• Biotechnology and Bioprocess Engineering:BBE
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• v.6 no.4
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• pp.212-230
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• 2001

Recent advances in recombinant DNA technology have resulted in development of many new protein drugs. Due to the unique properties of protein druges, they have to be delivered by parenteral injection Although delivery of protein drugs by other routes, such as pulmonary and nasal routes, has shown some promises, to date most protein drugs are administered by par-enteral routs. For long-term delivery of protein drugs by parenteral administration, they have been formulated into biodegradable microspheres. A number of microencapsulation methods have been developed, and the currently used microencapsulation methods are reviewed here, The microen-capsulation methods have been divided based on the method used. They are: solvent evapora-tion/extraction; phase separation (coacervation);spray drying; ionotropic gelation/polyelectrolyte complexation; interfacial polyumerization and supercritical fluid precipitation. Each method is de-scribed fro its applications, advantages, and limitations.

• Journal of Electrical Engineering and Technology
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• v.6 no.3
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• pp.423-430
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• 2011

Multi-input multi-output (MIMO) dynamic matrix control (DMC) technique is applied to control steam temperatures in a large-scale ultrasupercritical once-through boiler-turbine system. Specifically, four output variables (i.e., outlet temperatures of platen superheater, finish superheater, primary reheater, and finish reheater) are controlled using four input variables (i.e., two spray valves, bypass valve, and damper). The step-response matrix for the MIMO DMC is constructed using the four input and the four output variables. Online optimization is performed for the MIMO DMC using the model predictive control technique. The MIMO DMC controller is implemented in a full-scope power plant simulator with satisfactory performance.

• Journal of ILASS-Korea
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• v.9 no.4
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• pp.83-89
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• 2004

Vaporization characteristics of a liquid heptane droplet in high-pressure and temperature flow field are numerically studied. Variable thermodynamic and transport properties and high-pressure effects are taken into account in order to consider real gas effects. Droplet Vaporization in convective environments was investigated on the basis of droplet vaporization in quiescent and convective environment. In quiescent environments, droplet lifetime is directly proportional to pressure at the subcritical temperature range but it is inversely proportional to pressure at the supercritical temperature range. In convective environment, droplet deformation becomes stronger by increasing Reynolds number due to increase of velocity while droplet deformation is relatively weak at a higher pressure for the same Reynolds number cases.

• Journal of ILASS-Korea
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• v.26 no.4
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• pp.171-181
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• 2021

This study presents a prediction methodology of thermodynamic properties by using RK-PR Equation of State in a wide range of temperature and pressure conditions including both sub-critical and super-critical regions, in order to obtain thermophysical properties for hydrocarbon aviation fuels and their products resulting from endothermic reactions. The density and the constant pressure specific heat are predicted in the temperature range from 300 to 1000 K and the pressure from 0.1 to 5.0 MPa, which includes all of the liquid and gas phases and the super-critical region of three representative hydrocarbon fuels, and then compared with those data obtained from the NIST database. Results show that the averaged relative deviations of both predicted density and constant pressure specific heat are below 5% in the specified temperature and pressure conditions, and the major sources of the errors are observed near the saturation line and the critical point of each fuel.

• Journal of ILASS-Korea
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• v.27 no.2
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• pp.66-76
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• 2022

This study presents a prediction methodology of transport properties using the methane-based TRAPP (m-TRAPP) method in a wide range of temperature and pressure conditions including both subcritical and supercritical regions, in order to obtain thermo-physical properties for hydrocarbon aviation fuels and their products resulting from endothermic reactions. The viscosity and thermal conductivity are predicted in the temperature range from 300 to 1000 K and the pressure from 0.1 to 5.0 MPa, which includes all of the liquid, gas, and the supercitical regions of representative hydrocarbon fuels. The predicted values are compared with those data obtained from the NIST database. It was demonstrated that the m-TRAPP method can give reasonable predictions of both viscosity and thermal conductivity in the wide range of temperature and pressure conditions studied in this paper. However, there still exists large discrepancy between the current data and established values by NIST, especially for the liquid phase. Compared to the thermal conductivity predictions, the calculated viscosities are in better agreement with the NIST database. In order to consider a wide range of conditions, it is suggested to select an appropriate method through further comparison with another improved prediction methodologies of transport properties.

• The Korea Journal of Herbology
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• v.28 no.4
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• pp.71-76
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• 2013

Objectives : The biological activities and compound contents of herbal medicine vary depending on manufacturing processes. In this study, we compared anti-inflammatory effects and compound contents of three kinds of multi-herbal extract HT008 produced by different manufacturing processes in order to determine chemical and biological equivalence. Methods : HT008 was produced by three different manufacturing methods: 1. Freeze dried extract of Eleutherococcus senticosus, Scutellaria baicalensis and Angelica sinensis (HT008 FD), 2. Spray dried extract of E. senticosus and S. baicalensis combined with reflux extract of A. sinensis (HT008 SD), 3. Spray dried extract of E. senticosus and S. baicalensis combined with supercritial fluid extract of A. sinensis (HT008 SF). Anti-inflammatory effects were evaluated using acetic acid induced pain model and ${\lambda}$-carageenan induced paw edema model. Compound contents were evaluated by HPLC quantitative analysis of standard compounds of HT008, eleutheroside E, baicalin, z-ligustilide. Results : HT008 FD, HT008 SD and HT008 SF significantly decreased acetic acid induced pain index and ${\lambda}$-carrageenan induced paw edema volume compared with that of control group. There was no significant difference in efficacy among the HT008 FD, HT008 SD and HT008 SF. Standard compound contents of HT008 FD, HT008 SD and HT008 SF were quantified within the range of Korean pharmacopoeia or other research. Conclusions : Three different manufacturing methods of multi-herbal extracts have been developed without noticeable difference in the efficacy or compound contents. The results might be used to establish manufacturing process and industrialization of herbal extracts.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.47 no.6
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• pp.22-40
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• 2015

Cellulose fibers is one of the most abundant in nature. It has many distinctive features: abundant in nature, biodegradable, non-toxic, eco-friendly, sustainable, easy to fabricate, hydrophilic, and cost-effective. Cellulose fibers, known as pulp, is produced from cellulose-containing materials by the pulping process. As the raw material, wood has been most commonly used while recycled pulp has been also used to some degree. Thus, pulp usually refers to wood pulp. Generally, the pulp and paper industry is regarded as the commodity market where the cost should be much more important than the quality. It also belongs to a mature market where the growth is slow, or even in decline. Accordingly, technological development has been rather stagnant for the industry. Recently, however, the pulp and paper industry has faced very serious challenges. First, due to digital technology, there has been a steady decline in the need for pulp and paper products. The digital industry has continuously replaced printed products such as books, newspapers, and magazines. Second, there has been a trend initiated by developed countries to limit the use of wood as the raw material for the sake of environmental protection. This forces the industry to find a more efficient use of wood pulp as well as finding alternative, non-wood sources. Third, as an individual becomes wealthier and more conscious of health-care, the quality of a product becomes more important than the cost. Thus, a paradigm shift is needed from the cost-conscientious to the quality conscientious. The objective of this article is to review the technologies aimed at engineering cellulose fibers for producing high-value added paper products.