• 한국구조물진단유지관리공학회 논문집
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• 제25권6호
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• pp.209-217
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• 2021

이 논문은 고강도 후크형 강섬유 보강량과 형상비에 따른 콘크리트의 압축 및 휨 성능에 미치는 영향에 대하여 다룬다. 이를 위하여 총 10개 콘크리트 배합이 계획되었다. 설계기준강도 30 MPa인 콘크리트에 형상비(l/d)가 64, 67, 80인 강섬유를 0.25%, 0.50%, 0.75% 혼입하여 강섬유 보강콘크리트가 제조되었다. 형상비 64, 67, 80인 강섬유의 인장강도는 각각 2,000, 2,400, 2,100 MPa이다. 시험 결과로부터 고강도 후크형 강섬유의 혼입량은 콘크리트의 압축 및 휨 성능에 영향을 미치는 것으로 나타났다. 강섬유 혼입량이 증가함에 따라 푸아송비 및 압축인성은 향상되었으나 콘크리트의 압축강도 및 탄성계수에 큰 변화를 보이지 않았다. 강섬유 보강 콘크리트의 균열발생후 휨거동의 특성을 나타내는 잔여 휨강도 및 노치에서 시작된 균열면에서 에너지 소산능력은 강섬유의 혼입률 및 형상비에 따라 크게 좌우되었다. 특히 MC2010에서 정의된 사용 및 극한 상태한계에서의 잔여 휨강도는 강섬유 혼입량과 형상비가 증가함에 따라 증가되었다.

• Journal of Ginseng Research
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• 제46권6호
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• pp.759-770
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• 2022

Background: Aerobic cellular respiration provides chemical energy, adenosine triphosphate (ATP), to maintain multiple cellular functions. Sirtuin 1 (SIRT1) can deacetylate peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) to promote mitochondrial biosynthesis. Targeting energy metabolism is a potential strategy for the prevention and treatment of various diseases, such as cardiac and neurological disorders. Ginsenosides, one of the major bioactive constituents of Panax ginseng, have been extensively used due to their diverse beneficial effects on healthy subjects and patients with different diseases. However, the underlying molecular mechanisms of total ginsenosides (GS) on energy metabolism remain unclear. Methods: In this study, oxygen consumption rate, ATP production, mitochondrial biosynthesis, glucose metabolism, and SIRT1-PGC-1α pathways in untreated and GS-treated different cells, fly, and mouse models were investigated. Results: GS pretreatment enhanced mitochondrial respiration capacity and ATP production in aerobic respiration-dominated cardiomyocytes and neurons, and promoted tricarboxylic acid metabolism in cardiomyocytes. Moreover, GS clearly enhanced NAD⁺-dependent SIRT1 activation to increase mitochondrial biosynthesis in cardiomyocytes and neurons, which was completely abrogated by nicotinamide. Importantly, ginsenoside monomers, such as Rg1, Re, Rf, Rb1, Rc, Rh1, Rb2, and Rb3, were found to activate SIRT1 and promote energy metabolism. Conclusion: This study may provide new insights into the extensive application of ginseng for cardiac and neurological protection in healthy subjects and patients.

• 대한본초학회지
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• 제36권6호
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• pp.1-8
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• 2021

Objectives : Atractylodis rhizoma Alba has been traditionally used as a medicinal resource that is used for enhancing Qi (氣) in traditional medicine in Korea, China, and Japan. This study investigated the protective effects of Atractylodis rhizoma Alba extract (ARE) against trimethyltin (TMT), a neurotoxin that causes selective hippocampal injury, using both in vitro and in vivo models. Methods : We investigated the effects of ARE on TMT- (5mM) induced cytotoxicity in primary cultures of mouse hippocampal cells (7 days in vitro ) and on hippocampal injury in C57BL/6 mice injected with TMT (2.6 mg/kg). Results : We observed that ARE treatment (0 - 50 ㎍/mL) significantly reduced TMT-induced cytotoxicity in cultured hippocampal neurons in a dose-dependent manner, based on results of lactate dehydrogenase and 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide assays. Additionally, this study showed that orally administered ARE (5 mg/kg; between -6 and 0 days before TMT injection) significantly attenuated seizures in adult mice. Furthermore, quantitative analysis of allograft inflammatory factor-1 (Iba-1)- and glial fibrillary acidic protein (GFAP)- positive cells showed significantly reduced levels of Iba-1- and GFAP-positive cell bodies in the dentate gyrus of mice treated with ARE prior to TMT injection. These findings indicate the significant protective effects of ARE against the TMT-induced massive activation of microglia and astrocytes in the hippocampus. Conclusions : We conclude that ARE minimizes the detrimental effects of TMT-induced hippocampal neurotoxicity, both in vitro and in vivo . Our findings may serve as useful guidelines to support ARE administration as a promising pharmacotherapeutic approach to hippocampal degeneration.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2022년도 추계학술대회
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• pp.74-74
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• 2022

본 연구는 붉나무의 기능성 성분의 산업화 활용을 위한 고품질의 붉나무 1년생 용기묘 대량생산을 위해 실시되었다. 붉나무 1년생 용기묘의 묘목품질의 향상을 위해 다양한 농도의 시비처리하여 우량묘 생산에 적합한 시비수준을 구명하고자 하였다. 시비실험은 무시비구 포함하여 수용성 복합비료 (N:P:K=20:20:20, v/v)를 1,000mg·L^-1, 2,000mg·L^-1, 3,000mg·L^-1 수준으로 실시하였다. 시비처리는 붉나무 용기묘의 간장과 근원경 생장은 1,000mg·L^-1 시비처리구에서 생장이 가장 좋게 나타났으며 시비수준이 증가할수록 감소하는 경향을 보였다. 뿌리형태 특성분석에서도 전체뿌리길이, 투영단면적, 표면적 및 뿌리부피가 간장과 근원경 생장과 동일한 경향을 보이는 것으로 조사되었다. 건물 생산량은 부위별 잎, 줄기, 뿌리 및 전체가 모두 1,000mg·L^-1 시비처리구에서 가장 높았으며, 그 이상의 시비수준에서는 점점 감소하는 경향을 보였다. H/D(Hight/Root collar diameter)율은 전체가 3.82(무시비구) ~ 4.90, T/R(Top/Root)율은 전체가 0.56(1,000mg·L^-1 시비처리구) ~ 0.82로 조사되었다. 시비처리 에 의한 붉나무의 LWR(Leaf dry weight ratio)은 무시비구, SWR(Shoot dry weight ratio)은 3,000mg·L^-1 시비처리구, 그리고 RWR(Root dry weight ratio)은 1,000mg·L^-1 시비처리구에서 유의적 차이를 보이며 높게 나타났다. 묘목품질지수(QI)의 경우 1,000mg·L^-1 시비처리구에서 12.13으로 다른 시비수준들보다 월등히 높았다. 본 실험의 결과를 종합하면, 뿌리발달이 좋은 우량한 붉나무 생산에 적절한 시비수준은 1,000mg·L^-1 정도인 것으로 판단된다.

• Smart Structures and Systems
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• 제32권4호
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• pp.267-279
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• 2023

Data modelling and interpretation for structural health monitoring (SHM) field data are critical for evaluating structural performance and quantifying the vulnerability of infrastructure systems. In order to improve the data modelling accuracy, and extend the application range from data regression analysis to out-of-sample forecasting analysis, an improved most likely heteroscedastic Gaussian process (iMLHGP) methodology is proposed in this study by the incorporation of the outof-sample forecasting algorithm. The proposed iMLHGP method overcomes this limitation of constant variance of Gaussian process (GP), and can be used for estimating non-stationary typhoon-induced response statistics with high volatility. The first attempt at performing data regression and forecasting analysis on structural responses using the proposed iMLHGP method has been presented by applying it to real-world filed SHM data from an instrumented cable-stay bridge during typhoon events. Uncertainty quantification and correlation analysis were also carried out to investigate the influence of typhoons on bridge strain data. Results show that the iMLHGP method has high accuracy in both regression and out-of-sample forecasting. The iMLHGP framework takes both data heteroscedasticity and accurate analytical processing of noise variance (replace with a point estimation on the most likely value) into account to avoid the intensive computational effort. According to uncertainty quantification and correlation analysis results, the uncertainties of strain measurements are affected by both traffic and wind speed. The overall change of bridge strain is affected by temperature, and the local fluctuation is greatly affected by wind speed in typhoon conditions.

• 동의신경정신과학회지
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• 제34권4호
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• pp.335-347
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• 2023

Objectives: The study aimed to understand the current treatment patterns in Korean medicine to develop clinical practice guidelines for autonomic dysfunction in Korean medicine. Methods: This study sent an online survey vai text message to 25,900 Korean medicine doctors whose contact information was registered with the Association of Korean Medicine. A total of 1,410 Korean medical doctors completed the online survey. Results: When autonomic treating dysfunction clinically, 77% of the cases included only a description without entering a diagnosis code. The most commonly used information to diagnose o autonomic dysfunction was history-taking and symptoms (79%), and the main symptoms of autonomic dysfunction were palpitations, dizziness, sleeping difficulties, anxiety/nervousness, and depression/lethargy. The most frequently mentioned cause of autonomic dysfunction was mental problems (54%). The most commonly used Korean medicine treatment method for autonomic dysfunction was herbal medicine (70%), and Soyo-san/Gamisoyo-san is the most frequently used herbal medicine preparation. Liver qi depression used to indicate the most often mentioned Korean medicine pattern identification used to indicate autonomic dysfunction (31%). When asked whether cardiac neurosis in Chinese medicine can be considered autonomic dysfunction, opinions for and against it are determined almost equally. Conclusions: Our results serve are a foundation for developing clinical practice guidelines for autonomic dysfunction in Korean medicine and are expected to catalyst promoting future clinical research on autonomic dysfunction.

• Korean Journal of Radiology
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• 제24권12호
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• pp.1221-1231
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• 2023

Objective: To clinically validate the feasibility and accuracy of cine images acquired through the multitasking method, with no electrocardiogram gating and free-breathing, in measuring left ventricular (LV) function indices by comparing them with those acquired through the balanced steady-state free precession (bSSFP) method, with multiple breath-holds and electrocardiogram gating. Materials and Methods: Forty-three healthy volunteers (female:male, 30:13; mean age, 23.1 ± 2.3 years) and 36 patients requiring an assessment of LV function for various clinical indications (female:male, 22:14; 57.8 ± 11.3 years) were enrolled in this prospective study. Each participant underwent cardiac magnetic resonance imaging (MRI) using the multiple breath-hold bSSFP method and free-breathing multitasking method. LV function parameters were measured for both MRI methods. Image quality was assessed through subjective image quality scores (1 to 5) and calculation of the contrast-to-noise ratio (CNR) between the myocardium and blood pool. Differences between the two MRI methods were analyzed using the Bland-Altman plot, paired t-test, or Wilcoxon signed-rank test, as appropriate. Results: LV ejection fraction (LVEF) was not significantly different between the two MRI methods (P = 0.222 in healthy volunteers and P = 0.343 in patients). LV end-diastolic mass was slightly overestimated with multitasking in both healthy volunteers (multitasking vs. bSSFP, 60.5 ± 10.7 g vs. 58.0 ± 10.4 g, respectively; P < 0.001) and patients (69.4 ± 18.1 g vs. 66.8 ± 18.0 g, respectively; P = 0.003). Acceptable and comparable image quality was achieved for both MRI methods (multitasking vs. bSSFP, 4.5 ± 0.7 vs. 4.6 ± 0.6, respectively; P = 0.203). The CNR between the myocardium and blood pool showed no significant differences between the two MRI methods (18.89 ± 6.65 vs. 18.19 ± 5.83, respectively; P = 0.480). Conclusion: Multitasking-derived cine images obtained without electrocardiogram gating and breath-holding achieved similar image quality and accurate quantification of LVEF in healthy volunteers and patients.

• 대한한방소아과학회지
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• 제38권3호
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• pp.53-65
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• 2024

Objectives This study aimed to analyze herbal formulas for epilepsy recorded in nine herbal manuscripts regulated by the Ministry of Food and Drug Safety (MFDS). The goal was to identify the frequency and associations of the included herbs and to determine effective herbal combinations for epilepsy treatment. Methods The study analyzed formulas for epilepsy (癲癎) from nine herbal manuscripts regulated by the MFDS: 東醫寶鑑, 方藥合編, 鄕藥集成方, 景岳全書, 醫學入門, 濟衆新編, 廣濟秘笈, 東醫壽世保元, and 本草綱目. We examined the frequency of herbs, herb pairs, and their degree centrality within the network using Netminer 4.5. Results The analysis identified 143 different herbs across the 159 formulas. Frequently included herbs were 朱砂, 人蔘, 天南星, 麝香, 茯笭. The most common herb pairs included 朱砂-麝香, 茯笭-人蔘, 朱砂-天南星, 朱砂-人蔘, 朱砂-遠志, 半夏-天南星. Network analysis revealed four distinct clusters: Group 1 (tranquillizing by heavy settling and opening the orifices), Group 2 (dispelling phlegm and regulating qi), Group 3 (tonifying and tranquillizing), and Group 4 (pacifying the liver and extinguishing wind). Conclusion The herbal formulas for epilepsy in the nine MFDS-regulated manuscripts have antiepileptic effects through central nervous system sedation and neuroprotective actions.

• Journal of Acupuncture Research
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• 제17권1호
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• pp.27-41
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• 2000

The meridian system is the most essential and basic connecting structure that maintains the vital activities of viscera and bowels by connecting them with each part of body's surface. Doctors can understand the healthy condition, and the region and deficiency-excessiveness of disease by observing the condition of Qi flowing. Deficiency and excessiveness could be differentiated by various symptoms expressed in meridian system. Especially there could be several clues like pain, heat-cold, protuberance-depression, change of color and shine in the line of channel leads to the judgment of deficiency-excessiveness The diagnosis of deficiency and excessiveness can be generalized by quantification of elastic status in skin surface along the meridian system. By comparing data from measurement of elastic condition with those from traditional deficiency and excessiveness, it could be utilized for the development of oriental medicine. All biological activities in the human body are based on meridian system according to the oriental medicine. Also the meridian system is viewed as basic and essential structure connecting internal viscera and each part of body. The areas of expressed channel phenomena are muscle to bone, muscle to muscle and bone to bone. These areas are called depression where meridian system is present and any changing state on those points can be measured. It could be difficult in diagnosing the reaction of meridian system because doctor can depend on his own judgment. Therefore, it is necessary to quantify and indexate channel reactions. To quantify the channel reactions, specially manufactured instrument was used to quantify the protuberance and depression to differentiate the deficiency and excessiveness. The results follow as below; 1. The elastic index measurement by the equipment proved a pattern of agreement showing the values that ranged within standard deviation 0.05kgf/cm throughout the experiment except few cases' measurement in CV-17. 2. To evaluate the state of deficiency & excessiveness of elastic index measurements in frontal point, elastic index measurements in the front paint were compared to the elastic index measured surrounding the point within 2.5 cm. Such result of indexing procedure was closely matched to the concept of palpitation. 3. If the elastic index values in the surrounding front point closely located to the elastic index values in the front point, the judgement on the state of deficiency and excessiveness was delayed. Otherwise, it was judged as deficiency or excessiveness. 4. Out of total 12 cases of comparing the elastic index values to the elastic index values in the surrounding front point, Three to nine front points were judged as either in the state of deficiency or excessiveness. 5. Among the nine front points judged as either in the state of deficiency or excessiveness, Four cases were matched to the electric index measured by EAV that evaluating the internal organs by five different phases. If more clinical cases are accumulated, it is expected to systematically theorize and improve the concept of deficiency and excessiveness in the internal organs using the front point.

• 한국해양학회지:바다
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• 제19권3호
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• pp.169-179
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• 2014

황해 남동부 해역에 설치한 해양부이(YSROB)에서 약 27개월간 관측된 장파, 단파 복사량을 포함한 대기, 해양 변수와 COARE 3.0 알고리즘을 이용하여 월평균 해양-대기간 열속을 산출하고 기존 연구결과와 비교하였다. YSROB 위치에서 열속은 순 단파복사(Qi)에 의해 해양은 대기로부터 열을 얻고 순 장파복사($Q_b$), 현열($Q_h$), 잠열($Q_e$)에 의해서 열손실이 일어난다. 전체 열손실 중 $Q_e$에 의한 손실이 51%로 가장 크게 나타났으며 $Q_b$와 $Q_h$에 의한 손실은 각각 34%, 15% 이다. 순열속($Q_n$)은 $Q_i$가 최대인 5월에 최대($191.4W/m^2$)이며 모든 열속 성분이 최소인 12월에 최소($-264.9W/m^2$)이다. 연평균 $Q_n$은 $1.9W/m^2$ 이지만 관측기기의 정확도에 의한 오차산정 결과(최대 ${\pm}19.7W/m^2$)를 고려하면 무시할 정도로 작다. YSROB과 동일한 위치에서의 기존 월별 열속 산출 결과는 YSROB에서 실측값에 기반한 열속에 비해 여름철 $Q_i$가 약 $10{\sim}40W/m^2$ 과소 평가된 반면에 겨울철에는 $Q_e$와 $Q_h$에 의한 열 손실이 각각 약 $50W/m^2$, $30{\sim}70W/m^2$ 과다하게 산출되었다. 이로 인하여 해양이 열을 얻는 4월~8월에는 기존 연구에서의 열 획득량이 본 연구 결과보다 적게 나타나며, 해양이 열을 잃는 겨울철에는 기존 연구에서의 해양으로부터의 열 손실이 본 연구 결과에 비해 크게 나타난다. 특히, 12월과 1월의 $Q_n$ 차이는 약 $70{\sim}130W/m^2$에 달한다. 장기적인 재분석장(MERRA) 분석 결과에 의하면 이와 같은 월평균 열속의 차이는 연변동 등 시간 변동에 의한 것이 아니라 열속 산출 시 사용된 자료의 부정확성에 기인하는 것으로 판단된다. 본 연구 결과로부터 기존의 기후적인 열속을 연구에 활용하거나 수치모델에 사용함에 있어 주의가 요망된다.