 센서 노드에 최적화된 기능만을 제공한다. 둘째, 불필요한 데이터를 제거함으로써 데이터 전송량을 최소화하는 데이터 집계 질의처리 및 데이터 필터링을 통하여, 센서 노드의 에너지 효율성을 향상시킨다. 마지막으로, 기존 연구인 SwissQM과의 성능 평가를 통해 제안하는 미들웨어가 데이터 전송량과 평균 에너지 소모량 측면에서 에너지 효율적임을 보인다.

• 정보처리학회논문지D
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• 제8D권5호
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• pp.553-560
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• 2001

바이오정보학(bioinformatic)은 생물학 분야 특히 분자 수준의 유전체 연구에서 발생하는 데이터를 저장, 관리, 분석하여 실험 프로젝트를 지원함은 물론, 기능 예측 및 조절에 대한 실험 설계를 가능하게 하는 제반 컴퓨터 기술을 의미한다. 유전체 연구의 다양한 접근 방식 중 단백체학(proteomics)는 유전체의 최종 산물인 단백질을 직접적으로 다룬다는 측면에서 그 효용성에 대해 많은 기대를 모으고 있다. 본 논문에서는 단백질의 기능을 결정하는 가장 중요한 요소 중 하나인 단백질의 구조를 예측하기 위한 데이터 마이닝 기법을 제안한다. 단백질의 일차 구조인 아미노산 서열에 타나나는 부서열간의 연관성이 해당 단백질의 이차 혹은 삼차 구조를 결정하는 중요한 단서임을 설명하고, 아미노산 부서열간의 연관성을 표현하기 위한 모델로서 서열 연관 규직을 정의한다. 서열 연관 규칙의 유용성을 평가하기 위한 지지도와 신뢰도를 새롭게 정의하고, 주어진 단백질 집단으로부터 유용한 서열 연관 규칙을 발견하기 위한 기법을 제안한다. 아울러, SWISS-PROT 단백질 데이터베이스로부터 입수한 단백질 서열 데이터를 이용하여 제안한 기법의 성능을 평가한다.

• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part2
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• pp.1280-1281
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• 2006

The well-established Universal Powder Press UPP, designed by the Swiss press manufacturer Osterwalder AG in Lyss, went through a major improvement process. The result is a high efficient production machine with state-of-the-art technology. It will be shown the technical design, some process engineering as well as the influence of PRP - =Part-Related-Programming, first published in 1994 - on the set-up time. This development has enabled Osterwalder to round off their range of presses, the mechanical-hydraulic KPP as well as the hydraulic CA-NC II and UPP, to an attractive offer ranging from 120 kN up to 10'000 kN.

• 산업공학
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• 제19권3호
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• pp.181-189
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• 2006

This study introduces an overall framework for RFID applications in product lifecycle management(PLM). PLM is a new strategic approach to manage product related information efficiently over the whole product lifecycle. Recently, with emerging technologies such as radio frequency identification(RFID), global positioning system(GPS), and wireless communication, PLM provides a new environment that enables us to gather and analyze product lifecycle information, and make decisions on several issues without spatial and temporal constrains. However, a PLM system just provides us with new opportunities to gain the PLM system, first and foremost, it is necessary to look into its overall framework in the viewpoint of hardware, software, and business model. For this purpose, in this study, first, we introduce the technical framework of the new PLM environment with the concept of extended RFID system, called product embedded information device(PEID). Then, for each lifecycle phase such as beginning of life(BOL), middle of life(MOL), and end of life(EOL), we explore several research problems that become highlighted under the new PLM environment.

• 한국전문물리치료학회지
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• 제4권1호
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• pp.63-69
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• 1997

Asymmetrical posture during static stance has been identified as a common problem in persons with hemiplegia. This study examined the effect of a purposeful exercise training program on symmetrical weight bearing in three adult persons with hemiplegia. Multiple baseline design was used. The intervention program, including ball throwing and catching, rolling ball catching and throwing, and Swiss ball pulling and stopping was introduced for 15 minutes each day during each intervention phase. Quantitative measurement of the weight distribution was taken with the Limloader. Visual inspection and mean of data revealed a significant improvement in symmetrical weight distribution. This result suggests that a purposeful exercise training program can be effective in helping persons with hemiplegia achieve symmetric stances.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2001년도 가을 학술발표논문집 Vol.28 No.2 (1)
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• pp.67-69
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• 2001

Human Genome Project의 완성을 전후로 이루어진 생물학적 분석도구의 발달과 서열 데이터베이스의 축적으로 단백질 분석은 괄목할 만한 성장을 하였다. 단백질 분석에 사용되는 가장 중요한 단백질 식별(Identification)을 위한 도구들은 많이 개발되어 왔으나 기존의 도구들은 파일 기반으로 폭발적으로 증가하는 단백질 데이터를 효율적으로 관리하고 심험자들에게 빠르고 정확한 검색결과를 제공하는데 한계를 보여주고 있다. 우리는 SWISS-PROT flatfile을 분석하여 관계형 데이터베이스고 구축하고, 단백질 식별에서 가장 많이 사용하고 있는 ‘질량분석 후 데이터베이스 검색’방법을 사용하는 시스템을 DBMS 기반으로 설계하였으며, 다양한 실험조건과 절차에 의해 얻은 단백질 조각의 질량 값과 이론적인 계산에 의해 얻은 값을 비교하여 실험에 쓰인 단백질 조각과 일치하는 것을 단백질 데이터베이터베이스로부터 검색할 수 있는 도구를 설계하고 구현하였다.

• Nuclear Engineering and Technology
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• 제40권4호
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• pp.251-254
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• 2008

Issues and themes concerned with nuclear power plant uprating are examined. Attention is brought to the fact that many candidate nuclear power plants for uprating have anyway been operated below their rated power for a significant part of their operating life. The key issues remain safety and reliability in operation at all times, irrespective of the nuclear power plant's chronological or design age or power rating. The effects of power uprates are discussed in terms of material aspects and expected demands on the systems, structures and components. The impact on operation and maintenance methods is indicated in terms of changes to the ageing surveillance programmes. Attention is brought to the necessity checking or revising operator actions after power up-rating has been implemented.

• Restorative Dentistry and Endodontics
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• 제23권1호
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• pp.477-486
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• 1998

Recently the development of rotary instrument makes it possible that in root canal treatment operator saves much more time, maintans original curved canal shape and easily prepares continuous tapered root canal. The purpose of this experiment was to examine the smoothness of the internal surface of prepared root canal and the effectiveness of debridement in prepared root canal by SEM for the comparison of hand and Ni-Ti rotary instrument. 25 extracted human teeth were access opened and # 10 K-type file was introduced into canal until it was appeared at the apical foramen. The working length was established by subtracting 0.5mm from this measurement. Group 1. The root canal preparation was done to # 30 with working length and then step-back until # 45 with K-Flexofile (Maillefer, Swiss). Group 2. Root canal preparation was done by Naviflex Ni-Ti file (Brasseler, USA) as the same technique with group 1. Group 3. Canal was prepared by Profile .04 (Maillefer, Swiss) taper until #30. Group 4. With use of Quantec (Tycom, USA) root canal was prepared from file number 1 to 8. In group 1 and 2, the root canal irrigant was NaOCl and the other groups, NaOCl and RC-prep (Premine Dental Products, USA) was used. The prepared teeth were notched with high-speed bur as bucco-lingual direction and fractured with chisel and mallet, then examined with SEM. Group 1 showed smooth internal surface. There were scratches mainly to the axial direction. Group 2 showed similar characteristics to those in group 1. Group 3 showed more smoother and linear cutting surface with bised scratches. Group 4 has the almost same characteristics group 3 and there was no difference in the file design. Ni-Ti rotary root canal instrument prepare the dentinal wall more smoother than hand instrument. The effectiveness of debridement was not fully affected by file design. The isthmus area and accessory canals of the root canal system were not prepared in any group. According to the result, hand and rotary type instrumentation techniques were effective in removal of major amount of tissue from root canal but it was not complete. In the direction of cutting movement there was difference between them.

• 한국실내디자인학회논문집
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• 제22권5호
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• pp.11-21
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• 2013

The development of modern industry and the production of new materials of architecture have recognized as an important aspect. This study intended to discuss about the meaning of main elements of the architecture materials, its implications for properties, and, highlighted meaning of the properties of modern interior design. The purpose of this study is to analyze the case studies of Place and Physical materials of synaesthesia of modern architecture as well as modern architecture is not only concentrated in the visual aspect but also the larger ramifications of sensory. Synesthesia in architectural space can be called experiential existence that built in the space of human perception and based on the human emotion that targeted by physical architectural space. Accordingly, these case studies are to consider about how the materials being passed by any effect in a modern interior space presented, In order to find the essential meaning in modern interior space, this studies focused on Swiss architect Peter Zumthor's cases. Following analyze of Peter Zumthor's place of architectural space and materials, this study structured by the six kinds of synesthesia characters. First, time and remember to infer changes, Second, traditional and regional ingredients involve the substitution of one empirical space, Third, non-materiality through the neutralization, Fourth, auditory memory through the embodiment of everydayness, Fifth, trail through the sense of smell for the presence, Sixth, the relationship of natural and industrial products. Peter Zumthor's characteristics of these works are result of factors on the synesthetic relationship with the human response to architecture, the five senses, memories, experiences, and temperature. Also it is a synesthetic result of all human emotion to clarify of the architecture materials and non-material mediums by which light by a compound.