• Genomics & Informatics
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• v.16 no.2
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• pp.36-41
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• 2018

Kawasaki disease (KD) is an acute febrile vasculitis predominately affecting infants and children. The dominant incidence age of KD is from 6 months to 5 years of age, and the incidence is unusual in those younger than 6 months and older than 5 years of age. We tried to identify genetic variants specifically associated with KD in patients younger than 6 months or older than 5 years of age. We performed an age-stratified genome-wide association study using the Illumina HumanOmni1-Quad BeadChip data (296 cases vs. 1,000 controls) and a replication study (1,360 cases vs. 3,553 controls) in the Korean population. Among 26 candidate single nucleotide polymorphisms (SNPs) tested in replication study, only a rare nonsynonymous SNP (rs4365796: c.1106C>T, p.Thr369Met) in the lymphoid enhancer binding factor 1 (LEF1) gene was very significantly associated with KD in patients younger than 6 months of age (odds ratio [OR], 3.07; $p_{combined}=1.10{\times}10^{-5}$), whereas no association of the same SNP was observed in any other age group of KD patients. The same SNP (rs4365796) in the LEF1 gene showed the same direction of risk effect in Japanese KD patients younger than 6 months of age, although the effect was not statistically significant (OR, 1.42; p = 0.397). This result indicates that the LEF1 gene may play an important role as a susceptibility gene specifically affecting KD patients younger than 6 months of age.

• Korean Journal of Heritage: History & Science
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• v.55 no.2
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• pp.66-79
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• 2022

In the mid-Kofun period, the technology employed in the southern part of the Korean Peninsula had reached the Japanese archipelago, and a Japanese-style unglazed earthenware called Sueki was produced. During the early period of the spread of technology, regional elements from all over the Korean Peninsula remained strong, with production on the Japanese archipelago carried out only in very limited regions. After that, production in all parts of the archipelago began gradually. The Sueki culture was introduced to the Japanese archipelago with the technology of the Korean Peninsula; however, many excavations have been reported in the Korean Peninsula(these excavations are even called Suekitype). Many of these excavations were conducted in Jeolla-do, Yeongnam, and the Yeongsan River basin. As revealed in previous studies, however, many imitations were excavated around Jeolla-do, while Sueki of the Japanese archipelago were excavated from tombs in the Yeongnam area. The excavation period was generally from the late 5^th century to the early 6^th century(especially from the TK23 to MT15 stage), which is fundamentally different from that of Jeolla-do. Regarding the locations where Sueki were excavated, the majority were found in the tombs of local authorities. They were rarely excavated from the tombs of the royal people. Furthermore, there is no evidence of special meaning given to funeral ceremonies or Sueki in the Japanese archipelago form; therefore, most of them are thought to have been treated the same as unglazed earthenware. Considering the tombs as a whole, influential people(groups, families, and forces) were not only connected to certain areas of the Gaya region but also had complex and larger relationships. In other words, the Sueki excavated from the Yeongnam area may reflect the rise and fall of the forces in each Gaya region and the changes of the Yeongnam period. The role of negotiation and exchange can be seen not only from the fact that influential people in the central government of the Gaya region were involved but also from the existence of areas(groups, families, forces) discovered in the Gaya region indicating mutual relationships.