• Maxillofacial Plastic and Reconstructive Surgery
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• 제35권6호
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• pp.376-380
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• 2013

Frey syndrome is a disease characterized by abnormal sweating, facial redness, and rare pain by stimulation of taste sense on the limited area dominated by the auriculotemporal nerve and great auricular nerve. Although the developmental mechanism and histopathologic cause of Frey syndrome are still being debated, the most reliable theory is based on injury of the parathympathetic nerve connected to the auriculotemporal nerve continuing to abnormal regeneration. The other theory is that the sweat glands develop an increased sensitivity after degeneration of sympathetic fibers. Therapy of Frey syndrome includes drugs, radiographic treatment, and surgical treatment; however, in most cases, treatment is not satisfactory. This is a case report on a 24-year-old male patient with Frey syndrome caused by the fracture reduction with retromandibular approach after multiple facial traumas and spontaneous healing without any special treatment.

• 대한두경부종양학회지
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• 제36권2호
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• pp.41-44
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• 2020

Clear cell hidradenoma is a skin adnexal tumor originating from eccrine glands. The risk of local recurrence after surgical resection exceeds 50%, and 6-19% of cases are malignant. The rarity of clear cell hidradenoma and its diverse histological findings make this type of tumor a diagnostic challenge. We present a case of recurrent clear cell hidradenoma of the posterior neck in a 70-year-old woman. The tumor recurred once after complete excision, and did not recur again after 1-cm wide excision and reconstruction with a local bilobed flap. Recurrent clear cell hidradenomas are activated by surgical stimulation, increasing the risk for metastasis. Therefore, we suggest that wide excision with confirmation of a tumor-free margin by frozen-section biopsy should be the first-line treatment for recurrent benign clear cell hidradenoma.

• 대한수의학회지
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• 제54권4호
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• pp.253-256
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• 2014

In this study, we describe a case of epitheliogenesis imperfecta (EI) observed in the fetus of Korean native cattle. The fetus had multifocal areas of skin defect, especially on the distal portions of the four limbs, and the affected areas were bright-red and glistening. Histopathologically, these areas were characterized by complete absence of squamous epithelium, infiltration of inflammatory cells into the dermis, atrophy of hair follicles, sebaceous and sweat glands. To the best of our knowledge, this is the first report of epitheliogenesis imperfecta in Korean native cattle.

• 대한치과의사협회지
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• 제15권2호
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• pp.121-124
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• 1977

The most common and the most serious complication of the burn is infection, which is to a certain extent inevitable in the light of present knowledge and experience. From the burn wound as a rule there may be cultured at any given time the prevailing flora of the individual patient and of the hospital attendants and ward environ ment. Even without contamination from outside sources, organisms embedded in hair follicles and sweat glands survive the sterilizing effects of heat and serve as potential sources of localized and systemic infection. With necrotic tissue serving as nutrient material for pathogens there may occur, in succession, cellulitis, extending necrosis, lymphangitis and final septicemia. This is to report a case of osteomyelitis due to facial burn of 32 year old Korean male. The authors treated the patient by curettage and thin split thickness skin graft. The post operative course was uncomplicated and result was excellent.

• 대한두개안면성형외과학회지
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• 제25권2호
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• pp.90-94
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• 2024

Primary cutaneous mucinous carcinoma (PCMC) is a rare malignancy of the sweat glands that most commonly affects the periorbital area. It is characterized by slow growth over a prolonged period, and its morphology can be easily confused with a benign tumor, such as an epidermal cyst. Consequently, many patients experience recurrence after undergoing multiple resections. However, there are few reports concerning the surgical management of PCMC. We present two cases of PCMC originating in the periorbital area. The first case involved a 76-year-old man with a mass measuring 3.0×1.5 cm that had been increasing in size. The second case was a 61-year-old man with two masses, each measuring 1.0×1.0 cm, that were also growing. Both patients underwent wide excision with a 5-mm safety margin, which was determined based on the widest view of the cross-section of the mass on the magnetic resonance imaging. Subsequently, based on the intraoperative frozen biopsy results, both patients underwent additional excision with a 5-mm safety margin in only one direction. This report shows that, when determining the surgical margin of PCMC in periorbital area, employing imaging modalities and intraoperative frozen biopsies can be helpful for narrowing the surgical margin.

• 대한영상의학회지
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• 제83권1호
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• pp.194-198
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• 2022

투명 세포 열선 종(clear cell hidradenoma; 이하 CCH)은 외분비 또는 아포크린 분화 땀샘의 드문 종양이다. 신체의 어느 곳에서나 발생할 수 있지만 일반적으로 머리, 얼굴, 몸통과 사지에서 발생한다. 여러 보고에서 CCH의 초음파 소견에 대해 언급하였지만 변형 탄성 초음파(strain elastography; 이하 SE) 소견에 대한 연구는 겨드랑이의 병변에 대해 보고한 한 경우밖에 없다. 우리는 표피 종양(epidermoid tumor)처럼 보였던 종아리에서 발생한 CCH의 사례를 초음파 소견과 SE 소견을 함께 보고하는 바이다.

• Childhood Kidney Diseases
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• 제17권2호
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• pp.137-142
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• 2013

전신형 PHA 1은 ENaC의 ${\alpha}$ (SCNN1A), ${\beta}$ (SCNN1B), ${\gamma}$ (SCNN1G) 아단위를 암호화하는 유전자의 변이로 경상피나트륨 수송의 결함으로 발생하게 되며 신생아기에 생명을 위협하는 염분 소실, 고칼륨혈증, 대사성 산증이 발생하게 된다. 또한 신장 뿐 아니라 대장, 침샘, 땀샘 및 호흡기상피 등의 다양한 표적 기간에서 전신적으로 알도스테론에 대한 저항성이 나타난다. 최근 전신형 PHA 1의 임상상과 유전자형 및 이환된 환아들의 장기 추적 결과에 대한 보고가 되고 있으나 질환의 희소성으로 임상 표현형을 설명하기는 어려운 실정이다. 저자들은 사망을 초래할 수 있는 심각한 전해질 이상을 보인 환아에서 PHA를 의심하여 염분 및 양이온 교환수지를 투여하여 효과적으로 전해질 교정이 되어 추적관찰 중이며, 유전자 검사를 통해 missense mutation을 나타낸 전신형 PHA1을 경험하였기에 보고하는 바이다.

• Archives of Plastic Surgery
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• 제44권3호
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• pp.228-233
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• 2017

Background Hidradenitis suppurativa (HS) is a chronic skin condition that can affect any area with apocrine sweat glands and has the potential to involve multiple sites concurrently. Commonly affected sites include the axilla, groin, perineum and perianal areas. In this study we performed a literature review on the surgical methods for HS and describe an innovative technique for reconstructing axilla HS using an inner-arm transposition flap. Methods We reviewed all cases (5 cases from 4 patients) of transposition flap reconstruction performed by the senior author at a single London tertiary hospital from 2008-2013. Patient related outcome measures were collected using the Derriford appearance scale (DAS 24) and a study specific questionnaire. Results All patients were satisfied with their final result. One out of five cases had a complication but did not result in flap failure. There is no disease recurrence to date. DAS 24 scores collected demonstrated acceptable postoperative distress that did not deviate far from the norm tables while study specific questionnaire reveal desirable outcomes. Conclusions We have managed to achieve our aim through the use of the innovative inner-arm transposition flap. Our study hopes to provide an additional technique for axillary reconstruction. This technique offers the effective concealment of scars with the benefit of tightening of the arm tissue producing 'brachioplasty like' effects. All things considered it would be reasonable to conclude the innovative flap technique is a reliable, effective, and simple method that results in multiple benefits.

• BMB Reports
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• 제43권5호
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• pp.362-368
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• 2010

Dermcidin is a human antibiotic peptide that is secreted by the sweat glands and has no homology to other known antimicrobial peptides. As an initial step toward understanding dermcidin's mode of action at bacterial membranes, we used homonuclear and heteronuclear NMR to determine the conformation of the peptide in 50% trifluoroethanol solution. We found that dermcidin adopts a flexible amphipathic $\alpha$-helical structure with a helix-hinge-helix motif, which is a common molecular fold among antimicrobial peptides. Spin-down assays of dermcidin and several related peptides revealed that the affinity with which dermcidin binds to bacterial-mimetic membranes is primarily dependent on its amphipathic $\alpha$-helical structure and its length (>30 residues); its negative net charge and acidic pI have little effect on binding. These findings suggest that the mode of action of dermcidin is similar to that of other membrane-targeting antimicrobial peptides, though the details of its antimicrobial action remain to be determined.

• 대한두개안면성형외과학회지
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• 제18권1호
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• pp.44-45
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• 2017

Eccrine poroma is a common benign cutaneous tumor that originates in an intraepidermal eccrine duct. This tumor exhibits acral distribution (sole, palm), and is rarely encountered in the head and neck area. In fact eccrine poroma in the postauricular area has only been rarely reported. A 55-year-old female visited our hospital with a main complaint of a mass that first developed in the left postauricular area about a year previously. The mass was painless, soft, protruding, domed, and dark red in color, and had slowly enlarged (at presentation it measured $1\times1cm$). Excisional biopsy was performed. Histological examination showed distinct features, and eccrine poroma was diagnosed. Follow-up at 6 months postoperatively showed no recurrence. The frequency of eccrine poroma is dependent on eccrine sweat glands density, and thus, usually occurs on the palms or soles. For eccrine poroma in the head and neck region, the differential diagnosis must rule out other masses, such as nevus, skin tag, pyogenic granuloma, cyst, basal cell carcinoma, and seborrheic keratosis. Importantly, 18% of poromas show malignant transformation, and can develop into porocarcinoma. For these reasons, an eccrine poroma in the facial area requires histological examination, complete excision, and follow-up.