• Korean Journal of Veterinary Research
• /
• v.34 no.4
• /
• pp.735-744
• /
• 1994

Catheters were placed into the external jugular veins of immature female rats. On the following day (day 28 of age), the animals were injected subcutaneously with pregnant mare serm gonadotropin(PMSG): 4IU(control) or 20IU(superovulation). Each animal was sequentially bled at Ohr and 12hr and subsequently at 6hr intervals until sacrifice at 72hr after PMSG. The superovulatory dose of PMSG significantly(P<0.05) increased the ovulatory response by 4.0 fold above controls. On the other hand, superovulated oocytes displayed considerably different stages of meiotic maturation: prophase I (14.7%), anaphase I (36.2%), telophase I (10.3%), metaphase I/II (32.4%), while in control rats a majority of the oocytes examined(94.0%) consistently showed a metaphase II configuration. Serum luteinizing hormone(LH) levels were determined by RIA. Both groups exhibited a similar time relationship with two distinct peaks: an initial slight rise at 0-18hr and a second sharp rise at 54-60hr. However, there was a marked change in the magnitude of LH levels between the two groups. In superovulated animals, prior to the second peak, overall LH levels were significantly(P<0.001) higher than controls. In contrast, at the peak occurring at 60hr, LH concentrations were significantly(P<0.001) reduced by 54% below that of control. Additionally, a maximum increase of mean ${\Delta}LH$ between two peaks was much less in superovulated as compared to control rats. The initial prolonged elevation of serum LH before 54hr in superovulated rats was found to result from actual cross-reaction of the injected PMSG with LH antibody in the assay, while a precipitous second elevation between 54hr and 60hr resulted primarily from an endogenous LH surge. This study clearly defines time-course features of serum LH in PMSG-treated rats. The overall results indicate that, following superovulatory treatment with PMSG, the increased ovulatory response is primarily associated with PMSG-derived intrinsic gonadotropin, and that the recovery of immature or asynchronously mature oocytes at ovulation may reult from the circulatory alteration of LH activity characterized by an initial prolonged elevation of serum LH and its subsequent attenuation.

• Journal of Pharmaceutical Investigation
• /
• v.33 no.1
• /
• pp.67-71
• /
• 2003

Drug excipients are material used in the formulation of pharmacologically active drugs. They have a variety of roles including dilutents/fillers/bulking agents, binders/adhesives, propellant, disintegrants, lubricants/dlidants, colors, flavors, coating agents, polising agents, fragrance, sweeteening agent, polymers and waxes. Excipient should be inert or inactive and does not interfere with the test. Nowadays within industry there has been a recent surge of interest in novel excipient for novel dosage forms. The purpose of the review is to introduce the administration systems of drug excipient about kinds, matters to be attended to change of excipients.

• Transactions of The Korea Fluid Power Systems Society
• /
• v.7 no.2
• /
• pp.19-26
• /
• 2010

The typical trunk lid system for vehicle is composed of a hinge having 4-bar link and gas lifter. Here, the energy regenerative brake of hydraulic driven systems is applied to the tail gate system for vehicle and removed the gas lifter. The new tail gate system is composed of a hydraulic pump by electric motor, a hydraulic motor, four check valves, an accumulator, a relief valve and a directional control valve. The dynamic characteristics of the hydraulic motor system, such as the surge pressure and response time, are investigated in both brake action and acceleration action. The capacity selection method of accumulator by mathematical model is based upon trial and error approach and computer simulation by AMEsim software is carried out.

• Journal of the Korean Society for Precision Engineering
• /
• v.5 no.2
• /
• pp.33-42
• /
• 1988

In a large scale oil hydraulic system having repeatedly operated actuator, such as a large scale forging press, pressure surges often due to the recombination of oil column in a return line attached to the downstream side of a directional control valve. Expecially, the pressure surges appear very severe ones at a certain valve operating frequency. These pressure surges restrict the operating frequency of the hydraulic system. But related reports on the above mentioned phenomenon are rarely to be found. In this study, therefore, the authors investigate the exact reason why such severe pressure surges occur at a certain range of valve operating frequency. The study is performed by experiment and numerical computation on the relationship between pressure surges and valve operating frequency.

• Journal of Mechanical Science and Technology
• /
• v.15 no.2
• /
• pp.232-238
• /
• 2001

Fast Fourier Transformation is employed to convert the head variation of a pipeline in the time domain to the amplitude of the frequency domain. Applying method of characteristics to a pipeline provides a significant frequency range for a surge introduced from the valve modulation. Inverse Fast Fourier Transformation and a Finite Impulse Response Filter can be used to remove any possible noise existing from the significant frequency range of an unsteady condition. A filtered signal shows higher potential for the inverse calculation of leakage detection than the noise-added signal does. The respective performances of Inverse Fast Fourier Transformation and a Finite Impulse Response Filter are compared in terms of leakage detection capability. Characteristics of the frequency range for multiple leakages were investigated to validate the effectiveness of the noise control method in the frequency domain.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.16 no.2
• /
• pp.191-199
• /
• 1992

This paper presents in experimental study of the dynamic internal pressure within an oil hydraulic vane pump. The measurements of the dynamic internal pressures near the vane of a pressure balance type of an oil hydraulic vane pump with intravanes has been made to provide the essential information for the study of the pump dynamics and control, the pump design and the analysis of tribological problems in the sliding components. The influences of the discharge pressure and rotating speed of the vane on the dynamic pressure in four chambers surrounding a vane have been investigated. The results indicate that the surge pressures of the chambers at the instant moment of discharge and closure are affected by the rotating speed. The pressure in the intravane chamber maintains almost constant values, which remarkably effects the pulsating discharge pressure.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2012.05a
• /
• pp.211-212
• /
• 2012

Over the years, the recovery of the domestic construction market, which does not appear on the reverse, but rather due to a surge of construction materials cost of the construction sector is experiencing greater difficulties. Cement raw materials in the manufacturing process, if some of the waste recycling, cites quality control for products and measures for the thorough management is needed. In this study, three companies of the past four years in the production of cement against doejin physical performance test results conducted yearly and seasonal trends by analyzing changes in the years to review the cement for cement to utilize as a basis for management points is.

• Archives of Plastic Surgery
• /
• v.40 no.3
• /
• pp.263-266
• /
• 2013

Bleeding, is one of the most common postoperative complications after palatoplasty in patients with cleft palate. The purpose of this article is to present our experience using a Foley catheter balloon for perioperative palatoplasty bleeding management. A retrospective data analysis was performed for all cases of palatoplasty performed by the author from 1999 to 2012 that experienced postoperative hemorrhage. These patients were managed by utilizing posterior nasal compression with a Foley catheter balloon for the period 2006 to 2012. We have compared two methods (we use before 2006 the reoperative method) with regards to the later development of palatal fistulae and cases with reoperative hemostasis. The study found no statistically significant differences between the conventional and proposed method in relation to the development of palatal fistulae (P=0.7). These findings suggest that nasal packing using a Foley balloon is a safe and effective method for postoperative bleeding control after palatoplasty in patients with cleft palate.

• Water for future
• /
• v.12 no.2
• /
• pp.49-55
• /
• 1979

The purpose of this study is to develope the computer program to compute the unsteady, transient flow conditions in a hydraulic system. The unstready flow condition may be brought about due to power failure to pump motors, pump start-up or modulation of control valve. The program was written specially for analyzing the water-hammer in the pumping system. The pumping system which can be simulated by the program can contain pipelines, tunnel, surge tanks, branched lines, reservoirs, dead end pipes and valve controls. The use of a computer program to analyze haydranlic transients is of great benifit to the designers of transmission main and distribution systems. Advantages include time savings, the ability to analyze complex piping systems, and increased accuracy. The author outlines a pogram developed for the above system.

• Proceedings of the KIEE Conference
• /
• 1998.07e
• /
• pp.1578-1582
• /
• 1998

The ground potential rise generated by the switching surge or lightning stroke may be dangerous to personnel and cause damage to electronic control parts. For a first step to the transient performance analysis. high frequency impedances of grounding grids have been calculated and discussed. Grounding grids include 7 square grids from $10m{\times}10m$ to $80m{\times}80m$. The high frequency current was injected into the center and a corner of the grounding grid. The calculation results indicate that the impedance of the grounding grid is significantly influenced by frequency and the point of injection of the current. and the effective radius of a large grounding grid may be represented in $15{\sim}20m$.