• Pediatric Infection and Vaccine
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• v.16 no.2
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• pp.199-204
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• 2009

Purpose : Various proteins encoded in the early region 3 (E3) of adenoviruses protect cells from being killed by cytotoxic T cells and death-inducing cytokines. We sought to find out whether the genetic heterogeneity of the E3 gene might contribute to the molecular diversity of adenoviruses. Methods : Sequences in the E3 region were analyzed for 14 adenovirus type 3 (Ad3) strains that were isolated from children with lower respiratory tract infections in the Seoul National University Children's Hospital during the period 1991-2000. Full-length adenoviral DNA was purified from the infected A549 cell lysates using a modified Hirt procedure. Results : There was 98% homology between 14 Korean Ad3 strains with a reference strain (M15952). Homology within the Korean Ad3 strains was 98.7%. Variation was found in the region of transcripts 20.1 kDa, 20.6 kDa, truncated 7.7 kDa, 10.3 kDa, 14.9 kDa, and 15.3 kDa. In particular, all 14 Korean strains showed a missense single point mutation at the start codon of the truncated 7.7 kDa. In addition, a deletion was found in the truncated 7.7 kDa region by 58 base pairs in 10 strains and 94 base pairs in 4 strains. Variations in amino acids were observed in the receptor internalization and degradation complex (10.3 kDa/14.9 kDa) which stimulates the clearance from the cell surface and subsequent degradation of the receptors for the Fas ligand and TRAIL, while no variations were observed in another immunoregulatory transcript, 19 kDa. Conclusion : Sequence analysis of the immunoregulatory region of adenovirus E3 shows that genetic heterogeneities are related to genome type patterns.

• Journal of the Korean Wood Science and Technology
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• v.38 no.6
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• pp.587-601
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• 2010

This review attempted to overview characteristics of nanocellulose from various sources, its isolation methods, and properties of nanocellulose-based nanocomposites. Currently, nanocelluloses could be obtained from a variety of cellulose sources, including wood pulp, tunicate, bacterial cellulose etc., and are isolated by various ways such as chemical, physical, or biological methods. The length and width of nanocellulose is in the range of 100~300 nm long and 5~50 nm wide although characteristics of nanocellulose shows a wide variability, depending on sources and isolation method. Nanocellulose is also being used as a reinforcement in the nanocomposites via various methods. Many water soluble polymers were reinforced by the incorporation of nanocellulose, which significantly improves tensile and storage moduli of the nanocomposites. In order to be used for hydrophobic polymers, the surface of nanocellulose was modified. Even though there is a significant progress in the utilization of nanocellulose as a reinforcement of polymers, further research is required to find a niche market of nanocellulose-reinforced nanocomposites. In addition, isolation methods of producing the nanocellulose in a large quantity for commercial applications should be developed to extend the application of nanocellulose-based bio-nanocomposites in future.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.8 no.1
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• pp.35-43
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• 2003

Recent geomorphological changes and late Quaternary depositional sequences of Gwangyang Bay are studied based on bathymetric maps, surface sediments, and seismic profiles. As a result of the reclamation of coastal area for an industrial complex construction, the coastline of Gwangyang Bay has rapidly been changed and the area of it has now been reduced by about 25 ％ in the last 30 years. In addition, the bottom topography is actively modified by dredging for navigation channels. In surfical sediment distribution, the western part of Gwangyang Bay is dominated by mud facies, whereas the eastern part of the Bay is dominated by sand-mud mixing facies. Depositional sequences above the basement are divided into two units: Unit I in upper layer and Unit II in lower one. These depositional units are unconformably bounded by middle reflector-M. Unit II, mostly occupying the channel areas, is interpreted as fluvial-origin deposits during sea-level lowstand. Unit I typically shows a progradational pattern from the Seomjin River mouth to the Yeosu Strait, which is interpreted as deltaic deposits supplied from the Seomjin River during the Holocene sea-level highstand. The shallow gas within the sediments Is widely distributed in most area, and locally exposed onto the sea-bed due to dredging.

• Clinics in Shoulder and Elbow
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• v.16 no.2
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• pp.163-169
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• 2013

Designs of total elbow arthroplasty have been evolving with clinical experiences. Newer implants are expected to resolve current limitations and improve long term outcomes. This review article focuses on the basic knowledge of unlinked and convertible total elbow arthroplasty. There have been a variety of designs of unlinked total elbow prostheses. Some implants are still used in the market, while others are no longer commercially available. Modified and newer designs include more congruent contact surface, stemmed implant, and radiocapitellar arthroplasty. Two convertible elbow prostheses have been developed, and one implant is currently available in Korea. Conversion from an unlinked to a linked mode is performed by adding a linking cap. Unlinked total elbow arthroplasty, which restores native elbow kinematics, has a biomechanical rationale of lowering polyethylene wear and loosening of implants. It can be indicated in younger and higher demand patients, who have adequate bone stock and soft tissues. Convertible total elbow arthroplasty broadens implant selection and simplifies revision surgery. These newer prostheses possibly improve the long term outcomes and resolve disadvantages of linked prostheses in total elbow arthroplasty.

• Journal of Navigation and Port Research
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• v.30 no.8 s.114
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• pp.711-719
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• 2006

A series of geotechnical centrifuge model tests and numerical modelling have been performed to study engineering characteristics of the composite ground reinforced by both the Sand Compaction Piles(SCPs) and the deformation-reducing sheet piles. The research has covered several key issues such as the load-settlement relation, the stress concentration ratio and the final water content of the ground Totally three centrifuge tests have been conducted by changing configuration of the sheet piles, i.e., a test without the sheet pile, a test with the sheet pile at a single side and a test with the sheet piles at the both sides. In the model tests, a vertical load was applied in-flight on the ground surface. On the other hand, class-C type numerical modelling has been performed by using the SAGE-CRISP to compare the centrifuge test results using an elasto-plastic model for SCPs and the Modified Cam Clay model for the soft clay. It has been found that the sheet piles can restraint failure of foundation, thereby increasing yield stress of the ground. The stress concentration ratio was in the range of $2{\sim}4$. In addition, numerical analysis results showed reductions both in the ground heave($20{\sim}30%$) and in the horizontal movement($28{\sim}43%$), demonstrating the deformation-reducing effect of the sheet piles.

• Science of Emotion and Sensibility
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• v.8 no.4
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• pp.393-402
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• 2005

Subjective touch sensation for Korean traditional silk fabrics was evaluated, in order to compare tactile sensory aspects of Korean and American subjects and to determine mechanical properties of the fabrics affecting the sensation psychophysically. Eight aspects of touch sensation including hardness, smoothness, coarseness, coolness, pliability, crispness, heaviness, and thickness were rated by semantic deferential scale. The mechanical properties of fabrics were measured by Kawabata Evaluation System (KES). Both of Koreans and Americans showed fairly similarities to each other in subjective smoothness, coarseness, and crispness. On the contrary, as for coolness and pliability, Koreans were found as feeling the silk fabrics more sensitively than Americans were in that they rated some of modified leno fabrics as very cool and stiff in touch. Coolness and pliability by Koreans were affected mainly by surface and bending properties while those by Americans were determined mostly by compressional and tensile characteristics as well as sulfate properties

• Applied Chemistry for Engineering
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• v.17 no.5
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• pp.458-464
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• 2006

The Pd-Ni-Ag alloy composite membrane using modified porous stainless steel (PSS) as a substrate was prepared by a electroless plating technique. In this work, we have introduced the intermediate layer between Pd-based alloy and a metal substrate. As an intermediate layer, the mixtures of nickel powder and inorganic sol such as $SiO_{2}$ sol, $Al_{2}O_{3}$ sol, and $TiO_{2}$ sol were used. The intermediate layers were coated onto a PSS substrate according to various membrane preparation conditions and then $N_{2}$ fluxes through the membranes with different intermediate layers were measured. The surface morphology of the intermediate layer in the mixture of nickel powder and inorganic sol was analyzed using scanning electron microscope (SEM). Finally, the Pd-Ni-Ag alloy composite membrane using the support coated with the mixture of nickel powder and silica as an intermediate layer was fabricated and then the gas permeances for $H_{2}$ and $N_{2}$ through the Pd-based membrane were investigated. The selectivity of $H_2/N_2$ was infinite and the $H_{2}$ flux was $1.39{\times}10^{-2}mol/m^2{\cdot}s$ at the temperature of $500^{\circ}C$ and trans-membrane pressure difference of 1 bar.

• Journal of the Korean Geotechnical Society
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• v.20 no.2
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• pp.87-96
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• 2004

Application of the soil nailing method is continuously extending in maintaining stable excavations and slopes. However, ground anchor support system occasionally may not be used because of space limitations in urban excavation sites nearby the existing structures. In this case, soil nailing system with relatively short length of nails could be efficiently adopted as an alternative method. The general soil nailing support system, however, may result in excessive deformations particularly in an excavation zone of the existing weak subsoils. Pretensioning the soil nails then could play important roles to reduce deformations mainly in an upper part of the nailed-soil excavation system as well as to improve local stability. In this study, a newly modified soil nailing technology named as the PSN (Pretension Soil Nailing) is developed to reduce both facing displacements and ground surface settlements in top-down excavation process as well as to increase the global stability. Up to now, the PSN system has been investigated mainly focusing on an establishment of the design procedure. In the present study, laboratory model tests are carried out to investigate the failure mechanism and behavior characteristics of the PSN system. Various results of model tests are also analyzed to provide a fundamental basis for the efficient design.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.29 no.3
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• pp.151-156
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• 2003

This study was performed to develop a useful nerve conduit which provides favorable environment for Schwann cell viability and proliferation. Milipore membrane of $0.45{\mu}m$ pore size was selected because it permits nutritional inflow from the outside of the conduit and prevents from invading the fibrotic tissue into the conduit. The membrane was rolled and sealed to form a conduit of 2mm diameter and 20mm length. To improve the axonal regeneration and to render better environment for endogenous and exogenous Schwann cell behaviour, the microgeometry and surface of conduit was modified by coating with thin film of calcium phosphate. Cellular viability within the conduit and attachment to its wall were assessed with MTT assay and SEM study. Milipore filter conduit showed significantly higher rate of Schwann cell attachment and viability than the culture dish. However, the reverse was true in case of fibroblast. Coating with thin film of low crystalline calcium phosphate made more favorable environment for both cells with minimal change of pore size. These findings means the porous calcium phosphate coated milipore nerve conduit can provide much favorable environment for endogenous Schwann cell proliferation and exogenous ones, which are filled within the conduit for the more advanced strategy of peripheral nerve regeneration, with potential of reducing fibrotic tissue production.

• Polymer(Korea)
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• v.35 no.2
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• pp.157-160
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• 2011

In this paper, poly (dimethyl siloxane) (PDMS) was modified using electron beam irradiation and its property was investigated. PDMS sheets prepared using a conventional thermal curing method were irradiated by electron beams at absorbed doses between 20 and 200 kGy and their properties were characterized using swelling degree and contact angle measurements, universal testing machine (UTM), thermogravimetric analyzer (TGA), and X -ray photoelectron spectrometer (XPS). The results of the swelling degree measurements, UTM, and TGA revealed that the swelling degree of the irradiated PDMS sheets was reduced down to 24% in comparison to the control sheet, and their compression strength and thermal decomposition temperature increased up to maximum 2.5 MFa and $10^{\circ}C$, respectively, due to the increase in crosslinking density by irradiation. In addition, on the basis of the results of contact angle measurements and XPS, the wettability of the PDMS sheets was enhanced up to 24% owing to the generation of hydrophilic functional groups on the PDMS surface by oxidation during electron beam irradiation.