• Clinical and Experimental Reproductive Medicine
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• v.41 no.3
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• pp.97-107
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• 2014

The placenta is a temporary fetomaternal organ capable of supporting fetal growth and development during pregnancy. In particular, abnormal development and dysfunction of the placenta due to cha nges in the proliferation, differentiation, cell death, and invasion of trophoblasts induce several gynecological diseases as well as abnormal fetal development. Autophagy is a catalytic process that maintains cellular structures by recycling building blocks derived from damaged microorganelles or proteins resulting from digestion in lysosomes. Additionally, autophagy is necessary to maintain homeostasis during cellular growth, development, and differentiation, and to protect cells from nutritional deficiencies or factors related to metabolism inhibition. Induced autophagy by various environmental factors has a dual role: it facilitates cellular survival in normal conditions, but the cascade of cellular death is accelerated by over-activated autophagy. Therefore, cellular death by autophagy has been known as programmed cell death type II. Autophagy causes or inhibits cellular death via the other mechanism, apoptosis, which is programmed cell death type I. Recently, it has been reported that autophagy increases in placenta-related obstetrical diseases such as preeclampsia and intrauterine growth retardation, although the mechanisms are still unclear. In particular, abnormal autophagic mechanisms prevent trophoblast invasion and inhibit trophoblast functions. Therefore, the objectives of this review are to examine the characteristics and functions of autophagy and to investigate the role of autophagy in the placenta and the trophoblast as a regulator of cell death.

• Journal of the Korean housing association
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• v.26 no.6
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• pp.61-69
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• 2015

Current criticism regarding the "uniformity" of Korean apartments has shown not only tendencies of emotional and unscholarly criticism, but also lack of academic discourse. They tend to stay at the common-sense level and be quite subjective without supporting facts. This research began with questioning the phenomenon of seeing Korean apartments as an object of negative criticism. The research questions for this study are: 1. Of the living space of so-called apartment houses, what elements should be called uniform?; 2. How should the implications of the findings be interpreted? In this context, this study aims to reinterpret criticisms on the uniformity of apartments from a new point of view. First, literature review is done to examine characteristics of Korean apartments in the social-cultural, economic, and physical contexts. Next, existing non-academic, abstract criticisms are classified into three trends, to show that the way of understanding architectural spaces by those criticisms are limited and weighted towards visual perceptions focused only on the shape of architectural structures. Finally, it is argued that the viewpoints of space and residents' experience should be treated as important for the reinterpretation of criticisms on the uniformity. This is validated through presenting relevant cases such as changes of space uses, diversified lifestyles being accepted, and the expansion of living space.

• Proceedings of the Korean Geotechical Society Conference
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• 2006.03a
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• pp.268-275
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• 2006

Excavation works of cylindrical shafts and tunnels for the construction of a variety of infrastructures have been frequently going on in the urban areas. When ground excavations of cylindrical shafts and shallow tunnels proceed in the ground condition of high water level and silt particle component, ground water drawdown involving soil particle migration causes loosening of ground around tunnels and shafts, causes settlement and deformation of ground. Damages due to ground sinking and differential settlement can occur in the adjacent ground and structures. The extent and possibility of damage relevant to ground water drawdown and soil particle migration can't be so precisely expected in advance that we will face terrible damages in case of minor carefulness. This paper introduces two examples of construction management where using incremental deformation graph of inclinometer, we noticed the possibility of soil migration due to ground water drawdown in the excavation process of vertical shaft and shallow tunnel, analysed a series of measurement data in coupled connection, properly prepared countermeasures, so came into safe and successful completion of excavation work without terrible damages. The effort of this article aims to improve and develop the technique of design and construction in the coming projects having similar ground condition and supporting method.

• Steel and Composite Structures
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• v.28 no.6
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• pp.709-718
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• 2018

Masonry walls are sometimes removed in buildings to either make new passages or increase the usable space. This may change the loading paths in the structure, and require new beams to transfer the loads which are carried by the masonry walls that are to be removed. One possible method of creating such new beams is to attach steel plates onto part of the existing walls to form a steel plate-masonry composite (SPMC) beam, leading to a new structure with part of the masonry wall supported by a new SPMC beam. This paper presents an experimental investigation into the interaction between the SPMC beam and the masonry wall above. Five SPMC beams supporting a masonry wall were tested to study the influence of parameters including the height-to-span ratio of the masonry wall, height of the beam and thickness of the steel plates. The test results, including failure mode, load-carrying capacity, load-deflection curves and strain distribution, are presented and discussed. It is found that for developing better arching effect in the masonry wall the ratio of the in-plane flexural stiffness of the masonry wall to the flexural stiffness of the SPMC beam must be between 2.8 and 7.1.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2001.09a
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• pp.107-114
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• 2001

When group pile supporting structures are to be subjected to large lateral loads, generally, hatter piles are used in group pile with vertical piles. It is well known that batter piles resist lateral static loads which are acted upon the piles as axial farces quite well but, they show a poor performance under seismic loads. However, it is not yet known how the batter piles behave under dynamic loading and how to strengthen the batter piles to improve the seismic performance. Shaking table tests were performed to investigate the seismic behavior of the batter pile and to bring up the countermeasures to improve the seismic performance. As the result of the shaking table tests, batter piles failed due to not only the excessive increase of compressive force near the pile head but also that of tensile force. In case that the pile head was connected with pile cap by rubber joint, the max. acceleration at the pile cap was reduced due to the high damping ratio of rubber and the max. moment and max. axial farce at the pile head was decreased remarkably. When the inclinations(V:H) of the batter pile were 8:3 and 8:4, max. moment, max. shear force, and max. axial farce were reduced notably and max. acceleration and max. displacement at the pile cap was diminished, too.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.05a
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• pp.125-130
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• 2004

The vibration and buckling characteristics of the capsule for fuel irradiation test are studied. The natural frequencies of the capsule in air and under water are obtained by modal testing and finite element(FE) analysis using ANSYS program, and accelerations with flow are measured to estimate the compatibility with the operation requirement of the HANARO reactor. The experimental fundamental frequency of the capsule in the x and z direction is 8.5Hz and 8.75Hz in air, and 7.5Hz and 7.75Hz under water, respectively. The maximum amplitude of accelerations under the normal operating condition is measured as 11.0m/s$^2$ that is within the allowable vibrational limit(18.99m/s$^2$) of the reactor structure. Also, the maximum displacement at 100% flow is calculated as 0.13mm which is not interference with other nearby structures. FE analysis results show that the natural frequencies are found to be similar to those of the modal testing when three supporting parts are considered as simply supported conditions. From the buckling analysis, when the loading tool is applied, the critical buckling load of the capsule is 233N.

• Journal of the Korean Vacuum Society
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• v.7 no.4
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• pp.285-292
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• 1998

The vacuum vessel of the KSTAR tokamak has a so large poloidal cross- section that workers can enter into the inside the vessel. To produce a clean plasma with low impurity concentrations it is planned that the whole vessel including plasma facing components will be baked out at $350^{\circ}C$ and the base pressure of the vessel will be kept in the range of ultra high vacuum. Large thermal stresses are expected during bake-outs to a three-dimensionally complex structure of the vessel, consequent ununiformity of the temperature distribution and support systems to resist forces acting on the vessel. In this report variations of the thermal stress according to temperature gradients on the vessel and constraint conditions of supporting structures are studied and some possible counterplans are discussed.

• Journal of Ocean Engineering and Technology
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• v.23 no.1
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• pp.158-163
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• 2009

Many longitudinal pipes in ships are subject to considerable loads, caused by hull girder bending in the ships and/or thermal loads in some special pipes through which fluids with highly abnormal temperatures are conveyed. As these loads may cause failure in the pipes or their supporting structures, loops have been widely adopted to prevent such failure, based on the idea that they can lower the stress level in a pipe byabsorbing some portion of these loads. But as the loops also have some negative effects, such as causing extra manufacturing cost, deteriorating the function of the pipe, and occupying extra space, the number and dimensions of these loops need to be minimized. This research developed design formulas for pipe loops, modeling them as a spring element, for which the axial stiffness is calculated based on the beam theory, incorporating the flexibility effect of the straight portion of the pipe. The accuracy of the proposed design formulas was verified by comparing two results obtained from the proposed formulas and MSC/NASTRAN. This paper concludes with a sample application of the proposed formulas, showing their efficiency.

• Proceedings of the KSME Conference
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• 2003.11a
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• pp.1637-1641
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• 2003

Korea Gas Corporation(KOGAS) is a Liquified Natural Gas(LNG) supplier through out the Korea. LNG, which is imported wholly from foreign countries, is compressed 1/600 for easy transportation and is stored in a liquid state in the storage tanks at Incheon, Pyeongtaek and Tongyeong. At LNG receiving terminals, LNG is vaporized to natural gas before supplying to City Gas Consumer of Power Plant. The secondary pump is a equipment which compress LNG from 1- kgf/cm2 to 70 kgf/cm2. The secondary pump at Tongyeong LNG receiving terminal is consisted of two pumps in one underground PIT, and is connected to supporting structures. It is therefore expected that there is a vibration problem whit the pump and was found that high level vibration was occurred in a low frequency band($5^{\sim}10Hz$). In this paper, the vibration of secondary pump was analyzed, and the main cause of vibration was found out.

• Journal of KIISE:Software and Applications
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• v.26 no.10
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• pp.1167-1167
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• 1999

Although spatial databases support an efficient spatial management on objects in the real world, they have a characteristic that process only spatial information valid at current time, So in case of change in the spatial domain, it is very hard to support an efficient historical management for time-varying spatial information because they delete an old value and then replace with new value that is valid at current time. To solve these problems, there are rapidly increasing of interest for spatiotemporal databases, which serve historical functions for spatial information as well as spatial management functions for an object. However most of them presented in an abstract time-varying spatial phenomenon, but have not presented a concrete policy in spatiotemporal databases. In this paper, we propose a spatiotemporal data model that supports bitemporal time concepts in three dimensional architecture. In the proposed model, not only data types and their operation for object of spatiotemporal databases have been classified, but also mathematical expressions using formal semantics for them have been given. Then, the data structures and their operations based on relational database model as well as object-oriented database model are presented.