• KSII Transactions on Internet and Information Systems (TIIS)
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• v.6 no.5
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• pp.1333-1353
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• 2012

The robustness of a network is usually measured by error tolerance and attack vulnerability. Significant research effort has been devoted to determining the network design with optimal robustness. However, little attention has been paid to the problem of how to improve the robustness of existing networks. In this paper, we investigate how to optimize attack tolerance and communication efficiency of an existing network under the limited link addition. A survival fitness metric is defined to measure both the attack tolerance and the communication efficiency of the network. We show that network topology reconfiguration optimization with limited link addition (NTRLA) problem is NP-hard. Two approximate solution methods are developed. First, we present a degree-fitness parameter to guide degree-based link addition method. Second, a preferential configuration node-protecting cycle (PCNC) method is developed to do trade-off between network robustness and efficiency. The performance of PCNC method is demonstrated by numerical experiments.

• Safety and Health at Work
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• v.14 no.1
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• pp.131-134
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• 2023

The aim was to describe out-of-hospital cardiac arrest (OHCA) occurring in the workplace of a large emergency network, and compare the evolution of their management in the last 15 years. A retrospective study based on data from the Northern Alps Emergency Network compared characteristics of OHCA between cases in and out the workplace, and between cases occurring from January 2004 to December 2010 and from January 2011 to December 2017. Among the 15,320 OHCA cases included, 320 occurred in the workplace (2.1%). They were more often in younger men, and happened more frequently in an area with access to public defibrillation, had more often a shockable rhythm, had a cardiopulmonary resuscitation started by a bystander more frequently, and had a better outcome. Cardiopulmonary resuscitation started by a bystander was the only chain of survival link that improved for cases occurring after December 2010. Workplace OHCA seems to be managed more effectively than others; however, only a slight survival improvement was observed, suggesting that progress is still needed.

• Neonatal Medicine
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• v.25 no.1
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• pp.29-36
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• 2018

Purpose: The purpose of this study was to investigate the outcome after changes in the treatment strategies for very low birth weight infant (VLBWI) in a single neonatal intensive care unit (NICU) center. Methods: We performed a retrospective review of 300 VLBWI born from 1st January 2010 to 31th December 2016. We compared the outcomes including survival rate, birth weight (BW), gestational age (GA), and morbidities between period I (2010-2013, P-I) and period II (2014-2016, P-II). Results: The average survival rate was not different between P-I and P-II. However, the survival rate of ${\leq}24$ weeks' GA, 25 weeks' GA, 26 weeks' GA were 57%, 69%, 93% respectively in P-II and 31%, 59%, 87% in P-I respectively. The survival rate of infants with birth weight <500 g, 500-749 g, 750-999 g were 100%, 55%, 90% respectively in P- II and 50%, 24%, 80%, respectively in P-I. The incidence of bronchopulmonary dysplasia (BPD) was higher in P-II than in P-I (P=0.012) and moderate-to-severe BPD was also higher in P-II (P=0.004). Incidence of patent ductus arteriosus (PDA) with treatment, necrotizing enterocolitis (stage ${\geq}2$), and abnormal brain sonography were significantly lower in P-II (P=0.027, P=0.032, P=0.005). Incidences of retinopathy of prematurity (ROP) with laser treatment and early sepsis were not different. Conclusion: The survival rate and complications of VLBWI were improved in period II, especially in less than 750 g and below 26 weeks, except incidence of BPD. Changes of NICU strategies were effective to improve mortality and morbidity in VLBWI.

• IMMUNE NETWORK
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• v.21 no.3
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• pp.24.1-24.13
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• 2021

Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid to the development of artificial blood using other animals. Although mini-pigs are candidate animals, contamination of mini-pig T cells in artificial blood may cause a major safety concern. Therefore, it is important to analyze the cross-reactivity of IL-7, the major survival factor for T lymphocytes, between human, mouse, and mini-pig. Thus, we compared the protein sequences of IL-7 and found that porcine IL-7 was evolutionarily different from human IL-7. We also observed that when porcine T cells were cultured with either human or mouse IL-7, these cells did not increase the survival or proliferation compared to negative controls. These results suggest that porcine T cells do not recognize human or mouse IL-7 as their survival factor.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.734-741
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• 2002

The importance of efficient Supply Chain Management is increasing in accordance with recent industrial environment, such as globalization of business, complexity and diversity of company's management structure, and variety of customer's demand. In a rapidly changed environment of business, quick and efficient decision making is the important matter to the survival of the company. The purpose of this study supports decision making for efficient supply chain management. In this study, we consider simultaneously and mutually reflecting the preference of each constituent (Supplier, Manufacturing plant, Distribution center, Customer) on supply chain network, and decide company's strategic choice and coordinated production/distribution models of company. The Analytical Hierarchy Process is used for decision making of qualitative and quantitative elements. We use the results of AHP as inputs and propose mathematical models thru Mixed Integer Programming.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.22 no.5
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• pp.1007-1017
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• 1997

The existing survivability measure is defined as the only ratio of survival traffic volume on the given traffic demand. In this paper we suggest a new network survivability evaluation model. Sinceit depends on the importance of traffic, we can evaluatethe affect of telecommunication disaster. With the suggested evaluation model we formulate optimization models for restoration paths and traffic assinment on them. The optimization models are represented as mixed integer programming problems, which are difficult to find exact solutions. We develop heuristic algorithms according to the optimization models and apply them to an example network with 10 nodes and 17 links.

• Journal of Internet Computing and Services
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• v.19 no.6
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• pp.113-123
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• 2018

This study was conducted to empirically verify the effect of the technological entrepreneurship, network capability and technological innovation capability on the innovative performance of technology-based start-ups with the aim of determining the success factors of technology-based start-ups by defining the success of technology-based start-ups as the innovative performance through technology innovation activities. For the significance of this study, it suggested the importance of technology innovation as a survival strategy of technology-based start-ups, verified the dimensions, relationship and roles of technological entrepreneurship, network capability and technology innovation capability, thereby proving the theoretical expansion. This study has determined the success factors of technology-based start-ups and thereby suggested the strategic directions for enhancing the competitiveness of technology-based start-ups.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.10a
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• pp.457-458
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• 2022

The dissolved oxygen (DO) is one of the factors of ecosystem that affects survival of aquatic life. Artificial neural network - XGboost (ANN-XGB), which was trained by water quality and weather data obtained at Anyang-streamto, was employed to forecast DO after 1 hours. We document the perforamnce of ANN-XGB.

• IMMUNE NETWORK
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• v.11 no.6
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• pp.336-341
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• 2011

T cell receptor (TCR) signaling plays a critical role in T cell development, survival and differentiation. In the thymus, quantitative and/or qualitative differences in TCR signaling determine the fate of developing thymocytes and lead to positive and negative selection. Recently, it has been suggested that self-reactive T cells, escape from negative selection, should be suppressed in the periphery by regulatory T cells (Tregs) expressing Foxp3 transcription factor. Foxp3 is a master factor that is critical for not only development and survival but also suppressive activity of Treg. However, signals that determine Treg fate are not completely understood. The availability of mutant mice which harbor mutations in TCR signaling mediators will certainly allow to delineate signaling events that control intrathymic (natural) Treg (nTreg) development. Thus, we summarize the recent progress on the role of TCR signaling cascade components in nTreg development from the studies with murine model.

• Molecules and Cells
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• v.37 no.3
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• pp.189-195
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• 2014

The NF-${\kappa}B$ pathway transcriptionally controls a large set of target genes that play important roles in cell survival, inflammation, and immune responses. While many studies showed anti-tumorigenic and pro-survival role of NF-${\kappa}B$ in cancer cells, recent findings postulate that NF-${\kappa}B$ participates in a senescence-associated cytokine response, thereby suggesting a tumor restraining role of NF-${\kappa}B$. In this review, we discuss implications of the NF-${\kappa}B$ signaling pathway in cancer. Particularly, we emphasize the connection of NF-${\kappa}B$ with cellular senescence as a response to chemotherapy, and furthermore, present examples how distinct oncogenic network contexts surrounding NF-${\kappa}B$ produce fundamentally different treatment outcomes in aggressive B-cell lymphomas as an example.