• Title/Summary/Keyword: Survival time estimation

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A Theoretical Study for Estimation of Oxygen Effect in Radiation Therapy (방사선 조사시 산소가 세포에 미치는 영향의 이론적 분석)

  • Rena J. Lee;HyunSuk Suh
    • Progress in Medical Physics
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    • v.11 no.2
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    • pp.157-165
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    • 2000
  • Purpose: For estimation of yields of l)NA damages induced by radiation and enhanced by oxygen, a mathematical model was used and tested. Materials and Methods: Reactions of the products of water radiolysis were modeled as an ordinary time dependant equations. These reactions include formation of radicals, DNA damage, damage repair, restitution, and damage fixation by oxygen and H-radical. Several rate constants were obtained from literature while others were calculated by fitting an experimental data. Sensitivity studies were performed changing the chemical rate constant at a constant oxygen number density and varying the oxygen concentration. The effects of oxygen concentration as well as the damage fixation mechanism by oxygen were investigated. Oxygen enhancement ratio(OER) was calculated to compare the simulated data with experimental data. Results: Sensitivity studies with oxygen showed that DNA survival was a function of both oxygen concentration and the magnitude of chemical rate constants. There were no change in survival fraction as a function of dose while the oxygen concentration change from 0 to 1.0 x 10$^{7}$ . When the oxygen concentration change from 1.0 $\times$ 107 to 1.0 $\times$ 101o, there was significant decrease in cell survival. The OER values obtained from the simulation study were 2.32 at 10% cell survival level and 1.9 at 45% cell survival level. Conclusion: Sensitivity studies with oxygen demonstrated that the experimental data were reproduced with the effects being enhanced for the cases where the oxygen rate constants are largest and the oxygen concentration is increased. OER values obtained from the simulation study showed good agreement for a low level of cell survival. This indicated that the use of the semi-empirical model could predict the effect of oxygen in cell killing.

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The Rearch Of Method in the Appropriate number of Demand and Supply of OMD (한의사인력(韓醫師人力) 공급(供給)의 적정화방안(適定化方案) 연구(硏究))

  • Lee, Jong-Soo
    • The Journal of Korean Medicine
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    • v.19 no.1
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    • pp.299-326
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    • 1998
  • 1. Comparison of demand and supply A. Assumption of estimation of demand and supply we will briefly assumptions used for presumption once more before comparing the result of estimation of demand and supply examined previously 1) supply - The average applying rate for state. examination of graduate: ${\alpha}$=1.03109 - The ratio of successful applicants of state examinations: ${\beta}$=0.97091 - Mortality classified by age : presumed data of the Bureau of statistics - Emigrating rate: 0 % - Time of retire: unconsidered - An army doctor number: unconsidered and regard number of employed oriental medicine doctor. - Standard of 1995 : The number of survival oriental medicine doctor is 8195. the number of employed oriental medicine doctor is 7419. 2) demand - derivated demand method Daily the average amount of medical treatment: according to medical insurance federation data. there is 16 or 6 non allowance patient, we consider amount of medical treatment as 22 persons in practical because 21.94 persons (founded practical examination) are converted to allowance in comming demand. Daily the proper amount of medical treatment: 7 hours form -35 persons 5 hours 30 minutes form -28 persons. Yearly medical treatment days: 229 days. 255 days. 269 days . Increasing rate of visiting hospital days: -1996 year. 1997 year. 1998 year- . Rate of applying insurance: yearly average 71.51% (among the investigated patient) B. Comparison of total sum result 1) supply (provision) Table Ⅳ-1 below shows the estimation of the oriental medicine doctor in the future.

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  • Applying a Forced Censoring Technique with Accelerated Modeling for Improving Estimation of Extremely Small Percentiles of Strengths

    • Chen Weiwei;Leon Ramon V.;Young Timothy M.;Guess Frank M.
      • International Journal of Reliability and Applications
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      • v.7 no.1
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      • pp.27-39
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      • 2006
    • Many real world cases in material failure analysis do not follow perfectly the normal distribution. Forcing of the normality assumption may lead to inaccurate predictions and poor product quality. We examine the failure process of the internal bond (IB or tensile strength) of medium density fiberboard (MDF). We propose a forced censoring technique that closer fits the lower tails of strength distributions and better estimates extremely smaller percentiles, which may be valuable to continuous quality improvement initiatives. Further analyses are performed to build an accelerated common-shaped Weibull model for different product types using the $JMP^{(R)}$ Survival and Reliability platform. In this paper, a forced censoring technique is implemented for the first time as a software module, using $JMP^{(R)}$ Scripting Language (JSL) to expedite data processing, which is crucial for real-time manufacturing settings. Also, we use JSL to automate the task of fitting an accelerated Weibull model and testing model homogeneity in the shape parameter. Finally, a package script is written to readily provide field engineers customized reporting for model visualization, parameter estimation, and percentile forecasting. Our approach may be more accurate for product conformance evaluation, plus help reduce the cost of destructive testing and data management due to reduced frequency of testing. It may also be valuable for preventing field failure and improved product safety even when destructive testing is not reduced by yielding higher precision intervals at the same confidence level.

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    The estimation of lifetime income replacement rates (생존기간을 고려한 생애소득대체율의 추정)

    • Shin, Seunghee;Son, Hyunsub;Lee, Hangsuck
      • Journal of the Korean Data and Information Science Society
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      • v.25 no.6
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      • pp.1315-1331
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      • 2014
    • Replacement rates which shows the ratio of retirement income relative to preretirement income is used for a valuable evaluation measures while discussing social security benefit levels or the adequacy of retirement income. However, replacement rates has been only used for an index for evaluating benefit level at the time of retirement or specific retirement period in advanced research projects. This article analyzes how much the uncertainty of survival has an influence on retirement income, and shows replacement rates in conformity with the period of survival as an index. The researchers named this index lifetime income replacement rates. Analysis based on this index shows both life replacement income rates of 38.3% in men's case and of 41.1% in women's case while enrolled for 20years in three pension plans - national pension, retirement pension and individual annuity.

    A Study on Trade Area Analysis with the Use of Modified Probability Model (변형확률모델을 활용한 소매업의 상권분석 방안에 관한 연구)

    • Jin, Chang-Beom;Youn, Myoung-Kil
      • Journal of Distribution Science
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      • v.15 no.6
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      • pp.77-96
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      • 2017
    • Purpose - This study aims to develop correspondence strategies to the environment change in domestic retail store types. Recently, new types of retails have emerged in retail industries. Therefore, trade area platform has developed focusing on the speed of data, no longer trade area from district border. Besides, 'trade area smart' brings about change in retail types with the development of giga internet. Thus, context shopping is changing the way of consumers' purchase pattern through data capture, technology capability, and algorithm development. For these reasons, the sales estimation model has been shown to be flawed using the notion of former scale and time, and it is necessary to construct a new model. Research design, data, and methodology - This study focuses on measuring retail change in large multi-shopping mall for the outlook for retail industry and competition for trade area with the theoretical background understanding of retail store types and overall domestic retail conditions. The competition among retail store types are strong, whereas the borders among them are fading. There is a greater need to analyze on a new model because sales expectation can be hard to get with business area competition. For comprehensive research, therefore, the research method based on the statistical analysis was excluded, and field survey and literature investigation method were used to identify problems and propose an alternative. In research material, research fidelity has improved with complementing research data related with retail specialists' as well as department stores. Results - This study analyzed trade area survival and its pattern through sales estimation and empirical studies on trade areas. The sales estimation, based on Huff model system, counts the number of households shopping absorption expectation from trade areas. Based on the results, this paper estimated sales scale, and then deducted modified probability model. Conclusions - In times of retail store chain destruction and off-line store reorganization, modified Huff model has problems in estimating sales. Transformation probability model, supplemented by the existing problems, was analyzed to be more effective in competitiveness business condition. This study offers a viable alternative to figure out related trade areas' sale estimation by reconstructing new-modified probability model. As a result, the future task is to enlarge the borders from IT infrastructure with data and evidence based business into DT infrastructure.

    Pattern-Mixture Model of the Cox Proportional Hazards Model with Missing Binary Covariates (결측이 있는 이산형 공변량에 대한 Cox비례위험모형의 패턴-혼합 모델)

    • Youk, Tae-Mi;Song, Ju-Won
      • The Korean Journal of Applied Statistics
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      • v.25 no.2
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      • pp.279-291
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      • 2012
    • When fitting a Cox proportional hazards model with missing covariates, it is inefficient to exclude observations with missing values in the analysis. Furthermore, if the missing-data mechanism is not Missing Completely At Random(MCAR), it may lead to biased parameter estimation. Many approaches have been suggested to handle the Cox proportional hazards model when covariates are sometimes missing, but they are based on the selection model. This paper suggest an approach to handle Cox proportional hazards model with missing covariates by using the pattern-mixture model (Little, 1993). The pattern-mixture model is expressed by the joint distribution of survival time and the missing-data mechanism. In the pattern-mixture model, many models can be considered by setting up various restrictions, and different results under various restrictions indicate the sensitivity of the model due to missing covariates. A simulation study was conducted to show the sensitivity of parameter estimation under different restrictions in a pattern-mixture model. The proposed approach was also applied to mouse leukemia data.

    The Assessing Comparative Study for Statistical Process Control of Software Reliability Model Based on Musa-Okumo and Power-law Type (Musa-Okumoto와 Power-law형 NHPP 소프트웨어 신뢰모형에 관한 통계적 공정관리 접근방법 비교연구)

    • Kim, Hee-Cheul
      • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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      • v.8 no.6
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      • pp.483-490
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      • 2015
    • There are many software reliability models that are based on the times of occurrences of errors in the debugging of software. It is shown that it is possible to do likelihood inference for software reliability models based on finite failure model and non-homogeneous Poisson Processes (NHPP). For someone making a decision about when to market software, the conditional failure rate is an important variables. The infinite failure model are used in a wide variety of practical situations. Their use in characterization problems, detection of outlier, linear estimation, study of system reliability, life-testing, survival analysis, data compression and many other fields can be seen from the many study. Statistical process control (SPC) can monitor the forecasting of software failure and thereby contribute significantly to the improvement of software reliability. Control charts are widely used for software process control in the software industry. In this paper, proposed a control mechanism based on NHPP using mean value function of Musa-Okumo and Power law type property.

    Assessment of casting parts fatigue life for 3MW offshore wind turbine (3MW 해상풍력발전기 주물품의 내구수명 평가)

    • Roh, Gitae;Kang, Wonhyoung;Lee, Seongchan
      • 한국신재생에너지학회:학술대회논문집
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      • 2010.11a
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      • pp.189.2-189.2
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      • 2010
    • The purpose of this study is fatigue damage assessment for large sized casting parts (hub and mainframe) of the 3MW offshore wind turbine by computer simulation. Hub and mainframe durability assessment is necessary because wind turbine have to guarantee for 20 years. Fatigue life evaluation must be considered all of fatigue load conditions as the components are wind load transmission path. Palmgren-Miner linear damage accumulation hypothesis is applied for fatigue life estimation with stress-life approach. S-N curve for the spheroid graphite cast iron EN-GJS-400-18-LT is derived according to durability guidelines. Reduction factors were applied for survival probability, surface roughness, material quality and partial safety factor according to Germanischer Lloyd rules. To calculate fatigue damage, stress tensors, extracted from the unity load calculation from ANSYS is multiplied with time track of fatigue loads extracted from GH bladed. Damage accumulation is performed with all of fatigue load conditions at each finite element nodes. In this study maximum nodal damage value is under 1.0. casted parts are safe. This research was financially supported by the Ministry of Knowledge Economy(MKE), Korea Institute for Advancement of Technology(KIAT) and Honam Leading Industry Office through the Leading Industry Development for Economic Region.

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    Estimation of the Projections of the Incidence Rates, Mortality and Prevalence Due to Common Cancer Site in Isfahan, Iran

    • Moradpour, Farhad;Fatemi, Zeinab
      • Asian Pacific Journal of Cancer Prevention
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      • v.14 no.6
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      • pp.3581-3585
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      • 2013
    • Background: Accurate statistics on the cancer burden are essential, both for purposes of research and for setting priorities in healthcare management. So that in vast countries with partial registration coverage, such as Iran, local data are more useful. We here estimated the incidence, prevalence and mortality time trend of four major cancer site, lung, stomach, breast and prostate, over the period 2001-2010 and provided short-range projections to 2015 in Isfahan. Materials and Methods: Estimates were derived by applying the mortality-incidence analysis method, a back-calculation approach to estimate and project incidence, prevalence and mortality of chronic degenerative disease, starting from knowledge of mortality and relative survival information. Results: Age adjusted incidence, mortality and prevalence rates in Isfahan exhibited a clear upward trend for all four sites during the period 2001-2015, with marked increasees in prostate and breast predicted for the future. Difference in incidence trends between males and females might be attributable to the difference in risk factors specific to certain cancer sites, with smoking being the main risk factor. Conclusions: In this study, males and females displayed an increasing pattern for incidence and mortality rate over the entire study period until 2015. This information can be used as basis for planning healthcare management and allocating recourses in public health.

    A Study on Parameters Estimation of Storage Function Model Using the Genetic Algorithms (유전자 알고리듬을 이용한 저류함수모형의 매개변수 추정에 관한 연구)

    • Park, Bong-Jin;Cha, Hyeong-Seon;Kim, Ju-Hwan
      • Journal of Korea Water Resources Association
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      • v.30 no.4
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      • pp.347-355
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      • 1997
    • In this study, the applicability of genetic algorithms into the parameter estimation of storage function method for flood routing model is investigated. Genetic algorithm is mathematically established theory based on the process of Darwinian natural selection and survival of fittest. It can be represented as a kind of search algorithms for optima point in solution space and make a reach on optimal solutions through performance improvement of assumed model by applying the natural selection of life as mechanical learning province. Flood events recorded in the Daechung dam are selected and used for the parameter estimation and verification of the proposed parameter estimation method by the split sample method. The results are analyzed that the performance of the model are improved including peak discharge and time to peak and shown that the parameter Rsa, and f1 are most sensitive to storage function model. Based on the analysis for estimated parameters and the comparison with the results from experimental equations, the applicability of genetic algorithm is verified and the improvements of those equations will be used for the augmentation of flood control efficiency.

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