• Korean Journal of Radiology
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• 제24권8호
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• pp.729-738
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• 2023

Objective: When multiple surveillance mammograms are performed within an annual interval, the current guidance for oneyear follow-up to determine breast cancer status results in shared follow-up periods in which a single breast cancer diagnosis can be attributed to multiple preceding examinations, posing a challenge for standardized performance assessment. We assessed the impact of using follow-up periods that eliminate the artifactual inflation of second breast cancer diagnoses. Materials and Methods: We evaluated surveillance mammograms from 2007-2016 in women with treated breast cancer linked with tumor registry and pathology outcomes. Second breast cancers included ductal carcinoma in situ or invasive breast cancer diagnosed during one-year follow-up. The cancer detection rate, interval cancer rate, sensitivity, and specificity were compared using different follow-up periods: standard one-year follow-up per the American College of Radiology versus follow-up that was shortened at the next surveillance mammogram if less than one year (truncated follow-up). Performance measures were calculated overall and by indication (screening, evaluation for breast problem, and short interval follow-up). Results: Of 117971 surveillance mammograms, 20% (n = 23533) were followed by another surveillance mammogram within one year. Standard follow-up identified 1597 mammograms that were associated with second breast cancers. With truncated follow-up, the breast cancer status of 179 mammograms (11.2%) was revised, resulting in 1418 mammograms associated with unique second breast cancers. The interval cancer rate decreased with truncated versus standard follow-up (3.6 versus 4.9 per 1000 mammograms, respectively), with a difference (95% confidence interval [CI]) of -1.3 (-1.6, -1.1). The overall sensitivity increased to 70.4% from 63.7%, for the truncated versus standard follow-up, with a difference (95% CI) of 6.6% (5.6%, 7.7%). The specificity remained stable at 98.1%. Conclusion: Truncated follow-up, if less than one year to the next surveillance mammogram, enabled second breast cancers to be associated with a single preceding mammogram and resulted in more accurate estimates of diagnostic performance for national benchmarks.

• 대한산업공학회지
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• 제42권2호
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• pp.129-137
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• 2016

A colonoscopy is important because it detects the presence of polyps in the colon that can lead to colon cancer. How often one needs to repeat a colonoscopy may depend on various factors. The main purpose of this study is to determine personalized surveillance interval of colonoscopy based on characteristics of patients including their clinical information. The clustering analysis using a partitioning around medoids algorithm was conducted on 625 patients who had a medical examination at Korea University Anam Hospital and found several subgroups of patients. For each cluster, we then performed survival analysis that provides the probability of having polyps according to the number of days until next visit. The results of survival analysis indicated that different survival distributions exist among different patients' groups. We believe that the procedure proposed in this study can provide the patients with personalized medical information about how often they need to repeat a colonoscopy.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1994년도 교수 연수회(환경)
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• pp.651-657
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• 1994

To assess quantitatively the association between benzene exposure and leukemia, we examined the mortality rate of a cohort with occupational exposure to benzene. Cumulative exposure for each cohort member was estimated from historical air-sampling data and, when no sampling data existed, from interpolation on the basis of existing data. The overall standardized mortality ratio (a measure of relative risk multiplied by 100) for leukemia was 337 (95 percent confidence interval, 154 to 641), and that for multiple myeloma was 409 (95 percent confidence interval, 110 to 1047). With stratification according to levels of cumulative exposure, the standardized mortality ratios for leukemia increased from 109 to 322, 1186, and 6637 with increases in cumulative benzene exposure from less than 40 parts per million-years (ppm-years), to 40 to 199, 200 to 399, and 400 or more. respectively. A cumulative benzene exposure of 400 ppm years is equivalent to a mean annual exposure of 10 ppm over a 40-year working lifetime; 10 ppm is the currently enforceable standard in the United States for occupational exposure to benzene. To examine the shape of the exposure-response relation, we performed a conditional logistic-regression analysis, in which 10 controls were matched to each cohort member with leukemia. From this model, it can be calculated that protection from benzene induced leukemia would increase exponentially with any reduction in the permissible exposure limit.

• Clinical and Experimental Pediatrics
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• 제55권12호
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• pp.455-461
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• 2012

Following the Five Year Measles Elimination Program, measles has been declared eliminated from the Republic of Korea since 2006. However, there remain challenges related to the surveillance of measles in the postelimination phase. Even though the routine surveillance system has revealed a gradual decrease in the number of reported cases since 2002, 4 resurgences have occurred, notably due to outbreaks. Because vaccine-modified measles is becoming widespread due to high vaccination coverage, conducting laboratory confirmation in each case becomes important. Moreover, susceptible individuals with measles have been identified through seroprevalence studies. Lastly, the efforts to improve the timeliness of measles reporting have led to the establishment of an active laboratory-based surveillance network, which has shortened the interval between diagnosis and notification. In these circumstances, searching for more sensitive and effective surveillance measures is important for maintaining the elimination status and preventing future outbreaks of measles in Korea.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1999년도 추계학술발표회요약집
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• pp.89.2-89
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• 1999

• Journal of Astronomy and Space Sciences
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• 제28권3호
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• pp.193-201
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• 2011

A strategy for geostationary orbit (or geostationary earth orbit [GEO]) surveillance based on optical angular observations is presented in this study. For the dynamic model, precise analytical orbit model developed by Lee et al. (1997) is used to improve computation performance and the unscented Kalman filer (UKF) is applied as a real-time filtering method. The UKF is known to perform well under highly nonlinear conditions such as surveillance in this study. The strategy that combines the analytical orbit propagation model and the UKF is tested for various conditions like different level of initial error and different level of measurement noise. The dependencies on observation interval and number of ground station are also tested. The test results shows that the GEO orbit determination based on the UKF and the analytical orbit model can be applied to GEO orbit tracking and surveillance effectively.

• The Korean journal of internal medicine
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• 제39권4호
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• pp.547-554
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• 2024

The incidence and mortality of colorectal cancer (CRC) have decreased through regular screening colonoscopy, surveillance, and endoscopic treatment. However, CRC can still be diagnosed after negative colonoscopy. Such CRC is called interval CRC and accounts for 1.8-9.0% of all CRC cases. Most cases of interval CRC originate from missed lesions and incompletely resected lesions. Interval CRC can be minimized by improving the quality of colonoscopy. This has led to a growing interest in and demand for high-quality colonoscopy. It is important to reduce the risk of CRC and its associated mortality by improving the quality of colonoscopy. In this review article, we provide an overview of colonoscopy quality indicators, including bowel preparation adequacy, the cecal intubation rate, the adenoma detection rate, the colonoscopy withdrawal time, appropriate polypectomy, and complication of the procedure. Because colonoscopy is a highly endoscopist-dependent procedure, colonoscopists should be well-acquainted with quality indicators and strive to apply them in daily clinical practice for the prevention of CRC.

• Journal of Astronomy and Space Sciences
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• 제26권4호
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• pp.529-546
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• 2009

인공위성 광학 감시 시스템 적용에 가장 효과적인 고전적 예비궤도 결정법은 Gauss와 Laplace 방법이 있다. 이 두 방법은 세 쌍의 광학 관측 자료를 이용하여 위성의 궤도를 결정하는 방법으로 관측 시간간격에 따라 정밀도가 변화하는 특성이 있다. 이번 연구에서는 이러한 특성에 관련된 국내의 기존 연구 결과들에서 일부 상이한 점을 발견하여, 세 점의 시간간격에 대한 정밀도 변화 특성을 재검토해 보았다. 이러한 특성 연구는 다양한 위성 궤도 형태를 고려해야 하기 때문에 궤도 정보가 알려진 위성 전체를 대상으로 하였다. SGP4/SDP4 궤도전파 모델을 이용한 모의 관측 자료를 사용하여 방법론적인 정밀도 특성 을 확인하였고, 특정 위성의 실제 관측 자료를 사용 하여 인공위성 광학 감시 시스템에 적용할 시에 발생되는 특성을 확인하였다. 결과적으로, 세 점의 시간간격에 대한 최기궤도 결정의 정밀도 변화 특성은 관측된 위성의 위치로 인해 달라질 수 있음을 확인하였다.

• 한국항행학회논문지
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• 제18권4호
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• pp.278-287
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• 2014

ADS-B는 지속적으로 증가하는 항공 수요에 대응하기 위해 새롭게 개발된 항공 감시 기술로 레이더에 비해 높은 정확도와 빠른 갱신 주기를 제공하여 레이더를 대체하거나 보완할 수 있을 것으로 주목받고 있다. 하지만 지상 시스템과 항공기 간의 정보 교환에 무선 데이터링크를 사용하며 지상 시스템 내부의 정보 교환에 무결성이 보장되지 않는 프로토콜을 사용하기 때문에 ADS-B 시스템의 운용 상태를 감시할 수 있는 시스템이 반드시 필요하다. 본 논문에서는 ADS-B 시스템의 운용 상태 감시 기능과 더불어 ADS-B 감시 자료, 레이더 감시 자료, 비행 정보를 활용하여 항공 교통 상황을 종합적으로 현시할 수 있는 항공 교통 상황 종합 현시 기능을 갖는 ADS-B 모니터링 시스템을 설계하고 구현하였다. 구현한 시스템은 직접 구성한 ADS-B 지상 시스템과 연결하여 비행중인 항공기의 ADS-B 감시 자료와 레이더 감시 자료, 가상의 비행 정보를 수신한 뒤 현시하는 방법을 통하여 검증하였다.

• Journal of Yeungnam Medical Science
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• 제40권1호
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• pp.65-77
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• 2023

Background: This study aimed to compare clinical outcomes between surveillance and adjuvant therapy (AT) groups after R0 resection for cholangiocarcinoma (CCA). Methods: A total of 154 patients who underwent R0 resection for CCA at the Daegu Catholic University Medical Center between January 2010 and December 2019 were included. Overall survival (OS) and progression-free survival (PFS) were analyzed. Results: The median follow-up duration was 899 days. There were 109 patients in the AT group and 45 patients in the surveillance group. The patients in the AT group were younger (67 years vs. 74 years, p<0.001) and included more males (64.2% vs. 46.7%, p=0.044). The proportion of patients with stage III CCA was larger in the AT group than in the surveillance group (13.8% vs. 2.2%, p=0.005). In addition, AT did not improve OS (5-year OS rate, 69.3% in the AT group vs. 64.2% in the surveillance group, p=0.806) or PFS (5-year PFS rate, 42.6% in the AT group vs. 48.9% in the surveillance group, p=0.113). In multivariate analysis using the Cox proportional hazards model, stage III CCA (hazard ratio [HR], 10.81; 95% confidence interval [CI], 2.92-40.00; p<0.001) was a significant predictor of OS. American Society of Anesthesiologists classification II (HR, 0.50; 95% CI, 0.31-0.81; p=0.005), and American Joint Committee on Cancer stages II (HR, 3.14; 95% CI, 1.25-7.89; p=0.015) and III (HR, 8.08; 95% CI, 2.80-23.32; p<0.001) were independent predictors of PFS. Conclusion: AT after R0 resection for CCA did not improve OS or PFS.