• Korean Journal of Digital Imaging in Medicine
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• v.15 no.1
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• pp.27-31
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• 2013

Perfusion MR imaging is how to use exogenous and endogenous contrast agent. Exogenous perfusion MRI methods which are dynamic susceptibility contrast using $T2^*$ effect and dynamic contrast-enhanced using T1 weighted image after injection contrast media. An endogenous perfusion MRI method which is arterial spin labeling using arterial blood flow in body. In order to exam perfusion MRI in human, technical access are very important according to disease conditions. For instance, dynamic susceptibility contrast is used in patients with acute stroke because of short exam time, while dynamic susceptibility contrast or dynamic contrast enhancement provides the various perfusion information for patients with tumor, vascular stenosis. Arterial spin labeling is useful for children, women who are expected to be pregnant. In this regard, perfusion MR imaging is required to understanding, and the author would like to share information with clinical users

• Investigative Magnetic Resonance Imaging
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• v.22 no.3
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• pp.141-149
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• 2018

Purpose: The purpose of this study is to develop a simple method to measure magnetic susceptibility of arbitrarily shaped materials through MR imaging and numerical modeling. Materials and Methods: Our 3D printed phantom consists of a lower compartment filled with a gel (gel part) and an upper compartment for placing a susceptibility object (object part). The $B_0$ maps of the gel with and without the object were reconstructed from phase images obtained in a 3T MRI scanner. Then, their difference was compared with a numerically modeled $B_0$ map based on the geometry of the object, obtained by a separate MRI scan of the object possibly immersed in an MR-visible liquid. The susceptibility of the object was determined by a least-squares fit. Results: A total of 18 solid and liquid samples were tested, with measured susceptibility values in the range of -12.6 to 28.28 ppm. To confirm accuracy of the method, independently obtained reference values were compared with measured susceptibility when possible. The comparison revealed that our method can determine susceptibility within approximately 5%, likely limited by the object shape modeling error. Conclusion: The proposed gel-phantom-based susceptibility measurement may be used to effectively measure magnetic susceptibility of MR-compatible samples with an arbitrary shape, and can enable development of various MR engineering parts as well as test biological tissue specimens.

• Investigative Magnetic Resonance Imaging
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• v.23 no.2
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• pp.157-161
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• 2019

In this study, we report arterial spin labelling perfusion, proton MR spectroscopy and susceptibility-weighted MR findings of acute necrotizing encephalopathy in a child with rotavirus infection.

• Proceedings of the KOSOMBE Conference
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• v.1990 no.11
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• pp.19-23
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• 1990

A new technique for reducing the susceptibility artifact in gradient echo imaging which uses a tailored RF pulse is proposed. It is applied to the case of imaging where artifacts and distortions arise due to the high local magnetic field inhomogeneity i. e., the susceptibility. The signal loss and void phenomena due to susceptibility in a voxel are studied and a correction method using a tailored RF pulse is proposed. Applications of this method in imaging are given and experimental results obtained using an human volunteer with a 2.0 T KAIS NMR system are presented.

• Korean Journal of Radiology
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• v.24 no.11
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• pp.1131-1141
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• 2023

Objective: Cortical iron deposition has recently been shown to occur in Alzheimer's disease (AD). In this study, we aimed to evaluate how cortical gray matter iron, measured using quantitative susceptibility mapping (QSM), differs in the clinical cognitive impairment spectrum. Materials and Methods: This retrospective study evaluated 73 participants (mean age ± standard deviation, 66.7 ± 7.6 years; 52 females and 21 males) with normal cognition (NC), 158 patients with mild cognitive impairment (MCI), and 48 patients with AD dementia. The participants underwent brain magnetic resonance imaging using a three-dimensional multi-dynamic multi-echo sequence on a 3-T scanner. We employed a deep neural network (QSMnet+) and used automatic segmentation software based on FreeSurfer v6.0 to extract anatomical labels and volumes of interest in the cortex. We used analysis of covariance to investigate the differences in susceptibility among the clinical diagnostic groups in each brain region. Multivariable linear regression analysis was performed to study the association between susceptibility values and cognitive scores including the Mini-Mental State Examination (MMSE). Results: Among the three groups, the frontal (P < 0.001), temporal (P = 0.004), parietal (P = 0.001), occipital (P < 0.001), and cingulate cortices (P < 0.001) showed a higher mean susceptibility in patients with MCI and AD than in NC subjects. In the combined MCI and AD group, the mean susceptibility in the cingulate cortex (β = -216.21, P = 0.019) and insular cortex (β = -276.65, P = 0.001) were significant independent predictors of MMSE scores after correcting for age, sex, education, regional volume, and APOE4 carrier status. Conclusion: Iron deposition in the cortex, as measured by QSMnet+, was higher in patients with AD and MCI than in NC participants. Iron deposition in the cingulate and insular cortices may be an early imaging marker of cognitive impairment related neurodegeneration.

• Investigative Magnetic Resonance Imaging
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• v.23 no.4
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• pp.381-384
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• 2019

Spontaneous intracranial hypotension (SIH) can be a rare risk factor of cerebral venous thrombosis. We describe a case of isolated cortical vein thrombosis (CVT) secondary to SIH and discuss the value of susceptibility-weighted imaging for the detection of isolated CVT.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.571-574
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• 1997

fMRI, functional MRI introduced recently appears based on the gradient echo technique which is sensitive to the field inhomogeneity developed due to the local susceptibility changes of blood oxygenation and deoxygenation. Common to all the gradient echo techniques is that the signal due to the susceptibility effects is generally decreased with increasing inhomogeneity due to the $T2^*$ effect or conventionally known as blood oxygenation level dependent (BOLD) effect. It is, also found that the BOLD sensitivity is also dependent on the imaging modes, namely whether the imaging is in axial, or coronal or sagittal mode as well as the directions of the vessels against the main magnetic field. We have, therefore, launched a systematic study of imaging mode dependent signal change or BOLD sensitivity as well as the signal changes due to the tilting angle of the imaging planes. Study has been made or both TRFGE sequence and CGE sequence to compare the distinctions of the each mode since each technique has different sensitivity against susceptibility effect. Method of computation and both the computer simulations and their corresponding experimental results are presented.

• Investigative Magnetic Resonance Imaging
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• v.1 no.1
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• pp.66-74
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• 1997

fMRI, functional MRI introduced receently appears based on the gradient echo technique which is sensitive to the field inhomogeneity developed due to the local susceptibility changes of blood oxygenation and deoxygenation. There has been many variants of the basic gradient echo sequence which is sensitive to the local inhomogeniety, among others such as GRASS or SSFP to EPISTAR are the most commonly used gradient echo techniques. Common to all these gradient echo techniques is that the signal due to the susceptibility effects is generally decreased with increasing inhomogeneity due to the $T2^{*}$ effect or conventionally konwn as blood oxygenation level dependent(BOLD) effect. It is, also found that the BOLD sensitivity is also dependent on the imaging modes, namely whether the imaging is in axial, or coronal or sagittal mode as well as the directions of the vessels against the main magnetic field. We have, therefore, launched a systematic study of imaging mode dependent signal change or BOLD sensitivity as well as the signal changes due tothe tilting angle of the imaging planes. Study has been made for both TRFGE sequence and CGE sequence to compare the distinctions of the each mode since each technique has different sensitivity againsst susceptibility effect. Method of computation and both the computer simulations and their corresponding experimental results are presented.

• Investigative Magnetic Resonance Imaging
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• v.22 no.1
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• pp.37-49
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• 2018

Purpose: The effect of global inhomogeneity on quantitative susceptibility mapping (QSM) was investigated. A technique referred to as Simultaneous Unwrapping Phase with Error Recovery from inhomogeneity (SUPER) is suggested as a preprocessing to QSM to remove global field inhomogeneity-induced phase by polynomial fitting. Materials and Methods: The effect of global inhomogeneity on QSM was investigated by numerical simulations. Three types of global inhomogeneity were added to the tissue susceptibility phase, and the root mean square error (RMSE) in the susceptibility map was evaluated. In-vivo QSM imaging with volunteers was carried out for 3.0T and 7.0T MRI systems to demonstrate the efficacy of the proposed method. Results: The SUPER technique removed harmonic and non-harmonic global phases. Previously only the harmonic phase was removed by the background phase removal method. The global phase contained a non-harmonic phase due to various experimental and physiological causes, which degraded a susceptibility map. The RMSE in the susceptibility map increased under the influence of global inhomogeneity; while the error was consistent, irrespective of the global inhomogeneity, if the inhomogeneity was corrected by the SUPER technique. In-vivo QSM imaging with volunteers at 3.0T and 7.0T MRI systems showed better definition in small vascular structures and reduced fluctuation and non-uniformity in the frontal lobes, where field inhomogeneity was more severe. Conclusion: Correcting global inhomogeneity using the SUPER technique is an effective way to obtain an accurate susceptibility map on QSM method. Since the susceptibility variations are small quantities in the brain tissue, correction of the inhomogeneity is an essential element for obtaining an accurate QSM.

• Proceedings of the KOSOMBE Conference
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• v.1993 no.11
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• pp.23-26
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• 1993

In MR functional imaging, it is shown that the signal change during photic activation is composed of two terms, i.e. the inflow effect and the susceptibility effect. Relatively the inflow effect affects the data obtained by CGE on the condition of short $T_E$(15ms) and large $\alpha$(90degree). The susceptibility effect, however, mainly contributes to the data on the condition of large $T_E$(35ms) and small $\alpha$(30degree). In this apper, we will discriminate the susceptibility effect for the intermingled data affected both flow effect and susceptibility effect. Finally susceptibility only functional imaging is proposed by using TRFGE.